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About 2,996 results

ALLMedicine™ Chordoma Center

Research & Reviews  1,475 results

TGFB3 downregulation causing chordomagenesis and its tumor suppression role maintained ...
https://doi.org/10.1093/carcin/bgab022
Carcinogenesis Wang L, Guan X et. al.

May 31st, 2021 - Chordoma is a rare bone tumor arising from notochordal remnants, but the underlying mechanism remains elusive. By integrated mRNA and microRNA analyses, we found significant downregulation of TGFB3 along with upregulation of its inhibitor, miR-29 ...

Midterm prognosis and surgical implication for clival chordomas after extended transsph...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140514
BMC Neurology; Ogawa Y, Jokura H et. al.

May 23rd, 2021 - Treating chordoma through surgery alone is often ineffective. Thus, surgery often performed with irradiation, with a reported 5-year survival rate of 60-75%. The clinical course varies, and disease rarity prevents larger number of clinical investi...

Numerical Simulation of Nasal Airflow Aerodynamics, and Warming and Humidification in M...
https://doi.org/10.1016/j.resp.2021.103693
Respiratory Physiology & Neurobiology; Lou M, Zhang L et. al.

May 21st, 2021 - To study the effect of endoscopic endonasal surgery on nasal function for the treatment of clival chordoma. Pre and post-operative computed tomography (CT) scans of a case of chordoma treated with an endoscopic endonasal approach (EEA) were collec...

Tumor Growth Rate as a New Predictor of Progression-Free Survival After Chordoma Surgery.
https://doi.org/10.1093/neuros/nyab164
Neurosurgery Passeri T, di Russo P et. al.

May 14th, 2021 - Currently, different postoperative predictors of chordoma recurrence have been identified. Tumor growth rate (TGR) is an image-based calculation that provides quantitative information of tumor's volume changing over time and has been shown to pred...

Systematic review of charged-particle therapy for chordomas and sarcomas of the mobile ...
https://doi.org/10.3171/2021.2.FOCUS201059
Neurosurgical Focus; Pennington Z, Ehresman J et. al.

May 1st, 2021 - Long-term local control in patients with primary chordoma and sarcoma of the spine and sacrum is increasingly reliant upon en bloc resection with negative margins. At many institutions, adjuvant radiation is recommended; definitive radiation is al...

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Guidelines  2 results

NCCN Guidelines Insights: Bone Cancer, Version 2.2017
http://www.jnccn.org/content/15/2/155.full
Biermann, J.,et al

Jan 31st, 2017 - The NCCN Guidelines for Bone Cancer provide interdisciplinary recommendations for treating chordoma, chondrosarcoma, giant cell tumor of bone, Ewing sarcoma, and osteosarcoma. These NCCN Guidelines Insights summarize the NCCN Bone Cancer Panel's g.

Bone cancer.
https://doi.org/10.6004/jnccn.2013.0088
Journal of the National Comprehensive Cancer Network : JN... Biermann JS, Adkins DR et. al.

Jun 7th, 2013 - Primary bone cancers are extremely rare neoplasms, accounting for fewer than 0.2% of all cancers. The evaluation and treatment of patients with bone cancers requires a multidisciplinary team of physicians, including musculoskeletal, medical, and r...

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Clinicaltrials.gov  1,499 results

TGFB3 downregulation causing chordomagenesis and its tumor suppression role maintained ...
https://doi.org/10.1093/carcin/bgab022
Carcinogenesis Wang L, Guan X et. al.

May 31st, 2021 - Chordoma is a rare bone tumor arising from notochordal remnants, but the underlying mechanism remains elusive. By integrated mRNA and microRNA analyses, we found significant downregulation of TGFB3 along with upregulation of its inhibitor, miR-29 ...

Midterm prognosis and surgical implication for clival chordomas after extended transsph...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140514
BMC Neurology; Ogawa Y, Jokura H et. al.

May 23rd, 2021 - Treating chordoma through surgery alone is often ineffective. Thus, surgery often performed with irradiation, with a reported 5-year survival rate of 60-75%. The clinical course varies, and disease rarity prevents larger number of clinical investi...

Numerical Simulation of Nasal Airflow Aerodynamics, and Warming and Humidification in M...
https://doi.org/10.1016/j.resp.2021.103693
Respiratory Physiology & Neurobiology; Lou M, Zhang L et. al.

May 21st, 2021 - To study the effect of endoscopic endonasal surgery on nasal function for the treatment of clival chordoma. Pre and post-operative computed tomography (CT) scans of a case of chordoma treated with an endoscopic endonasal approach (EEA) were collec...

Tumor Growth Rate as a New Predictor of Progression-Free Survival After Chordoma Surgery.
https://doi.org/10.1093/neuros/nyab164
Neurosurgery Passeri T, di Russo P et. al.

May 14th, 2021 - Currently, different postoperative predictors of chordoma recurrence have been identified. Tumor growth rate (TGR) is an image-based calculation that provides quantitative information of tumor's volume changing over time and has been shown to pred...

Systematic review of charged-particle therapy for chordomas and sarcomas of the mobile ...
https://doi.org/10.3171/2021.2.FOCUS201059
Neurosurgical Focus; Pennington Z, Ehresman J et. al.

May 1st, 2021 - Long-term local control in patients with primary chordoma and sarcoma of the spine and sacrum is increasingly reliant upon en bloc resection with negative margins. At many institutions, adjuvant radiation is recommended; definitive radiation is al...

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News  11 results

FDA places tazemetostat trials on partial hold
https://www.mdedge.com/hematology-oncology/article/184994/lymphoma-plasma-cell-disorders/fda-places-tazemetostat-trials-partial-hold
HT Staff

Apr 25th, 2018 - The US Food and Drug Administration (FDA) has placed a partial hold on clinical trials of tazemetostat, an EZH2 inhibitor being developed to treat solid tumors and lymphomas. The hold has halted enrollment in US-based trials of tazemetostat, but s.

Treating Bone and Soft Tissue Sarcomas
https://www.onclive.com/publications/oncology-live/2015/october-2015/treating-bone-and-soft-tissue-sarcomas

Oct 15th, 2015 - Jonathan C. Trent, MD, PhD Breelyn A. Wilky, MD Sylvester Comprehensive Cancer Center University of Miami Miller School of Medicine Miami, FL Determining the best course of treatment for sarcomas of the bone and soft tissues is a complex process. ...

New Guidelines for Chordoma
https://www.mdedge.com/neurology/article/98601/new-guidelines-chordoma

Apr 8th, 2015 - Patients with chordoma, caregivers, and health care professionals have a new resource to aid in their fight against chordoma, with the publication of the first detailed, multidisciplinary treatment guidelines in the journal The Lancet Oncology. Th.

New guidelines for chordoma
https://www.mdedge.com/neurology/article/98606/rare-diseases/new-guidelines-chordoma

Apr 8th, 2015 - Chordoma patients, caregivers, and health care professionals have a new resource to aid in their fight against chordoma, with the publication of the first detailed, multidisciplinary treatment guidelines in the journal The Lancet Oncology. These r.

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Patient Education  9 results see all →