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Randomized Controlled Phase 2a Study of RPh201 in Previous Nonarteritic Anterior Ischemic Optic Neuropathy
https://journals.lww.com/jneuro-ophthalmology/Abstract/publishahead/Randomized_Controlled_Phase_2a_Study_of_RPh201_in.99147.aspx
Rath, E. et. al.

Jul 21st, 2019 - Background: No proven treatment exists for nonarteritic anterior ischemic optic neuropathy (NAION), either in the acute or late phase. Objective: To assess safety and changes in visual function and structure after RPh201/placebo treatment in participants with previous NAION. Design and Setting: Phase 2a, single-site, prospective, randomized, placebo-controlled, double-masked trial (regist...

Acute Myeloid Leukemia - AML | ARUPConsult Lab Test Selection
https://arupconsult.com/content/acute-myeloid-leukemia

Jun 30th, 2019 - Acute myeloid leukemias (AMLs) are a heterogeneous group of disorders characterized by the clonal expansion of myeloid blasts (eg, undifferentiated myeloid precursors) in the peripheral blood, bone marrow, and/or other tissues, which results in impaired hematopoiesis and bone marrow failure. 1, 2, 3, 4 AML is the most common acute leukemia in adults (~80% of leukemia cases) and accounts for the...

Acute Myeloid Leukemia, Version 3.2019, NCCN Clinical Practice Guidelines in Oncology
https://jnccn.org/view/journals/jnccn/17/6/article-p721.xml
Journal of the National Comprehensive Cancer Network;

Jun 14th, 2019 - Acute myeloid leukemia (AML) is the most common form of acute leukemia among adults and accounts for the largest number of annual deaths due to leukemias in the United States. Recent advances have resulted in an expansion of treatment options for AML, especially concerning targeted therapies and low-intensity regimens. This portion of the NCCN Clinical Practice Guidelines in Oncology (NCCN Guid...

FDA Approves Eylea (Aflibercept) Injection For Diabetic Retinopathy
https://investor.regeneron.com/news-releases/news-release-details/fda-approves-eylear-aflibercept-injection-diabetic-retinopathy

May 12th, 2019 - Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) today announced that the U.S. Food and Drug Administration (FDA) has approved EYLEA® (aflibercept) Injection to treat all stages of diabetic retinopathy (DR), and thereby reduce the risk of blindness. "Millions of people have been robbed of their vision due to the progression of diabetic retinopathy," said David Brown, M.D., F.A.C.S., an investi...

23rd Annual International Congress on Hematologic Malignancies®: Focus on Leukemias, Lymphomas, and Myeloma
https://www.gotoper.com/conferences/hem/meetings/23rd-international-congress-on-hematologic-malignancies-focus-on-leukemias-lymphomas-and-myeloma

Feb 27th, 2019 - Now in its 23rd year, the annual International Congress on Hematologic Malignancies®: Focus on Leukemias, Lymphomas, and Myeloma provides practitioners who manage hematologic malignancies the practical tools to translate emerging data into the best therapy for patients with these tumors, personalize care based upon patient and tumor characteristics, and apply novel management strategies to thei...

The incidence of leukemia, lymphoma, and multiple myeloma among atomic bomb survivors: 1950 – 2001
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875218/
Radiation Research;

Dec 28th, 2013 - Incident cases used in the analyses presented here were identified by the Leukemia and Tumor/Tissue Registries in Hiroshima and Nagasaki with follow-up through the end of 2001 – 55 years after the bombings and 14 years beyond that used in the previous comprehensive report. Analyses are presented for all leukemias other than chronic lymphocytic leukemia (CLL) or adult T-cell leukemia (ATL) as a ...

Allergic conjunctivitis: a comprehensive review of the literature
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640929/
Italian Journal of Pediatrics; La Rosa, M. et. al.

Mar 13th, 2013 - Ocular allergy represents one of the most common conditions encountered by allergists and ophthalmologists. Allergic conjunctivitis is often underdiagnosed and consequently undertreated. Basic and clinical research has provided a better understanding of the cells, mediators, and immunologic events, which occur in ocular allergy. New pharmacological agents have improved the efficacy and safety o...

Better Functional Outcomes With Infantile Primary Congenital Glaucoma
https://www.medscape.com/viewarticle/923472

Jan 8th, 2020 - NEW YORK (Reuters Health) - Long-term functional outcomes of primary congenital glaucoma are better with infantile than with neonatal subtypes, researchers from India report. Primary congenital glaucoma (PCG) - that is, glaucoma occurring before 3 years of age - is treated with a variety of surgical approaches to control intraocular pressure (IOP) with the aim of preserving the patient's visual...

A Breakthrough Year in Retina Research
https://www.medscape.com/viewarticle/922992

Dec 26th, 2019 - What an exciting year 2019 turned out to be for the management of retinal disease. As the year draws to a close, it's an ideal time to take a look back at some of the biggest stories, including the introduction of a new US Food and Drug Administration (FDA)–approved pharmaceutical agent for neovascular age-related macular degeneration (nAMD), positive data on interventions capable of slowing ge...

Iscalimab normalizes thyroid hormone levels in subset of Graves disease patients
https://www.mdedge.com/endocrinology/article/214453/pituitary-thyroid-adrenal-disorders/iscalimab-normalizes-thyroid?channel=53
Kari Oakes

Dec 17th, 2019 - CHICAGO – The investigational monoclonal antibody iscalimab reduced levels of thyroid hormone and thyroid-stimulating hormone–receptor antibodies (TSHR-Ab) in some patients with Graves disease in a small study. Of 15 patients with Graves disease, 7 patients, or 47%, saw their thyroid hormone levels normalize, and levels of TSHR-Ab normalized in 4 patients, or 27% of the cohort.

