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Randomized Controlled Phase 2a Study of RPh201 in Previous Nonarteritic Anterior Ischemic Optic Neuropathy
https://journals.lww.com/jneuro-ophthalmology/Abstract/publishahead/Randomized_Controlled_Phase_2a_Study_of_RPh201_in.99147.aspx
Rath, E. et. al.

Jul 21st, 2019 - Background: No proven treatment exists for nonarteritic anterior ischemic optic neuropathy (NAION), either in the acute or late phase. Objective: To assess safety and changes in visual function and structure after RPh201/placebo treatment in participants with previous NAION. Design and Setting: Phase 2a, single-site, prospective, randomized, placebo-controlled, double-masked trial (regist...

Daily headaches • associated nausea • obesity • Dx?
https://www.mdedge.com/familymedicine/article/198204/neurology/page/0/1?channel=258
MDedge Family Medicine;

Apr 4th, 2019 - Recently, a classification of IIH without papilledema has been acknowledged by the International Headache Society. 2,8 Specific MRI findings have been suggested to help make this diagnosis5,9 (TABLE 55).

Optic-nerve-sheath Meningioma Commonly Misdiagnosed as Optic Neuritis
https://www.medscape.com/viewarticle/906905

Dec 30th, 2018 - NEW YORK (Reuters Health) - A variety of errors contributes to the common initial misdiagnosis of optic-nerve-sheath meningioma (ONSM) as optic neuritis, researchers have found. ONSM classically presents as the triad of progressive visual loss, optic atrophy and the presence of retinal-choroidal collaterals, but it is rare that all three findings occur simultaneously. Still, timely diagnosis an...

Does a Patient's Blurry Vision Signal a Serious Condition?
https://www.medscape.com/viewarticle/906081

Dec 10th, 2018 - Clinical Presentation A 38-year-old white woman came to the emergency room complaining of painful, blurry vision in the left eye for 2 weeks. A review of her symptoms uncovered an episode of right arm numbness 2 years prior that resolved after 1 week. There were no bowel or bladder symptoms. Her past medical history was unremarkable. She takes no medications, has no allergies, and doesn't smoke...

Idiopathic Intracranial Hypertension in Pregnancy
https://www.mdedge.com/fedprac/article/104174/womens-health/idiopathic-intracranial-hypertension-pregnancy/page/0/2?channel=104

Nov 12th, 2015 - In patients with rapidly progressive vision loss but with minimal headache, optic nerve sheath fenestration (ONSF) is the surgical treatment of choice. 2,3,6 In this procedure, a window or series of slits are created behind the globe in the optic nerve sheath.

Case Report: Recurrent Sagittal Sinus Thrombosis
https://www.mdedge.com/emergencymedicine/article/97336/mental-health/case-report-recurrent-sagittal-sinus-thrombosis/page/0/1?channel=248

Feb 1st, 2015 - Symptoms and Signs Common symptoms and signs of CVST include headache, nausea, vomiting, seizure, and focal neurological deficit. Papilledema is present in 40% of cases, primarily in patients with delayed diagnosis or a chronic course.

Acetazolamide, Low-Cal Diet Help Intracranial Hypertension
https://www.medscape.com/viewarticle/827821

Jul 2nd, 2014 - LOS ANGELES — Patients with idiopathic intracranial hypertension (IIH) who are treated with acetazolamide and follow a weight-loss diet have significantly improved visual field function, papilledema grade, quality of life, and cerebrospinal fluid pressure, and the treatment is well tolerated, according to results of new multicenter, randomized, placebo-controlled study. Although patients follow...

Drug Improves Vision in Idiopathic Intracranial Hypertension
https://www.medscape.com/viewarticle/824073

Apr 23rd, 2014 - Acetazolamide modestly improved vision in patients with idiopathic intracranial hypertension (IIH) and mild vision loss in a new study. "This is the first strong evidence that the drug works in this condition," Michael Wall, MD, from the University of Iowa, Iowa City, told Medscape Medical News. He added: "Acetazolamide has been shown effective before at reducing spinal pressure but not for imp...

Elderly Diabetics at More Risk of Anterior Ischemic Optic Neuropathy
https://www.medscape.com/viewarticle/740852

Apr 17th, 2011 - By David Douglas NEW YORK (Reuters Health) Apr 14 - Diabetes mellitus significantly increases the risk of nonarteritic anterior ischemic optic neuropathy (NAION) in the elderly, researchers reported March 24th online in Ophthalmology. This is the first study to show that the incidence of NAION is increased among diabetics, coauthor Dr. Michael S. Lee told Reuters Health by email. "The annual in...

Anterior Ischemic Optic Neuropathy 'Possible' Side Effect of Interferon
https://www.medscape.com/viewarticle/726364

Aug 5th, 2010 - By Frederik Joelving NEW YORK (Reuters Health) Aug 04 - Interferon alpha therapy might rarely be linked with anterior ischemic optic neuropathy (AION), a new case series suggests. "It's probably a real side effect but I can only classify it as 'possible' right now," said Dr. Rick W. Fraunfelder of the Oregon Health and Science University Casey Eye Institute, who co-wrote the article with his fa...

