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About 5,540 results

ALLMedicine™ Retinoblastoma Center

Research & Reviews  2,052 results

Merkel cell polyomavirus large T antigen binding to pRb promotes skin hyperplasia and t...
https://doi.org/10.1371/journal.ppat.1010551
PLoS Pathogens; Spurgeon ME, Cheng J et. al.

May 14th, 2022 - Clear evidence supports a causal link between Merkel cell polyomavirus (MCPyV) and the highly aggressive human skin cancer called Merkel cell carcinoma (MCC). Integration of viral DNA into the human genome facilitates continued expression of the M...

DREAM Interrupted: Severing LIN-35-MuvB association in Caenorhabditis elegans impairs D...
https://doi.org/10.1093/genetics/iyac073
Genetics Goetsch PD, Strome S

May 14th, 2022 - The mammalian pocket protein family, which includes the Retinoblastoma protein (pRb) and Rb-like pocket proteins p107 and p130, regulates entry into and exit from the cell cycle by repressing cell cycle gene expression. Although pRb plays a domina...

Abemaciclib in Patients With HIV-associated and HIV-negative Kaposi Sarcoma
https://clinicaltrials.gov/ct2/show/NCT04941274

May 13th, 2022 - Background: Kaposi Sarcoma (KS) is a multicentric angioproliferative tumor, caused by Kaposi sarcoma-associated herpesvirus, that most frequently involves the skin, but may also involve lymph nodes, lungs, bone and gastrointestinal tract. It is mo...

Rb-E2F-HDAC Repressor Complexes Control Interferon-Induced Repression of Adenovirus To ...
https://doi.org/10.1128/jvi.00442-22
Journal of Virology; Snaider S, Zheng Y et. al.

May 13th, 2022 - Interferons (IFNs) are cytokines that induce a global change in the cell to establish antiviral immunity. We previously demonstrated that human adenovirus (HAdV) exploits IFN-induced viral repression to persist in infected cells. Although this in ...

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Guidelines  1 results

Guidelines for imaging retinoblastoma: imaging principles and MRI standardization.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256324
Pediatric Radiology; de Graaf P, Göricke S et. al.

Aug 19th, 2011 - Retinoblastoma is the most common intraocular tumor in children. The diagnosis is usually established by the ophthalmologist on the basis of fundoscopy and US. Together with US, high-resolution MRI has emerged as an important imaging modality for ...

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Drugs  19 results see all →

Clinicaltrials.gov  60 results

Abemaciclib in Patients With HIV-associated and HIV-negative Kaposi Sarcoma
https://clinicaltrials.gov/ct2/show/NCT04941274

May 13th, 2022 - Background: Kaposi Sarcoma (KS) is a multicentric angioproliferative tumor, caused by Kaposi sarcoma-associated herpesvirus, that most frequently involves the skin, but may also involve lymph nodes, lungs, bone and gastrointestinal tract. It is mo...

Combination Chemotherapy and Cyclosporine Followed by Focal Therapy for Bilateral Retinoblastoma
https://clinicaltrials.gov/ct2/show/NCT00110110

May 4th, 2022 - OBJECTIVES: Primary Compare the efficacy of neoadjuvant high-dose carboplatin and etoposide, vincristine, and cyclosporine (CSA) followed by ophthalmic focal therapy comprising cryotherapy and/or laser therapy to historical world data of chemother...

Studying Health Outcomes After Treatment in Patients With Retinoblastoma
https://clinicaltrials.gov/ct2/show/NCT03932786

Apr 22nd, 2022 - PRIMARY OBJECTIVES: I. Define acute toxicity, subsequent malignant neoplasm (SMN) risk and visual outcomes in retinoblastoma (RB) survivors and compare patient centered psychosocial and neurocognitive and physical outcomes in survivors with normat...

A Study of Palbociclib in Addition to Standard Endocrine Treatment in Hormone Receptor Positive Her2 Normal Patients With Residual Disease After Neoadjuvant Chemotherapy and Surgery
https://clinicaltrials.gov/ct2/show/NCT01864746

Apr 12th, 2022 - About one third of patients with hormone-receptor (HR)-positive, HER2- normal breast cancer and residual disease after neoadjuvant chemotherapy have a substantial risk of relapse. The clinical-pathologic stage - estrogen/grade (CPS-EG)1 combining ...

Mobile Health Case Management System for Reducing Pediatric Treatment Abandonment
https://clinicaltrials.gov/ct2/show/NCT03677128

Mar 22nd, 2022 - Each year, approximately 220,000 children globally are newly diagnosed with cancer. Over 85% of these new diagnoses are made in low- and middle-income countries (LMICs). Survival rates in LMICs are 5-25% compared to 80% in high-income countries (H...

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News  79 results

Net Guides: Childhood Tumors
https://www.onclive.com/view/net-guides-childhood-tumors

Mar 15th, 2022 - //THE ONLINE ONCOLOGIST™ American Society of Pediatric Hematology/Oncology The American Society of Pediatric Hematology/Oncology (ASPHO) is a multidisciplinary organization that works to promote the care of children and adolescents with blo...

Brachytherapy Represents a Potential Strategy in AYA Patients With Rhabdomyosarcoma
https://www.onclive.com/view/brachytherapy-represents-a-potential-strategy-in-aya-patients-with-rhabdomyosarcoma

Feb 9th, 2022 - Although brachytherapy (BT) is rarely utilized as a treatment for pediatric and adolescent/young adult (AYA) patients in the United States, AYA patients with rhabdomyosarcoma (RMS) treated with BT had favorable survival outcomes, according to find...

Trilaciclib Prior to Myelosuppressive Chemo Reduces Need for Supportive Care in Small Cell Lung Cancer
https://www.onclive.com/view/trilaciclib-prior-to-myelosuppressive-chemo-reduces-need-for-supportive-care-in-small-cell-lung-cancer

Oct 6th, 2021 - Trilaciclib administered prior to chemotherapy in patients with extensive-stage small cell lung cancer (ES-SCLC) helped to reduce chemotherapy-induced myelosuppression and limit the need for granulocyte colony-stimulating factors (G-CSF), erythrop...

iPhone Flash Helps Nurse Identify Her Infant Son's Retinoblastoma
https://www.medscape.com/viewarticle/957441

Aug 27th, 2021 - Josie Rock was taking pictures of her 3-month-old son Asher when the lighting in the room suddenly dimmed, initiating the flash on her iPhone. Asher's eyes opened wide, but instead of his pupils glowing red, as they normally do when a flash is use...

FDA Approval of Ribociclib for Metastatic Breast Cancer
https://www.onclive.com/view/fda-approval-of-ribociclib-for-metastatic-breast-cancer

Apr 2nd, 2021 - Transcript:Adam M. Brufsky, MD, PhD: Hello, and thank you for joining us in this OncLive Peer Exchange® titled Questions and Controversies in Treating Breast Cancer. Evidence-based management of breast cancer has become increasingly complex owing ...

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Patient Education  5 results see all →