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Randomized Controlled Phase 2a Study of RPh201 in Previous Nonarteritic Anterior Ischemic Optic Neuropathy
https://journals.lww.com/jneuro-ophthalmology/Abstract/publishahead/Randomized_Controlled_Phase_2a_Study_of_RPh201_in.99147.aspx
Rath, E. et. al.

Jul 21st, 2019 - Background: No proven treatment exists for nonarteritic anterior ischemic optic neuropathy (NAION), either in the acute or late phase. Objective: To assess safety and changes in visual function and structure after RPh201/placebo treatment in participants with previous NAION. Design and Setting: Phase 2a, single-site, prospective, randomized, placebo-controlled, double-masked trial (regist...

Acute Myeloid Leukemia - AML | ARUPConsult Lab Test Selection
https://arupconsult.com/content/acute-myeloid-leukemia

Jun 30th, 2019 - Acute myeloid leukemias (AMLs) are a heterogeneous group of disorders characterized by the clonal expansion of myeloid blasts (eg, undifferentiated myeloid precursors) in the peripheral blood, bone marrow, and/or other tissues, which results in impaired hematopoiesis and bone marrow failure. 1, 2, 3, 4 AML is the most common acute leukemia in adults (~80% of leukemia cases) and accounts for the...

Acute Myeloid Leukemia, Version 3.2019, NCCN Clinical Practice Guidelines in Oncology
https://jnccn.org/view/journals/jnccn/17/6/article-p721.xml
Journal of the National Comprehensive Cancer Network;

Jun 14th, 2019 - Acute myeloid leukemia (AML) is the most common form of acute leukemia among adults and accounts for the largest number of annual deaths due to leukemias in the United States. Recent advances have resulted in an expansion of treatment options for AML, especially concerning targeted therapies and low-intensity regimens. This portion of the NCCN Clinical Practice Guidelines in Oncology (NCCN Guid...

FDA Approves Eylea (Aflibercept) Injection For Diabetic Retinopathy
https://investor.regeneron.com/news-releases/news-release-details/fda-approves-eylear-aflibercept-injection-diabetic-retinopathy

May 12th, 2019 - Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) today announced that the U.S. Food and Drug Administration (FDA) has approved EYLEA® (aflibercept) Injection to treat all stages of diabetic retinopathy (DR), and thereby reduce the risk of blindness. "Millions of people have been robbed of their vision due to the progression of diabetic retinopathy," said David Brown, M.D., F.A.C.S., an investi...

23rd Annual International Congress on Hematologic Malignancies®: Focus on Leukemias, Lymphomas, and Myeloma
https://www.gotoper.com/conferences/hem/meetings/23rd-international-congress-on-hematologic-malignancies-focus-on-leukemias-lymphomas-and-myeloma

Feb 27th, 2019 - Now in its 23rd year, the annual International Congress on Hematologic Malignancies®: Focus on Leukemias, Lymphomas, and Myeloma provides practitioners who manage hematologic malignancies the practical tools to translate emerging data into the best therapy for patients with these tumors, personalize care based upon patient and tumor characteristics, and apply novel management strategies to thei...

The incidence of leukemia, lymphoma, and multiple myeloma among atomic bomb survivors: 1950 – 2001
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875218/
Radiation Research;

Dec 28th, 2013 - Incident cases used in the analyses presented here were identified by the Leukemia and Tumor/Tissue Registries in Hiroshima and Nagasaki with follow-up through the end of 2001 – 55 years after the bombings and 14 years beyond that used in the previous comprehensive report. Analyses are presented for all leukemias other than chronic lymphocytic leukemia (CLL) or adult T-cell leukemia (ATL) as a ...

Allergic conjunctivitis: a comprehensive review of the literature
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640929/
Italian Journal of Pediatrics; La Rosa, M. et. al.

Mar 13th, 2013 - Ocular allergy represents one of the most common conditions encountered by allergists and ophthalmologists. Allergic conjunctivitis is often underdiagnosed and consequently undertreated. Basic and clinical research has provided a better understanding of the cells, mediators, and immunologic events, which occur in ocular allergy. New pharmacological agents have improved the efficacy and safety o...

Methimazole for Graves Disease Linked to Acute Pancreatitis
https://www.medscape.com/viewarticle/920778

Nov 3rd, 2019 - CHICAGO — The treatment of Graves disease with the antithyroid drug methimazole is associated with a significantly increased risk of acute pancreatitis, and although cases are rare, the risk justifies warnings about this potential adverse event, according to a nationwide controlled study in Denmark spanning more than 20 years. "The data are very strong and convincing, (showing) that the risk of...

Severe hypercalcemia in a 54-year-old woman
https://www.mdedge.com/ccjm/article/211105/emergency-medicine/severe-hypercalcemia-54-year-old-woman/page/0/1?channel=263

Nov 1st, 2019 - Malignancy The probability that malignancy is causing the hypercalcemia increases with calcium levels greater than 13 mg/dL. Epidemiologically, in hospitalized patients with hypercalcemia, the source tends to be malignancy.

Retinal artery blockage doesn’t necessarily portend stroke
https://www.mdedge.com/vascularspecialistonline/article/210055/stroke/retinal-artery-blockage-doesnt-necessarily-portend?channel=301
Richard Mark Kirkner, MDedge News

Oct 14th, 2019 - CHICAGO – Occlusion of the retinal artery has been thought to be a predictor of stroke, but an analysis of patients with diagnosed retinal artery occlusion at Cleveland Clinic has found that their risk of stroke is about the same as the general population, a researcher reported at the annual meeting of the Midwestern Vascular Surgery Society. Dr.