AAN 2009: Weight Loss Proves Successful in Relieving Idiopathic Intracranial Hypertension
https://www.medscape.com/viewarticle/702157

Apr 29th, 2009 - April 30, 2009 (Seattle, Washington) — Weight loss in obese patients with idiopathic intracranial hypertension (IIH) reduces intracranial pressure (ICP), eases headaches, and improves papilledema, according to a new study. The trial is the first to conclusively show that weight loss reduces ICP in patients with IIH, a condition characterized by pressure in the subarachnoid space, which can lead...

The Relationship Between Nonarteritic Anterior Ischemic Optic Neuropathy and Refractive Error
https://www.medscape.com/viewarticle/585615

Jan 4th, 2009 - Introduction Nonarteritic anterior ischemic optic neuropathy (NAION) is the most common acute optic neuropathy in patients older than the age of 50 years. Although the precise cause is not known, vascular risk factors, including hypertension, diabetes mellitus, and hypercholesterolemia are thought to predispose the patient to ischemia of the optic nerve head. Despite these conditions, another i...

NAION and the Optic Disc
https://www.medscape.com/viewarticle/580437

Oct 1st, 2008 - Introduction Nonarteritic anterior ischemic optic neuropathy (NAION) is the most common acute optic neuropathy occurring in patients older than the age of 50 years. Optic disc edema is accompanied by variable loss of visual acuity, field, and color vision. The premorbid configuration of the optic disc has been noted to be an important risk for the development of NAION, with most patients having...

Restoring sexual function: Which medications show benefit?
https://www.mdedge.com/authors/colm-oherlihy-md-frcog

Jun 1st, 2008 - Table 2 Duration of action of PDE-5 inhibitors Drug Duration Sildenafil 4 hours Vardenafil 4 hours Tadalafil 24 to 36 hours PDE-5: phosphodiesterase type 5 Cases of sudden loss of hearing or vision (nonarteritic anterior ischemic optic neuropathy) have been associated with PDE-5 inhibitor use. 10,11 To date, there is insufficient evidence to determine if these adverse events are chance associat.

The Natural History of NAION
https://www.medscape.com/viewarticle/572717

Apr 20th, 2008 - Introduction Nonarteritic anterior ischemic optic neuropathy (NAION) is the most common acute optic neuropathy occurring in patients older than 50 years of age. Despite an increasing amount of research into the condition, there remains no definitive treatment for NAION. The Ischemic Optic Neuropathy Decompression Trial (IONDT) provided a wealth of information on ischemic optic neuropathy, inclu...

Anterior Ischemic Optic Neuropathy in Young Patients
https://www.medscape.com/viewarticle/569631

Feb 11th, 2008 - Introduction Anterior ischemic optic neuropathy (AION) classically occurs in patients older than 55 years. In these patients, optic hypoperfusion and infarction lead s to vision loss.[1,2,3] This study focused on patients younger than age 50, a group previously not described in detail. Anterior Ischemic Optic Neuropathy in Patients Younger than 50 Years Preechawat P, Bruce BB, Newman NJ, Biouss...

Characteristics of Younger Patients With AION
https://www.medscape.com/viewarticle/567000

Jan 7th, 2008 - Introduction Nonarteritic anterior ischemic optic neuropathy (NAION), which comprises 95% of AION, is the most common acute optic neuropathy in patients older than the age of 50 years. The pathogenesis of NAION remains unclear but may involve ischemia to the optic nerve head from insufficient perfusion of the short posterior ciliary arteries.[1] Although vascular risk factors have been identifi...

Reactivation of Graves' Orbitopathy
https://www.medscape.com/viewarticle/560116

Aug 9th, 2007 - Introduction Thyroid-related orbitopathy (TRO) or Graves' orbitopathy can present with proptosis and compressive optic neuropathy in severe cases. Although medical therapy, including corticosteroids and radiation therapy, are effective in select scenarios, bony orbital decompression is the surgical treatment of choice for stable proptosis or compressive optic neuropathy that is poorly responsiv...

Identifying Lesion Locations in the Eye
https://www.medscape.com/viewarticle/557411

Jul 4th, 2007 - Introduction With few exceptions, lesions posterior to the optic chiasm cause visual field loss within the same side of the visual field, or homonymous visual field defects.[1,2] Complete lesions involving the optic tract, lateral geniculate nuclear, or cortical projections from the lateral geniculate cause complete homonymous hemianopias (HH) which generally do not have additional localizing v...

Author's Reply to "Reader's Response to 'There Have Been Inadequate Warnings That Erectile Dysfunction Drugs Can Cause Blindness'"
https://www.medscape.com/viewarticle/524972

Mar 19th, 2006 - To the Editor, In addition to our study showing an 18-fold increased rate of reports to the FDA [US Food and Drug Administration] of nonarteritic anterior ischemic optic neuropathy (NAION) per million prescriptions with sildenafil (Viagra) compared with atorvastatin (Lipitor),[1] a recent case-control study found that for those men with either hypertension or a history of myocardial infarction ...