About 3,776 results
Randomized Controlled Phase 2a Study of RPh201 in Previous Nonarteritic Anterior Ischemic Optic Neuropathy
Rath, E. et. al.

Jul 21st, 2019 - Background: No proven treatment exists for nonarteritic anterior ischemic optic neuropathy (NAION), either in the acute or late phase. Objective: To assess safety and changes in visual function and structure after RPh201/placebo treatment in participants with previous NAION. Design and Setting: Phase 2a, single-site, prospective, randomized, placebo-controlled, double-masked trial (regist...

Acute Myeloid Leukemia - AML | ARUPConsult Lab Test Selection

Jun 30th, 2019 - Acute myeloid leukemias (AMLs) are a heterogeneous group of disorders characterized by the clonal expansion of myeloid blasts (eg, undifferentiated myeloid precursors) in the peripheral blood, bone marrow, and/or other tissues, which results in impaired hematopoiesis and bone marrow failure. 1, 2, 3, 4 AML is the most common acute leukemia in adults (~80% of leukemia cases) and accounts for the...

Acute Myeloid Leukemia, Version 3.2019, NCCN Clinical Practice Guidelines in Oncology
Journal of the National Comprehensive Cancer Network;

Jun 14th, 2019 - Acute myeloid leukemia (AML) is the most common form of acute leukemia among adults and accounts for the largest number of annual deaths due to leukemias in the United States. Recent advances have resulted in an expansion of treatment options for AML, especially concerning targeted therapies and low-intensity regimens. This portion of the NCCN Clinical Practice Guidelines in Oncology (NCCN Guid...

FDA Approves Eylea (Aflibercept) Injection For Diabetic Retinopathy

May 12th, 2019 - Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) today announced that the U.S. Food and Drug Administration (FDA) has approved EYLEA® (aflibercept) Injection to treat all stages of diabetic retinopathy (DR), and thereby reduce the risk of blindness. "Millions of people have been robbed of their vision due to the progression of diabetic retinopathy," said David Brown, M.D., F.A.C.S., an investi...

23rd Annual International Congress on Hematologic Malignancies®: Focus on Leukemias, Lymphomas, and Myeloma

Feb 27th, 2019 - Now in its 23rd year, the annual International Congress on Hematologic Malignancies®: Focus on Leukemias, Lymphomas, and Myeloma provides practitioners who manage hematologic malignancies the practical tools to translate emerging data into the best therapy for patients with these tumors, personalize care based upon patient and tumor characteristics, and apply novel management strategies to thei...

The incidence of leukemia, lymphoma, and multiple myeloma among atomic bomb survivors: 1950 – 2001
Radiation Research;

Dec 28th, 2013 - Incident cases used in the analyses presented here were identified by the Leukemia and Tumor/Tissue Registries in Hiroshima and Nagasaki with follow-up through the end of 2001 – 55 years after the bombings and 14 years beyond that used in the previous comprehensive report. Analyses are presented for all leukemias other than chronic lymphocytic leukemia (CLL) or adult T-cell leukemia (ATL) as a ...

Allergic conjunctivitis: a comprehensive review of the literature
Italian Journal of Pediatrics; La Rosa, M. et. al.

Mar 13th, 2013 - Ocular allergy represents one of the most common conditions encountered by allergists and ophthalmologists. Allergic conjunctivitis is often underdiagnosed and consequently undertreated. Basic and clinical research has provided a better understanding of the cells, mediators, and immunologic events, which occur in ocular allergy. New pharmacological agents have improved the efficacy and safety o...

Better Functional Outcomes With Infantile Primary Congenital Glaucoma

Jan 8th, 2020 - NEW YORK (Reuters Health) - Long-term functional outcomes of primary congenital glaucoma are better with infantile than with neonatal subtypes, researchers from India report. Primary congenital glaucoma (PCG) - that is, glaucoma occurring before 3 years of age - is treated with a variety of surgical approaches to control intraocular pressure (IOP) with the aim of preserving the patient's visual...

A Breakthrough Year in Retina Research

Dec 26th, 2019 - What an exciting year 2019 turned out to be for the management of retinal disease. As the year draws to a close, it's an ideal time to take a look back at some of the biggest stories, including the introduction of a new US Food and Drug Administration (FDA)–approved pharmaceutical agent for neovascular age-related macular degeneration (nAMD), positive data on interventions capable of slowing ge...

Iscalimab normalizes thyroid hormone levels in subset of Graves disease patients
Kari Oakes

Dec 17th, 2019 - CHICAGO – The investigational monoclonal antibody iscalimab reduced levels of thyroid hormone and thyroid-stimulating hormone–receptor antibodies (TSHR-Ab) in some patients with Graves disease in a small study. Of 15 patients with Graves disease, 7 patients, or 47%, saw their thyroid hormone levels normalize, and levels of TSHR-Ab normalized in 4 patients, or 27% of the cohort.

Micropulse Transscleral Diode Laser Photocoagulation: What We Do and Don't Know

Dec 15th, 2019 - In the treatment of glaucoma, the ability of continuous-wave (CW) transscleral laser photocoagulation (TSCPC) to lower intraocular pressure (IOP) must be weighed against its established risks. Attempting to reap these benefits without the safety concerns has led to the development of micropulse (MP) TSCPC, which differs from CW-TSCPC in that the energy to the ciliary body is delivered in short ...

Albinism awareness goes global in dermatologists’ nonprofit work
Kari Oakes

Dec 12th, 2019 - A dermatologist-led nonprofit organization has entered into a partnership with the United Nations to achieve global progress towards greater inclusivity for people with albinism. Courtesy NYDG Foundation Ms.

