Rath, E. et. al.
Jul 21st, 2019 - Background: No proven treatment exists for nonarteritic anterior ischemic optic neuropathy (NAION), either in the acute or late phase. Objective: To assess safety and changes in visual function and structure after RPh201/placebo treatment in participants with previous NAION. Design and Setting: Phase 2a, single-site, prospective, randomized, placebo-controlled, double-masked trial (regist...
Jun 30th, 2019 - Acute myeloid leukemias (AMLs) are a heterogeneous group of disorders characterized by the clonal expansion of myeloid blasts (eg, undifferentiated myeloid precursors) in the peripheral blood, bone marrow, and/or other tissues, which results in impaired hematopoiesis and bone marrow failure. 1, 2, 3, 4 AML is the most common acute leukemia in adults (~80% of leukemia cases) and accounts for the...
Journal of the National Comprehensive Cancer Network;
Jun 14th, 2019 - Acute myeloid leukemia (AML) is the most common form of acute leukemia among adults and accounts for the largest number of annual deaths due to leukemias in the United States. Recent advances have resulted in an expansion of treatment options for AML, especially concerning targeted therapies and low-intensity regimens. This portion of the NCCN Clinical Practice Guidelines in Oncology (NCCN Guid...
May 12th, 2019 - Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) today announced that the U.S. Food and Drug Administration (FDA) has approved EYLEA® (aflibercept) Injection to treat all stages of diabetic retinopathy (DR), and thereby reduce the risk of blindness. "Millions of people have been robbed of their vision due to the progression of diabetic retinopathy," said David Brown, M.D., F.A.C.S., an investi...
Feb 27th, 2019 - Now in its 23rd year, the annual International Congress on Hematologic Malignancies®: Focus on Leukemias, Lymphomas, and Myeloma provides practitioners who manage hematologic malignancies the practical tools to translate emerging data into the best therapy for patients with these tumors, personalize care based upon patient and tumor characteristics, and apply novel management strategies to thei...
AAO OTAC Pediatric Ophthalmology/Strabismus Panel,
Jan 16th, 2019 - Orthokeratology may be effective in slowing myopic progression for children and adolescents, with a potentially greater effect when initiated at an early age (6–8 years). Safety remains a concern because of the risk of potentially blinding microbial keratitis from contact lens wear.
AAO OTAC Glaucoma Panel
Jan 6th, 2019 - Intravitreal injection of anti-VEGF agents results in an immediate and transient increase in IOP. A long-term increase in IOP also may be seen, and further studies are needed to determine at-risk populations.
Nov 12th, 2018 - Evidence-based update using Cochrane Eyes and Vision Group-identified systematic reviews for the initial evaluation, diagnosis, and management of post-LASIK and other corneal ectasias.
Nov 12th, 2018 - Evidence-based update using Cochrane Eyes and Vision Group-identified systematic reviews for the initial evaluation and diagnosis of corneal edema and corneal opacification.
Nov 12th, 2018 - Evidence-based update using Cochrane Eyes and Vision Group-identified systematic reviews for the initial evaluation of conjunctivitis patients and discussion of associated or predisposing factors.
Hutchinson, A.,et al
Jul 31st, 2018 - There is limited evidence to support the safety and efficacy of both topical and systemic ?-blockers to promote regression of periocular hemangiomas. Additional research may confirm the best dosage and route of administration to maximize efficacy in reducing induced astigmatism and amblyopia associated with periocular hemangiomas while minimizing side effects.
Ophthalmic Instrument Cleaning and Sterilization (OICS) Task Force
Mar 31st, 2018 - Postoperative infectious endophthalmitis and toxic anterior segment syndrome (TASS) are rare, but potentially sight-threatening complications of cataract and other intraocular surgery. The small volume of the eye and its sensitivity to minute amounts of chemical or microbial contaminants means that improper instrument cleaning or sterilization practices might pose a significant risk to patients.
Feb 20th, 2018 - These clinical performance measures are designed for individual quality improvement. Some of the measures may also be appropriate for accountability if appropriate sample sizes and implementation rules are achieved.
Sophie X. Deng
Jan 31st, 2018 - The evidence reviewed supports DMEK as a safe and effective treatment for endothelial failure. With respect to visual recovery time, visual outcomes, and rejection rates, DMEK seems to be superior to DSEK and to induce less refractive error with similar surgical risks and EC loss compared with DSEK.
