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Association of Testosterone Therapy With Risk of Venous Thromboembolism Among Men With and Without Hypogonadism
https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2754091
JAMA Internal Medicine; Rob F. Walker, et al

Nov 30th, 2019 - Testosterone therapy is increasingly prescribed in patients without a diagnosis of hypogonadism. This therapy may be associated with increased risk of venous thromboembolism (VTE) through several mechanisms, including elevated hematocrit levels, which increase blood viscosity.

Fasting Triglycerides & Glucose Index: A Useful Screening Test for Assessing Insulin Resistance in Patients Diagnosed with Rheumatoid Arthritis & Systemic Lupus Erythematosus
https://dmsjournal.biomedcentral.com/articles/10.1186/s13098-019-0495-x
Diabetology & Metabolic Syndrome; Contreras-Haro B, et al

Nov 26th, 2019 - Insulin resistance (IR) is frequently observed in patients with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE). In clinical practice, IR assessment is limited to a low proportion of patients due to cost and equipment and technical expertise requirements. The surrogate index of triglycerides and glucose (TyG index) has been validated in non-rheumatic populations, showing adequat...

Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction
https://www.nejm.org/doi/full/10.1056/NEJMoa1912388?query=featured_home
New England Journal of Medicine; Tardif JC et al

Nov 16th, 2019 - Experimental and clinical evidence support the role of inflammation in atherosclerosis and its complications. Colchicine is an orally administered, potent antiinflammatory medication that is indicated for the treatment of gout and pericarditis.

FDA Approves Botox® (Onabotulinumtoxina) For Pediatric Patients With Lower Limb Spasticity, Excluding Spasticity Caused By Cerebral Palsy
https://www.allergan.com/News/Details/2019/10/FDA%20Approves%20BOTOX%20onabotulinumtoxinA%20for%20Pediatric%20Patients%20with%20Lower%20Limb%20Spasticity%20Excluding%20Sp

Oct 23rd, 2019 - Allergan plc (NYSE: AGN) today announced that the U.S. Food and Drug Administration (FDA) approved the company's supplemental Biologics License Application (sBLA) for BOTOX® for the treatment of pediatric patients (2 to 17 years of age) with lower limb spasticity, excluding spasticity caused by cerebral palsy (CP). This marks the 11th BOTOX® therapeutic indication, having been approved for pedi...

U.S. FDA Approves XARELTO® (rivaroxaban) to Help Prevent Blood Clots in Acutely Ill Medical Patients
https://www.jnj.com/u-s-fda-approves-xarelto-rivaroxaban-to-help-prevent-blood-clots-in-acutely-ill-medical-patients

Oct 13th, 2019 - he Janssen Pharmaceutical Companies of Johnson & Johnson announced today that the U.S. Food and Drug Administration (FDA) has approved XARELTO® (rivaroxaban) for the prevention of venous thromboembolism (VTE), or blood clots, in hospitalized acutely ill medical patients at risk for thromboembolic complications who are not at high risk of bleeding. With the approval of this new indication, XAREL...

Anticoagulation: Updated Guidelines for Outpatient Management
https://www.aafp.org/afp/2019/1001/p426.html
American Family Physician;

Sep 30th, 2019 - Anticoagulation therapy is recommended for preventing, treating, and reducing the recurrence of venous thromboembolism, and preventing stroke in persons with atrial fibrillation. Direct oral anticoagulants are first-line agents for eligible patients for treating venous thromboembolism and preventing stroke in those with nonvalvular atrial fibrillation. Vitamin K antagonists are recommended for ...

Sjögren’s Syndrome in Systemic Lupus Erythematosus - a Subset Characterized by a Systemic Inflammatory State
http://www.jrheum.org/content/early/2019/09/11/jrheum.190250
J Rheumatology; Ruacho G, et al

Sep 20th, 2019 - Secondary Sjögren’s syndrome (SLE-sSS) is an often-neglected subset of patients with Systemic lupus erythematosus (SLE). Furthermore, primary Sjögren’s syndrome overlaps and can be difficult to delineate from SLE. To shed light on the SLE-sSS subset, we investigated a large and well-characterized SLE cohort comparing patients with SLE-sSS versus SLE patients without SS (SLE-nonsSS) and controls.

Osteosarcoma and Malignant Fibrous Histiocytoma of Bone Treatment (PDQ®)–Health Professional Version
https://www.cancer.gov/types/bone/hp/osteosarcoma-treatment-pdq?cid=eb_govdel

Aug 21st, 2019 - Osteosarcoma and malignant fibrous histiocytoma (MFH) of bone treatment depends on site, extent of disease, and grade. Treatment options include surgery, chemotherapy, radiation therapy, and targeted therapy. Get detailed treatment information for osteosarcoma and MFH in this summary for clinicians

Unraveling the Safety Profile of Proton-Pump Inhibitors
https://www.jwatch.org/na49660/2019/08/19/unraveling-safety-profile-proton-pump-inhibitors
Journal Watch;

Aug 19th, 2019 - Proton-pump inhibitors (PPIs) provide important clinical benefits for many patients. However, observational studies have suggested an association between PPI use and a variety of adverse events, including dementia, osteoporosis, bone fractures, micronutrient deficiencies, pneumonia, spontaneous bacterial peritonitis, kidney disease, and enteric infections. We have observed that some patients wi...

Spinal muscular atrophy - Genetics Home Reference - NIH
https://ghr.nlm.nih.gov/condition/spinal-muscular-atrophy

Aug 5th, 2019 - Spinal muscular atrophy is a genetic disorder characterized by weakness and wasting (atrophy) in muscles used for movement (skeletal muscles). It is caused by a loss of specialized nerve cells, called motor neurons that control muscle movement. The weakness tends to be more severe in the muscles that are close to the center of the body (proximal) compared to muscles away from the body's center ...

Venous Thromboembolism Prophylaxis and Treatment in Patients With Cancer
https://ascopubs.org/doi/full/10.1200/JCO.19.01461

Aug 4th, 2019 - PURPOSE To provide updated recommendations about prophylaxis and treatment of venous thromboembolism (VTE) in patients with cancer. METHODS PubMed and the Cochrane Library were searched for randomized controlled trials (RCTs) and meta-analyses of RCTs published from August 1, 2014, through December 4, 2018. ASCO convened an Expert Panel to review the evidence and revise previous recommenda...

FDA Approves Daiichi Sankyo’s TURALIO™ (pexidartinib) for the Treatment of Select Patients with TGCT, a Rare and Debilitating Tumor
https://dsi.com/press-releases/-/article/364091/10481984

Aug 1st, 2019 - TURALIO is the first and only approved therapy for adult patients with symptomatic tenosynovial giant cell tumor (TGCT) associated with severe morbidity or functional limitations and not amenable to improvement with surgery

Acupuncture for Pain
https://www.aafp.org/afp/2019/0715/p89.html
American Family Physician; Kelly, R. et. al.