Federal Health Care Cancer Data Trends 2019
https://www.mdedge.com/fedprac/article/209596/federal-health-care-cancer-data-trends-2019?channel=27011

Oct 7th, 2019 - Click here to access Federal Health Care Cancer Data Trends 2019 Table of Contents Introduction Cancer in the VA: The Big Picture Hepatocellular Carcinoma Prostate Cancer Multiple Myeloma Lung Cancer in the VA at a National Level Lung Cancer – Regional Snapshot: Kansas City VA Colorectal Cancer Leukemias Lymphomas Renal Cell Carcinoma Bladder Cancer Afterword.

A1c Swings Tied to More Diabetes Complications Long Term
https://www.medscape.com/viewarticle/919300

Oct 1st, 2019 - BARCELONA, Spain — Patients with newly diagnosed type 2 diabetes who had highly variable A1c levels between visits were more likely to have macro- and microvascular complications of diabetes in long-term follow-up, a study shows. The heightened risk of 10 adverse outcomes — major adverse cardiovascular events (MACE), all-cause mortality, cardiovascular death, coronary artery disease, ischemic s...

Leukemia Federal Health Care Data Trends
https://www.mdedge.com/fedprac/article/208837/oncology/leukemia-federal-health-care-data-trends?channel=263
Joao L. Ascensao, MD, PhD, FACP

Sep 25th, 2019 - (function(n){var r="_ion_ionizer",t=n. getElementsByTagName("script"),i;t=t[t.

Does this patient have bacterial conjunctivitis?
https://www.mdedge.com/pediatrics/article/208473/infectious-diseases/does-patient-have-bacterial-conjunctivitis?channel=41022
McKenzie Momany, Douglas Paauw, MD, MACP

Sep 20th, 2019 - A 54-year-old pharmacist with a history of gout, hypertension, and conjunctivitis presents for evaluation of pink eye in the summer. The morning before coming into the office, he noticed that his right eye was red and inflamed.

Severe Pretibial Myxedema Refractory to Systemic Immunosuppressants
https://www.mdedge.com/dermatology/article/207923/mixed-topics/severe-pretibial-myxedema-refractory-systemic?channel=44
Sirunya Silapunt, MD, Abiara V. Agwu, MD et. al.

Sep 10th, 2019 - To the Editor: A 55-year-old man with a history of Graves disease treated with radioactive iodine and Graves ophthalmopathy was referred to our dermatology clinic by his endocrinologist with a 2-year history of severe pretibial myxedema (PM) that had failed treatment with systemic immunosuppressants after diagnosis by an outside dermatologist in the United Kingdom approximately 2 years prior. I.

Expert spotlights telltale clinical signs of xeroderma pigmentosum
https://www.mdedge.com/pediatrics/article/207921/pediatrics/expert-spotlights-telltale-clinical-signs-xeroderma-pigmentosum?channel=39313
Doug Brunk

Sep 10th, 2019 - AUSTIN, TEX. – If a child presents with acute photosensitivity at a young age, onset of freckling before the age of 2 years, and severe sun damage of the lips and eyes, think xeroderma pigmentosum (XP), a rare autosomal recessive disorder.

How to distinguish Stevens-Johnson syndrome from its mimickers
https://www.mdedge.com/dermatology/article/207882/medical-dermatology/how-distinguish-stevens-johnson-syndrome-its?channel=39313
Kari Oakes

Sep 10th, 2019 - NEW YORK – Inpatient dermatology consults can make all the difference when a serious dermatology complication is suspected, said Lucia Seminario-Vidal, MD, PhD, speaking at a hospital dermatology–focused session of the summer meeting of the American Academy of Dermatology. Even before histopathologic results are available, dermatologists can help take some of the panic out of the room when Stev.

Two uveitis treatment options yield similar success
https://www.mdedge.com/internalmedicine/article/207854/ankylosing-spondylitis/two-uveitis-treatment-options-yield-similar/page/0/1?channel=39313

Sep 10th, 2019 - Overall, 64 patients given methotrexate (67%) and 56 of those given mycophenolate (57%) achieved treatment success at 6 months. Treatment success included inflammation control defined as “less than or equal to 0.

New Fixed-Dose, Once-Daily Combo Eyedrop Shows Efficacy in Glaucoma
https://www.medscape.com/viewarticle/917683

Sep 9th, 2019 - The introduction of Rocklatan, a once-daily, fixed-dose combination of the rho kinase inhibitor netarsudil and the prostaglandin analogue latanoprost, has broadened the spectrum of medical management for patients with open-angle glaucoma or ocular hypertension. Three-month data from the randomized, double-masked MERCURY 1 trial[1] provided compelling evidence to support its recent approval by t...

Web resources on diabetic eye disease mostly poor quality
https://www.reuters.com/article/us-health-diabetes-internet/web-resources-on-diabetic-eye-disease-mostly-poor-quality-idUSKCN1VU1YP

Sep 9th, 2019 - Diabetes-related eye disease is a leading cause of blindness, but finding accurate, readable information about it online isn’t easy, a U.S. study finds. Researchers rated 11 top search-engine-ranked websites about diabetic retinopathy. They found that some were accurate and complete but too technical, while others were easy to read but lacked in quality. None scored highly on all of the standar...