The Next 'Big Thing' for Blood Cancers Featured at ASH 2019

Dec 6th, 2019 - The prospect of an "off-the-shelf" product, rather than one that needs to be grown individually for each patient, is a "very exciting" proposition, say experts discussing new data that will be presented at the forthcoming American Society of Hematology (ASH) meeting. For the last few years, much attention has been focused on chimeric antigen receptor (CAR) T cell products for the treatment of l...

Aphakia, Age Tied to Increased Glaucoma Risk After Pediatric Lensectomy

Dec 2nd, 2019 - NEW YORK (Reuters Health) - Glaucoma or glaucoma suspect may develop in the first year after pediatric lensectomy, and infants three months or younger and those with post-procedure aphakia are especially at risk, a multicenter registry study revealed. "We found that glaucoma does occur (after cataract removal) and the age effect seems to be more dominant than expected," Dr. Sharon Freedman of D...

Desquamating pustular rash
Kevin Bryan Uy Lo, MD, Zurab Azmaiparashvili, MD

Dec 2nd, 2019 - A 66-year-old man presented with burning pain and erythema over the left axilla, and pustules that had ruptured and crusted over. The rash also involved the right axilla, trunk, abdomen, and face.

AI Screening for Diabetic Retinopathy Moves to Retail Clinics

Nov 25th, 2019 - Retail health clinics have been part of the trend in making healthcare more convenient, and now another option is being offered — testing for diabetic retinopathy. However, an ophthalmologist won't make the diagnosis at the clinic; instead, it will be made by an artificial intelligence (AI) system called IDx-DR. Testing will be offered through CarePortMD, the first retail health clinic to adopt...

Markedly Elevated Sarcoma Risk in Long-Term Survivors of Hereditary Retinoblastoma

Nov 25th, 2019 - NEW YORK (Reuters Health) - The risk of bone and soft-tissue sarcoma is markedly elevated in long-term survivors of hereditary retinoblastoma treated with radiation, researchers report. "We provide novel data that after radiotherapy for hereditary retinoblastoma, if sarcoma develops, it occurs in distinctive patterns by the type of sarcoma and location on the body," Dr. Lindsay M. Morton of the...

Peripheral Fields Key in Predicting Diabetic Retinopathy

Nov 21st, 2019 - A new machine learning model can predict how quickly diabetic retinopathy will progress in individual patients. Unexpectedly, the algorithm relies on information clinicians rarely consider in routine diabetic retinopathy screening, according to a study published online in NPJ Digital Medicine.  Using images from a single doctor's visit, the algorithm, developed by researchers at Roche and Genen...

Double Trouble: 4 Things to Do in Patients With Diplopia

Nov 12th, 2019 - Tim (not his real name) was on his way to work when he was startled by two blue cars that suddenly appeared near his car. He swerved to avoid a collision and then quickly pulled onto the shoulder of the road. While trying to collect himself, he looked around and realized that he was seeing two of many objects. Panicked, he called his wife, who immediately brought him to the emergency department...

Seborrhea Herpeticum: Cutaneous Herpes Simplex Virus Infection Within Infantile Seborrheic Dermatitis
Laryn Steadman, MD, Katherine Hrynewycz, MD et. al.

Nov 5th, 2019 - Classically, eczema herpeticum is associated with atopic dermatitis (AD), but it also has been previously reported in the setting of pemphigus vulgaris, Darier disease, ichthyosis vulgaris, burns, psoriasis, and irritant contact dermatitis. 1,2 Descriptions of cutaneous herpes simplex virus (HSV) in the setting of seborrheic dermatitis are lacking.

Teprotumumab Improves Bulging, QOL in Thyroid Eye Disease

Nov 4th, 2019 - CHICAGO — Teprotumumab, a monoclonal antibody inhibitor of the IGF1 receptor, shows efficacy, including improvements in quality of life, in the treatment of moderate to severe thyroid eye disease. "In the largest placebo-controlled evaluation thus far conducted in patients with active to severe thyroid eye disease, teprotumumab reduced proptosis, inflammation, and diplopia, resulting in marked ...

Intravitreous Ranibizumab Cost-Effective for Some With Proliferative Diabetic Retinopathy

Nov 4th, 2019 - NEW YORK (Reuters Health) - At five years, intravitreous ranibizumab therapy for proliferative diabetic retinopathy (PDR) appears to be cost-effective relative to panretinal photocoagulation (PRP), but only in eyes with vision-impairing center-involved diabetic macular edema (CI-DME), according to new findings. "These cost-effectiveness analyses may be relevant to decisions made on a broader, p...

Methimazole for Graves Disease Linked to Acute Pancreatitis

Nov 3rd, 2019 - CHICAGO — The treatment of Graves disease with the antithyroid drug methimazole is associated with a significantly increased risk of acute pancreatitis, and although cases are rare, the risk justifies warnings about this potential adverse event, according to a nationwide controlled study in Denmark spanning more than 20 years. "The data are very strong and convincing, (showing) that the risk of...

Retinal artery blockage doesn’t necessarily portend stroke
Richard Mark Kirkner, MDedge News

Oct 14th, 2019 - CHICAGO – Occlusion of the retinal artery has been thought to be a predictor of stroke, but an analysis of patients with diagnosed retinal artery occlusion at Cleveland Clinic has found that their risk of stroke is about the same as the general population, a researcher reported at the annual meeting of the Midwestern Vascular Surgery Society. Dr.