Jul 14th, 2019 - Acupuncture has been increasingly used as an integrative or complementary therapy for pain. It is well-tolerated with little risk of serious adverse effects. Traditional acupuncture and nontraditional techniques, such as electroacupuncture and dry needling, often result in reported pain improvement. Multiple factors may contribute to variability in acupuncture's therapeutic effects, including n...

Machine learning approaches to predict lupus disease activity from gene expression data
https://www.nature.com/articles/s41598-019-45989-0
Scientific Reports; Kegerreis, B. et. al.

Jul 2nd, 2019 - The integration of gene expression data to predict systemic lupus erythematosus (SLE) disease activity is a significant challenge because of the high degree of heterogeneity among patients and study cohorts, especially those collected on different microarray platforms. Here we deployed machine learning approaches to integrate gene expression data from three SLE data sets and used it to classify...

Arthritis Prevalence Statistics
https://www.rheumatology.org/Learning-Center/Statistics/Prevalence-Statistics

Jun 26th, 2019 - View overall prevalence of arthritis and rheumatic diseases as well as prevalence among specific racial and ethnic groups.

The Nature and Prevalence of Spinal Muscular Atrophy
https://www.neurologylive.com/peer-exchange/understanding-spinal-muscular-atrophy/the-nature-and-prevalence-of-spinal-muscular-atrophy

May 28th, 2019 - A panel of experts begin their discussion by reviewing the etiology and epidemiology of spinal muscular atrophy (SMA).

AveXis receives FDA approval for Zolgensma®, the first and only gene therapy for pediatric patients with spinal muscular atrophy (SMA)
https://www.avexis.com/content/pdf/press_release.pdf

May 23rd, 2019 - AveXis, a Novartis company, today announced the US Food and Drug Administration (FDA) has approved Zolgensma® (onasemnogene abeparvovec-xioi) for the treatment of pediatric patients less than 2 years of age with spinal muscular atrophy (SMA) with bi-allelic mutations in the survival motor neuron 1 (SMN1) gene. Zolgensma is designed to address the genetic root cause of SMA by providing a fun...

Time in remission and low disease activity state (LDAS) are associated with a better quality of life in patients with systemic lupus erythematosus: results from LUMINA (LXXIX), a multiethnic, multi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560976/
RMD Open;

May 22nd, 2019 - Aims To determine whether the proportion of time systemic lupus erythematosus patients achieve remission/low disease activity state (LDAS) is associated with a better quality of life (QoL). Patients and methods Patients from a well-established multiethnic, multicentre US cohort were included: remission: Systemic Lupus Activity Measure (SLAM) score=0, prednisone≤5 mg/day and no immunosuppre...

Pediatric Systemic Lupus Erythematosus Workup
https://emedicine.medscape.com/article/1008066-workup

Apr 26th, 2019 - The initial laboratory evaluation should include a complete blood count (CBC) with platelets and reticulocyte count; a complete chemistry panel to evaluate electrolytes, liver, and kidney function; urine analysis; and a measure of acute phase reactants (eg, erythrocyte sedimentation rate [ESR] or C-reactive protein [CRP]).

Lupus Erythematosus - StatPearls
https://www.ncbi.nlm.nih.gov/books/NBK535405/

Apr 19th, 2019 - The acute form of systemic lupus erythematosus (SLE) differs from the chronic form. It disseminates differently, and it is highly fatal. Kaposi was the first in recognizing SLE in 1872, and then Pernet described it in 1908. Before that time SLE was considered to be a non-fatal disfiguring skin disease. It is now to be considered a chronic inflammatory disease characterized by a course of altern...

FDA Approves EVENITY™ (romosozumab-aqqg) For The Treatment Of Osteoporosis In Postmenopausal Women At High Risk For Fracture
https://wwwext.amgen.com/media/news-releases/2019/04/fda-approves-evenity-romosozumabaqqg-for-the-treatment-of-osteoporosis-in-postmenopausal-women-at-high-risk-for-fracture/

Apr 8th, 2019 - Amgen (NASDAQ: AMGN) and UCB (Euronext Brussels: UCB) today announced that the U.S. Food and Drug Administration (FDA) has approved EVENITY™ (romosozumab-aqqg) for the treatment of osteoporosis in postmenopausal women at high risk for fracture. EVENITY is the first and only bone builder with a unique dual effect that both increases bone formation and to a lesser extent reduces bone resorption (...

2019 update of the EULAR recommendations for the management of systemic lupus erythematosus
https://ard.bmj.com/content/78/6/736
Annals of the Rheumatic Diseases; Fanouriakis, A. et. al.

Mar 28th, 2019 - Our objective was to update the EULAR recommendations for the management of systemic lupus erythematosus (SLE), based on emerging new evidence. We performed a systematic literature review (01/2007–12/2017), followed by modified Delphi method, to form questions, elicit expert opinions and reach consensus. Treatment in SLE aims at remission or low disease activity and prevention of flares. Hydrox...

TRILURON™ - P180040
https://www.fda.gov/MedicalDevices/ProductsandMedicalProcedures/DeviceApprovalsandClearances/Recently-ApprovedDevices/ucm635176.htm

Mar 25th, 2019 - TRILURON™ is a single-use syringe prefilled with sodium hyaluronate. Hyaluronate is a chemical found in the body, and it is present in joint tissues and in the fluid that fills the joints. The body's own hyaluronate acts like a lubricant and a shock absorber in the joint, and it is needed for the joint to work properly. In osteoarthritis, there may not be enough hyaluronate, and there may be a ...

Osteoporosis (Secondary) - StatPearls
https://www.ncbi.nlm.nih.gov/books/NBK470166/
Ganesan, K. et. al.

Mar 1st, 2019 - Osteoporosis is a bone disorder which is characterized by a decrease in bone strength, resulting from reduced bone mineral density, microarchitectural disruption, and skeletal fragility, thereby causing an increased risk of fracture. Secondary osteoporosis, which occurs due to the presence of underlying disease or medications, can also lead to low bone mass, resulting in increased risk of fract...

Apixaban to Prevent Venous Thromboembolism in Patients with Cancer
https://www.nejm.org/doi/10.1056/NEJMoa1814468
The New England Journal of Medicine; Carrier, M. et. al.

Feb 20th, 2019 - Patients with active cancer have an increased risk of venous thromboembolism, which results in substantial morbidity, mortality, and health care expenditures. The Khorana score (range, 0 to 6, with higher scores indicating a higher risk of venous thromboembolism) has been validated to identify patients with cancer at elevated risk for this complication and may help select those who could benefi...

Rivaroxaban for Thromboprophylaxis in High-Risk Ambulatory Patients with Cancer
https://doi.org/10.1056/NEJMoa1814630
Khorana. A., et al

Feb 20th, 2019 - Ambulatory patients receiving systemic cancer therapy are at varying risk for venous thromboembolism. However, the benefit of thromboprophylaxis in these patients is uncertain. In high-risk ambulatory patients with cancer, treatment with rivaroxaban did not result in a significantly lower incidence of venous thromboembolism or death due to venous thromboembolism in the 180-day trial period. Dur...

