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About 279,028 results
Evaluation of two tools for the early screening of osteoporosis in postmenopausal Chine...
https://doi.org/10.1177/0300060520903889
The Journal of International Medical Research; Tang JL, Pan BB et. al.

Mar 25th, 2020 - Evaluation of two tools for the early screening of osteoporosis in postmenopausal Chinese women with type 2 diabetes mellitus.|2020|Tang JL,Pan BB,Shu Y,Gu YF,Liu S,|

Multinodular Plaque on the Penis
https://www.mdedge.com/dermatology/article/219594/dermatopathology/multinodular-plaque-penis?channel=113
Derek W. Nickerson, MD, Jessica R. Dowling, MD et. al.

Mar 25th, 2020 - The Diagnosis: Tophaceous Gout Biopsy revealed amorphous pink material within the center of palisading granulomas lined by histiocytes and giant cells. Scattered crystal remnants also were identified within the center of the granulomas; however, the majority of the crystals were dissolved during the formalin processing of the tissue to become the amorphous material.

Right Heart Failure Due to Secondary Chondrosarcoma in the Right Atrium.
https://doi.org/10.1161/CIRCIMAGING.119.009824
Circulation. Cardiovascular Imaging; Haslinger M, Dinges C et. al.

Mar 24th, 2020 - Right Heart Failure Due to Secondary Chondrosarcoma in the Right Atrium.|2020|Haslinger M,Dinges C,Granitz M,Klieser E,Hoppe UC,|

Audiological disturbances in patients with primary antiphospholipid syndrome.
https://doi.org/10.1177/0961203320904780
Lupus Erez D, Abarbuch E et. al.

Mar 24th, 2020 - Audiological disturbances in patients with primary antiphospholipid syndrome.|2020|Erez D,Abarbuch E,Natour A,Meyer A,Natour A,|

Higher MMP2 abundance and gelatinolytic activity in 28- & 70-d mdx compared with wild-t...
https://doi.org/10.1152/ajpcell.00437.2019
American Journal of Physiology. Cell Physiology; Ren X, Xu H et. al.

Mar 24th, 2020 - Duchenne muscular dystrophy (DMD) is a severe, progressive muscle wasting disorder that leads to early death. The mdx mouse is a naturally occurring mutant model for DMD. It lacks dystrophin and displays peak muscle cell necrosis at ~28 days (D28), but in contrast to DMD, mdx mice experience muscle regeneration by D70. We hypothesised that matrix metalloproteinase-2 (MMP2) and/or MMP9 play key ...

Immunosuppressant Use and Gout in the Prevalent Solid Organ Transplantation Population.
https://doi.org/10.1177/1526924820913514
Progress in Transplantation (Aliso Viejo, Calif.); Brigham MD, Milgroom A et. al.

Mar 24th, 2020 - Gout is a common comorbidity among solid organ transplantation patients and is usually attributed to the use of cyclosporine. This study aims to evaluate the prevalence of gout among solid organ transplantation patients to determine the prevalence in the tacrolimus era. To what degree is cyclosporine still used among prevalent solid organ transplantation patients? How prevalent is gout in the s...

Untargeted metabolomics revealed therapeutic mechanisms of icariin on low bone mineral ...
https://doi.org/10.1039/c9fo02882j
Food & Function; Huang J, Hu Y et. al.

Mar 24th, 2020 - Osteoporosis is a common chronic disease in the elderly population and in some domestic animals. Caged layer osteoporosis (CLO) is a common bone metabolism disease that was recently recommended as an ideal animal model for osteoporosis. This study aimed to investigate the therapeutic effect and mechanism of dietary icariin (ICA), the main bioactive component of the Chinese herb Epimedium, on lo...

Comparing Methods to Determine the Minimal Clinically Important Differences in Patient-...
https://doi.org/10.1001/jamasurg.2020.0024
JAMA Surgery; Kuo AC, Giori NJ et. al.

Mar 24th, 2020 - The minimal clinically important difference (MCID) in a patient-reported outcome measure (PROM) is the smallest change that patients perceive as beneficial. Accurate MCIDs are required when PROMs are used to evaluate the value of surgical interventions. To use well-defined distribution-based and anchor-based methods to calculate MCIDs in the Hip Disability and Osteoarthritis Outcome Score (HOOS...

Chondromyxoid Fibroma of the Mastoid: A Rare Entity with Comprehensive Literature Review.
https://doi.org/10.5152/iao.2019.6911
The Journal of International Advanced Otology; Elsamanody A, den Aardweg MV et. al.

Mar 24th, 2020 - Chondromyxoid fibroma (CMF) is the least commonly occurring bone tumor of cartilaginous origin. It is usually situated in the metaphysis of long bones of the lower limbs. Localization of the tumor in the skull is extremely rare. The definitive diagnosis is challenging and depends on radiological and histological examinations. To the best of our knowledge, only 14 cases of CMF involving the temp...

Deterioration of hematopoietic autophagy is linked to osteoporosis.
https://doi.org/10.1111/acel.13114
Aging Cell REFERENCES; Yuan Y, Fang Y et. al.

Mar 24th, 2020 - Hematopoietic disorders are known to increase the risk of complications such as osteoporosis. However, a direct link between hematopoietic cellular disorders and osteoporosis has been elusive. Here, we demonstrate that the deterioration of hematopoietic autophagy is coupled with osteoporosis in humans. With a conditional mouse model in which autophagy in the hematopoietic system is disrupted by...

Congenital posterior cervical spine malformation due to biallelic c.240-4T>G RIPPLY2 va...
https://doi.org/10.1002/ajmg.a.61549
American Journal of Medical Genetics. Part A REFERENCES; Serey-Gaut M, Scala M et. al.

