About 4,873 results

ALLMedicine™ Retinitis Pigmentosa Center

Research & Reviews  1,742 results

Multimodal image alignment aids in the evaluation and monitoring of sector retinitis pi...
Ophthalmic Genetics; Kwan JT, Ramsey DJ

Jul 1st, 2022 - To present a semi-automated method of image alignment to aid in monitoring the progression of inherited retinal degenerations (IRDs). A 22-year-old woman presented with nyctalopia and a family history of retinitis pigmentosa (RP), but with no prio...

Occult Macular Dystrophy: a case report and major review.
Ophthalmic Genetics; Luoma-Overstreet G, Jewell A et. al.

Jun 30th, 2022 - Occult Macular Dystrophy (OMD), a rare autosomal dominant disorder caused by mutations in the retinitis pigmentosa 1-like protein 1 gene (RP1L1), is characterized by loss of central visual acuity in the absence of fundoscopic abnormalities. In pat...

Arap1 loss causes retinal pigment epithelium phagocytic dysfunction and subsequent phot...
Disease Models & Mechanisms; Shao A, Lopez AJ et. al.

Jun 28th, 2022 - Retinitis Pigmentosa (RP), a retinal degenerative disease, is the leading cause of heritable blindness. Previously, we described that Arap1-/- mice develop a similar pattern of photoreceptor degeneration. Arap1 is an Arf-directed GTPase-activating...

Biocompatibility of Human Induced Pluripotent Stem Cell-Derived Retinal Progenitor Cell...
Cell Transplantation; Han IC, Bohrer LR et. al.

Jun 28th, 2022 - Loss of photoreceptor cells is a primary feature of inherited retinal degenerative disorders including age-related macular degeneration and retinitis pigmentosa. To restore vision in affected patients, photoreceptor cell replacement will be requir...

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Drugs  1 results see all →

Clinicaltrials.gov  157 results

Retinitis Pigmentosa Clinical Measures and Repeatability Testing of Potential Outcome Measures

Jun 24th, 2022 - Pr(SqrRoot)(Copyright)cis Objective: The objective of this study is to investigate the nature of photoreceptor dysfunction in retinitis pigmentosa (RP) patients using focal static and kinetic psychophysical tests to develop functional outcome meas...

Cell Collection to Study Eye Diseases

Jun 24th, 2022 - This study will establish a repository of biospecimens to generate induced pluripotent stem (iPS) cells, which will be used to determine molecular mechanisms for potentially blinding eye diseases including but not limited to: Best Vitelliform Dyst...

An Observational Study of Japanese Participants With X-linked Retinitis Pigmentosa

Jun 22nd, 2022 - The purpose of the study is to identify a cohort of Japanese participants with X-linked retinitis pigmentosa (XLRP) associated with pathogenic variants in the retinitis pigmentosa GTPase regulator (RPGR) gene and to investigate their associated ph...

Environmental Localization Mapping and Guidance for Visual Prosthesis Users

Jun 22nd, 2022 - About 1.3 million Americans aged 40 and older are legally blind, a majority because of diseases with onset later in life, such as glaucoma and age-related macular degeneration. Second Sight Medical Products (SSMP) has developed the world's first F...

Dose Escalation Study to Evaluate the Safety/Tolerability and Efficacy of EA-2353 in Subjects With Retinitis Pigmentosa

Jun 15th, 2022 - This is an open-label, multiple ascending dose study to evaluate the safety, tolerability, and efficacy of EA-2353 in subjects with RP. There will be up to 4 cohorts. Each of the first three cohorts will treat 3 subjects with 4 weekly injections o...

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News  44 results

Optogenetics Scientists Take 2021 Lasker Prize for Basic Research 

Sep 28th, 2021 - Three researchers who have been integral to the discovery and development of using light-sensitive proteins to determine the function of neurons ­— and possibly control them — have won the 2021 Albert Lasker Basic Medical Research Award. The techn...

A First: Blind Man's Sight Restored With Optogenetic Therapy

May 25th, 2021 - The vision of a man who lost his sight because of retinitis pigmentosa (RP) has been partially restored with optogenetic therapy in the first reported case of functional recovery in a neurodegenerative disease following this novel treatment. "It w...

Optogenetic Tx Partially Restores Vision in Blind Man After 40 Years

May 24th, 2021 - Optogenetic therapy restored partial vision in a blind 58-year-old man diagnosed with retinitis pigmentosa almost 40 years ago, according to a case report from the ongoing PIONEER study. In this open-label phase I/IIa study, intraocular injection ...

Unsafe Ocular Stem Cell Treatments Prevalent

Jul 27th, 2018 - VANCOUVER, Canada — Experimental stem cell therapies for eye conditions are being offered at dozens of unregulated clinics in the United States, and some of these procedures are harmful, researchers report. Clinicians should warn their patients ag...

A Boy With Suddenly Failing Vision

Apr 18th, 2018 - Case Diagnosis X-linked retinoschisis (XLRS), an inherited mutation that causes early-onset retinoschisis, or splitting of the retina, is the correct diagnosis. The affected RS1 gene, which encodes the protein retinoschisin, causes a disruption of...

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Patient Education  5 results see all →