Triassic Cancer—Osteosarcoma in a 240-Million-Year-Old Stem-Turtle
https://jamanetwork.com/journals/jamaoncology/fullarticle/2723578
Hairdy, Y. et. al.

Feb 6th, 2019 - Paleopathology, the study of ancient disease, is a vital way by which we understand the evolution of pathogens, immune systems, healing physiology, and ultimately the environment. Cancer research has focused on its prevalence in various organisms and has found that although some animals have a high propensity for cancer,1 others seem to be resistant.2 The prevalence of cancer in the tree of lif...

Gout Activity Score has predictive validity and is sensitive to change: results from the Nottingham Gout Treatment Trial (Phase II)
https://academic.oup.com/rheumatology/advance-article/doi/10.1093/rheumatology/key446/5306645
Chinchilla, S. et. al.

Feb 3rd, 2019 - Objectives To examine the predictive validity of the Gout Activity Score (GAS), its correlation with the Gout Impact Scale (GIS) and their sensitivity to change. Methods Data from a clinical trial in which participants with one or more gout flares in the previous year were recruited from primary care and randomized to nurse-led or continuing usual care were used in this study. GAS and GIS were ...

Prevalence, symptom burden, and natural history of deep vein thrombosis in people with advanced cancer in specialist palliative care units (HIDDen): a prospective longitudinal observational study
https://www.thelancet.com/journals/lanhae/article/PIIS2352-3026(18)30215-1/fulltext
White, C. et. al.

Jan 31st, 2019 - The prevalence of deep venous thrombosis in patients with advanced cancer is unconfirmed and it is unknown whether current international thromboprophylaxis guidance is applicable to this population. We aimed to determine prevalence and predictors of femoral deep vein thrombosis in patients admitted to specialist palliative care units (SPCUs).

Intra-articular corticosteroids and the risk of knee osteoarthritis progression: results from the Osteoarthritis Initiative
https://www.oarsijournal.com/article/S1063-4584(19)30033-0/fulltext
Zeng, C. et. al.

Jan 27th, 2019 - Objective A recent randomized clinical trial reported that repeated intra-articular corticosteroids (IACs) were associated with a greater cartilage loss. This study aimed to examine the relation of IACs to knee radiographic osteoarthritis (ROA) progression in a real-world setting. Design A cohort that initiated IACs and a comparison cohort without IACs from participants with mild to moderate kn...

The association between diet and glucocorticoid treatment in patients with SLE
https://lupus.bmj.com/content/3/1/e000135
Lupus Science & Medicine; Lourdudoss, C. et. al.

Jan 18th, 2019 - Background Some studies suggest that the risk for and severity of systemic lupus erythematosus (SLE) can be modified by certain nutrients. The aim of this study was to investigate the association between diet and glucocorticoid (GC) treatment, as a proxy for disease activity, in patients with SLE. Methods We included 111 patients with SLE from the SLE Vascular Impact Cohort (SLEVIC). Dietary...

Correlation between Xerostomia index, Clinical Oral Dryness Scale, and ESSPRI with different hyposalivation tests
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324613/
Open Access Rheumatology; Hijjaw, O. et. al.

Jan 3rd, 2019 - Xerostomia is a subjective measure of dry mouth, while hyposalivation is an objective measure of reduced saliva flow rate. In this study, we aim to assess the association between commonly used xerostomia scoring systems, with different hyposalivation measures among Sjogren Syndrome (SS) patients.

Spinal Muscular Atrophy - NORD (National Organization for Rare Disorders)
https://rarediseases.org/rare-diseases/spinal-muscular-atrophy/

Dec 12th, 2018 - Spinal muscular atrophy (SMA) is a group of inherited disorders characterized by a loss of certain nerve cells in the spinal cord called motor neurons or anterior horn cells. Motor neurons receive the nerve impulses transmitted from the brain to the spinal cord (brainstem) and, in turn, transmit the impulses to the muscle via the peripheral nerves. The loss of motor neurons leads to progressive...

Significance and impact of dietary factors on systemic lupus erythematosus pathogenesis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327661/
Experimental and Therapeutic Medicine;

Nov 15th, 2018 - Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown etiology, although its mechanisms involve genetic, epigenetic and environmental risk factors. Considering that SLE pathogenesis is yet to be explored, recent studies aimed to investigate the impact of diet, in terms of triggering or altering the course of the disease. To study the impact of diet on SLE pathogenesis, we condu...

Osteoporosis - StatPearls
https://www.ncbi.nlm.nih.gov/books/NBK441901/
Porter, J. et. al.

Nov 14th, 2018 - Osteoporosis is defined as low bone mineral density caused by altered bone microstructure ultimately predisposing patients to low-impact, fragility fractures. Osteoporotic fractures lead to a significant decrease in quality of life, with an increased morbidity, mortality, and disability.[1] Over 50% of postmenopausal Caucasian women will have an osteoporotic-related fracture. Only 33% of senior...

Psoriatic arthritis – new perspectives
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524178/
Archives of Medical Science; Krakowski, P.

Aug 22nd, 2018 - Psoriatic arthritis (PsA) is a seronegative arthropathy with many clinical manifestations, and it may affect nearly a half of patients with psoriasis. PsA should be diagnosed as early as possible to slow down joint damage and progression of disability. To improve the diagnosis of PsA, physicians should look for peripheral inflammatory pain, axial inflammatory pain, dactylitis, and buttock and s...

Spinal Muscular Atrophy: Epidemiology and Genetics
https://hcp.smanewstoday.com/spinal-muscular-atrophy-epidemiology-and-genetics/

Aug 14th, 2018 - With an estimated incidence of approximately 1 in 10,00-11,00 live births, Spinal Muscular Atrophy (SMA) is the second most common autosomal recessive cause of death in children in the United States; incidence in European countries may be higher.1-3 The estimated prevalence of SMA in the United States, Europe, and Australia is less than 9,000 patients.2 SMA presents in five different forms, SMA...

NIH Fact Sheets - Lupus
https://report.nih.gov/nihfactsheets/ViewFactSheet.aspx?csid=47

Jun 28th, 2018 - Lupus statistics (systemic lupus erythematosus) is a serious and potentially fatal disease that mainly affects young women. The cause of the disease is not known, but it is believed to be an autoimmune disease (an illness that occurs when the body mistakenly detects its own tissue as foreign and attacks itself).The disease often starts between the ages of 15 and 44. The manifestations of lupus ...

Systemic lupus erythematosus images | DermNet NZ
https://www.dermnetnz.org/topics/systemic-lupus-erythematosus-images/

Dec 30th, 2017 - Systemic lupus erythematosus images. SLE. Authoritative facts about the skin from DermNet New Zealand Trust.

An update on diet and nutritional factors in systemic lupus erythematosus management
https://www.cambridge.org/core/journals/nutrition-research-reviews/article/an-update-on-diet-and-nutritional-factors-in-systemic-lupus-erythematosus-management/992C22937FC53A6B1D3D30BC97B331E9
Nutrition Research Reviews; Aparicio-Soto, M. et. al.