Michael T. Yen
Dec 31st, 2017 - For MALT lymphomas, local control, disease-free survival, and overall survival are good with radiation treatment. The results of treatment of non-MALT lymphomas using radiotherapy also were good, but they were not as favorable as the treatment results of MALT lymphomas.
Daniel A. Arber
Sep 30th, 2017 - The guideline provides a framework for the multiple steps, including laboratory testing, in the evaluation of acute leukemia samples. Some aspects of the guideline, especially molecular genetic testing in acute leukemia, are rapidly changing with new supportive literature, which will require on-going updates for the guideline to remain relevant.
Daniel A. Arber
Sep 30th, 2017 - Twenty-seven guideline statements were established, which ranged from recommendations on what clinical and laboratory information should be available as part of the diagnostic and prognostic evaluation of acute leukemia samples to what types of testing should be performed routinely, with recommendations on where such testing should be performed and how the results should be reported.
David K. Wallace
Sep 8th, 2017 - Treatment of refractive error alone can improve visual acuity in children who have untreated anisometropic and strabismic amblyopia. Visual acuity of children who have bilateral refractive amblyopia also can substantially improve with refractive correction alone.
David K. Wallace
Sep 8th, 2017 - Amblyopia meets the World Health Organization guidelines for a disease that benefits from screening because it is an important health problem for which there is an accepted treatment, it has a recognizable latent or early symptomatic stage, and a suitable test or examination is available to diagnose the condition before permanent vision loss occurs.
David K. Wallace
Sep 8th, 2017 - Strabismus in children under 4 months of age sometimes resolves, particularly if the deviation is intermittent, variable, or measures less than 40 prism diopters. Repeat cycloplegic refraction is indicated when esotropia does not respond to the initial prescription of hyperopic refraction or when the esotropia recurs after surgery.
Justis P. Ehlers
Aug 31st, 2017 - Current level I evidence suggests that intravitreal pharmacotherapy with anti-VEGF agents is effective and safe for ME secondary to BRVO. Prolonged delay in treatment is associated with less improvement in visual acuity (VA).
US Preventive Services Task Force
Aug 31st, 2017 - The USPSTF recommends vision screening at least once in all children aged 3 to 5 years to detect amblyopia or its risk factors. The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of vision screening in children younger than 3 years.
O'Donnell, M.,et al
Jun 30th, 2017 - Acute myeloid leukemia (AML) is the most common form of acute leukemia among adults and accounts for the largest number of annual deaths due to leukemias in the United States. This portion of the NCCN Guidelines for AML focuses on management and provides recommendations on the workup, diagnostic evaluation, and treatment options for younger (age <60 years) and older (age ≥60 years) adult patients.
American Academy of Ophthalmology (AAO)
Mar 31st, 2017 - Adult strabismus results in visual, physical, and psychosocial disabilities. Affected individuals may not be offered appropriate surgical treatment because of misconceptions about adult strabismus.
Scott D. Schoenberger
Feb 28th, 2017 - Polymerase chain reaction testing of ocular fluid is useful in supporting a clinical diagnosis of ARN, but treatment should not be delayed while awaiting PCR results. Initial oral or intravenous antiviral therapy is effective in treating ARN.
American Society of Hematology
Feb 28th, 2017 - Guide to intial diagnostic workup of acute leukemia.
Timothy W. Olsen
Sep 8th, 2016 - An ophthalmic artery occlusion (OAO) or retinal artery occlusion (RAO), central retinal artery occlusion (CRAO), or, less commonly, a branch retinal artery occlusion (BRAO) in patients over 50 years of age should raise immediate clinical suspicion for giant cell arteritis (GCA) or other life-threatening conditions (e. g.
International Diabetes Federation
Dec 31st, 2014 - The guide was developed by the International Diabetes Federation and the Fred Hollows Foundation, and builds upon the ICO Guidelines for Diabetic Eye Care. This guide encourages and facilitates good diabetes management, early diagnosis and treatment of diabetic eye disease, as well encouraging integration and cooperation across the health system.