Mar 24th, 2020 - The clinical and radiological spectrum of spondylocostal dysostosis syndromes encompasses distinctive costo-vertebral anomalies. RIPPLY2 biallelic pathogenic variants were described in two distinct cervical spine malformation syndromes: Klippel-Feil syndrome and posterior cervical spine malformation. RIPPLY2 is involved in the determination of rostro-caudal polarity and somite patterning during...

Is Respiratory Epithelial Adenomatoid Hamartoma Related to Central Compartment Atopic D...
https://doi.org/10.1177/1945892420914212
American Journal of Rhinology & Allergy; Schertzer JS, Levy JM et. al.

Mar 23rd, 2020 - Is Respiratory Epithelial Adenomatoid Hamartoma Related to Central Compartment Atopic Disease?|2020|Schertzer JS,Levy JM,Wise SK,Magliocca KR,DelGaudio JM,|

Obesity increases the incidence of new-onset lupus nephritis and organ damage during fo...
https://doi.org/10.1177/0961203320913616
Lupus Kang JH, Xu H et. al.

Mar 23rd, 2020 - Obesity increases the incidence of new-onset lupus nephritis and organ damage during follow-up in patients with systemic lupus erythematosus.|2020|Kang JH,Xu H,Choi SE,Park DJ,Lee JK,|

Diagnostic value of urinary monocyte chemoattractant protein-1 in evaluating the activi...
https://doi.org/10.1177/0961203320914372
Lupus Xia YR, Li QR et. al.

Mar 23rd, 2020 - Diagnostic value of urinary monocyte chemoattractant protein-1 in evaluating the activity of lupus nephritis: a meta-analysis.|2020|Xia YR,Li QR,Wang JP,Guo HS,Bao YQ,|

An analysis of clinical risk factors for adolescent scoliosis caused by spinal cord abn...
https://doi.org/10.1186/s12891-020-3182-z
BMC Musculoskeletal Disorders; Xu W, Zhang X et. al.

Mar 23rd, 2020 - Approximately 80% of adolescent scoliosis cases are idiopathic, and some non-idiopathic scoliosis cases caused by spinal cord abnormalities are misdiagnosed as idiopathic scoliosis. This study examined the risk factors for non-idiopathic scoliosis with intramedullary abnormalities, explored the feasibility of whole-spine MRI, and provided a theoretical basis for the routine diagnosis and treatm...

Mid- to long-term results of modified non-vascularized allogeneic fibula grafting combi...
https://doi.org/10.1186/s13018-020-1565-3
Journal of Orthopaedic Surgery and Research; Changjun C, Donghai L et. al.

Mar 23rd, 2020 - The aim of this study was to determine mid-and-long term follow-up results of patients with early femoral head osteonecrosis who were treated by modified free vascularized fibular grafting combined with core decompression and bone grafting. Forty-four patients at early ONFH were included in this study. Visual analog scale (VAS) pain scores, range of hip motion (ROM), and Harris hip score (HHS) ...

Post-traumatic osteoarthritis following ACL injury.
https://doi.org/10.1186/s13075-020-02156-5
Arthritis Research & Therapy; Wang LJ, Zeng N et. al.

Mar 23rd, 2020 - Post-traumatic osteoarthritis (PTOA) develops after joint injury. Specifically, patients with anterior cruciate ligament (ACL) injury have a high risk of developing PTOA. In this review, we outline the incidence of ACL injury that progresses to PTOA, analyze the role of ACL reconstruction in preventing PTOA, suggest possible mechanisms thought to be responsible for PTOA, evaluate current diagno...

Open resection and reconstruction of a Nasoseptal Chondrosarcoma: case report and liter...
https://doi.org/10.1186/s40463-020-00409-6
Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale; Lee C, Forner D et. al.

Mar 23rd, 2020 - Primary chondrosarcomas of the nasal septum are rare, with a variety of clinical features that evade detection and treatment. While endoscopic surgery has become increasingly accessible, open approaches may be needed to provide adequate visualization for tumour ablation and reconstruction. We report the resection and reconstructive considerations of a septal chondrosarcoma. A 75-year-old woman ...

Phase I Study of the Mutant IDH1 Inhibitor Ivosidenib: Safety and Clinical Activity in ...
https://doi.org/10.1200/JCO.19.02492
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology; Tap WD, Villalobos VM et. al.

Mar 23rd, 2020 - Surgery is the primary therapy for localized chondrosarcoma; for locally advanced and/or metastatic disease, no known effective systemic therapy exists. Mutations in the isocitrate dehydrogenase 1/2 (IDH1/2) enzymes occur in up to 65% of chondrosarcomas, resulting in accumulation of the oncometabolite D-2-hydroxyglutarate (2-HG). Ivosidenib (AG-120) is a selective inhibitor of mutant IDH1 appro...

Biomarker panels may be superior over single molecules in prediction of renal flares in...
https://doi.org/10.1093/rheumatology/keaa074
Rheumatology (Oxford, England); Fasano S, Pierro L et. al.

Mar 23rd, 2020 - Recent evidence suggests that some urinary biomarkers, namely Vascular Cell Adhesion Molecule-1 (VCAM-1), Intercellular Adhesion Molecule-1 (ICAM-1), Monocyte Chemoattractant Protein 1 (MCP-1), Neutrophil Gelatinase Associated Lipocalcin and Lipocalin-type Prostaglandin D-Synthetase (L-PGDS), might discriminate SLE patients with ongoing renal activity from those with stable disease. The objecti...