AI Sparks Legal Debate Over Machine-Generated Mistakes

Oct 8th, 2019 - SAN FRANCISCO — When the US Food and Drug Administration authorized marketing of the IDx-DR, the decision marked the first time regulators have ever allowed a patient to be diagnosed by a computer rather than a person. "All of medicine is looking at us to see how we do this," said Michael Abramoff, MD, PhD, chief executive officer of IDx, the company that created the AI system for diagnosing di...

Federal Health Care Cancer Data Trends 2019

Oct 7th, 2019 - Click here to access Federal Health Care Cancer Data Trends 2019 Table of Contents Introduction Cancer in the VA: The Big Picture Hepatocellular Carcinoma Prostate Cancer Multiple Myeloma Lung Cancer in the VA at a National Level Lung Cancer – Regional Snapshot: Kansas City VA Colorectal Cancer Leukemias Lymphomas Renal Cell Carcinoma Bladder Cancer Afterword.

A1c Swings Tied to More Diabetes Complications Long Term

Oct 1st, 2019 - BARCELONA, Spain — Patients with newly diagnosed type 2 diabetes who had highly variable A1c levels between visits were more likely to have macro- and microvascular complications of diabetes in long-term follow-up, a study shows. The heightened risk of 10 adverse outcomes — major adverse cardiovascular events (MACE), all-cause mortality, cardiovascular death, coronary artery disease, ischemic s...

Topical Prostaglandin Use May Have Negative Impact on Ptosis Repair

Oct 1st, 2019 - NEW YORK (Reuters Health) - Topical use of prostaglandin analogues (PGAs) appears to be associated with a poorer outcome following surgery for ptosis (blepharoptosis) repair, according to a retrospective review. "Our main take-away is that increased awareness is necessary when counseling patients taking prostaglandins who undergo ptosis repair," Dr. Michael T. Yen of Baylor College of Medicine,...

Albinism: epidemiology, genetics, cutaneous characterization, psychosocial factors
An Bras Dermatology; Marcon CR, et al

Sep 29th, 2019 - Oculocutaneous albinism is an autosomal recessive disease caused by the complete absence or decrease of melanin biosynthesis in melanocytes. Due to the reduction or absence of melanin, albinos are highly susceptible to the harmful effects of ultraviolet radiation and are at increased risk of actinic damage and skin cancer.

Leukemia Federal Health Care Data Trends
Joao L. Ascensao, MD, PhD, FACP

Sep 25th, 2019 - (function(n){var r="_ion_ionizer",t=n. getElementsByTagName("script"),i;t=t[t.

Does this patient have bacterial conjunctivitis?
McKenzie Momany, Douglas Paauw, MD, MACP

Sep 20th, 2019 - A 54-year-old pharmacist with a history of gout, hypertension, and conjunctivitis presents for evaluation of pink eye in the summer. The morning before coming into the office, he noticed that his right eye was red and inflamed.

EMA Panel Backs Netarsudil for Elevated Intraocular Pressure

Sep 19th, 2019 - The European Medicines Agency's (EMA's) Committee for Medicinal Products for Human Use (CHMP) recommended marketing authorization for netarsudil ophthalmic solution 0.02% (Rhokiinsa; Aerie Pharmaceuticals) for the treatment of adults with glaucoma or ocular hypertension. The full indication is "reduction of elevated intraocular pressure (IOP) in adult patients with primary open-angle glaucoma o...

Severe Pretibial Myxedema Refractory to Systemic Immunosuppressants
Sirunya Silapunt, MD, Abiara V. Agwu, MD et. al.

Sep 10th, 2019 - To the Editor: A 55-year-old man with a history of Graves disease treated with radioactive iodine and Graves ophthalmopathy was referred to our dermatology clinic by his endocrinologist with a 2-year history of severe pretibial myxedema (PM) that had failed treatment with systemic immunosuppressants after diagnosis by an outside dermatologist in the United Kingdom approximately 2 years prior. I.

Expert spotlights telltale clinical signs of xeroderma pigmentosum
Doug Brunk

Sep 10th, 2019 - AUSTIN, TEX. – If a child presents with acute photosensitivity at a young age, onset of freckling before the age of 2 years, and severe sun damage of the lips and eyes, think xeroderma pigmentosum (XP), a rare autosomal recessive disorder.

How to distinguish Stevens-Johnson syndrome from its mimickers
Kari Oakes

Sep 10th, 2019 - NEW YORK – Inpatient dermatology consults can make all the difference when a serious dermatology complication is suspected, said Lucia Seminario-Vidal, MD, PhD, speaking at a hospital dermatology–focused session of the summer meeting of the American Academy of Dermatology. Even before histopathologic results are available, dermatologists can help take some of the panic out of the room when Stev.

Two uveitis treatment options yield similar success

Sep 10th, 2019 - Overall, 64 patients given methotrexate (67%) and 56 of those given mycophenolate (57%) achieved treatment success at 6 months. Treatment success included inflammation control defined as “less than or equal to 0.

New Fixed-Dose, Once-Daily Combo Eyedrop Shows Efficacy in Glaucoma

Sep 9th, 2019 - The introduction of Rocklatan, a once-daily, fixed-dose combination of the rho kinase inhibitor netarsudil and the prostaglandin analogue latanoprost, has broadened the spectrum of medical management for patients with open-angle glaucoma or ocular hypertension. Three-month data from the randomized, double-masked MERCURY 1 trial[1] provided compelling evidence to support its recent approval by t...

Web resources on diabetic eye disease mostly poor quality

Sep 9th, 2019 - Diabetes-related eye disease is a leading cause of blindness, but finding accurate, readable information about it online isn’t easy, a U.S. study finds. Researchers rated 11 top search-engine-ranked websites about diabetic retinopathy. They found that some were accurate and complete but too technical, while others were easy to read but lacked in quality. None scored highly on all of the standar...

