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About 54,638 results

ALLMedicine™ Systemic Lupus Erythematosus Center

Research & Reviews  25,937 results

Identification of circulating miR-22-3p and let-7a-5p as novel diagnostic biomarkers fo...
https://www.ncbi.nlm.nih.gov/pubmed/33635234
Clinical and Experimental Rheumatology; Tang J, Lin J et. al.

Feb 26th, 2021 - Early and correct diagnosis would be beneficial for outcomes of rheumatoid arthritis (RA), but there are some limitations in current diagnostic tools. In this study, we aimed to evaluate the diagnostic value of circulating miR-22-3p and let-7a-5p ...

Modulation of miR-548m encoded by X chromosome on the PTEN pathway in systemic lupus er...
https://www.ncbi.nlm.nih.gov/pubmed/33635226
Clinical and Experimental Rheumatology; Yang X, Shi L et. al.

Feb 26th, 2021 - Systemic lupus erythematosus (SLE) is a typical autoimmune disease, which is associated with many factors, such as miRNAs. The effect of miRNAs encoded by X chromosome (X-linked miRNAs) plays a crucial role in autoimmune disease. This study aims t...

The modulatory roles of T cell glycosylation in systemic lupus erythematosus.
https://www.ncbi.nlm.nih.gov/pubmed/33635227
Clinical and Experimental Rheumatology; Long Y, Hu C et. al.

Feb 26th, 2021 - Systemic lupus erythematosus (SLE) is a complex and challenging disorder. At present, abnormal T cells are considered to be the key point in the pathogenesis of SLE, including the losing central immune tolerance of self-reactive T cells in the thy...

Sepsis Mortality Is high in Patients With Connective Tissue Diseases Admitted to the In...
https://doi.org/10.1177/0885066621996257
Journal of Intensive Care Medicine; Krasselt M, Baerwald C et. al.

Feb 26th, 2021 - Patients with connective tissue diseases (CTD) such as systemic lupus erythematosus (SLE) have an increased risk for infections. This study investigated the outcome and characteristics of CTD patients under intensive care unit (ICU) treatment for ...

Niclosamide suppresses the expansion of follicular helper T cells and alleviates diseas...
https://doi.org/10.1186/s12967-021-02760-2 10.1056/NEJMra1100359 10.1002/art.39818 10.1002/art.39441 10.1016/j.clim.2017.07.004 10.1146/annurev-immunol-031210-101400 10.1084/jem.192.11.1545 10.1016/j.immuni.2009.07.002 10.1038/nri3447 10.1126/science.1175870 10.1074/jbc.M111.324046 10.1016/j.cytogfr.2016.05.001 10.1016/j.it.2015.11.001 10.1016/j.celrep.2015.08.049 10.1016/j.ejca.2005.08.016 10.4049/jimmunol.1502043 10.1016/j.clim.2015.04.004 10.1016/j.phymed.2019.152965 10.1016/j.cellsig.2017.04.001 10.1093/jnci/djr190 10.1158/1535-7163.MCT-12-0002 10.1002/jcp.29413 10.1016/j.kint.2017.01.018 10.1021/ml100146z 10.1186/s13075-017-1402-1 10.1172/JCI87037 10.1038/icb.2013.62 10.1073/pnas.1801196115 10.1038/cmi.2010.18 10.1038/nrrheum.2012.58 10.1084/jem.20171976 10.1038/sj.gene.6364286 10.1371/journal.pone.0062855 10.1038/s41419-019-1315-9 10.1073/pnas.0631696100 10.1002/art.38298 10.1182/blood-2009-08-238543 10.1002/eji.201545760 10.1016/j.cyto.2009.07.003 10.1016/j.immuni.2014.02.005 10.1073/pnas.1714717115 10.1038/ki.2015.296 10.1146/annurev.immunol.26.021607.090241 10.1016/S1074-7613(00)00020-0 10.1084/jem.20051611 10.1038/ng.468 10.1038/ni.1704 10.1038/ni.3229 10.1038/mi.2015.131 10.1038/cmi.2014.58 10.1016/j.canlet.2014.04.003 10.3389/fimmu.2018.01605
Journal of Translational Medicine; Jang SG, Lee J et. al.

Feb 26th, 2021 - Autoantibody production against endogenous cellular components is pathogenic feature of systemic lupus erythematosus (SLE). Follicular helper T (TFH) cells aid in B cell differentiation into autoantibody-producing plasma cells (PCs). The IL-6 and ...