Mar 14th, 2017 - Systemic lupus erythematosus (SLE) is a chronic inflammatory and autoimmune disease characterised by multiple organ involvement and a large number of complications. SLE management remains complicated owing to the biological heterogeneity between patients and the lack of safe and specific targeted therapies. There is evidence that dietary factors can contribute to the geoepidemiology of autoimmu...

Lupus: Using Diet and Nutrition to Improve Symptoms and Outcomes
https://www.rheumatologyadvisor.com/home/topics/systemic-lupus-erythematosus/lupus-using-diet-and-nutrition-to-improve-symptoms-and-outcomes/
Rodriguez, T.

Mar 5th, 2017 - A healthy diet is important in general, but perhaps even more so for the roughly 1 million Americans and 3 million people worldwide who suffer from systemic lupus erythematosus (SLE).1 Because of the multifaceted challenges presented by the disease, consuming adequate amounts of the right nutrients — and limiting others — can help relieve symptoms and improve outcomes

Get the Facts: Sugar-Sweetened Beverages and Consumption
https://www.cdc.gov/nutrition/data-statistics/sugar-sweetened-beverages-intake.html

Feb 26th, 2017 - Sugar-sweetened beverages (SSBs) or sugary drinks are leading sources of added sugars in the American diet. Frequently drinking sugar-sweetened beverages is associated with weight gain/obesity, type 2 diabetes, heart disease, kidney diseases, non-alcoholic liver disease, tooth decay and cavities, and gout, a type of arthritis.1-4 Limiting the amount of SSB intake can help individuals maintain a...

Systemic Lupus Erythematosus: Primary Care Approach to Diagnosis and Management
https://www.aafp.org/afp/2016/0815/p284.html
American Family Physician;

Aug 14th, 2016 - Systemic lupus erythematosus is an autoimmune disease that affects many systems, including the skin, musculoskeletal, renal, neuropsychiatric, hematologic, cardiovascular, pulmonary, and reproductive systems. Family physicians should be familiar with the manifestations of lupus to aid in early diagnosis, monitoring patients with mild disease, recognizing warning signs that require referral to a...

FDA Grants Breakthrough Therapy Designation for Daiichi Sankyo and Plexxikon's Investigational CSF-1R Inhibitor Pexidartinib (PLX3397) in Tenosynovial Giant Cell Tumo
https://www.prnewswire.com/news-releases/fda-grants-breakthrough-therapy-designation-for-daiichi-sankyo-and-plexxikons-investigational-csf-1r-inhibitor-pexidartinib-plx3397-in-tenosynovial-giant-cell-tumor-300169556.html

Oct 10th, 2015 - Daiichi Sankyo, Inc. and Plexxikon Inc., a member of the Daiichi Sankyo Group, today announced that the U.S. Food and Drug Administration (FDA) has granted Breakthrough Therapy Designation to its investigational oral CSF-1R inhibitor pexidartinib (formerly PLX3397) for the treatment of tenosynovial giant cell tumor (TGCT) where surgical removal of the tumor would be associated with potentially ...

Four Strategies for Managing Opioid-Induced Side Effects in Older Adults
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418642/
Rogers, E. et. al.

Apr 4th, 2014 - Opioid medications are considered key therapeutic interventions in the management of both acute pain and cancer-related pain among patients of all ages; however, their role in treating patients with chronic noncancer pain remains controversial. While the debate about the appropriate role of opioids in the treatment of chronic pain continues, the fact remains that many clinicians prescribe opioi...

Efficacy and cost-effectiveness of nurse-led care involving education and engagement of...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196879
Lancet (London, England); Doherty M, Jenkins W et. al.

Oct 22nd, 2018 - In the UK, gout management is suboptimum, with only 40% of patients receiving urate-lowering therapy, usually without titration to achieve a target serum urate concentration. Nurses successfully manage many diseases in primary care. We compared nurse-led gout care to usual care led by general practitioners (GPs) for people in the community. Research nurses were trained in best practice manageme...

Baricitinib for systemic lupus erythematosus: a double-blind, randomised, placebo-contr...
https://doi.org/10.1016/S0140-6736(18)31363-1
Lancet (London, England); Wallace DJ, Furie RA et. al.

Jul 25th, 2018 - Patients with systemic lupus erythematosus have substantial unmet medical need. Baricitinib is an oral selective Janus kinase (JAK)1 and JAK2 inhibitor that we hypothesised might have therapeutic benefit in patients with systemic lupus erythematosus. In this double-blind, multicentre, randomised, placebo-controlled, 24-week phase 2 study, patients were recruited from 78 centres in 11 countries....

Screening for Osteoporosis to Prevent Fractures: US Preventive Services Task Force Reco...
https://doi.org/10.1001/jama.2018.7498
JAMA , Curry SJ et. al.

Jun 27th, 2018 - By 2020, approximately 12.3 million individuals in the United States older than 50 years are expected to have osteoporosis. Osteoporotic fractures, particularly hip fractures, are associated with limitations in ambulation, chronic pain and disability, loss of independence, and decreased quality of life, and 21% to 30% of patients who experience a hip fracture die within 1 year. The prevalence o...

Association of Varicose Veins With Incident Venous Thromboembolism and Peripheral Arter...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838574
JAMA Chang SL, Huang YL et. al.

Feb 27th, 2018 - Varicose veins are common but rarely associated with serious health risks. Deep venous thrombosis (DVT), pulmonary embolism (PE), and peripheral artery disease (PAD) are also vascular diseases but associated with serious systemic effects. Little is known about the association between varicose veins and the incidence of other vascular diseases including DVT, PE, and PAD. To investigate whether v...

Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Wome...
https://doi.org/10.1001/jama.2017.16952
JAMA Gartlehner G, Patel SV et. al.

Dec 13th, 2017 - Postmenopausal status coincides with increased risks for chronic conditions such as heart disease, osteoporosis, cognitive impairment, or some types of cancers. Previously, hormone therapy was used for the primary prevention of these chronic conditions. To update evidence for the US Preventive Services Task Force on the benefits and harms of hormone therapy in reducing risks for chronic conditi...

Edoxaban for the Treatment of Cancer-Associated Venous Thromboembolism.
https://doi.org/10.1056/NEJMoa1711948
The New England Journal of Medicine; Raskob GE, van Es N et. al.

Dec 12th, 2017 - Low-molecular-weight heparin is the standard treatment for cancer-associated venous thromboembolism. The role of treatment with direct oral anticoagulant agents is unclear. In this open-label, noninferiority trial, we randomly assigned patients with cancer who had acute symptomatic or incidental venous thromboembolism to receive either low-molecular-weight heparin for at least 5 days followed b...

Long-term effects of glucocorticoids on function, quality of life, and survival in pati...
https://doi.org/10.1016/S0140-6736(17)32160-8
Lancet (London, England); McDonald CM, Henricson EK et. al.

