Rath, E. et. al.
Jul 21st, 2019 - Background: No proven treatment exists for nonarteritic anterior ischemic optic neuropathy (NAION), either in the acute or late phase. Objective: To assess safety and changes in visual function and structure after RPh201/placebo treatment in participants with previous NAION. Design and Setting: Phase 2a, single-site, prospective, randomized, placebo-controlled, double-masked trial (regist...
Jun 30th, 2019 - Acute myeloid leukemias (AMLs) are a heterogeneous group of disorders characterized by the clonal expansion of myeloid blasts (eg, undifferentiated myeloid precursors) in the peripheral blood, bone marrow, and/or other tissues, which results in impaired hematopoiesis and bone marrow failure. 1, 2, 3, 4 AML is the most common acute leukemia in adults (~80% of leukemia cases) and accounts for the...
Journal of the National Comprehensive Cancer Network;
Jun 14th, 2019 - Acute myeloid leukemia (AML) is the most common form of acute leukemia among adults and accounts for the largest number of annual deaths due to leukemias in the United States. Recent advances have resulted in an expansion of treatment options for AML, especially concerning targeted therapies and low-intensity regimens. This portion of the NCCN Clinical Practice Guidelines in Oncology (NCCN Guid...
May 12th, 2019 - Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) today announced that the U.S. Food and Drug Administration (FDA) has approved EYLEA® (aflibercept) Injection to treat all stages of diabetic retinopathy (DR), and thereby reduce the risk of blindness. "Millions of people have been robbed of their vision due to the progression of diabetic retinopathy," said David Brown, M.D., F.A.C.S., an investi...
Feb 27th, 2019 - Now in its 23rd year, the annual International Congress on Hematologic Malignancies®: Focus on Leukemias, Lymphomas, and Myeloma provides practitioners who manage hematologic malignancies the practical tools to translate emerging data into the best therapy for patients with these tumors, personalize care based upon patient and tumor characteristics, and apply novel management strategies to thei...
AAO OTAC Pediatric Ophthalmology/Strabismus Panel,
Jan 16th, 2019 - Orthokeratology may be effective in slowing myopic progression for children and adolescents, with a potentially greater effect when initiated at an early age (6–8 years). Safety remains a concern because of the risk of potentially blinding microbial keratitis from contact lens wear.
AAO OTAC Glaucoma Panel
Jan 6th, 2019 - Intravitreal injection of anti-VEGF agents results in an immediate and transient increase in IOP. A long-term increase in IOP also may be seen, and further studies are needed to determine at-risk populations.
Nov 12th, 2018 - Evidence-based update using Cochrane Eyes and Vision Group-identified systematic reviews for the initial evaluation, diagnosis, and management of post-LASIK and other corneal ectasias.
Nov 12th, 2018 - Evidence-based update using Cochrane Eyes and Vision Group-identified systematic reviews for the initial evaluation and diagnosis of corneal edema and corneal opacification.
Nov 12th, 2018 - Evidence-based update using Cochrane Eyes and Vision Group-identified systematic reviews for the initial evaluation of conjunctivitis patients and discussion of associated or predisposing factors.
Hutchinson, A.,et al
Jul 31st, 2018 - There is limited evidence to support the safety and efficacy of both topical and systemic ?-blockers to promote regression of periocular hemangiomas. Additional research may confirm the best dosage and route of administration to maximize efficacy in reducing induced astigmatism and amblyopia associated with periocular hemangiomas while minimizing side effects.
Ophthalmic Instrument Cleaning and Sterilization (OICS) Task Force
Mar 31st, 2018 - Postoperative infectious endophthalmitis and toxic anterior segment syndrome (TASS) are rare, but potentially sight-threatening complications of cataract and other intraocular surgery. The small volume of the eye and its sensitivity to minute amounts of chemical or microbial contaminants means that improper instrument cleaning or sterilization practices might pose a significant risk to patients.
Feb 20th, 2018 - These clinical performance measures are designed for individual quality improvement. Some of the measures may also be appropriate for accountability if appropriate sample sizes and implementation rules are achieved.
Sophie X. Deng
Jan 31st, 2018 - The evidence reviewed supports DMEK as a safe and effective treatment for endothelial failure. With respect to visual recovery time, visual outcomes, and rejection rates, DMEK seems to be superior to DSEK and to induce less refractive error with similar surgical risks and EC loss compared with DSEK.
Michael T. Yen
Dec 31st, 2017 - For MALT lymphomas, local control, disease-free survival, and overall survival are good with radiation treatment. The results of treatment of non-MALT lymphomas using radiotherapy also were good, but they were not as favorable as the treatment results of MALT lymphomas.
Daniel A. Arber
Sep 30th, 2017 - The guideline provides a framework for the multiple steps, including laboratory testing, in the evaluation of acute leukemia samples. Some aspects of the guideline, especially molecular genetic testing in acute leukemia, are rapidly changing with new supportive literature, which will require on-going updates for the guideline to remain relevant.
Daniel A. Arber
Sep 30th, 2017 - Twenty-seven guideline statements were established, which ranged from recommendations on what clinical and laboratory information should be available as part of the diagnostic and prognostic evaluation of acute leukemia samples to what types of testing should be performed routinely, with recommendations on where such testing should be performed and how the results should be reported.
David K. Wallace
Sep 8th, 2017 - Treatment of refractive error alone can improve visual acuity in children who have untreated anisometropic and strabismic amblyopia. Visual acuity of children who have bilateral refractive amblyopia also can substantially improve with refractive correction alone.
David K. Wallace
Sep 8th, 2017 - Amblyopia meets the World Health Organization guidelines for a disease that benefits from screening because it is an important health problem for which there is an accepted treatment, it has a recognizable latent or early symptomatic stage, and a suitable test or examination is available to diagnose the condition before permanent vision loss occurs.
David K. Wallace
Sep 8th, 2017 - Strabismus in children under 4 months of age sometimes resolves, particularly if the deviation is intermittent, variable, or measures less than 40 prism diopters. Repeat cycloplegic refraction is indicated when esotropia does not respond to the initial prescription of hyperopic refraction or when the esotropia recurs after surgery.