Ocular Complications of Atopic Dermatitis

Sep 4th, 2019 - Keratoconus Keratoconus is a noninflammatory ocular disorder characterized by progressive thinning and conelike protrusion of the cornea. The corneal topographic changes result in high irregular astigmatism and reduced visual acuity, which can manifest as image blurring or distortion (Figure 2).

Retinal Vein Occlusion Clinical Practice Guidelines (2019)

Sep 2nd, 2019 - In August 2019, the European Society of Retina Specialists (EURETINA) published clinical practice guidelines on the management of retinal vein occlusion (RVO).[1] Patients with suspected retinal vein occlusion (RVO) should undergo a full ophthalmologic examination, including measurement of visual acuity (VA), evaluation of the fundus, and (to rule out neovascularization) assessment of the iris....

A 65-Year-Old Man With Diplopia and a Drooping Eyelid

Aug 20th, 2019 - Editorial Note: The Case Challenge series includes difficult-to-diagnose conditions, some of which are not frequently encountered by most clinicians but are nonetheless important to accurately recognize. Test your diagnostic and treatment skills using the following patient scenario and corresponding questions. If you have a case that you would like to suggest for a future Case Challenge, please...

Bimatoprost-Induced Iris Hyperpigmentation: Beauty in the Darkened Eye of the Beholder

Aug 20th, 2019 - Reports of bimatoprost eye drops used for treatment of glaucoma have shown a high incidence of iris hyperpigmentation with long-term use. A prospective study conducted in 2012 investigated the adverse events of bimatoprost eye drops in 52 Japanese patients with glaucoma or ocular hypertension.

Cancer centers announce new faculty
Jennifer Smith

Aug 12th, 2019 - Jorge E. Cortes, MD, is set to become director of the Georgia Cancer Center in Augusta on Sept.

Peeling skin with chills
MDedge Family Medicine;

Aug 8th, 2019 - The physician thought that this was most likely toxic epidermal necrolysis (TEN). He was in a small hospital without a burn unit, so he drew baseline labs and blood cultures, and started to give intravenous fluids to treat the dehydration.

FDA Drug Approvals, Ophthalmology — 2019 Midyear Review

Aug 7th, 2019 - Notable new ophthalmology approvals Xeomin (incobotulinumtoxinA) was approved as first-line treatment of blepharospasm. Eylea (aflibercept intravitreal) is now approved for all stages of diabetic retinopathy. Rocklatan (netarsudil/latanoprost) was approved for reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Avaclyr (acyclovir ophthalmic) w...

Rubbery Nodule on the Face of an Infant
John R. Chancellor, MD, MS, Laura A. Gonzalez-Krellwitz, MD et. al.

Aug 6th, 2019 - The Diagnosis: Juvenile Xanthogranuloma Juvenile xanthogranuloma (JXG) was first described in 1905 by Adamson1 as solitary or multiple plaquiform or nodular lesions that are yellow to yellowish brown. In 1954, Helwig and Hackney2 coined the term juvenile xanthogranuloma to define this histiocytic cutaneous granulomatous tumor.

Peripapillary Retinal Nerve Thinning Faster in People With Diabetes

Aug 2nd, 2019 - NEW YORK (Reuters Health) - People with type 2 diabetes show accelerated thinning of the peripapillary retinal nerve fiber layer (pRNFL), even in the absence of diabetic retinopathy (DR), according to South Korean researchers. "Our results suggest that the pRNFL status as well as DR status should be checked periodically," Dr. Jung Yeul Kim of Chungnam National University Hospital, in Daejeon, a...

A 3-Year-Old Girl Whose Eyes Appear Misaligned

Jul 25th, 2019 - Case Presentation A healthy 3-year-old girl presented to the ophthalmology clinic for evaluation of misaligned eyes. The mother stated that she noticed the misalignment when the child looked up or to the right. When the child was looking straight ahead, no abnormality was noted. The patient's visual acuity was 20/20 in both eyes without correction using the HOTV matching method. She also had mi...

New Age-Related Macular Degeneration Common in Untreated Fellow Eyes

Jul 17th, 2019 - NEW YORK (Reuters Health) - New age-related macular degeneration (AMD) develops in about a quarter of fellow eyes to those treated for neovascular AMD with intravitreal anti-VEGF agents, according to a post hoc analysis of the VIEW 1 and VIEW 2 studies. "Patients with neovascular AMD in one eye should be followed regularly to check for subtle clinical and imaging findings indicating conversion ...

AD patients prescribed dupilumab: Regularly examine for conjunctivitis
Jeff Craven

Jul 12th, 2019 - Patients with atopic dermatitis receiving dupilumab should regularly be asked about conjunctivitis and referred to an ophthalmologist for diagnosis and therapy, according to a recent position statement from the International Eczema Council. Copyright Wikimedia Commons/Joyhill09 Patients with atopic dermatitis (AD) who develop conjunctivitis from dupilumab may experience “bilateral inflammation.

Patients with AD should routinely be asked about conjunctivitis
Jeff Craven

Jul 12th, 2019 - Patients with atopic dermatitis (AD) should regularly be asked about conjunctivitis and referred to an ophthalmologist for diagnosis and therapy, if they develop conjunctivitis, according to a recent position statement from the International Eczema Council. Copyright Wikimedia Commons/Joyhill09 Patients with AD who develop conjunctivitis during dupilumab treatment may experience “bilateral infl.