Nov 27th, 2017 - Glucocorticoid treatment is recommended as a standard of care in Duchenne muscular dystrophy; however, few studies have assessed the long-term benefits of this treatment. We examined the long-term effects of glucocorticoids on milestone-related disease progression across the lifespan and survival in patients with Duchenne muscular dystrophy. For this prospective cohort study, we enrolled male p...

Seasonal Variation in the Activity of Systemic Lupus Erythematosus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597113/
Journal of Rheumatology;

May 31st, 2012 - Objective To determine whether there is any seasonal variation in the activity of systemic lupus erythematosus (SLE) overall and by individual organs. Methods The study group comprised 2102 patients with SLE who were followed in a prospective longitudinal cohort study. In this cohort, 92.3% of the patients were women. The mean ± SD age of the patients was 47.9 ± 13.9 years, 56.3% were whit...

Systemic lupus erythematosus in the elderly
https://link.springer.com/article/10.1007%2Fs00296-010-1744-3
Rheumatology International; Achour, A. et. al.

May 1st, 2012 - Onset of the disease above the age of 65 years is unusual. This study was undertaken to determine retrospectively the clinical and laboratory features in SLE patients aged over 65 years. It is a retrospective study about 18 elderly patients with SLE out of 342 diagnosed between 1994 and 2009 in the center of Tunisia. All patients had at least 4 of 11 revised ACR criteria of SLE. The frequency o...

Neurodevelopmental outcome at 2 years for preterm children born at 22 to 34 weeks' gest...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558213
BMJ (Clinical Research Ed.); Pierrat V, Marchand-Martin L et. al.

Aug 17th, 2017 - Objectives To describe neurodevelopmental outcomes at 2 years corrected age for children born alive at 22-26, 27-31, and 32-34 weeks' gestation in 2011, and to evaluate changes since 1997.Design Population based cohort studies, EPIPAGE and EPIPAGE-2.Setting France.Participants 5567 neonates born alive in 2011 at 22-34 completed weeks' gestation, with 4199 survivors at 2 years corrected age incl...

Romosozumab (sclerostin monoclonal antibody) versus teriparatide in postmenopausal wome...
https://doi.org/10.1016/S0140-6736(17)31613-6
Lancet (London, England); Langdahl BL, Libanati C et. al.

Aug 1st, 2017 - Previous bisphosphonate treatment attenuates the bone-forming effect of teriparatide. We compared the effects of 12 months of romosozumab (AMG 785), a sclerostin monoclonal antibody, versus teriparatide on bone mineral density (BMD) in women with postmenopausal osteoporosis transitioning from bisphosphonate therapy. This randomised, phase 3, open-label, active-controlled study was done at 46 si...

Detection of Osteomyelitis in the Diabetic Foot by Imaging Techniques: A Systematic Rev...
https://doi.org/10.2337/dc17-0532
Diabetes Care; Lauri C, Tamminga M et. al.

Jul 24th, 2017 - Diagnosing bone infection in the diabetic foot is challenging and often requires several diagnostic procedures, including advanced imaging. We compared the diagnostic performances of MRI, radiolabeled white blood cell (WBC) scintigraphy (either with 99mTc-hexamethylpropyleneamineoxime [HMPAO] or 111In-oxine), and [18F]fluorodeoxyglucose positron emission tomography (18F-FDG-PET)/computed tomogr...

Ataluren in patients with nonsense mutation Duchenne muscular dystrophy (ACT DMD): a mu...
https://doi.org/10.1016/S0140-6736(17)31611-2
Lancet (London, England); McDonald CM, Campbell C et. al.

Jul 21st, 2017 - Duchenne muscular dystrophy (DMD) is a severe, progressive, and rare neuromuscular, X-linked recessive disease. Dystrophin deficiency is the underlying cause of disease; therefore, mutation-specific therapies aimed at restoring dystrophin protein production are being explored. We aimed to assess the efficacy and safety of ataluren in ambulatory boys with nonsense mutation DMD. We did this multi...

Safety and efficacy of edaravone in well defined patients with amyotrophic lateral scle...
https://doi.org/10.1016/S1474-4422(17)30115-1
The Lancet. Neurology; ,

May 19th, 2017 - In a previous phase 3 study in patients with amyotrophic lateral sclerosis (ALS), edaravone did not show a significant difference in the Revised ALS Functional Rating Scale (ALSFRS-R) score compared with placebo. Post-hoc analysis of these data revealed that patients in an early stage with definite or probable diagnosis of ALS, defined by the revised El Escorial criteria, who met a select set o...

Measures of self‐efficacy: Arthritis Self‐Efficacy Scale (ASES), Arthritis Self‐Efficacy Scale‐8 Item (ASES‐8), Children's Arthritis Self‐Efficacy Scale (CASE), Chronic Disease Self‐Efficacy Scale ...
https://onlinelibrary.wiley.com/doi/full/10.1002/acr.20567
Arthritis Care & Research; Brady, T.

Nov 6th, 2011 - Enhancing self‐efficacy has become an essential feature of many arthritis management interventions because of its robust relationships with health behaviors and health status. Empirical studies document that self‐efficacy predicts health behaviors such as physical activity, eating behaviors, and pain coping strategies (1). In rheumatoid arthritis and osteoarthritis, self‐efficacy has also been ...

Spinal muscular atrophy
https://ojrd.biomedcentral.com/articles/10.1186/1750-1172-6-71/
Orphanet Journal of Rare Diseasesvolume;

Nov 2nd, 2011 - Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease characterized by degeneration of alpha motor neurons in the spinal cord, resulting in progressive proximal muscle weakness and paralysis. Estimated incidence is 1 in 6,000 to 1 in 10,000 live births and carrier frequency of 1/40-1/60. This disease is characterized by generalized muscle weakness and atrophy predominati...

The Dietary Approaches to Stop Hypertension (DASH) diet, Western diet, and risk of gout...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423545
BMJ (Clinical Research Ed.); Rai SK, Fung TT et. al.

May 10th, 2017 - Objective To prospectively examine the relation between the Dietary Approaches to Stop Hypertension (DASH) and Western diets and risk of gout (ie, the clinical endpoint of hyperuricemia) in men.Design Prospective cohort study.Setting The Health Professionals Follow-up Study.Participants 44 444 men with no history of gout at baseline. Using validated food frequency questionnaires, each participa...

Effect of a near-universal hospitalization-based prophylaxis regimen on annual number o...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510788
Blood Heit JA, Crusan DJ et. al.

May 9th, 2017 - The annual number of US venous thromboembolism (VTE) events, the number of potentially preventable events, and the effect of hospitalization-based prophylaxis are uncertain. We estimated VTE attack (incident plus recurrent VTE) rates and the total annual number of US VTE events related and unrelated to hospitalization using Rochester Epidemiology Project resources to identify all Olmsted County...

Predicting the higher rate of intracranial hemorrhage in glioma patients receiving ther...
https://doi.org/10.1182/blood-2017-02-767285
Blood Mantia C, Uhlmann EJ et. al.