American Optometric Association
Feb 6th, 2014 - Optometrists are often the first health care practitioners to examine persons with undiagnosed diabetes mellitus or ocular manifestations of diabetes. This Evidence-Based Clinical Practice Guideline on Eye Care of the Patient with Diabetes Mellitus provides doctors of optometry with examination and management recommendations designed to preserve vision and reduce the risk of vision loss in pers.
Dec 28th, 2013 - Incident cases used in the analyses presented here were identified by the Leukemia and Tumor/Tissue Registries in Hiroshima and Nagasaki with follow-up through the end of 2001 – 55 years after the bombings and 14 years beyond that used in the previous comprehensive report. Analyses are presented for all leukemias other than chronic lymphocytic leukemia (CLL) or adult T-cell leukemia (ATL) as a ...
Italian Journal of Pediatrics; La Rosa, M. et. al.
Mar 13th, 2013 - Ocular allergy represents one of the most common conditions encountered by allergists and ophthalmologists. Allergic conjunctivitis is often underdiagnosed and consequently undertreated. Basic and clinical research has provided a better understanding of the cells, mediators, and immunologic events, which occur in ocular allergy. New pharmacological agents have improved the efficacy and safety o...
JAMA , Grossman DC et. al.
Sep 5th, 2017 - One of the most important causes of vision abnormalities in children is amblyopia (also known as "lazy eye"). Amblyopia is an alteration in the visual neural pathway in a child's developing brain that can lead to permanent vision loss in the affected eye. Among children younger than 6 years, 1% to 6% have amblyopia or its risk factors (strabismus, anisometropia, or both). Early identification o...
Robert P. Rutstein
Jun 27th, 2004 - The optometrist should emphasize the examination, diagnosis, timely and appropriate treatment and management, and careful follow-up of patients with strabismus. Proper care can result in reduction of personal suffering for those involved, as well as a substantial cost savings for persons with strabismus and their families.
Michael W. Rouse
Jun 25th, 2004 - Untreated amblyopic patients are at a greater risk for loss of vision in the better eye. The optometrist should carefully outline the possible outcome without treatment, including the risk for impact on future occupational opportunities, the possibility of harm to the good eye, and the importance of protective eye wear and regular monitoring of the patient's condition.
The British Journal of Dermatology; Creamer D, Walsh SA et. al.
Jun 18th, 2016 - U.K. guidelines for the management of Stevens-Johnson syndrome/toxic epidermal necrolysis in adults 2016.|2016|Creamer D,Walsh SA,Dziewulski P,Exton LS,Lee HY,|therapeutic use,methods,therapeutic use,therapy,therapy,methods,therapeutic use,therapy,therapy,methods,therapy,methods,methods,etiology,pathology,therapy,
Clinical Pharmacology and Therapeutics; Caudle KE, Rettie AE et. al.
Aug 7th, 2014 - Phenytoin is a widely used antiepileptic drug with a narrow therapeutic index and large interpatient variability, partly due to genetic variations in the gene encoding cytochrome P450 (CYP)2C9 (CYP2C9). Furthermore, the variant allele HLA-B*15:02, encoding human leukocyte antigen, is associated with an increased risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in response to phen...
Clinical Pharmacology and Therapeutics; Leckband SG, Kelsoe JR et. al.
May 22nd, 2013 - Human leukocyte antigen B (HLA-B) is a gene that encodes a cell surface protein involved in presenting antigens to the immune system. The variant allele HLA-B*15:02 is associated with an increased risk of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in response to carbamazepine treatment. We summarize evidence from the published literature supporting this association and ...
Pediatric Radiology; de Graaf P, Göricke S et. al.
Aug 18th, 2011 - Retinoblastoma is the most common intraocular tumor in children. The diagnosis is usually established by the ophthalmologist on the basis of fundoscopy and US. Together with US, high-resolution MRI has emerged as an important imaging modality for pretreatment assessment, i.e. for diagnostic confirmation, detection of local tumor extent, detection of associated developmental malformation of the ...
Ophthalmology Lin A, Rhee MK et. al.
Oct 27th, 2018 - Bacterial Keratitis Preferred Practice Pattern®.|2018|Lin A,Rhee MK,Akpek EK,Amescua G,Farid M,|organization & administration,therapeutic use,isolation & purification,diagnosis,drug therapy,microbiology,diagnosis,drug therapy,microbiology,organization & administration,standards,
The Journal of Headache and Pain; Hoffmann J, Mollan SP et. al.