Idiopathic Intracranial Hypertension May Double Cardiovascular Risk

Jul 11th, 2019 - Idiopathic intracranial hypertension (IIH) in women appears to be associated with an increased cardiovascular risk, new research shows. "This is a landmark study in that the possible long-term sequelae of idiopathic intracranial hypertension have not really been considered before," senior author Alexandra J. Sinclair, PhD, University of Birmingham, United Kingdom, told Medscape Medical News. "O...

Double-Barreled Biologic for Diabetic Retinopathy Emerging

Jul 9th, 2019 - CHICAGO — Investigators searching for new ways to manage diabetic macular edema are targeting pathways beyond vascular endothelial growth factor (VEGF), the only pathway for which there are approved therapies, and are developing treatments that can be administered less often. Phase 2 results from the BOULEVARD trial (NCT02699450), which is comparing faricimab, the first biologic to target both ...

A 14-Year-Old Boy With Painful Periorbital Edema

Jul 9th, 2019 - Case Presentation 1A 14-year-old boy with no significant medical history presented to the emergency department with painful periorbital edema and erythema in his right eye for 2 days. He denied any vision change, ocular trauma, insect bite, discharge, fever, viral prodrome, or other constitutional symptoms. On exam, visual acuity was 20/20 bilaterally. Motility exam showed a −3 abduction and su...

What is your diagnosis? - July 2019
Wai See Ma, MD, Hadi Moattar, MD, MBChB, PhD

Jun 28th, 2019 - The diagnosis von Hippel-Lindau disease The diagnosis is von Hippel-Lindau disease (VHL). Subsequent brain and renal magnetic resonance imaging showed features suggestive of a 5-mm right cerebellar hemangioblastoma and right renal cell carcinoma (RCC), respectively.

A 50-Year-Old Man With Optic Disc Edema

Jun 24th, 2019 - Case Presentation A 50-year-old man noted blurred vision in his left eye. He had a history of exotropia since childhood. He has a history of hypertension, for which he takes lisinopril and nebivolol, and obesity (body mass index, 37.95 kg/m2). He drinks alcohol occasionally and does not use tobacco. There is no family history of visual loss. Visual acuity was 20/20 in the right eye and 20/60 in...

Post-Approval Study Finds No Surprises With Argus II Retinal Implant

Jun 10th, 2019 - NEW YORK (Reuters Health) - Post-approval follow-up of the Argus II Retinal Prosthesis System shows safety and visual function outcomes similar to those in previous trials, according to a company-funded study. With a CE mark granted in 2011, the device became the first retinal prosthesis to be approved for use in Europe. For the new work, Dr. Jessy D. Dorn of Second Sight Medical Products, in S...

Fast Five Quiz: Ocular Rosacea

Jun 3rd, 2019 - Ocular rosacea, a chronic condition characterized by redness, burning, and itching of the eyes, is a comorbidity commonly seen in patients with a history of facial rosacea. In a minority of patients, however, ocular rosacea may present prior to onset of cutaneous manifestations. The underlying pathophysiology of rosacea is thought to be associated with abnormalities in the body's immune respons...

Central Retinal Vein Occlusion Rarely Complicates Ulcerative Colitis

May 21st, 2019 - NEW YORK (Reuters Health) - Central retinal vein occlusion (CRVO) can rarely complicate the course of inflammatory bowel disease (IBD), according to a case series. As many as 11.8% of patients with IBD can develop ophthalmological complications, including episcleritis, scleritis, and uveitis. Dr. Carine Bou-Abboud Matta from Case Western Reserve University School of Medicine, Cleveland, Ohio an...

FDA OKs Aflibercept (Eylea) for Diabetic Retinopathy

May 13th, 2019 - The US Food and Drug Administration (FDA) has approved aflibercept (Eylea, Regeneron) injection solution to treat all stages of diabetic retinopathy, the manufacturer has announced. Aflibercept, a vascular endothelial growth factor (VEGF) inhibitor, is already approved in the United States for neovascular (wet) age-related macular degeneration, macular edema after central retinal vein occlusion...

Dexamethasone Injection May Speed IOP Drop in Angle-Closure Glaucoma

May 13th, 2019 - NEW YORK (Reuters Health) - In acute primary angle closure (APAC), subconjunctival dexamethasone injection helps high intraocular pressure (IOP) drop more quickly and improves treatment success rate, researchers in China report. "The anti-inflammatory treatment of combined subconjunctival injection of dexamethasone for APAC eyes has significant clinical importance," they write in the British Jo...

FDA OKs IncobotulinumtoxinA (Xeomin) First-Line in Blepharospasm

May 12th, 2019 - PHILADELPHIA — The US Food and Drug Administration (FDA) has approved broadening the indication for incobotulinumtoxinA (Xeomin, Merz Pharmaceuticals) as first-line therapy for blepharospasm in adult patients, the manufacturer has announced. Benign essential blepharospasm (BEB) causes involuntary and excessive closure of the eyelids. The intramuscular injectable drug was already indicated for p...

Botulinum Toxin Effective for Blepharospasm in Toxin-Naïve Patients

May 9th, 2019 - PHILADELPHIA — IncobotulinumtoxinA (Xeomin, Merz Pharmaceuticals) conveys long-term safety and efficacy in patients with benign essential blepharospasm (BEB) who are botulinum toxin-naïve, new research suggests. BEB is a focal dystonia that causes involuntary and excessive closure of the eyelids. The intramuscular injectable study drug is currently indicated for patients with BEB who have been ...

