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About 3,030 results

ALLMedicine™ Fibrosarcoma Center

Research & Reviews  1,503 results

Cellular Radiosensitivity of Soft Tissue Sarcoma.
https://doi.org/10.1667/RADE-20-00226.1
Radiation Research; Haas RL, Floot BGJ et. al.

Apr 29th, 2021 - Currently, all soft tissue sarcomas (STS) are irradiated by the same regimen, disregarding possible subtype-specific radiosensitivities. To gain further insight, cellular radiosensitivity was investigated in a panel of sarcoma cell lines. Fourteen...

Cleavable poly(ethylene glycol) branched chain-modified Antheraea pernyi silk fibroin a...
https://doi.org/10.2217/nnm-2020-0481
Nanomedicine (London, England); Liu X, Luo H et. al.

Apr 23rd, 2021 - Aim: To obtain a gene carrier that can effectively deliver loaded therapeutic genes to tumor cells, avoid toxic effects on normal cells and reduce nonspecific adsorption of plasma proteins. Methods: The conjugate of poly(ethylene glycol) (PEG) and...

Ameloblastic fibrosarcoma of the maxilla with EGFR exon 20 insertions: Relevance of who...
https://doi.org/10.1016/j.anl.2021.03.025
Auris, Nasus, Larynx; Terada K, Yamada Y et. al.

Apr 19th, 2021 - Ameloblastic fibrosarcoma (AFS) is the most common odontogenic sarcoma, but the incidence is relatively low, and its molecular biology is poorly understood. We experienced a young female patient with a rapidly growing soft tissue tumor of the left...

Novel BRAF gene fusions and activating point mutations in spindle cell sarcomas with hi...
https://doi.org/10.1038/s41379-021-00806-w 10.1002/1097-0142(196209/10)15:5<1028::AID-CNCR2820150520>3.0.CO;2-X 10.1002/1097-0142(197608)38:2<729::AID-CNCR2820380216>3.0.CO;2-Z 10.1016/0165-4608(89)90224-0 10.1016/0165-4608(89)90156-8 10.1016/S0002-9440(10)65732-X 10.1097/00000478-200111000-00021 10.1097/PAS.0000000000001203 10.1038/modpathol.2017.127 10.1177/1093526617712639 10.1002/gcc.22470 10.1111/his.14082 10.1097/PAS.0000000000001297 10.1038/s41467-018-04650-6 10.1097/PAS.0000000000000938 10.1016/S1470-2045(18)30119-0 10.1101/mcs.a005645 10.1158/2159-8290.CD-15-0443 10.1186/1756-8722-7-8 10.1007/s11060-020-03558-w 10.1016/j.plabm.2020.e00153 10.1038/nm.3729 10.1016/j.jmoldx.2012.09.003 10.1016/j.jmoldx.2015.10.002 10.1158/1078-0432.CCR-19-2004 10.1158/2159-8290.CD-18-1321 10.1002/pbc.25272 10.1007/s10549-017-4156-1 10.1007/s00401-016-1616-3 10.1101/mcs.a003848 10.1186/s40478-017-0440-x 10.1158/1078-0432.CCR-16-0758 10.1038/nrc3431 10.1158/1078-0432.CCR-13-1746 10.1200/JCO.2018.78.9990 10.1309/AJCPPCKGA2QGBJ1R 10.1097/PAS.0000000000000913 10.1097/PAS.0000000000000899 10.1016/j.eururo.2012.05.051 10.1097/PAS.0000000000000603 10.1186/s12881-020-01143-6 10.1097/00000478-200007000-00003 10.1002/gcc.22671 10.1097/PAS.0000000000000675 10.1002/gcc.22877 10.1186/s13000-018-0759-z 10.1002/path.4010 10.1038/nature08902 10.1016/j.ccell.2015.08.001 10.1073/pnas.1219232110 10.18632/oncotarget.14004 10.1080/14740338.2019.1607289 10.1038/nature14982 10.1038/s41591-018-0274-5
Modern Pathology : an Official Journal of the United Stat... Penning AJ, Al-Ibraheemi A et. al.