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Guidelines  87 results

ACR Convergence 2020: Study Data for Lupus & Rheumatoid Arthritis
https://www.the-rheumatologist.org/article/acr-convergence-2020-study-data-for-lupus-rheumatoid-arthritis/
The Rheumatologist; Hickman RJ.

Nov 8th, 2020 - At the annual meeting’s second Plenary Session, Saturday, Nov. 7, speakers highlighted phase 2 results of a potential new biologic for systemic lupus erythematosus (SLE), as well as data on remission maintenance in rheumatoid arthritis (RA) after ...

Cardiac adverse events associated with chloroquine and hydroxychloroquine exposure in 20 years of drug safety surveillance reports
https://pubmed.ncbi.nlm.nih.gov/33154498/
Scientific Reports; Cohen IV, Makunts T et. al.

Nov 4th, 2020 - Chloroquine (CQ) and hydroxychloroquine (HCQ) are on the World Health Organization's List of Essential Medications for treating non-resistant malaria, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). In addition, both drugs are cu...

Do Menopause and Aging Affect the Onset and Progression of Rheumatoid Arthritis and Systemic Lupus Erythematosus?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557711/
Cureus Shah L

Oct 11th, 2020 - Rheumatoid arthritis and systemic lupus erythematosus (SLE) are autoimmune diseases that are commonly seen in the female population. Rheumatoid arthritis mainly consists of distal symmetrical deforming polyarthritis. SLE patients have immune compl...

Fasting Triglycerides & Glucose Index: A Useful Screening Test for Assessing Insulin Resistance in Patients Diagnosed with Rheumatoid Arthritis & Systemic Lupus Erythematosus
https://dmsjournal.biomedcentral.com/articles/10.1186/s13098-019-0495-x
Diabetology & Metabolic Syndrome; Contreras-Haro B,et al

Nov 26th, 2019 - Insulin resistance (IR) is frequently observed in patients with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE). In clinical practice, IR assessment is limited to a low proportion of patients due to cost and equipment and technical...

Sjögren’s Syndrome in Systemic Lupus Erythematosus - a Subset Characterized by a Systemic Inflammatory State
http://www.jrheum.org/content/early/2019/09/11/jrheum.190250
J Rheumatology; Ruacho G,et al

Sep 20th, 2019 - Secondary Sjögren’s syndrome (SLE-sSS) is an often-neglected subset of patients with Systemic lupus erythematosus (SLE). Furthermore, primary Sjögren’s syndrome overlaps and can be difficult to delineate from SLE. To shed light on the SLE-sSS subs...

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Drugs  27 results see all →

Clinicaltrials.gov  26,899 results

Identification of circulating miR-22-3p and let-7a-5p as novel diagnostic biomarkers fo...
https://www.ncbi.nlm.nih.gov/pubmed/33635234
Clinical and Experimental Rheumatology; Tang J, Lin J et. al.

Feb 26th, 2021 - Early and correct diagnosis would be beneficial for outcomes of rheumatoid arthritis (RA), but there are some limitations in current diagnostic tools. In this study, we aimed to evaluate the diagnostic value of circulating miR-22-3p and let-7a-5p ...

Modulation of miR-548m encoded by X chromosome on the PTEN pathway in systemic lupus er...
https://www.ncbi.nlm.nih.gov/pubmed/33635226
Clinical and Experimental Rheumatology; Yang X, Shi L et. al.

Feb 26th, 2021 - Systemic lupus erythematosus (SLE) is a typical autoimmune disease, which is associated with many factors, such as miRNAs. The effect of miRNAs encoded by X chromosome (X-linked miRNAs) plays a crucial role in autoimmune disease. This study aims t...

The modulatory roles of T cell glycosylation in systemic lupus erythematosus.
https://www.ncbi.nlm.nih.gov/pubmed/33635227
Clinical and Experimental Rheumatology; Long Y, Hu C et. al.

Feb 26th, 2021 - Systemic lupus erythematosus (SLE) is a complex and challenging disorder. At present, abnormal T cells are considered to be the key point in the pathogenesis of SLE, including the losing central immune tolerance of self-reactive T cells in the thy...

Sepsis Mortality Is high in Patients With Connective Tissue Diseases Admitted to the In...
https://doi.org/10.1177/0885066621996257
Journal of Intensive Care Medicine; Krasselt M, Baerwald C et. al.