May 4th, 2017 - Venous thromboembolism occurs in up to one-third of patients with primary brain tumors. Spontaneous intracranial hemorrhage (ICH) is also a frequent occurrence in these patients, but there is limited data on the safety of therapeutic anticoagulation. To determine the rate of ICH in patients treated with enoxaparin, we performed a matched, retrospective cohort study with blinded radiology review...

A randomised controlled trial of the efficacy and safety of allopurinol dose escalation...
https://doi.org/10.1136/annrheumdis-2016-210872
Annals of the Rheumatic Diseases; Stamp LK, Chapman PT et. al.

Mar 20th, 2017 - To determine the efficacy and safety of allopurinol dose escalation using a treat-to-target serum urate (SU) approach. A randomised, controlled, parallel-group, comparative clinical trial was undertaken. People with gout receiving at least creatinine clearance (CrCL)-based allopurinol dose for ≥1 month and SU ≥6 mg/dL were recruited. Participants were randomised to continue current dose (contro...

Association Between Maternal Body Mass Index in Early Pregnancy and Incidence of Cerebr...
https://doi.org/10.1001/jama.2017.0945
JAMA Villamor E, Tedroff K et. al.

Mar 7th, 2017 - Maternal overweight and obesity are associated with increased risks of preterm delivery, asphyxia-related neonatal complications, and congenital malformations, which in turn are associated with increased risks of cerebral palsy. It is uncertain whether risk of cerebral palsy in offspring increases with maternal overweight and obesity severity and what could be possible mechanisms. To study the ...

The effect of patient age at intervention on risk of implant revision after total repla...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522532
Lancet (London, England); Bayliss LE, Culliford D et. al.

Feb 17th, 2017 - Total joint replacements for end-stage osteoarthritis of the hip and knee are cost-effective and demonstrate significant clinical improvement. However, robust population based lifetime-risk data for implant revision are not available to aid patient decision making, which is a particular problem in young patient groups deciding on best-timing for surgery. We did implant survival analysis on all ...

Postmenopausal hormone therapy and Alzheimer disease: A prospective cohort study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384835
Neurology Imtiaz B, Tuppurainen M et. al.

Feb 16th, 2017 - To explore the association between postmenopausal hormone therapy (HT) and Alzheimer disease (AD). Twenty-year follow-up data from the Kuopio Osteoporosis Risk Factor and Prevention study cohort were used. Self-administered questionnaires were sent to all women aged 47-56 years, residing in Kuopio Province starting in 1989 until 2009, every 5th year. Register-based information on HT prescriptio...

Thromboprophylaxis after Knee Arthroscopy and Lower-Leg Casting.
https://doi.org/10.1056/NEJMoa1613303
The New England Journal of Medicine; van Adrichem RA, Nemeth B et. al.

Dec 13th, 2016 - The use of thromboprophylaxis to prevent clinically apparent venous thromboembolism after knee arthroscopy or casting of the lower leg is disputed. We compared the incidence of symptomatic venous thromboembolism after these procedures between patients who received anticoagulant therapy and those who received no anticoagulant therapy. We conducted two parallel, pragmatic, multicenter, randomized...

The cost-effectiveness of HLA-B*5801 screening to guide initial urate-lowering therapy ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403555
Seminars in Arthritis and Rheumatism; Jutkowitz E, Dubreuil M et. al.

Dec 5th, 2016 - Positive HLA-B*5801 carriers are at greater risk of experiencing rare but severe allopurinol hypersensitivity syndrome (AHS) [i.e., Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)]; however, HLA-B*5801 prevalence and AHS risk vary by race/ethnicity. We evaluated the cost-effectiveness of HLA-B*5801 testing according to race/ethnicity in the United States. We determined the c...

HIV-associated motor neuron disease: HERV-K activation and response to antiretroviral t...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089528
Neurology Bowen LN, Tyagi R et. al.

Oct 25th, 2016 - To determine whether there is activation of human endogenous retrovirus K (HERV-K) in amyotrophic lateral sclerosis in HIV infection and whether it might respond to treatment with antiretroviral drugs. In this case series, we present 5 patients with HIV infection who subsequently developed motor neuron disease involving both upper and lower motor neurons. We monitored HERV-K levels in plasma of...

Lack of Evidence Linking Calcium With or Without Vitamin D Supplementation to Cardiovas...
https://doi.org/10.7326/M16-1743
Annals of Internal Medicine; Kopecky SL, Bauer DC et. al.

Oct 24th, 2016 - Calcium is the dominant mineral present in bone and a shortfall nutrient in the American diet. Supplements have been recommended for persons who do not consume adequate calcium from their diet as a standard strategy for the prevention of osteoporosis and related fractures. Whether calcium with or without vitamin D supplementation is beneficial or detrimental to vascular health is not known. The...

Early diaphragm pacing in patients with amyotrophic lateral sclerosis (RespiStimALS): a...
https://doi.org/10.1016/S1474-4422(16)30233-2
The Lancet. Neurology; Gonzalez-Bermejo J, Morélot-Panzini C et. al.

Oct 18th, 2016 - Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder associated with respiratory muscle weakness and respiratory failure. Non-invasive ventilation alleviates respiratory symptoms and prolongs life, but is a palliative intervention. Slowing the deterioration of diaphragm function before respiratory failure would be desirable. We aimed to assess whether early diaphragm pacing could...

Hereditary risk factors for thrombophilia and probability of venous thromboembolism dur...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813719
Blood Gerhardt A, Scharf RE et. al.

Sep 10th, 2016 - Venous thromboembolism (VTE) is a leading cause of maternal mortality. Few studies have evaluated the individual risk of gestational VTE associated with heritable thrombophilia, and current recommendations for antenatal thromboprophylaxis in women with severe thrombophilia such as homozygous factor V Leiden mutation (FVL) depend on a positive family history of VTE. To better stratify thrombopro...

Effect of Abaloparatide vs Placebo on New Vertebral Fractures in Postmenopausal Women W...
https://doi.org/10.1001/jama.2016.11136
JAMA Miller PD, Hattersley G et. al.

Aug 17th, 2016 - Additional therapies are needed for prevention of osteoporotic fractures. Abaloparatide is a selective activator of the parathyroid hormone type 1 receptor. To determine the efficacy and safety of abaloparatide, 80 μg, vs placebo for prevention of new vertebral fracture in postmenopausal women at risk of osteoporotic fracture. The Abaloparatide Comparator Trial In Vertebral Endpoints (ACTIVE) w...

Change in Bone Mineral Density Is an Indicator of Treatment-Related Antifracture Effect...
https://doi.org/10.7326/M15-2937
Annals of Internal Medicine; Leslie WD, Majumdar SR et. al.

Jul 18th, 2016 - Whether change in bone mineral density (BMD) is an accurate indicator of antifracture effect in clinical practice is unknown. To evaluate repeated BMD testing as an indicator of treatment-related fracture risk reduction. Registry-based cohort study. Manitoba, Canada. 6629 women aged 40 years or older initiating osteoporosis treatment with 2 consecutive dual-energy x-ray absorptiometry scans (me...