Outpatient Management and Follow-up Recommendations for Adverse Drug Reactions: Guidelines for Posthospitalization Care

May 3rd, 2019 - Long-term Sequelae Endocrine Thyroid gland abnormalities secondary to DRESS syndrome include Graves disease and Hashimoto disease as well as variations in biomarkers including elevated free thyroxine and low and elevated thyroid-stimulating hormone levels. 16,17 Type 1 diabetes mellitus also has been seen after DRESS syndrome, developing within the first 10 months after onset with unknown pathog.

Watchful Waiting OK in Diabetic Macular Edema With Good Vision

May 2nd, 2019 - Among patients with center-involved diabetic macular edema (CI-DME) who had good visual acuity, there were no significant differences in vision loss over a 2-year period for those who were initially managed with watchful waiting as compared with those who underwent treatment with laser photocoagulation or aflibercept (multiple brands). Aflibercept is administered as an anti-VEGF (vascular endot...

Review Questions Need for Ophthalmic Screening After Candida Bloodstream Infection

Apr 25th, 2019 - NEW YORK (Reuters Health) - Although candida bloodstream infection is associated with sight-threatening fungal endophthalmitis, routine ophthalmic testing does not seem to improve outcomes and might be harmful, researchers say. "Candida bloodstream infection is a rare, but serious cause of blindness that has led to recommendations for universal ophthalmic screening of these patients by the Infe...

Acquired Hypertrichosis of the Periorbital Area and Malar Cheek
Caitlin G. Purvis, BS, Justin P. Bandino, MD et. al.

Apr 22nd, 2019 - The Diagnosis: Bimatoprost-Induced Hypertrichosis Latanoprost, a prostaglandin analogue, typically is prescribed by ophthalmologists as eye drops to reduce intraocular pressure in open-angle glaucoma. 1 Common adverse reactions of latanoprost drops include blurred vision, ocular irritation, darkening of the eyelid skin, and pigmentation of the iris.

Pulse Pressure Better Than Systolic BP for Predicting Severe Diabetic Retinopathy

Apr 18th, 2019 - NEW YORK (Reuters Health) - Pulse pressure (PP), the difference between systolic and diastolic blood pressure, is a better predictor of severe diabetic retinopathy than is systolic blood pressure, researchers from Japan report. "This study implies the importance of diastolic blood pressure and PP in addition to systolic blood pressure for prevention of severe eye diseases in diabetes," Dr. Kazu...

Can immune checkpoint inhibitors treat PML?

Apr 17th, 2019 - Finally, Ondine Walter, of Toulouse (France) University Hospital and colleagues described the case of a 60-year-old woman with PML who received nivolumab on a compassionate-use basis. Two weeks after treatment, JC viral load in CSF and blood had decreased.

Asboe-Hansen Sign in Toxic Epidermal Necrolysis
Jessica R. Dowling, BA, Kathryn L. Anderson, MD et. al.

Apr 11th, 2019 - To the Editor: A 25-year-old woman with no notable medical history was admitted to the hospital for suspected Stevens-Johnson syndrome (SJS). The patient was started on amoxicillin 7 days prior to the skin eruption for prophylaxis before removal of an intrauterine device.

High-Dose Steroids: Worth the Risk in Bacterial Keratitis?

Apr 8th, 2019 - As eye care physicians, we often encounter corneal infections in our patients. Fortunately, most of these infections are mild, respond quickly to standard topical antibiotic treatment alone, and resolve without significant corneal scarring or decreased vision. In those infections that are more severe, however, the risk of visually significant scarring is substantial. The corneal damage that lea...

Daily headaches • associated nausea • obesity • Dx?
MDedge Family Medicine;

Apr 4th, 2019 - Recently, a classification of IIH without papilledema has been acknowledged by the International Headache Society. 2,8 Specific MRI findings have been suggested to help make this diagnosis5,9 (TABLE 55).

Testosterone May Underlie Rare Blindness Condition in Women

Apr 1st, 2019 - A disease that causes chronic headaches and even blindness in women, and has puzzled researchers for more than 100 years, may be caused by excess androgens, particularly testosterone, that modulate secretion of cerebrospinal fluid (CSF), UK investigators have discovered. Although a rare condition, idiopathic intracranial hypertension (IIH), which is characterized by increased intracranial press...

IStent Inject Device Lowers IOP After Cataract Surgery in Glaucoma Patients

Apr 1st, 2019 - NEW YORK (Reuters Health) - In patients with mild to moderate glaucoma and cataract, the second-generation iStent inject system, with two redesigned stents, reduces intraocular pressure (IOP) more than cataract surgery alone, according to results of a new pivotal trial. "The most important finding is that the iStent inject, when done with cataract surgery, can improve the likelihood that unmedi...

Aldeyra's eye drug meets main goal in late-stage study, shares surge

Mar 26th, 2019 - (Reuters) - Aldeyra Therapeutics Inc said on Tuesday its drug reproxalap to treat a form of allergic reaction to the eye met the main goal in a late-stage trial, sending shares up more than 60 percent. The study tested two doses of the drug in 318 patients with seasonal allergic conjunctivitis, an allergic reaction to substances such as pollen or spores causing eye inflammation. Both concentrat...

Make the diagnosis
Donna Bilu Martin, MD

Mar 20th, 2019 - Ichthyosis vulgaris Ichthyoses describe a group of disorders of cornification in which the epidermis differentiates abnormally, leading to generalized scaling of the skin. Ichthyosis is derived from the Greek word for fish, “ichthys.

