ALLMedicine™ Marfan Syndrome Center

Jan 21st, 2023 - The presence of adhesions is a common source of pain and dysfunction after hip arthroscopic surgery and an indication for revision surgery. The placement of a capsular spacer in the capsulolabral recess after lysis of adhesions has been developed ...

Jan 21st, 2023 - Congenital ectopia lentis (EL) refers to the congenital dysplasia or weakness of the lens suspensory ligament, resulting in an abnormal position of the crystalline lens, which can appear as isolated EL or as an ocular manifestation of a syndrome, ...

Jan 6th, 2023 - Collagen, the most abundant human protein, is a significant component of the extracellular matrix (ECM) in tissues and organs like skin, bone, ligaments, and tendons. Collagen secretion is a complex, multistage process involving many molecules. A ...

Dec 30th, 2022 - Over the past 20 years valve-sparing aortic root replacement has aroused increasing interest because of a progressive attitude towards the preservation of natural tissue. Aortic reimplantation is the most used technique to spare the valve, allowin...

Dec 29th, 2022 - To evaluate the characteristics and associated factors of choroidal thickness (ChT) and choriocapillaris flow deficit percentage (CC FD%) in children with Marfan syndrome (MFS). This is a cross-sectional study. The ChT of the subfoveal area and ot...

Apr 1st, 2016 - Surgical aortic specimens are usually examined in Pathology Departments as a result of treatment of aneurysms or dissections. A number of diseases, genetic syndromes (Marfan syndrome, Loeys-Dietz syndrome, etc.), and vasculopathic aging processes ...

Jan 13th, 2012 - ACMG standards and guidelines are designed primarily as an educational resource for medical geneticists and other health care providers to help them provide quality medical genetic services. Adherence to these standards and guidelines does not nec...

Dec 22nd, 2022 - To study the effect of losartan (an angiotensin receptor blocker-ARB) on aortic root growth in patients with Marfan syndrome, already treated with beta-blockers (BB). The effect of losartan will be compared to placebo. Losartan or placebo will be ...

Dec 16th, 2022 - Bicuspid aortic valve, along with other congenital conditions affecting the aortic wall, has been associated with elastic fibre loss, decrease in size of elastic lamellae, increased collagen deposition and smooth muscle loss compared to healthy co...

Nov 30th, 2022 - Marfan syndrome is an autosomal dominant disease (incidence 1/5000) characterized by ocular, cardiac and skeletal abnormalities. More recently, a decrease in fat and muscle mass has been demonstrated, associated with a decrease in exercise enduran...

Oct 28th, 2022 - Stretch marks or striae are common skin condition occurring in both genders, but they are more prevalent among women. These are linear dermal scars that are accompanied by epidermal atrophy. They usually occur frequently in numerous physiological ...

Oct 24th, 2022 - Loeys-Dietz syndrome (LDS) is a rare vascular genetic disorder (estimated prevalence 1/25,000-1/100,000) due primarily to mutations in the Transforming growth factor beta (TGF-β) cytokine receptor 1 and 2 genes. In addition to a common vascular ph...

Dec 6th, 2022 - Vaccination against the flu showed mixed results for cardiovascular prevention in a large international trial. (The Lancet Global Health) Dietary supplements with the strongest evidence for cardiometabolic benefits: omega-3 fatty acids, folic acid...

Aug 31st, 2022 - Beta-blockers have long been recommended to prevent aortic dissection associated with Marfan syndrome despite limited evidence, but a new analysis also supports a benefit from angiotensin receptors blockers (ARBs) and further suggests that beta-bl.

Aug 31st, 2022 - Beta-blockers have long been recommended to prevent aortic dissection associated with Marfan syndrome despite limited evidence, but a new analysis also supports a benefit from angiotensin receptors blockers (ARBs) and further suggests that beta-bl...

Apr 15th, 2021 - Patients with aortic dissection (AD) or aortic aneurysm (AA) should not be given fluoroquinolones unless no other treatment options are available, the authors of a new report conclude. In a retrospective cohort study which used data from the Taiwa...

Apr 12th, 2021 - For the first time, fluoroquinolone exposure was tied to aortic complications in patients with established aortic disease in a large study. In the cohort study from Taiwan, people with an existing aortic dissection (AD) or aortic aneurysm (AA) wer...