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About 1,507 results

ALLMedicine™ Von Hippel-Lindau Disease Center

Research & Reviews  743 results

Impact of Pancreatic Neuroendocrine Tumor on Mortality in Patients with von Hippel-Lind...
https://doi.org/10.1016/j.eprac.2021.03.005
Endocrine Practice : Official Journal of the American Col... Arnon L, Halperin R et. al.

Mar 19th, 2021 - The main causes for morbidity and mortality in von Hippel-Lindau (VHL) disease are central nervous system hemangioblastoma and clear cell renal cell carcinoma, whereas the effect of VHL-related pancreatic neuroendocrine tumors (PNET) on patient ou...

Multiple Hepatic and Pulmonary Tumours Combined with Bilateral Adrenal Masses in a Youn...
https://doi.org/10.1053/j.gastro.2021.02.033
Gastroenterology Kolokotronis T, Reis H

Feb 21st, 2021 - Multiple Hepatic and Pulmonary Tumours Combined with Bilateral Adrenal Masses in a Young Female with von Hippel-Lindau Disease.|2021|Kolokotronis T,Reis H,|

Retrobulbar Hemangioblastomas in von Hippel-Lindau Disease: Clinical Course and Managem...
https://doi.org/10.1093/neuros/nyaa565
Neurosurgery Alvarez R, Mastorakos P et. al.

Jan 14th, 2021 - Retrobulbar hemangioblastomas involving the optic apparatus in patients with von Hippel-Lindau disease (VHL) are rare, with only 25 reported cases in the literature. To analyze the natural history of retrobulbar hemangioblastomas in a large cohort...

Algorithmic assessment of missense mutation severity in the Von-Hippel Lindau protein.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644048
PloS One; Fields FR, Suresh N et. al.

Nov 5th, 2020 - Von Hippel-Lindau disease (VHL) is an autosomal dominant rare disease that causes the formation of angiogenic tumors. When functional, pVHL acts as an E3 ubiquitin ligase that negatively regulates hypoxia inducible factor (HIF). Genetic mutations ...

Intronic mutation of the VHL gene associated with central nervous system hemangioblasto...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528461
BMC Medical Genetics; Liu Z, Zhou J et. al.

Oct 2nd, 2020 - Central nervous system (CNS) hemangioblastomas are the most frequent cause of mortality in patients with Von Hippel-Lindau (VHL) disease, an autosomal dominant genetic disease resulting from germline mutations in the VHL tumor suppressor gene, wit...

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Guidelines  1 results

Von Hippel-Lindau Disease (PDQ®)–Health Professional Version
https://www.cancer.gov/types/kidney/hp/renal-cell-carcinoma-genetics/vhl-syndrome?cid=eb_govdel
National Cancer Institute

Von Hippel-Lindau disease (VHL) is an autosomal dominant disease with a predisposition to multiple neoplasms. Germline pathogenic variants in the VHL gene predispose individuals to specific types of both benign and malignant tumors and cysts in ma...

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Clinicaltrials.gov  753 results

Impact of Pancreatic Neuroendocrine Tumor on Mortality in Patients with von Hippel-Lind...
https://doi.org/10.1016/j.eprac.2021.03.005
Endocrine Practice : Official Journal of the American Col... Arnon L, Halperin R et. al.

Mar 19th, 2021 - The main causes for morbidity and mortality in von Hippel-Lindau (VHL) disease are central nervous system hemangioblastoma and clear cell renal cell carcinoma, whereas the effect of VHL-related pancreatic neuroendocrine tumors (PNET) on patient ou...

Multiple Hepatic and Pulmonary Tumours Combined with Bilateral Adrenal Masses in a Youn...
https://doi.org/10.1053/j.gastro.2021.02.033
Gastroenterology Kolokotronis T, Reis H

Feb 21st, 2021 - Multiple Hepatic and Pulmonary Tumours Combined with Bilateral Adrenal Masses in a Young Female with von Hippel-Lindau Disease.|2021|Kolokotronis T,Reis H,|

Retrobulbar Hemangioblastomas in von Hippel-Lindau Disease: Clinical Course and Managem...
https://doi.org/10.1093/neuros/nyaa565
Neurosurgery Alvarez R, Mastorakos P et. al.

