ALLMedicine™ Detailed topics Center - Guidelines
https://dailynews.ascopubs.org/do/10.1200/ADN.20.200234/full/
Jul 1st, 2020 - CAR T-cell therapy with BCMA-targeting idecabtagene-vicleucel (ide-cel) has emerged to be a game-changer as shown by this first pivotal phase II trial of CAR T-cell therapy in multiple myeloma (MM). Ide-cel is a first-in-class BCMA-directed CAR T-cell therapy, with 4-1BB costimulatory domain and CD3Z T-cell activation domain.
https://dailynews.ascopubs.org/do/10.1200/ADN.20.200231/full/
Jul 1st, 2020 - Donafenib, a deuterated derivative of sorafenib, was tested against sorafenib in the frontline setting in hepatitis B– associated hepatocellular carcinoma (HCC) in a large, multi-institutional study in China (Abstract 4506).
https://dailynews.ascopubs.org/do/10.1200/ADN.20.200233/full/
Jul 2nd, 2020 - DESKTOP III (Abstract 6000) is a prospective, multicenter, randomized phase III study of > 400 patients with platinum-sensitive, recurrent ovarian cancer that demonstrated a clinically meaningful 7.7 month improvement in median overall survival with secondary cytoreductive surgery (53.7 months) compared with no surgery (46 months).
https://dailynews.ascopubs.org/do/10.1200/ADN.20.200227/full/
Jul 2nd, 2020 - Head and neck cancers account for approximately 4% of all cancers in the United States1 and are the eighth most common cancer affecting men in the United States.2 The diagnosis of recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) carries a poor prognosis, with an overall survival (OS) of approximately 1 year.
https://onlinelibrary.wiley.com/doi/full/10.1002/acn3.50991
Annals of Clinical and Translational Neurology;
Feb 6th, 2020 - To investigate whether the burden of white matter hyperintensities (WMHs) is associated with the risk of developing levodopa‐induced dyskinesia (LID) in Parkinson’s disease (PD).
https://www.onclive.com/view/dr-usmani-on-activity-of-teclistamab-in-relapsed-refractory-multiple-myeloma
May 30th, 2020
https://www.medpagetoday.com/meetingcoverage/asco/86840
Jun 1st, 2020
https://www.medpagetoday.com/meetingcoverage/asco/86836
Jun 1st, 2020
https://www.onclive.com/view/dr-gwin-on-the-mechanism-of-action-of-alphatea-in-her2positive-metastatic-breast-cancer
Jun 4th, 2020
https://www.onclive.com/view/dr-mascarenhas-on-the-impact-of-ruxolitinib-on-the-myelofibrosis-treatment-paradigm
Jun 4th, 2020
https://www.medpagetoday.com/meetingcoverage/asco/86802
May 31st, 2020
https://www.medpagetoday.com/meetingcoverage/asco/86804
May 31st, 2020
https://www.medpagetoday.com/meetingcoverage/asco/86811
May 31st, 2020
https://www.onclive.com/view/dr-richardson-on-phase-1-data-with-cc92480-in-multiple-myeloma
May 31st, 2020
https://www.onclive.com/view/dr-zakashansky-on-the-benefit-of-maintenance-olaparib-in-brca-ovarian-cancer
Jun 1st, 2020
https://www.onclive.com/view/dr-poveda-on-the-results-of-the-solo2-trial-in-ovarian-cancer
May 31st, 2020
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204727/
Individuals with Familial Hypercholesterolaemia (FH) are at very high risk of cardiovascular disease, which is associated with poor outcomes from coronavirus infections. COVID-19 puts strain on healthcare systems and may impair access to routine FH services. On behalf of the International Lipid Expert Panel (ILEP) and the European FH Patient Network (FH Europe), we present brief recommendations...
https://onlinelibrary.wiley.com/doi/10.1111/joim.13070
Early data from Wuhan, China, show that patients with COVID‐19 are typically male, aged 40 to 60 years, and about one‐third have comorbidities. Moreover, of 138 COVID‐19 patients hospitalized in Wuhan and treated in an intensive care unit (ICU), 25% had cardiovascular disease and 58% hypertension; the respective figures for non‐ICU‐treated COVID‐19 patients were10% and 22% [1]. Based on these e...
https://academic.oup.com/qjmed/advance-article/doi/10.1093/qjmed/hcaa121/5818885
Lungs from patients with coronavirus disease 2019 (COVID-19) have shown typical signs of acute respiratory distress syndrome (ARDS), formation of hyaline membrane mainly composed of fibrin and ‘ground-glass’ opacity. Previously, we showed plasminogen itself is a key regulator in fibrin degradation, wound healing and infection.
https://aip.scitation.org/doi/10.1063/5.0013318
Currently, a novel coronavirus named “SARS-CoV-2” is spreading rapidly across the world, causing a public health crisis, economic losses, and panic. Fecal–oral transmission is a common transmission route for many viruses, including SARS-CoV-2. Blocking the path of fecal–oral transmission, which occurs commonly in toilet usage, is of fundamental importance in suppressing the spread of viruses. H...
