ALLMedicine™ Best Disease Center

Aug 9th, 2022 - This study will establish a repository of biospecimens to generate induced pluripotent stem (iPS) cells, which will be used to determine molecular mechanisms for potentially blinding eye diseases including but not limited to: Best Vitelliform Dyst...

Mar 22nd, 2022 - To highlight cases of adult-onset bestrophinopathy mistaken as central serous chorioretinopathy (CSCR). Retrospective case series. Two unrelated adult males (54 years old and 43 years old) with serous macular detachments were managed as CSCR. One ...

Feb 1st, 2022 - The study is designed as a Phase II, multi-center double-blind trial that randomizes patients with high risk Multiple Myeloma to Ixazomib maintenance or placebo 60-120 days after allogeneic HSCT. The primary objective of this randomized trial is t...

Jan 6th, 2022 - The PI on this proposal has been studying BEST1 and the protein encoded (Best1) since its discovery in 1998. Best1 is an integral membrane protein that in the eye is expressed only by retinal pigment epithelial (RPE) cells where it is localized to...

Nov 23rd, 2021 - To report clinical and multimodal imaging features of Best disease in patients presenting with subretinal pigment epithelium hyperreflective lesions. Retrospective study. Clinical examination findings and multimodal imaging features, including col...

Aug 9th, 2022 - This study will establish a repository of biospecimens to generate induced pluripotent stem (iPS) cells, which will be used to determine molecular mechanisms for potentially blinding eye diseases including but not limited to: Best Vitelliform Dyst...

Feb 1st, 2022 - The study is designed as a Phase II, multi-center double-blind trial that randomizes patients with high risk Multiple Myeloma to Ixazomib maintenance or placebo 60-120 days after allogeneic HSCT. The primary objective of this randomized trial is t...

Jan 6th, 2022 - The PI on this proposal has been studying BEST1 and the protein encoded (Best1) since its discovery in 1998. Best1 is an integral membrane protein that in the eye is expressed only by retinal pigment epithelial (RPE) cells where it is localized to...

Feb 15th, 2019 - The study will establish baseline expectations for Event Free Survival (EFS), Overall Survival (OS), MRD responses and quality of life measures for older patients of all ages and pre-morbid states; disclose how best to use knowledge of pre-morbid ...

Sep 23rd, 2021 - The combination of durvalumab (Imfinzi) plus either olaparib (Lynparza) or cediranib resulted in disease stabilization of 33% in patients with leiomyosarcoma (LMS), which supports further immunophenotype characterization in this disease, according...

Jun 11th, 2021 - Arundathi Jayatilleke, MD In the approach to treatment of patients with rheumatoid arthritis (RA), methotrexate monotherapy is often followed by addition of a biologic disease modifying anti-rheumatic drugs (bDMARDs) for best disease outcomes. Com.

Apr 2nd, 2021 - Transcript: Caron Jacobson, MD: In our series, we didn’t do the propensity score analysis, so we weren’t able to subtract the high-risk disease characteristics. But we also saw a decrease in overall survival and an increase in nonrelapse morta...

Dec 4th, 2020 - Kavitha Ramchandran, MD, a medical oncologist and clinical associate professor of medicine at Stanford University, discusses considerations as patients with thoracic malignancies enter palliative care. Palliative care is the optimal supportive ca...

Feb 12th, 2013 - Active MS Is Associated With Accelerated Retinal Ganglion Cell/Inner Plexiform Layer Thinning Ratchford JN, Saidha S, Sotirchos ES, et al Neurology. 2013;80:47-54. Optical Coherence Tomography Optical coherence tomography (OCT) has improved the ab...