One versus two years of elastic compression stockings for prevention of post-thrombotic...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886508
BMJ (Clinical Research Ed.); Mol GC, van de Ree MA et. al.

Jun 1st, 2016 - To study whether stopping elastic compression stockings (ECS) after 12 months is non-inferior to continuing them for 24 months after proximal deep venous thrombosis. Multicentre single blind non-inferiority randomised controlled trial. Outpatient clinics in eight teaching hospitals in the Netherlands, including one university medical centre. Patients compliant with compression therapy for 12 mo...

Wells Rule and d-Dimer Testing to Rule Out Pulmonary Embolism: A Systematic Review and ...
https://doi.org/10.7326/M16-0031
Annals of Internal Medicine; van Es N, van der Hulle T et. al.

May 17th, 2016 - The performance of different diagnostic strategies for pulmonary embolism (PE) in patient subgroups is unclear. To evaluate and compare the efficiency and safety of the Wells rule with fixed or age-adjusted d-dimer testing overall and in inpatients and persons with cancer, chronic obstructive pulmonary disease, previous venous thromboembolism, delayed presentation, and age 75 years or older. ME...

Pregnancy-Related Venous Thromboembolism Risk in Asymptomatic Women With Antithrombin D...
https://doi.org/10.1097/AOG.0000000000001347
Obstetrics and Gynecology; Rhéaume M, Weber F et. al.

Mar 9th, 2016 - To evaluate the risk of pregnancy-associated venous thromboembolism in women with asymptomatic antithrombin deficiency. The search was performed on MEDLINE (Ovid and PubMed databases) for the period 1966 to June 2012 and ClinicalTrials.gov as of December 15, 2015. A systematic review including randomized controlled trials, cohort studies, and case-control studies was conducted. Selection criter...

Oral Prednisolone in the Treatment of Acute Gout: A Pragmatic, Multicenter, Double-Blin...
https://doi.org/10.7326/M14-2070
Annals of Internal Medicine; Rainer TH, Cheng CH et. al.

Feb 23rd, 2016 - Two recent double-blind, randomized, controlled trials (RCTs) showed that oral steroids and nonsteroidal anti-inflammatory drugs have similar analgesic effectiveness for management of gout, but the trials had small sample sizes and other methodological limitations. To compare the effectiveness and safety of oral prednisolone versus oral indomethacin in patients presenting to emergency departmen...

Practice guideline update summary: Corticosteroid treatment of Duchenne muscular dystro...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773944
Neurology Gloss D, Moxley RT et. al.

Feb 2nd, 2016 - To update the 2005 American Academy of Neurology (AAN) guideline on corticosteroid treatment of Duchenne muscular dystrophy (DMD). We systematically reviewed the literature from January 2004 to July 2014 using the AAN classification scheme for therapeutic articles and predicated recommendations on the strength of the evidence. Thirty-four studies met inclusion criteria. In children with DMD, pr...

Safety and Clinical Effects of Mesenchymal Stem Cells Secreting Neurotrophic Factor Tra...
https://doi.org/10.1001/jamaneurol.2015.4321
JAMA Neurology; Petrou P, Gothelf Y et. al.

Jan 11th, 2016 - Preclinical studies have shown that neurotrophic growth factors (NTFs) extend the survival of motor neurons in amyotrophic lateral sclerosis (ALS) and that the combined delivery of these neurotrophic factors has a strong synergistic effect. We have developed a culture-based method for inducing mesenchymal stem cells (MSCs) to secrete neurotrophic factors. These MSC-NTF cells have been shown to ...

Gastrointestinal Findings in the Largest Series of Patients With Hereditary Biallelic M...
https://doi.org/10.1038/ajg.2015.392
The American Journal of Gastroenterology; Aronson M, Gallinger S et. al.

Jan 5th, 2016 - Hereditary biallelic mismatch repair deficiency (BMMRD) is caused by biallelic mutations in the mismatch repair (MMR) genes and manifests features of neurofibromatosis type 1, gastrointestinal (GI) polyposis, and GI, brain, and hematological cancers. This is the first study to characterize the GI phenotype in BMMRD using both retrospective and prospective surveillance data. The International BM...

Recurrent venous thromboembolism and abnormal uterine bleeding with anticoagulant and h...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832477
Blood Martinelli I, Lensing AW et. al.

Dec 23rd, 2015 - Women receiving vitamin K antagonists (VKAs) require adequate contraception because of the potential for fetal complications. It is unknown whether the use of hormonal therapy, especially those containing estrogens, is associated with recurrent venous thromboembolism (VTE) during anticoagulation. Despite the absence of data, World Health Organization guidelines state that use of estrogen-contai...

Anastrozole-Induced Carpal Tunnel Syndrome: Results From the International Breast Cance...
https://doi.org/10.1200/JCO.2015.63.4972
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology; Spagnolo F, Sestak I et. al.

Nov 25th, 2015 - Carpal tunnel syndrome (CTS) occurs when the median nerve is compressed at the wrist in the carpal tunnel. It has been suggested that hormonal risk factors may be involved in the pathogenesis of CTS, and a higher incidence of CTS has been reported in randomized clinical trials with aromatase inhibitors (AIs) compared with tamoxifen. This was an exploratory analysis of the International Breast C...

A Randomized, Controlled Trial of Total Knee Replacement.
https://doi.org/10.1056/NEJMoa1505467
The New England Journal of Medicine; Skou ST, Roos EM et. al.

Oct 21st, 2015 - More than 670,000 total knee replacements are performed annually in the United States; however, high-quality evidence to support the effectiveness of the procedure, as compared with nonsurgical interventions, is lacking. In this randomized, controlled trial, we enrolled 100 patients with moderate-to-severe knee osteoarthritis who were eligible for unilateral total knee replacement. Patients wer...

Use of Whole-Exome Sequencing for Diagnosis of Limb-Girdle Muscular Dystrophy: Outcomes...
https://doi.org/10.1001/jamaneurol.2015.2274
JAMA Neurology; Ghaoui R, Cooper ST et. al.

Oct 5th, 2015 - To our knowledge, the efficacy of transferring next-generation sequencing from a research setting to neuromuscular clinics has never been evaluated. To translate whole-exome sequencing (WES) to clinical practice for the genetic diagnosis of a large cohort of patients with limb-girdle muscular dystrophy (LGMD) for whom protein-based analyses and targeted Sanger sequencing failed to identify the ...

Angiogenic factor imbalance early in pregnancy predicts adverse outcomes in patients wi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698098
American Journal of Obstetrics and Gynecology; Kim MY, Buyon JP et. al.

Oct 3rd, 2015 - Over 20% of pregnancies in patients with systemic lupus erythematosus (SLE) and/or antiphospholipid antibodies (APL) result in an adverse pregnancy outcome (APO) related to abnormal placentation. The ability to identify, early in pregnancy, patients who are destined for poor outcomes would significantly impact care of this high-risk population. In nonautoimmune patients, circulating angiogenic ...

