ALLMedicine™ Retinoschisis Center
Research & Reviews 279 results
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Eye (London, England); Hsia Y, Lee CY et. al.
May 14th, 2022 - To study the development, evolution, outcomes, and prognostic factors of lamellar macular hole (LMH) in highly myopic (HM) patients. Fifty eyes from 47 HM patients with LMHs were retrospectively enrolled. Relevant pre- and post-LMH optical coheren...
https://clinicaltrials.gov/ct2/show/NCT00055029
May 13th, 2022 - Objectives: The overall goal of this protocol is to better understand the etiology of XLRS disease to facilitate further research to identify a potential treatment for the disease. The specific primary objectives of this study are to: 1. Investiga...
https://clinicaltrials.gov/ct2/show/NCT02317887
May 13th, 2022 - Objective: To evaluate the safety and tolerability of ocular AAV-RS1 vector (AAV8-scRS/IRBPhRS) gene transfer to the retina of participants affected with X-linked juvenile retinoschisis (XLRS). Study Population: Male participants affected with XLR...
https://doi.org/10.1016/j.survophthal.2022.03.007
Survey of Ophthalmology; Cheong KX, Xu L et. al.
Apr 4th, 2022 - Myopic traction maculopathy (MTM), one of the complications of pathologic myopia, is a spectrum of pathological conditions that are attributed to tractional changes in the eye characterized by retinoschisis, lamellar or full thickness macular hole...
https://doi.org/10.3928/23258160-20220211-03
Ophthalmic Surgery, Lasers & Imaging Retina; Liao A, Barnett J et. al.
Mar 12th, 2022 - To provide an overview of progressive retinoschisis-related retinal detachment (RSRD) management at a tertiary referral center. Single-institution retrospective case series from January 1, 2003, to May 1, 2020. Progressive RSRD occurred in 0.9% of...
Clinicaltrials.gov 8 results
https://clinicaltrials.gov/ct2/show/NCT02317887
May 13th, 2022 - Objective: To evaluate the safety and tolerability of ocular AAV-RS1 vector (AAV8-scRS/IRBPhRS) gene transfer to the retina of participants affected with X-linked juvenile retinoschisis (XLRS). Study Population: Male participants affected with XLR...
https://clinicaltrials.gov/ct2/show/NCT00055029
May 13th, 2022 - Objectives: The overall goal of this protocol is to better understand the etiology of XLRS disease to facilitate further research to identify a potential treatment for the disease. The specific primary objectives of this study are to: 1. Investiga...
https://clinicaltrials.gov/ct2/show/NCT02416622
Jul 14th, 2020 - This will be a non-randomized, open label, Phase 1/2 dose escalation study. Up to 27 participants will be enrolled. Each participant will receive the study agent by intravitreal injection in one eye on a single occasion. Enrollment will begin with...
https://clinicaltrials.gov/ct2/show/NCT04278079
Feb 20th, 2020 - Performing pars plana vitrectomy for highly myopic patients with decreased visual acuity is the standard of care for patients with myopic traction. A variety of findings are seen by Optical Coherence Tomography. Epiretinal membranes, retinoschisis...
https://clinicaltrials.gov/ct2/show/NCT02317354
Dec 9th, 2019 - Objective: The objective of this study is to understand the factors that influence patient expectations when enrolling in an early-phase RS1 ocular gene transfer clinical trial and to assess the psychological impact of patient expectations over ti...
News 5 results
https://www.medscape.com/viewarticle/895120_2
Apr 18th, 2018 - Case Diagnosis X-linked retinoschisis (XLRS), an inherited mutation that causes early-onset retinoschisis, or splitting of the retina, is the correct diagnosis. The affected RS1 gene, which encodes the protein retinoschisin, causes a disruption of...
https://www.reuters.com/article/us-biogen-agtc/biogen-enters-eye-treatment-arena-with-agtc-deal-idUSKCN0PC1KR20150702
Jul 2nd, 2015 - (Reuters) - Biogen said on Thursday it had forged a deal with AGTC to develop gene-based therapies for a range of eye diseases, marking the company’s entry into opthalmology. Shares of AGTC, formally known as Applied Genetic Technologies Corp, sur...
https://www.medscape.com/viewarticle/732780
Nov 24th, 2010 - Clinical Presentation A previously healthy 10-month-old boy presented to the emergency department after his mother found him unresponsive at home. He had been under the care of his aunt's boyfriend, who admitted to police that he had shaken the pa...
https://www.medscape.com/viewarticle/558018
Jun 9th, 2007 - June 8, 2007 — The US Food and Drug Administration (FDA) has granted orphan drug designation for AMT 011 for the treatment of lipoprotein lipase deficiency, axitinib for the treatment of pancreatic cancer, and adeno-associated viral vector express...
https://www.medscape.com/viewarticle/772188_4
Pathophysiology of Vitreomacular Traction In symptomatic VMA, the continuous tangential and antero posterior stretching on the macula can lead to VMT, which, if allowed to progress, can lead to sight-threatening complications, such as the formatio...