Micropulse Transscleral Diode Laser Photocoagulation: What We Do and Don't Know
https://www.medscape.com/viewarticle/922387

Dec 15th, 2019 - In the treatment of glaucoma, the ability of continuous-wave (CW) transscleral laser photocoagulation (TSCPC) to lower intraocular pressure (IOP) must be weighed against its established risks. Attempting to reap these benefits without the safety concerns has led to the development of micropulse (MP) TSCPC, which differs from CW-TSCPC in that the energy to the ciliary body is delivered in short ...

Albinism awareness goes global in dermatologists’ nonprofit work
https://www.mdedge.com/dermatology/article/214220/pigmentation-disorders/albinism-awareness-goes-global-dermatologists?channel=27980
Kari Oakes

Dec 12th, 2019 - A dermatologist-led nonprofit organization has entered into a partnership with the United Nations to achieve global progress towards greater inclusivity for people with albinism. Courtesy NYDG Foundation Ms.

The Next 'Big Thing' for Blood Cancers Featured at ASH 2019
https://www.medscape.com/viewarticle/921942

Dec 6th, 2019 - The prospect of an "off-the-shelf" product, rather than one that needs to be grown individually for each patient, is a "very exciting" proposition, say experts discussing new data that will be presented at the forthcoming American Society of Hematology (ASH) meeting. For the last few years, much attention has been focused on chimeric antigen receptor (CAR) T cell products for the treatment of l...

Aphakia, Age Tied to Increased Glaucoma Risk After Pediatric Lensectomy
https://www.medscape.com/viewarticle/921914

Dec 2nd, 2019 - NEW YORK (Reuters Health) - Glaucoma or glaucoma suspect may develop in the first year after pediatric lensectomy, and infants three months or younger and those with post-procedure aphakia are especially at risk, a multicenter registry study revealed. "We found that glaucoma does occur (after cataract removal) and the age effect seems to be more dominant than expected," Dr. Sharon Freedman of D...

Desquamating pustular rash
https://www.mdedge.com/ccjm/article/213108/dermatology/desquamating-pustular-rash?channel=325
Kevin Bryan Uy Lo, MD, Zurab Azmaiparashvili, MD

Dec 2nd, 2019 - A 66-year-old man presented with burning pain and erythema over the left axilla, and pustules that had ruptured and crusted over. The rash also involved the right axilla, trunk, abdomen, and face.

AI Screening for Diabetic Retinopathy Moves to Retail Clinics
https://www.medscape.com/viewarticle/921828

Nov 25th, 2019 - Retail health clinics have been part of the trend in making healthcare more convenient, and now another option is being offered — testing for diabetic retinopathy. However, an ophthalmologist won't make the diagnosis at the clinic; instead, it will be made by an artificial intelligence (AI) system called IDx-DR. Testing will be offered through CarePortMD, the first retail health clinic to adopt...

Markedly Elevated Sarcoma Risk in Long-Term Survivors of Hereditary Retinoblastoma
https://www.medscape.com/viewarticle/921735

Nov 25th, 2019 - NEW YORK (Reuters Health) - The risk of bone and soft-tissue sarcoma is markedly elevated in long-term survivors of hereditary retinoblastoma treated with radiation, researchers report. "We provide novel data that after radiotherapy for hereditary retinoblastoma, if sarcoma develops, it occurs in distinctive patterns by the type of sarcoma and location on the body," Dr. Lindsay M. Morton of the...

Peripheral Fields Key in Predicting Diabetic Retinopathy
https://www.medscape.com/viewarticle/921743

Nov 21st, 2019 - A new machine learning model can predict how quickly diabetic retinopathy will progress in individual patients. Unexpectedly, the algorithm relies on information clinicians rarely consider in routine diabetic retinopathy screening, according to a study published online in NPJ Digital Medicine.  Using images from a single doctor's visit, the algorithm, developed by researchers at Roche and Genen...

Double Trouble: 4 Things to Do in Patients With Diplopia
https://www.medscape.com/viewarticle/920911

Nov 12th, 2019 - Tim (not his real name) was on his way to work when he was startled by two blue cars that suddenly appeared near his car. He swerved to avoid a collision and then quickly pulled onto the shoulder of the road. While trying to collect himself, he looked around and realized that he was seeing two of many objects. Panicked, he called his wife, who immediately brought him to the emergency department...

Seborrhea Herpeticum: Cutaneous Herpes Simplex Virus Infection Within Infantile Seborrheic Dermatitis
https://www.mdedge.com/dermatology/article/211565/pediatrics/seborrhea-herpeticum-cutaneous-herpes-simplex-virus-infection?channel=45
Laryn Steadman, MD, Katherine Hrynewycz, MD et. al.

Nov 5th, 2019 - Classically, eczema herpeticum is associated with atopic dermatitis (AD), but it also has been previously reported in the setting of pemphigus vulgaris, Darier disease, ichthyosis vulgaris, burns, psoriasis, and irritant contact dermatitis. 1,2 Descriptions of cutaneous herpes simplex virus (HSV) in the setting of seborrheic dermatitis are lacking.