Apr 14th, 2021 - Infantile fibrosarcoma (IFS)/cellular congenital mesoblastic nephroma (cCMN) commonly harbors the classic ETV6-NTRK3 translocation. However, there are recent reports of mesenchymal tumors with IFS-like morphology harboring fusions of other recepto...

Independent domains for recruitment of PRC1 and PRC2 by human XIST.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016261
PLoS Genetics; Dixon-McDougall T, Brown CJ

Mar 22nd, 2021 - XIST establishes inactivation across its chromosome of origin, even when expressed from autosomal transgenes. To identify the regions of human XIST essential for recruiting heterochromatic marks we generated a series of overlapping deletions in an...

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Guidelines  1 results

Canadian Consensus for Biomarker Testing and Treatment of TRK Fusion Cancer in Pediatri...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903261
Current Oncology (Toronto, Ont.); Perreault S, Chami R et. al.

Jan 13th, 2021 - Neurotrophic tyrosine receptor kinase gene fusions (NTRK) are oncogenic drivers present at a low frequency in most tumour types (<5%), and at a higher frequency (>80%) in a small number of rare tumours (e.g., infantile fibrosarcoma [IFS]) and cons...

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Clinicaltrials.gov  1,509 results

Cellular Radiosensitivity of Soft Tissue Sarcoma.
https://doi.org/10.1667/RADE-20-00226.1
Radiation Research; Haas RL, Floot BGJ et. al.

Apr 29th, 2021 - Currently, all soft tissue sarcomas (STS) are irradiated by the same regimen, disregarding possible subtype-specific radiosensitivities. To gain further insight, cellular radiosensitivity was investigated in a panel of sarcoma cell lines. Fourteen...

Cleavable poly(ethylene glycol) branched chain-modified Antheraea pernyi silk fibroin a...
https://doi.org/10.2217/nnm-2020-0481
Nanomedicine (London, England); Liu X, Luo H et. al.

Apr 23rd, 2021 - Aim: To obtain a gene carrier that can effectively deliver loaded therapeutic genes to tumor cells, avoid toxic effects on normal cells and reduce nonspecific adsorption of plasma proteins. Methods: The conjugate of poly(ethylene glycol) (PEG) and...

Ameloblastic fibrosarcoma of the maxilla with EGFR exon 20 insertions: Relevance of who...
https://doi.org/10.1016/j.anl.2021.03.025
Auris, Nasus, Larynx; Terada K, Yamada Y et. al.

Apr 19th, 2021 - Ameloblastic fibrosarcoma (AFS) is the most common odontogenic sarcoma, but the incidence is relatively low, and its molecular biology is poorly understood. We experienced a young female patient with a rapidly growing soft tissue tumor of the left...

Novel BRAF gene fusions and activating point mutations in spindle cell sarcomas with hi...
https://doi.org/10.1038/s41379-021-00806-w 10.1002/1097-0142(196209/10)15:5<1028::AID-CNCR2820150520>3.0.CO;2-X 10.1002/1097-0142(197608)38:2<729::AID-CNCR2820380216>3.0.CO;2-Z 10.1016/0165-4608(89)90224-0 10.1016/0165-4608(89)90156-8 10.1016/S0002-9440(10)65732-X 10.1097/00000478-200111000-00021 10.1097/PAS.0000000000001203 10.1038/modpathol.2017.127 10.1177/1093526617712639 10.1002/gcc.22470 10.1111/his.14082 10.1097/PAS.0000000000001297 10.1038/s41467-018-04650-6 10.1097/PAS.0000000000000938 10.1016/S1470-2045(18)30119-0 10.1101/mcs.a005645 10.1158/2159-8290.CD-15-0443 10.1186/1756-8722-7-8 10.1007/s11060-020-03558-w 10.1016/j.plabm.2020.e00153 10.1038/nm.3729 10.1016/j.jmoldx.2012.09.003 10.1016/j.jmoldx.2015.10.002 10.1158/1078-0432.CCR-19-2004 10.1158/2159-8290.CD-18-1321 10.1002/pbc.25272 10.1007/s10549-017-4156-1 10.1007/s00401-016-1616-3 10.1101/mcs.a003848 10.1186/s40478-017-0440-x 10.1158/1078-0432.CCR-16-0758 10.1038/nrc3431 10.1158/1078-0432.CCR-13-1746 10.1200/JCO.2018.78.9990 10.1309/AJCPPCKGA2QGBJ1R 10.1097/PAS.0000000000000913 10.1097/PAS.0000000000000899 10.1016/j.eururo.2012.05.051 10.1097/PAS.0000000000000603 10.1186/s12881-020-01143-6 10.1097/00000478-200007000-00003 10.1002/gcc.22671 10.1097/PAS.0000000000000675 10.1002/gcc.22877 10.1186/s13000-018-0759-z 10.1002/path.4010 10.1038/nature08902 10.1016/j.ccell.2015.08.001 10.1073/pnas.1219232110 10.18632/oncotarget.14004 10.1080/14740338.2019.1607289 10.1038/nature14982 10.1038/s41591-018-0274-5
Modern Pathology : an Official Journal of the United Stat... Penning AJ, Al-Ibraheemi A et. al.

