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Randomized Controlled Phase 2a Study of RPh201 in Previous Nonarteritic Anterior Ischemic Optic Neuropathy
https://journals.lww.com/jneuro-ophthalmology/Abstract/publishahead/Randomized_Controlled_Phase_2a_Study_of_RPh201_in.99147.aspx
Rath, E. et. al.

Jul 21st, 2019 - Background: No proven treatment exists for nonarteritic anterior ischemic optic neuropathy (NAION), either in the acute or late phase. Objective: To assess safety and changes in visual function and structure after RPh201/placebo treatment in participants with previous NAION. Design and Setting: Phase 2a, single-site, prospective, randomized, placebo-controlled, double-masked trial (regist...

Acute Myeloid Leukemia - AML | ARUPConsult Lab Test Selection
https://arupconsult.com/content/acute-myeloid-leukemia

Jun 30th, 2019 - Acute myeloid leukemias (AMLs) are a heterogeneous group of disorders characterized by the clonal expansion of myeloid blasts (eg, undifferentiated myeloid precursors) in the peripheral blood, bone marrow, and/or other tissues, which results in impaired hematopoiesis and bone marrow failure. 1, 2, 3, 4 AML is the most common acute leukemia in adults (~80% of leukemia cases) and accounts for the...

Acute Myeloid Leukemia, Version 3.2019, NCCN Clinical Practice Guidelines in Oncology
https://jnccn.org/view/journals/jnccn/17/6/article-p721.xml
Journal of the National Comprehensive Cancer Network;

Jun 14th, 2019 - Acute myeloid leukemia (AML) is the most common form of acute leukemia among adults and accounts for the largest number of annual deaths due to leukemias in the United States. Recent advances have resulted in an expansion of treatment options for AML, especially concerning targeted therapies and low-intensity regimens. This portion of the NCCN Clinical Practice Guidelines in Oncology (NCCN Guid...

FDA Approves Eylea (Aflibercept) Injection For Diabetic Retinopathy
https://investor.regeneron.com/news-releases/news-release-details/fda-approves-eylear-aflibercept-injection-diabetic-retinopathy

May 12th, 2019 - Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) today announced that the U.S. Food and Drug Administration (FDA) has approved EYLEA® (aflibercept) Injection to treat all stages of diabetic retinopathy (DR), and thereby reduce the risk of blindness. "Millions of people have been robbed of their vision due to the progression of diabetic retinopathy," said David Brown, M.D., F.A.C.S., an investi...

23rd Annual International Congress on Hematologic Malignancies®: Focus on Leukemias, Lymphomas, and Myeloma
https://www.gotoper.com/conferences/hem/meetings/23rd-international-congress-on-hematologic-malignancies-focus-on-leukemias-lymphomas-and-myeloma

Feb 27th, 2019 - Now in its 23rd year, the annual International Congress on Hematologic Malignancies®: Focus on Leukemias, Lymphomas, and Myeloma provides practitioners who manage hematologic malignancies the practical tools to translate emerging data into the best therapy for patients with these tumors, personalize care based upon patient and tumor characteristics, and apply novel management strategies to thei...

The incidence of leukemia, lymphoma, and multiple myeloma among atomic bomb survivors: 1950 – 2001
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875218/
Radiation Research;

Dec 28th, 2013 - Incident cases used in the analyses presented here were identified by the Leukemia and Tumor/Tissue Registries in Hiroshima and Nagasaki with follow-up through the end of 2001 – 55 years after the bombings and 14 years beyond that used in the previous comprehensive report. Analyses are presented for all leukemias other than chronic lymphocytic leukemia (CLL) or adult T-cell leukemia (ATL) as a ...

Allergic conjunctivitis: a comprehensive review of the literature
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640929/
Italian Journal of Pediatrics; La Rosa, M. et. al.

Mar 13th, 2013 - Ocular allergy represents one of the most common conditions encountered by allergists and ophthalmologists. Allergic conjunctivitis is often underdiagnosed and consequently undertreated. Basic and clinical research has provided a better understanding of the cells, mediators, and immunologic events, which occur in ocular allergy. New pharmacological agents have improved the efficacy and safety o...

Vision Screening in Children Aged 6 Months to 5 Years: US Preventive Services Task Forc...
https://doi.org/10.1001/jama.2017.11260
JAMA , Grossman DC et. al.

Sep 5th, 2017 - One of the most important causes of vision abnormalities in children is amblyopia (also known as "lazy eye"). Amblyopia is an alteration in the visual neural pathway in a child's developing brain that can lead to permanent vision loss in the affected eye. Among children younger than 6 years, 1% to 6% have amblyopia or its risk factors (strabismus, anisometropia, or both). Early identification o...

Vision Screening in Children Aged 6 Months to 5 Years: Evidence Report and Systematic R...
https://doi.org/10.1001/jama.2017.9900
JAMA Jonas DE, Amick HR et. al.

Sep 5th, 2017 - Preschool vision screening could allow detection and treatment of vision abnormalities during a critical developmental stage, preserving function and quality of life. To review the evidence on screening for and treatment of amblyopia, its risk factors, and refractive error in children aged 6 months to 5 years to inform the US Preventive Services Task Force. MEDLINE, Cochrane Library, CINAHL, an...

The cost-effectiveness of HLA-B*5801 screening to guide initial urate-lowering therapy ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403555
Seminars in Arthritis and Rheumatism; Jutkowitz E, Dubreuil M et. al.

Dec 5th, 2016 - Positive HLA-B*5801 carriers are at greater risk of experiencing rare but severe allopurinol hypersensitivity syndrome (AHS) [i.e., Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)]; however, HLA-B*5801 prevalence and AHS risk vary by race/ethnicity. We evaluated the cost-effectiveness of HLA-B*5801 testing according to race/ethnicity in the United States. We determined the c...