Oral apixaban for the treatment of venous thromboembolism in cancer patients: results f...
https://doi.org/10.1111/jth.13153
Journal of Thrombosis and Haemostasis : JTH; Agnelli G, Buller HR et. al.

Sep 26th, 2015 - The AMPLIFY trial compared apixaban with enoxaparin followed by warfarin for the treatment of acute venous thromboembolism (VTE). To perform a subgroup analysis to compare the efficacy and safety of apixaban and enoxaparin followed by warfarin for the treatment of VTE in patients with cancer enrolled in AMPLIFY. Patients with symptomatic VTE were randomized to a 6-month course of apixaban or en...

Immunogenicity of a new routine vaccination schedule for global poliomyelitis preventio...
https://doi.org/10.1016/S0140-6736(15)00237-8
Lancet (London, England); Sutter RW, Bahl S et. al.

Sep 21st, 2015 - Polio eradication needs a new routine immunisation schedule--three or four doses of bivalent type 1 and type 3 oral poliovirus vaccine (bOPV) and one dose of inactivated poliovirus vaccine (IPV), but no immunogenicity data are available for this schedule. We aimed to assess immunogenicity of this vaccine schedule. We did an open-label, randomised controlled trial in four centres in India. After...

Dexamethasone Therapy for Septic Arthritis in Children.
https://doi.org/10.1542/peds.2014-4025
Pediatrics Fogel I, Amir J et. al.

Sep 8th, 2015 - Prospective studies of children with septic arthritis report that adding dexamethasone to antibiotic therapy contributes significantly to clinical and laboratory improvement. This study sought to evaluate the effect of this regimen outside of a randomized controlled trial. The sample consisted of children with septic arthritis hospitalized at a tertiary pediatric medical center in 2008 to 2013....

Total joint arthroplasty and the risk of myocardial infarction: a general population, p...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581914
Arthritis & Rheumatology (Hoboken, N.J.); Lu N, Misra D et. al.

Sep 3rd, 2015 - To replicate recent findings indicating that total knee arthroplasty (TKA) or total hip arthroplasty (THA) surgery will substantially reduce the risk of serious cardiovascular events among patients with osteoarthritis. A time-stratified, propensity score-matched cohort study was conducted to assess the incidence of myocardial infarction (MI) in a UK general population. The study population incl...

Tinzaparin vs Warfarin for Treatment of Acute Venous Thromboembolism in Patients With A...
https://doi.org/10.1001/jama.2015.9243
JAMA Lee AYY, Kamphuisen PW et. al.

Aug 18th, 2015 - Low-molecular-weight heparin is recommended over warfarin for the treatment of acute venous thromboembolism (VTE) in patients with active cancer largely based on results of a single, large trial. To study the efficacy and safety of tinzaparin vs warfarin for treatment of acute, symptomatic VTE in patients with active cancer. A randomized, open-label study with blinded central adjudication of st...

Aerobic training and postexercise protein in facioscapulohumeral muscular dystrophy: RC...
https://doi.org/10.1212/WNL.0000000000001808
Neurology Andersen G, Prahm KP et. al.

Jul 14th, 2015 - To investigate the effect of regular aerobic training and postexercise protein-carbohydrate supplementation in patients with facioscapulohumeral muscular dystrophy (FSHD). In this randomized, double-blind, placebo-controlled parallel study, we randomized untrained men (n = 21) and women (n = 20) with FSHD (age 19-65 years) to 2 training groups-training with protein supplement (n = 18) and train...

Utility of magnetic resonance imaging in diagnosing cervical spine injury in children w...
https://doi.org/10.1097/TA.0000000000000646
The Journal of Trauma and Acute Care Surgery; Qualls D, Leonard JR et. al.

Jul 7th, 2015 - Evaluation of children for cervical spine injuries (CSIs) after blunt trauma is complicated, particularly if the patient is unresponsive because of severe traumatic brain injury. Plain radiography and computed tomography (CT) are commonly used, but CT combined with magnetic resonance imaging (MRI) is still considered the gold standard in CSI detection. However, MRI is expensive and can delay ce...

Denosumab and teriparatide transitions in postmenopausal osteoporosis (the DATA-Switch ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620731
Lancet (London, England); Leder BZ, Tsai JN et. al.

Jul 6th, 2015 - Unlike most chronic diseases, osteoporosis treatments are generally limited to a single drug at a fixed dose and frequency. Nonetheless, no approved therapy is able to restore skeletal integrity in most osteoporotic patients and the long-term use of osteoporosis drugs is controversial. Thus, many patients are treated with the sequential use of two or more therapies. The DATA study showed that c...

Screening for Occult Cancer in Unprovoked Venous Thromboembolism.
https://doi.org/10.1056/NEJMoa1506623
The New England Journal of Medicine; Carrier M, Lazo-Langner A et. al.

Jun 22nd, 2015 - Venous thromboembolism may be the earliest sign of cancer. Currently, there is a great diversity in practices regarding screening for occult cancer in a person who has an unprovoked venous thromboembolism. We sought to assess the efficacy of a screening strategy for occult cancer that included comprehensive computed tomography (CT) of the abdomen and pelvis in patients who had a first unprovoke...

Predictors of Pregnancy Outcomes in Patients With Lupus: A Cohort Study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113288
Annals of Internal Medicine; Buyon JP, Kim MY et. al.

Jun 22nd, 2015 - Because systemic lupus erythematosus (SLE) affects women of reproductive age, pregnancy is a major concern. To identify predictors of adverse pregnancy outcomes (APOs) in patients with inactive or stable active SLE. Prospective cohort. Multicenter. 385 patients (49% non-Hispanic white; 31% with prior nephritis) with SLE in the PROMISSE (Predictors of Pregnancy Outcome: Biomarkers in Antiphospho...

Use of combined oral contraceptives and risk of venous thromboembolism: nested case-con...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444976
BMJ (Clinical Research Ed.); Vinogradova Y, Coupland C et. al.

May 27th, 2015 - To investigate the association between use of combined oral contraceptives and risk of venous thromboembolism, taking the type of progestogen into account. Two nested case-control studies. General practices in the United Kingdom contributing to the Clinical Practice Research Datalink (CPRD; 618 practices) and QResearch primary care database (722 practices). Women aged 15-49 years with a first d...

The Association Between PICC Use and Venous Thromboembolism in Upper and Lower Extremit...
https://doi.org/10.1016/j.amjmed.2015.03.028
The American Journal of Medicine; Greene MT, Flanders SA et. al.

May 5th, 2015 - Peripherally inserted central catheters are associated with upper-extremity deep vein thrombosis. Whether they also are associated with lower-extremity deep vein thrombosis or pulmonary embolism is unknown. We examined the risk of venous thromboembolism in deep veins of the arm, leg, and chest after peripherally inserted central catheter placement. We conducted a multicenter, retrospective coho...