Apr 14th, 2021 - Infantile fibrosarcoma (IFS)/cellular congenital mesoblastic nephroma (cCMN) commonly harbors the classic ETV6-NTRK3 translocation. However, there are recent reports of mesenchymal tumors with IFS-like morphology harboring fusions of other recepto...

Independent domains for recruitment of PRC1 and PRC2 by human XIST.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016261
PLoS Genetics; Dixon-McDougall T, Brown CJ

Mar 22nd, 2021 - XIST establishes inactivation across its chromosome of origin, even when expressed from autosomal transgenes. To identify the regions of human XIST essential for recruiting heterochromatic marks we generated a series of overlapping deletions in an...

see more →

News  17 results

Psoriasiform Drug Eruption Secondary to Sorafenib: Case Series and Review of the Literature
https://www.mdedge.com/dermatology/article/208379/psoriasis/psoriasiform-drug-eruption-secondary-sorafenib-case-series-and/page/0/1?channel=45

Sep 19th, 2019 - Comment Sorafenib is an oral tyrosine kinase inhibitor that blocks tumor cell proliferation and angiogenesis due to its activity against vascular endothelial growth factor (VEGF) receptor, platelet-derived growth factor receptor, stem cell growth.

Conference Coverage: ASCO 2019
https://www.mdedge.com/sarcomajournal/article/208274/ewings-sarcoma/conference-coverage-asco-2019/page/0/10?channel=50183

Sep 17th, 2019 - TRK fusion cancer is a rare malignancy seen in a wide variety of adult and childhood tumor types. Among pediatric malignancies, infantile fibrosarcoma and congenital mesoblastic nephroma are rare, but have high NTRK gene fusion frequency.

Drug Yields 93% Response in TRK-Fusion Pediatric Cancers
https://www.medpagetoday.com/hematologyoncology/othercancers/72225

Apr 9th, 2018 - Action Points Note that this phase I/II study of the TRK-inhibitor larotrectinib demonstrated near universal efficacy in terms of objective response among individuals with TRK-fusion tumors. Be aware that TRK-fusion tumors are rare, but may be mor...

Fast Five Quiz: Test Your Knowledge of Soft-Tissue Sarcomas
https://reference.medscape.com/viewarticle/890598_4

Jan 2nd, 2018 - The histologic appearance shows a highly cellular fibroblastic proliferation of cells in parallel sheets arranged in intertwining whorls; this is commonly referred to as "herringbone architecture." Grossly, the tumors are fleshy, hemorrhagic, and ...

Targeting gene rearrangements shows promise in early study
https://www.mdedge.com/chestphysician/article/108163/lung-cancer/targeting-gene-rearrangements-shows-promise-early-study
Daniel M. Keller, MDedge News

Apr 19th, 2016 - Entrectinib, an investigational drug that targets several abnormal fusion proteins, showed antitumor activity and was safe in patients with several different types of advanced solid tumors. The patients had never before been exposed to drugs targe.

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