Notes from the Field: Health Care-Associated Outbreak of Epidemic Keratoconjunctivitis-...
https://doi.org/10.15585/mmwr.mm6514a5
MMWR. Morbidity and Mortality Weekly Report; Massey J, Henry R et. al.

Apr 14th, 2016 - On September 4, 2015, the West Virginia Bureau for Public Health (WVBPH) was notified by an urban ophthalmology practice of 13 patients with epidemic keratoconjunctivitis (EKC) diagnosed during the preceding 3 weeks. EKC is an eye infection characterized by severe inflammation of the conjunctiva and cornea, and can result in vision loss. Pathogens commonly detected in EKC outbreaks are human ad...

The 2016 revision to the World Health Organization classification of myeloid neoplasms ...
https://doi.org/10.1182/blood-2016-03-643544
Blood Arber DA, Orazi A et. al.

Apr 13th, 2016 - The World Health Organization (WHO) classification of tumors of the hematopoietic and lymphoid tissues was last updated in 2008. Since then, there have been numerous advances in the identification of unique biomarkers associated with some myeloid neoplasms and acute leukemias, largely derived from gene expression analysis and next-generation sequencing that can significantly improve the diagnos...

Association Between Oral Fluoroquinolone Use and Retinal Detachment.
https://doi.org/10.1001/jamaophthalmol.2015.6205
JAMA Ophthalmology; Raguideau F, Lemaitre M et. al.

Mar 11th, 2016 - Several studies have focused on the current use of oral fluoroquinolones and the risk for retinal detachment (RD), but the existence of this association is under debate. Given the widespread fluoroquinolone use, investigation of this association is essential. To assess the association between oral fluoroquinolone use and the risk for RD, including the rhegmatogenous and exudative types. This ca...

The Distinctive Mutational Spectra of Polyomavirus-Negative Merkel Cell Carcinoma.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573907
Cancer Research; Harms PW, Vats P et. al.

Aug 4th, 2015 - Merkel cell carcinoma (MCC) is a rare but highly aggressive cutaneous neuroendocrine tumor. Merkel cell polyomavirus (MCPyV) may contribute to tumorigenesis in a subset of tumors via inhibition of tumor suppressors such as retinoblastoma (RB1) by mutated viral T antigens, but the molecular pathogenesis of MCPyV-negative MCC is largely unexplored. Through our MI-ONCOSEQ precision oncology study,...

Outbreak of Mycoplasma pneumoniae-Associated Stevens-Johnson Syndrome.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516944
Pediatrics Olson D, Watkins LK et. al.

Jul 28th, 2015 - Stevens-Johnson syndrome (SJS) is an uncommon, sporadic disease and outbreaks are rare. In November 2013, an outbreak of SJS was identified at Children's Hospital Colorado. Outbreak cases were children aged 5-21 with a discharge diagnosis of SJS admitted from September 1 to November 30, 2013. Medical charts were reviewed using standardized data collection forms. Respiratory specimens were teste...

Genetic variants associated with phenytoin-related severe cutaneous adverse reactions.
https://doi.org/10.1001/jama.2014.7859
JAMA Chung WH, Chang WC et. al.

Aug 6th, 2014 - The antiepileptic drug phenytoin can cause cutaneous adverse reactions, ranging from maculopapular exanthema to severe cutaneous adverse reactions, which include drug reactions with eosinophilia and systemic symptoms, Stevens-Johnson syndrome, and toxic epidermal necrolysis. The pharmacogenomic basis of phenytoin-related severe cutaneous adverse reactions remains unknown. To investigate the gen...

Retrospective review of Stevens-Johnson syndrome/toxic epidermal necrolysis treatment c...
https://doi.org/10.1016/j.jaad.2014.07.016
Journal of the American Academy of Dermatology; Kirchhof MG, Miliszewski MA et. al.

Aug 4th, 2014 - Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are mucocutaneous reactions, typically to medications, that are associated with a high patient mortality. Controversy exists over which systemic treatments decrease mortality associated with SJS/TEN. In this study we sought to determine whether intravenous immunoglobulin (IVIg) or cyclosporine use for SJS/TEN results in better ...

Effect of acetazolamide on visual function in patients with idiopathic intracranial hyp...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362615
JAMA , Wall M et. al.

Apr 23rd, 2014 - Acetazolamide is commonly used to treat idiopathic intracranial hypertension (IIH), but there is insufficient information to establish an evidence base for its use. To determine whether acetazolamide is beneficial in improving vision when added to a low-sodium weight reduction diet in patients with IIH and mild visual loss. Multicenter, randomized, double-masked, placebo-controlled study of ace...

Ketamine and intraocular pressure in children.
https://doi.org/10.1016/j.annemergmed.2014.01.029
Annals of Emergency Medicine; Wadia S, Bhola R et. al.

Mar 3rd, 2014 - We determine the increase in intraocular pressure during pediatric procedural sedation with ketamine, and the proportion of children whose increase might be clinically important (at least 5 mm Hg). We prospectively enrolled children aged 8 to 18 years, chosen to receive ketamine sedation in a pediatric emergency department. We measured intraocular pressure before sedation, immediately after ket...

Point-of-Care Ultrasonography in the Diagnosis of Retinal Detachment, Vitreous Hemorrha...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481597
JAMA Network Open; Lahham S, Shniter I et. al.

Apr 12th, 2019 - Ocular symptoms represent approximately 2% to 3% of all emergency department (ED) visits. These disease processes may progress to permanent vision loss if not diagnosed and treated quickly. Use of ocular point-of-care ultrasonography (POCUS) may be effective for early and accurate detection of ocular disease. To perform a large-scale, multicenter study to determine the utility of POCUS for diag...