Feb 26th, 2021 - Patients with connective tissue diseases (CTD) such as systemic lupus erythematosus (SLE) have an increased risk for infections. This study investigated the outcome and characteristics of CTD patients under intensive care unit (ICU) treatment for ...

Niclosamide suppresses the expansion of follicular helper T cells and alleviates diseas...
https://doi.org/10.1186/s12967-021-02760-2 10.1056/NEJMra1100359 10.1002/art.39818 10.1002/art.39441 10.1016/j.clim.2017.07.004 10.1146/annurev-immunol-031210-101400 10.1084/jem.192.11.1545 10.1016/j.immuni.2009.07.002 10.1038/nri3447 10.1126/science.1175870 10.1074/jbc.M111.324046 10.1016/j.cytogfr.2016.05.001 10.1016/j.it.2015.11.001 10.1016/j.celrep.2015.08.049 10.1016/j.ejca.2005.08.016 10.4049/jimmunol.1502043 10.1016/j.clim.2015.04.004 10.1016/j.phymed.2019.152965 10.1016/j.cellsig.2017.04.001 10.1093/jnci/djr190 10.1158/1535-7163.MCT-12-0002 10.1002/jcp.29413 10.1016/j.kint.2017.01.018 10.1021/ml100146z 10.1186/s13075-017-1402-1 10.1172/JCI87037 10.1038/icb.2013.62 10.1073/pnas.1801196115 10.1038/cmi.2010.18 10.1038/nrrheum.2012.58 10.1084/jem.20171976 10.1038/sj.gene.6364286 10.1371/journal.pone.0062855 10.1038/s41419-019-1315-9 10.1073/pnas.0631696100 10.1002/art.38298 10.1182/blood-2009-08-238543 10.1002/eji.201545760 10.1016/j.cyto.2009.07.003 10.1016/j.immuni.2014.02.005 10.1073/pnas.1714717115 10.1038/ki.2015.296 10.1146/annurev.immunol.26.021607.090241 10.1016/S1074-7613(00)00020-0 10.1084/jem.20051611 10.1038/ng.468 10.1038/ni.1704 10.1038/ni.3229 10.1038/mi.2015.131 10.1038/cmi.2014.58 10.1016/j.canlet.2014.04.003 10.3389/fimmu.2018.01605
Journal of Translational Medicine; Jang SG, Lee J et. al.

Feb 26th, 2021 - Autoantibody production against endogenous cellular components is pathogenic feature of systemic lupus erythematosus (SLE). Follicular helper T (TFH) cells aid in B cell differentiation into autoantibody-producing plasma cells (PCs). The IL-6 and ...

see more →

News  1,673 results

Meta-Analysis Finds Much Less Lupus Than Expected
https://www.medscape.com/viewarticle/945116

Feb 1st, 2021 - The prevalence of systemic lupus erythematosus (SLE) appears to be much lower than previously believed and may pose "a potential risk to research funding for the disease," according to results of a meta-analysis involving a network of population-b...

High Hydroxychloroquine Blood Level May Lower Thrombosis Risk in Lupus
https://www.medscape.com/viewarticle/943726

Jan 6th, 2021 - Maintaining an average hydroxychloroquine whole blood level above 1,068 ng/mL significantly reduced the risk of thrombosis in adults with systemic lupus erythematosus, based on data from 739 patients. Hydroxychloroquine (HCQ) is a common treatment...

FDA Expands Belimumab Indication to Adults With Lupus Nephritis
https://www.medscape.com/viewarticle/942894

Dec 17th, 2020 - The US Food and Drug Administration (FDA) has expanded the indication for belimumab (Benlysta) to adults with active lupus nephritis who are receiving standard therapy. Roughly 40% of patients with systemic lupus erythematosus (SLE) develop lupus ...

High-Need, High-Cost Lupus Patients Described for First Time
https://www.medscape.com/viewarticle/942712

Dec 15th, 2020 - A small group of patients with systemic lupus erythematosus (SLE) who have high costs and needs and frequent hospitalizations can be identified through a shared set of sociodemographic characteristics and risk factors that distinguish them from ot...

Worse AMI Outcomes for Lupus, Systemic Sclerosis Patients
https://www.medscape.com/viewarticle/942688

Dec 15th, 2020 - NEW YORK (Reuters Health) - Patients with systemic lupus erythematosus (SLE) are less likely to receive invasive treatment for acute myocardial infarction (AMI) and have worse AMI outcomes than do patients without autoimmune rheumatic disease (AIR...

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Patient Education  15 results see all →