A 13-month-old, healthy black male presented with a 6-month history of dry, scaly skin on the body
Donna Bilu Martin, MD

Mar 20th, 2019 - Ichthyosis vulgaris Ichthyoses describe a group of disorders of cornification in which the epidermis differentiates abnormally, leading to generalized scaling of the skin. Ichthyosis is derived from the Greek word for fish, “ichthys.

Five Eye Emergencies That Need Quick Referral to Specialist

Mar 19th, 2019 - PHILADELPHIA — Not all eye emergencies will be accompanied by pain, but that doesn't mean they aren't serious, said Stephanie Marioneaux, MD, an ophthalmologist in private practice in Chesapeake, Virginia. Marioneaux will be speaking about eye emergencies and how to predict pathologies from a patient's complaints at the upcoming American College of Physicians Internal Medicine (IM) Meeting 2019...

User-Friendly Visual-Acuity Chart Shows Good Agreement With Existing Charts

Mar 17th, 2019 - NEW YORK (Reuters Health) - The Runge near-vision card is user-friendly and shows good agreement with the Early Treatment Diabetic Retinopathy Study (ETDRS) and Snellen visual-acuity charts, researchers report. "The Runge near-vision card has been validated and has potential for improving eye evaluations in primary- and urgent-care settings by virtue of its simplicity, portability, and ease of ...

FDA OKs Rocklatan, a New Once-Daily Eye Drop for Glaucoma

Mar 12th, 2019 - The US Food and Drug Administration (FDA) has approved a once-daily treatment with netarsudil and latanoprost ophthalmic solution (Rocklatan, Aerie Pharmaceuticals) to decrease elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension, the company has announced. Rocklatan is the first and only once-daily, fixed-dose combination of a prostaglandin analog (la...

Glycemic Threshold for Retinopathy Varies by Race

Feb 27th, 2019 - NEW YORK (Reuters Health) - Optimal glycemic thresholds for predicting diabetic retinopathy (DR) vary among whites, blacks and Hispanics, new research shows. "Glycemic control may affect diabetic retinopathy risk differently across race/ethnicity," said study authors Dr. Kevin J. Moore and Dr. Tulay Koru-Sengul of the University of Miami Miller School of Medicine and Dr. Erin C. Dunn of the Flo...

Penetrating Keratoplasty Effective for Corneal Complications of Shingles

Feb 24th, 2019 - NEW YORK (Reuters Health) - Even in eyes with preoperative risks, penetrating keratoplasty (PKP) can achieve favorable results for the corneal complications of herpes zoster ophthalmicus (HZO), researchers say. "What we learned is corneal transplants can make a significant difference in visual acuity, but it's important to control inflammation before transplant," Dr. Christopher Hood of the Uni...

Second-Generation, Two-Stent Injection Lowers IOP and Medication Burden in Various Glaucoma Types

Feb 24th, 2019 - Prospective, Nonrandomized, 36-Month Study of Second-Generation Trabecular Microbypass Stents With Phacoemulsification in Eyes With Various Types of Glaucoma Hengerer FH, Auffarth GU, Riffel C, Conrad-Hengerer I Ophthalmol Ther. 2018;7:405-415 Study Summary This prospective, nonrandomized, consecutive cohort study aimed to assess 36-month outcomes after cataract surgery and implantation of two ...

Diabetic kidney disease, retinopathy associated with PAD in patients with foot ulcers
Mark S. Lesney

Feb 20th, 2019 - Patients with diabetic foot ulcers have a high incidence of associated chronic vascular disease, including kidney disease, retinopathy, and peripheral artery disease (PAD). In addition, there was statistically significant association between both diabetic retinopathy and diabetic kidney disease and PAD, according to a study reported by Magdy H.

Medicare Moves Closer to CAR-T Coverage Policy

Feb 17th, 2019 - Medicare has proposed a national coverage policy for chimeric antigen receptor T-cell (CAR-T) therapy with several conditions attached, including monitoring of patients enrolled in an approved registry or clinical trial for at least 2 years after treatment. The Centers for Medicare & Medicaid Services (CMS) has unveiled a proposed national coverage decision (NCD) memo. The NCD would be Medicare...

Corneal Crosslinking: Is Using an Epithelium-On Technique Effective?

Feb 13th, 2019 - Corneal collagen crosslinking (CXL) has been available in Europe for nearly 15 years, beginning with its discovery in 1997 by the German ophthalmologist Theo Seiler and the subsequent publishing of its first clinical results in 2003 by Wollensak and colleagues.[1] The goal of CXL is to halt the progression of keratoconus, and in general, it does and often flattens keratometry by 1-2 diopters. T...

Diabetes Eye Exam Frequency in US Is 'Alarmingly Low'

Feb 11th, 2019 - The frequency of eye exams among insured patients with type 1 and type 2 diabetes in the United States is "alarmingly low," new research indicates.  Findings from an analysis of nationwide IBM Watson Health claims data were recently published online in Diabetes Care by Stephen R. Benoit, MD, of the Centers for Disease Control and Prevention, Atlanta, Georgia, and colleagues.  Among nearly 300,0...

Diabetic Retinopathy: 2-Year Screening Interval May Be Okay

Feb 7th, 2019 - People with diabetes who have minimal or no retinopathy at initial screening are unlikely to progress to the point of requiring retinopathy treatment within 2 years, but the question of optimal screening intervals is still open, new research and commentary suggest.  Results from a retrospective analysis of data from the large Kaiser Permanente Southern California Eye Monitoring Center populatio...

More Diabetic Retinopathy Screening? Primary Care May Be the Answer

Feb 5th, 2019 - Primary care may be an untapped resource for diabetic retinopathy screening, a new study suggested. In a survey of over 3,200 adults with diabetes, nearly 88% visited a primary care physician within 12 months, reported Diane Gibson, PhD, of Baruch College at City University of New York, in JAMA Ophthalmology. However, out of those who did not have a dilated eye exam within the previous year, 82...