Jan 14th, 2021 - Retrobulbar hemangioblastomas involving the optic apparatus in patients with von Hippel-Lindau disease (VHL) are rare, with only 25 reported cases in the literature. To analyze the natural history of retrobulbar hemangioblastomas in a large cohort...

Algorithmic assessment of missense mutation severity in the Von-Hippel Lindau protein.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644048
PloS One; Fields FR, Suresh N et. al.

Nov 5th, 2020 - Von Hippel-Lindau disease (VHL) is an autosomal dominant rare disease that causes the formation of angiogenic tumors. When functional, pVHL acts as an E3 ubiquitin ligase that negatively regulates hypoxia inducible factor (HIF). Genetic mutations ...

Intronic mutation of the VHL gene associated with central nervous system hemangioblasto...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528461
BMC Medical Genetics; Liu Z, Zhou J et. al.

Oct 2nd, 2020 - Central nervous system (CNS) hemangioblastomas are the most frequent cause of mortality in patients with Von Hippel-Lindau (VHL) disease, an autosomal dominant genetic disease resulting from germline mutations in the VHL tumor suppressor gene, wit...

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News  9 results

Fast Five Quiz: Can You Correctly Identify the Various Aspects of Renal Cell Carcinoma?
https://reference.medscape.com/viewarticle/826053_2

Aug 5th, 2019 - Von Hippel-Lindau disease is an autosomal dominant syndrome that confers predisposition to various neoplasms. Renal cell carcinoma develops in nearly 40% of patients with von Hippel-Lindau disease and is a major cause of death among these patients...

What is your diagnosis? - July 2019
https://www.mdedge.com/gihepnews/article/203798/what-your-diagnosis-july-2019?channel=27662
Wai See Ma, MD, Hadi Moattar, MD, MBChB, PhD

Jun 28th, 2019 - The diagnosis von Hippel-Lindau disease The diagnosis is von Hippel-Lindau disease (VHL). Subsequent brain and renal magnetic resonance imaging showed features suggestive of a 5-mm right cerebellar hemangioblastoma and right renal cell carcinoma (.

Pazopanib is active against renal, other neoplasms of von Hippel-Lindau disease
https://www.mdedge.com/hematology-oncology/article/176202/renal-cell-carcinoma/pazopanib-active-against-renal-other
Susan London

Oct 2nd, 2018 - The oral, multitargeted tyrosine kinase inhibitor pazopanib (Votrient) is active and safe in patients with renal cell carcinoma and other neoplasms caused by von Hippel-Lindau disease, a phase 2 trial has found. Eric Jonasch, MD, and his coinvesti.

VHL Alliance Publishes Suggested VHL Surveillance Guidelines
https://www.mdedge.com/neurology/article/118235/rare-diseases/vhl-alliance-publishes-suggested-vhl-surveillance-guidelines

Nov 7th, 2016 - The VHL Alliance has published suggested surveillance guidelines approved by the VHLA Clinical Advisory Council regarding testing for individuals at risk for von Hippel-Lindau disease (VHL) who do not yet have symptoms or those who are known to ha.

Integrating Genetic Counseling Into an Oncology Practice Can Benefit High-Risk Families
https://www.onclive.com/publications/oncology-business-news/2014/february-2014/integrating-genetic-counseling-into-an-oncology-practice-can-benefit-high-risk-families

Feb 25th, 2014 - Ellen T. Matloff, MS, CGC Genetic counseling—including testing and risk assessment—is one of the most rapidly growing areas of oncology and has become the standard of care for patients with a personal and family history of breast, ovary, or colon ...

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Patient Education  1 results see all →