Oct 9th, 2018 - Idiopathic Intracranial Hypertension (IIH) is characterized by an elevation of intracranial pressure (ICP no identifiable cause. The aetiology remains largely unknown, however observations made in a number of recent clinical studies are increasing the understanding of the disease and now provide the basis for evidence-based treatment strategies. The Embase, CDSR, CENTRAL, DARE and MEDLINE datab...
Journal of the National Comprehensive Cancer Network : JNCCN; Wierda WG, Byrd JC et. al.
Nov 9th, 2017 - Hairy cell leukemia (HCL) is a rare type of indolent B-cell leukemia, characterized by symptoms of fatigue and weakness, organomegaly, pancytopenia, and recurrent opportunistic infections. Classic HCL should be considered a distinct clinical entity separate from HCLvariant (HCLv), which is associated with a more aggressive disease course and may not respond to standard HCL therapies. Somatic hy...
Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie; Hooper P, Boucher MC et. al.
Oct 27th, 2017 - Excerpt from the Canadian Ophthalmological Society evidence-based clinical practice guidelines for the management of diabetic retinopathy.|2017|Hooper P,Boucher MC,Cruess A,Dawson KG,Delpero W,|epidemiology,epidemiology,diagnosis,epidemiology,therapy,organization & administration,
Aug 30th, 2017 - Clinical Summary: Vision Screening in Children Aged 6 Months to 5 Years Population Children aged 3 to 5 y Children younger than 3 y Recommendation Screen at least once to detect amblyopia or its risk factors. Grade: B No recommendation. Grade: I (insufficient evidence) Risk Assessment All children aged 3 to 5 years are at risk of vision abnormalities and should b...
The Journal of Dermatology; Moriwaki S, Kanda F et. al.
Aug 4th, 2017 - Xeroderma pigmentosum (XP) is a genetic photosensitive disorder in which patients are highly susceptibe to skin cancers on the sun-exposed body sites. In Japan, more than half of patients (30% worldwide) with XP show complications of idiopathic progressive, intractable neurological symptoms with poor prognoses. Therefore, this disease does not merely present with dermatological symptoms, such a...
Journal of the National Comprehensive Cancer Network : JNCCN; O'Donnell MR, Tallman MS et. al.
Jul 8th, 2017 - Acute myeloid leukemia (AML) is the most common form of acute leukemia among adults and accounts for the largest number of annual deaths due to leukemias in the United States. This portion of the NCCN Guidelines for AML focuses on management and provides recommendations on the workup, diagnostic evaluation, and treatment options for younger (age <60 years) and older (age ≥60 years) adult patien...
Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus; Margeta MA, Kuo AN et. al.
Jan 20th, 2017 - To provide guidelines for safe implantation of glaucoma drainage devices (GDDs) in small and pediatric eyes to avoid contact between the optic nerve (ON) and the posterior edge of the GDD plate. We developed a formula for calculating limbus-to-ON distance to estimate the available "real estate" for GDD placement in small eyes. The formula was validated using eyes of pediatric decedents undergoi...
Neurosurgery Newman SA, Turbin RE et. al.
Sep 16th, 2016 - Nonfunctioning pituitary adenomas (NFPAs) are the most frequent pituitary tumors. Visual symptoms from NFPAs are common and include visual field defects, loss of central vision, and motility problems resulting in diplopia. To create evidence-based guidelines in an attempt to formulate guidance for preoperative ophthalmologic evaluation of NFPA patients. An extensive literature search was perfor...
Ophthalmology Prum BE, Lim MC et. al.
Nov 19th, 2015 - PRIMARY OPEN-ANGLE GLAUCOMA SUSPECT PREFERRED PRACTICE PATTERN® Evidence-based update of the Primary Open-Angle Suspect Glaucoma Preferred Practice Pattern® (PPP) guidelines, describing the diagnosis and management of patients with primary open-angle glaucoma suspect with detailed recommendations for evaluation and treatment options.
Cornea Gomes JA, Tan D et. al.