Glycemic Control Tied to Better Outcome of Anti-VEGF Therapy for Diabetic Macular Edema

Feb 4th, 2019 - NEW YORK (Reuters Health) - Strong glycemic control may optimize vision outcomes in patients with diabetic macular edema (DME) treated with anti-vascular endothelial growth factor (anti-VEGF) therapy, researchers say. Dr. Jennifer Sun, chair of Diabetes Initiatives for the Diabetic Retinopathy Clinical Research (DRCR) Network, and colleagues conducted a post hoc analysis of the network’s multic...

Ranibizumab and Aflibercept Prompt Comparable Visual Gain in AMD

Jan 30th, 2019 - NEW YORK (Reuters Health) - In patients with neovascular age-related macular degeneration (nAMD), aflibercept and ranibizumab achieve similar average visual acuity increases, according Australian researchers. In a January 24 online paper in JAMA Ophthalmology, Dr. Mark C. Gillies of Sydney Hospital and colleagues report on a preplanned one-year interim analysis of the RIVAL randomized trial, wh...

Anti-VEGF Efficacy in DME: Early Response Is Not Always Predictive of Long-term Destiny

Jan 22nd, 2019 - Early Response to Anti-Vascular Endothelial Growth Factor and Two-Year Outcomes Among Eyes With Diabetic Macular Edema in Protocol T Bressler NM, Beaulieu WT, Maguire MG, et al; Diabetic Retinopathy Clinical Research Network Am J Ophthalmol. 2018;195:93-100 Study Summary Previous studies have shown that eyes with diabetic macular edema (DME) with extensive early improvements in visual acuity (V...

Four Ocular Abnormalities Not to Overlook in Children

Jan 16th, 2019 - Because the visual system is still developing in children, the consequences of missing ocular or vision abnormalities in these patients are profound, possibly resulting in a lifetime of disability. Even a subtle ocular sign can be the initial manifestation of a life-threatening diagnosis, such as retinoblastoma, so knowledge of the associated signs of these conditions is critical. Clinicians th...

Glaucoma Drug Reduces IOP Spike After Anti-VEGF Injections

Jan 11th, 2019 - NEW YORK (Reuters Health) - Prophylaxis with brimonidine prevents sharp increases in intraocular pressure (IOP) in patients who undergo intravitreal injections with anti-vascular endothelial growth factor (anti-VEGF), according to a new study. "Most importantly, our findings demonstrate that brimonidine also plays a protective role by significantly reducing the risk of eyes reaching very elevat...

Statins Cut Retinopathy Risk in Type 2 Diabetes

Jan 10th, 2019 - Treatment with statins was associated with a significantly decreased risk of diabetic retinopathy in patients with type 2 diabetes and high cholesterol in a large cohort study from Taiwan. Statin therapy was also associated with a lower need for invasive treatments for vision-threatening diabetic retinopathy, and the benefits of statin treatment were dose dependent. While several widely reporte...

Statins Cut Retinopathy Risk in Type 2 Diabetes

Jan 10th, 2019 - Treatment with statins was associated with a significantly decreased risk of diabetic retinopathy in patients with type 2 diabetes and high cholesterol in a large cohort study from Taiwan. Statin therapy was also associated with a lower need for invasive treatments for vision-threatening diabetic retinopathy, and the benefits of statin treatment were dose dependent. While several widely reporte...

Take Diabetes Into Consideration When Assessing for Glaucoma

Jan 9th, 2019 - Diabetes and hyperglycemia are associated with thicker central corneal thickness (CCT), which could lead to overestimation of intraocular pressure when assessing patients for glaucoma, new research suggests. The findings were published online January 4 in JAMA Network Open by Xiao-Yang Luo, MD, PhD, of Guangdong Eye Institute, Guangdong General Hospital, Guangzhou, China, and colleagues. CCT is...

Variable Diplopia and Upper Eyelid Ptosis in a 74-Year-Old Man

Jan 1st, 2019 - Clinical Presentation A 74-year-old man presents with a 2-month history of painless diplopia. The patient reports that while the diplopia is improved in the morning, it becomes progressively worse throughout the day. The patient also notes ptosis of the left upper eyelid, which he stated began around the time the diplopia developed. He initially denied symptoms of jaw claudication, scalp tender...

Netarsudil Lowers IOP, but When Should It Be Given?

Jan 1st, 2019 - Two Phase 3 Clinical Trials Comparing the Safety and Efficacy of Netarsudil to Timolol in Patients With Elevated Intraocular Pressure: Rho Kinase Elevated IOP Treatment Trial 1 and 2 (ROCKET-1 and ROCKET-2) Serle JB, Katz LJ, McLaurin E, et al; ROCKET-1 and ROCKET-2 Study Groups Am J Ophthalmol. 2018;186:116-127 Study Summary The double-masked ROCKET-1 and ROCKET-2 trials evaluated the efficacy...

Optic-nerve-sheath Meningioma Commonly Misdiagnosed as Optic Neuritis

Dec 30th, 2018 - NEW YORK (Reuters Health) - A variety of errors contributes to the common initial misdiagnosis of optic-nerve-sheath meningioma (ONSM) as optic neuritis, researchers have found. ONSM classically presents as the triad of progressive visual loss, optic atrophy and the presence of retinal-choroidal collaterals, but it is rare that all three findings occur simultaneously. Still, timely diagnosis an...