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About 2,903 results

ALLMedicine™ Marfan Syndrome Center

Research & Reviews  1,061 results

Oral Health Status in Marfan Syndrome: A Systematic Review and Meta-Analysis of 353 Cases.
https://doi.org/10.3390/ijerph19095048
International Journal of Environmental Research and Publi... Alam MK, Alfawzan AA et. al.

May 15th, 2022 - This meta-analysis aimed to compare Marfan syndrome (MFS) patients with non-MFS populations based on orofacial health status to combine publicly available scientific information while also improving the validity of primary study findings. A compre...

Fibrillin-1 deficiency in the outer perichondrium causes longitudinal bone overgrowth i...
https://doi.org/10.1093/hmg/ddac107
Human Molecular Genetics; Sedes L, Wondimu E et. al.

May 15th, 2022 - A disproportionate tall stature is the most evident manifestation in Marfan syndrome (MFS), a multisystem condition caused by mutations in the extracellular protein and TGFβ modulator, fibrillin-1. Unlike cardiovascular manifestations, there has b...

Prevalence and Outcomes of Primary Left Ventricular Dysfunction in Marfan Syndrome.
https://doi.org/10.1016/j.amjcard.2022.04.012
The American Journal of Cardiology; Connor BS, Algaze CA et. al.

May 14th, 2022 - Even in the absence of significant valvular disease, patients with Marfan syndrome (MFS) have evidence of impaired left ventricular (LV) performance, suggestive of a primary cardiomyopathy. However, the true prevalence and long-term outcomes of th...

The role of elastin on the mechanical properties of the anterior leaflet in porcine tri...
https://doi.org/10.1371/journal.pone.0267131
PloS One; Salinas SD, Farra YM et. al.

May 14th, 2022 - Elastin is present in the extracellular matrix (ECM) of connective tissues, and its mechanical properties are well documented. In Marfan syndrome, however, the inability to properly code for the protein fibrillin-1 prematurely leads to the degrada...

The impact of sex and gender on aortic events in patients with Marfan syndrome.
https://doi.org/10.1093/ejcts/ezac305
European Journal of Cardio-thoracic Surgery : Official Jo... Nucera M, Heinisch PP et. al.

May 12th, 2022 - Aim of this study was to explore sex and gender differences regarding aortic events in Marfan patients. We analysed all data from our connective tissue disorder database. Only patients with Marfan syndrome were included. For analysis, patients wer...

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Guidelines  2 results

Consensus statement on surgical pathology of the aorta from the Society for Cardiovascu...
https://doi.org/10.1016/j.carpath.2016.03.002
Cardiovascular Pathology : the Official Journal of the So... Halushka MK, Angelini A et. al.

Apr 1st, 2016 - Surgical aortic specimens are usually examined in Pathology Departments as a result of treatment of aneurysms or dissections. A number of diseases, genetic syndromes (Marfan syndrome, Loeys-Dietz syndrome, etc.), and vasculopathic aging processes ...

Evaluation of the adolescent or adult with some features of Marfan syndrome.
https://doi.org/10.1038/gim.2011.48
Genetics in Medicine : Official Journal of the American C... Pyeritz RE,

Jan 13th, 2012 - ACMG standards and guidelines are designed primarily as an educational resource for medical geneticists and other health care providers to help them provide quality medical genetic services. Adherence to these standards and guidelines does not nec...

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Clinicaltrials.gov  15 results

Pathogenetic Basis of Aortopathy and Aortic Valve Disease
https://clinicaltrials.gov/ct2/show/NCT03440697

Jan 20th, 2022 - Thoracic aortic aneurysm (TAA) is a type of aortopathy describing dilation of the proximal aortic dimensions including the aortic root, which is a risk factor for aortic dissection and sudden cardiac death. TAA and other forms of aortopathy (e.g. ...

Assessment of Risk in Thoracic Aortopathy Using 18F-Sodium Fluoride
https://clinicaltrials.gov/ct2/show/NCT04083118

Apr 28th, 2021 - Bicuspid aortic valve, along with other congenital conditions affecting the aortic wall, has been associated with elastic fibre loss, decrease in size of elastic lamellae, increased collagen deposition and smooth muscle loss compared to healthy co...

The Oscillation of Crystalline and Intraocular Lenses
https://clinicaltrials.gov/ct2/show/NCT04274634

Jul 29th, 2020 - The crystalline lens of the human eye helps to sharpen vision. There can be issues with the support/stability of the lens. This could be seen with the naked eye of an external observer or with the use of a slit lamp. Certain eye conditions can pre...

Classifying Ectopia Lentis in Marfan Syndrome Into Five Grades of Increasing Severity
https://clinicaltrials.gov/ct2/show/NCT04319107

Mar 27th, 2020 - Marfan syndrome is characterized by musculoskeletal manifestations, cardiovascular disease and ocular abnormalities, particularly ectopia lentis. Diagnosis depends on clinical evaluation, family history and molecular data: mutation in the fibrilli...

Positive Exposure: A Photography and Video Intervention for Individuals With Craniofacial Differences
https://clinicaltrials.gov/ct2/show/NCT00340964

Dec 12th, 2019 - This proposed pilot study aims to describe the use of an intervention, developed by Positive Exposure, for adolescents and young adults who may be challenged by the stigma associated with craniofacial differences. This non-profit organization uses...

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News  68 results

New Evidence Against Use of Fluoroquinolones in Aortic Disease
https://www.medscape.com/viewarticle/949358

Apr 15th, 2021 - Patients with aortic dissection (AD) or aortic aneurysm (AA) should not be given fluoroquinolones unless no other treatment options are available, the authors of a new report conclude. In a retrospective cohort study which used data from the Taiwa...

MHRA Highlights Risk of Heart Valve Regurgitation with Fluoroquinolones
https://www.medscape.com/viewarticle/943287

Dec 29th, 2020 - The Medicines and Healthcare products Regulatory Agency (MHRA) has issued a drug safety update highlighting a small risk of heart valve regurgitation with the use of systemic and inhaled fluoroquinolones. The update follows a European review of ep...

Multiple Eruptive Syringomas on the Penis
https://www.mdedge.com/dermatology/article/201251/pediatrics?channel=44
Weihuang Vivian Ning, MD, Sameer Bashey, MD et. al.

May 20th, 2019 - To the Editor: Syringomas are small, benign, asymptomatic eccrine or apocrine tumors that present as multiple discrete flesh-colored papules. They are more common in females than males.

FDA Warns of Aortic Aneurysm Risk With Fluoroquinolones
https://www.staging.medscape.com/viewarticle/906867

Dec 20th, 2018 - The US Food and Drug Administration (FDA) issued a warning today that fluoroquinolone use can increase the risk of aortic aneurysm. The agency is urging healthcare providers to avoid prescribing the powerful antibiotics to patients with or at risk...

FDA Warns of Aortic Aneurysm Risk With Fluoroquinolones
https://www.medscape.com/viewarticle/906867

Dec 20th, 2018 - The US Food and Drug Administration (FDA) issued a warning today that fluoroquinolone use can increase the risk of aortic aneurysm. The agency is urging healthcare providers to avoid prescribing the powerful antibiotics to patients with or at risk...

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Patient Education  15 results see all →