Mar 4th, 2015 - Despite extensive knowledge regarding the diagnosis and management of keratoconus and ectatic corneal diseases, many controversies still exist. For that reason, there is a need for current guidelines for the diagnosis and management of these conditions. This project aimed to reach consensus of ophthalmology experts from around the world regarding keratoconus and ectatic diseases, focusing on th...
Optometry and Vision Science : Official Publication of the American Academy of Optometry; Cotter SA, Cyert LA et. al.
Jan 6th, 2015 - This article provides recommendations for screening children aged 36 to younger than 72 months for eye and visual system disorders. The recommendations were developed by the National Expert Panel to the National Center for Children's Vision and Eye Health, sponsored by Prevent Blindness, and funded by the Maternal and Child Health Bureau of the Health Resources and Services Administration, Unit...
Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association; Hammes HP, Lemmen KD et. al.
Jul 11th, 2014 - Diabetic retinopathy and maculopathy.|2014|Hammes HP,Lemmen KD,Bertram B, ,|diagnosis,epidemiology,therapy,complications,epidemiology,complications,epidemiology,diagnosis,epidemiology,etiology,therapy,standards,standards,diagnosis,epidemiology,etiology,therapy,
Jul 2nd, 2013 - SCREENING FOR GLAUCOMA CLINICAL SUMMARY OF U.S. PREVENTIVE SERVICES TASK FORCE RECOMMENDATION Population Adults without vision symptoms who are seen in primary care Recommendation No recommendation. Grade: I statement Risk Assessment Important risk factors for open-angle glaucoma are increased intraocular pressure, older age, family history of glaucoma, and African...
Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus; Donahue SP, Arthur B et. al.
Jan 30th, 2013 - In 2003 the American Association for Pediatric Ophthalmology and Strabismus Vision Screening Committee proposed criteria for automated preschool vision screening. Recent literature from epidemiologic and natural history studies, randomized controlled trials of amblyopia treatment, and field studies of screening technologies have been reviewed for the purpose of updating these criteria. The prev...
Pediatric Blood & Cancer; Chantada G, Luna-Fineman S et. al.
Jan 21st, 2013 - Retinoblastoma remains incurable in many regions of the world. The major obstacles to cure are delayed diagnosis, poor treatment compliance, and lack of evidence-based recommendations for clinical management. Although enucleation is curative for intraocular disease, in developing countries retinoblastoma is often diagnosed after the disease has disseminated beyond the eye. A SIOP-PODC committee...
European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology; Martin L, O'Donoghue JM et. al.
Jan 16th, 2013 - Tissue expansion with delayed insertion of a definitive prosthesis is the most common form of immediate breast reconstruction performed in the United Kingdom. However, achieving total muscle coverage of the implant and natural ptosis is a key technical challenge. The use of acellular dermal matrices (ADM) to supplement the pectoralis major muscle at the lower and lateral aspects of the breast h...
Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie; Hooper P, Boucher MC et. al.
May 31st, 2012 - Canadian Ophthalmological Society evidence-based clinical practice guidelines for the management of diabetic retinopathy.|2012|Hooper P,Boucher MC,Cruess A,Dawson KG,Delpero W,|epidemiology,complications,epidemiology,complications,epidemiology,diagnosis,epidemiology,therapy,organization & administration,
Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie; , Hooper P et. al.
May 8th, 2012 - Canadian Ophthalmological Society Evidence-based Clinical Practice Guidelines for the Management of Diabetic Retinopathy - executive summary.|2012| ,Hooper P,Boucher MC,Cruess A,Dawson KG,|therapeutic use,epidemiology,complications,complications,diagnosis,epidemiology,therapy,organization & administration,antagonists & inhibitors,
Ophthalmology , et. al.
Dec 5th, 2011 - To describe the underlying principles used to develop a web-based algorithm that incorporated intravitreal anti-vascular endothelial growth factor (anti-VEGF) treatment for diabetic macular edema (DME) in a Diabetic Retinopathy Clinical Research Network (DRCR.net) randomized clinical trial. Discussion of treatment protocol for DME. Subjects with vision loss resulting from DME involving the cent...
Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie;
Dec 31st, 2008 - National Retinoblastoma Strategy Canadian Guidelines for Care: Stratégie thérapeutique du rétinoblastome guide clinique canadien.|2009| ,|diagnosis,genetics,psychology,therapy,diagnosis,genetics,psychology,therapy,