ALLMedicine™ Osteogenesis Imperfecta Center

May 14th, 2022 - To explore the experiences of women of short stature, including women with dwarfism and osteogenesis imperfecta (OI), during the perinatal period. Qualitative descriptive. Telephone interviews with women of short stature from across the United Sta...

May 14th, 2022 - Evaluating the genotype-phenotype relationship and the effect of treatment on the clinical course of Osteogenesis imperfecta (OI). We established a Chinese hospitalized OI cohort and followed up for an average of 6 years. All the patients were con...

May 13th, 2022 - This protocol seeks to formalize the application of accepted diagnostic and therapeutic measures in the study of individuals with known or suspected bone-related connective tissue disorders, including Osteogenesis Imperfecta and melorheostosis. It...

May 2nd, 2022 - Practice Essentials Osteoporosis is common and the risk of fracture is high among patients who have undergone solid organ transplantation. [1] The pretransplant bone evaluation should include a careful history, with particular attention to risk fa...

May 2nd, 2022 - Osteoporosis is common and the risk of fracture is high among patients who have undergone solid organ transplantation.[1] The pretransplant bone evaluation should include a careful history, with particular attention to risk factors for osteoporosi...

Mar 6th, 2018 - Bisphosphonate therapy is the mainstay of pharmacological intervention in young people with skeletal fragility. The evidence of its use in a variety of conditions remains limited despite over three decades of clinical experience. On behalf of the ...

May 13th, 2022 - This protocol seeks to formalize the application of accepted diagnostic and therapeutic measures in the study of individuals with known or suspected bone-related connective tissue disorders, including Osteogenesis Imperfecta and melorheostosis. It...

Apr 28th, 2022 - Ehlers-Danlos Syndrome (EDS) is a genetic disease that affects collagen synthesis and structure resulting in multisystem connective tissue involvement with twelve different subtypes. The clinical manifestations of EDS include skin hyperextensibili...

Mar 31st, 2022 - The proposed investigation is a pilot study that involves pediatric patients affected by spinal deformity (Adolescent Idiopathic Scoliosis and Osteogenesis Imperfecta). The main goal is to evaluate the acceptability, the safety and the overall sat...

Feb 28th, 2022 - Osteogenesis imperfecta (OI) is a heritable connective tissue disorder leading to frequent fractures and bone deformities. In about 90% of individuals with OI, the disease is caused by dominant mutations in one of the two genes coding for collagen...

Feb 24th, 2022 - Participants in Cohort A will be randomized 1:1:1 to receive setrusumab (low or high dose) or placebo. Participants will continue receiving their assigned dose of setrusumab until the phase 3 dose is determined. After the phase 3 dose(s) of setrus...

Feb 28th, 2022 - NEW YORK (Reuters Health) - In adults with osteogenesis imperfecta (OI), a single administration of fresolimumab, a pan-anti-TGF-beta neutralizing antibody, improved bone mass and turnover in a phase 1 study. Currently, there is no specific therap...

Jul 14th, 2020 - NEW YORK (Reuters Health) - Fetal gene and stem-cell therapies are emerging as treatment options for select conditions, according to a new review. "Fetal cellular and gene therapies are feasible and primed to become viable treatments for a number ...

Feb 28th, 2018 - PRENATAL SCREENING FOR SINGLE-GENE DISORDERS Vistara®, a non-invasive prenatal test (NIPT) from Natera, Inc, screens for single-gene disorders after 9 weeks’ gestation. Complementing the Panorama® NIPT, Vistara tests for major anatomic abnormaliti.

Feb 20th, 2018 - July 13-15, 2018, will be the dates of the biennial conference of the Osteogenesis Imperfecta Foundation. To take place in Baltimore, the program will feature forums with leading experts, practical living advice and research.

Jan 8th, 2018 - The Osteogenesis Imperfecta Foundation (OIF) will host its biennial national conference in Baltimore July 13-15, 2018. The program will feature sessions on medical advances and practical living guidance, along with forums with leading experts in o.