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About 1,352 results
Amyloid burden is associated with self-reported sleep in nondemented late middle-aged a...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523445
Neurobiology of Aging; Sprecher KE, Bendlin BB et. al.

Jun 10th, 2015 - Midlife may be an ideal window for intervention in Alzheimer's disease (AD). To determine whether sleep is associated with early signs of AD neuropathology (amyloid deposition) in late midlife, we imaged brain amyloid deposits using positron emission tomography with [C-11]Pittsburgh Compound B (PiB), and assessed sleep with the Epworth Sleepiness Scale and the Medical Outcomes Study Sleep Scale...

Multicenter prospective cohort study of the incidence of adverse events associated with...
https://doi.org/10.1001/jamadermatol.2014.2494
JAMA Dermatology; Alam M, Kakar R et. al.

Nov 5th, 2014 - Common noninvasive to minimally invasive cosmetic dermatologic procedures are widely believed to be safe given the low incidence of reported adverse events, but reliable incidence data regarding adverse event rates are unavailable to date. To assess the incidence of adverse events associated with noninvasive to minimally invasive cosmetic dermatologic procedures, including those involving laser...

Injectable and topical neurotoxins in dermatology: Indications, adverse events, and con...
https://doi.org/10.1016/j.jaad.2016.11.012
Journal of the American Academy of Dermatology; Giordano CN, Matarasso SL et. al.

May 19th, 2017 - The use of neuromodulators for therapeutic and cosmetic indications has proven to be remarkably safe. While aesthetic and functional adverse events are uncommon, each anatomic region has its own set of risks of which the physician and patient must be aware before treatment. The therapeutic usages of botulinum toxins now include multiple specialties and multiple indications. New aesthetic indica...

Injectable and topical neurotoxins in dermatology: Basic science, anatomy, and therapeu...
https://doi.org/10.1016/j.jaad.2016.11.022
Journal of the American Academy of Dermatology; Giordano CN, Matarasso SL et. al.

May 19th, 2017 - Botulinum toxin is a potentially deadly anaerobic bacterial toxin that acts by inhibiting release of acetylcholine at the neuromuscular junction, thereby inhibiting contraction of the exposed striated muscle. There are currently 4 botulinum toxin preparations approved by the US Food and Drug Administration (FDA): onabotulinumtoxin, abobotulinumtoxin, incobotulinumtoxin and rimabotulinumtoxin. W...

Emerging options for the management of scorpion stings.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401053
Drug Design, Development and Therapy; Chippaux JP

Jul 24th, 2012 - Scorpion stings are common in many tropical countries. Although most scorpion stings cause only localized pain without life-threatening envenoming, about one third of stings cause systemic envenoming which can result in death. Children are particularly sensitive to scorpion envenoming. The severity of scorpion stings is related to the presence of neurotoxins in the venom that cause a sudden rel...

Amphetamines, the pregnant woman and her children: a review.
https://doi.org/10.1038/jp.2012.59
Journal of Perinatology : Official Journal of the California Perinatal Association; Oei JL, Kingsbury A et. al.

Jun 1st, 2012 - The objective of this study is to review and summarize available evidence regarding the impact of amphetamines on pregnancy, the newborn infant and the child. Amphetamines are neurostimulants and neurotoxins that are some of the most widely abused illicit drugs in the world. Users are at high risk of psychiatric co-morbidities, and evidence suggests that perinatal amphetamine exposure is associ...

Advances in the use of botulinum neurotoxins in facial esthetics.
https://doi.org/10.1111/j.1473-2165.2011.00593.x
Journal of Cosmetic Dermatology; Flynn TC

Feb 29th, 2012 - To present the latest findings and future developments in the cosmetic use of botulinum neurotoxin. Review of recent literature and new scientific developments. Botulinum neurotoxin type A preparations onabotulinumtoxinA (BOTOX(®) Cosmetic/Vistabel(®), Allergan Inc.) and abobotulinumtoxinA (Dysport(®) /Azzalure(®) /Reloxin(®) , Ipsen Pharma,) have been used for many years and are effective and ...

Efficacy and safety of long-term botulinum toxin treatment in craniocervical dystonia: ...
https://doi.org/10.1007/s12640-012-9314-y
Neurotoxicity Research; Colosimo C, Tiple D et. al.

Feb 23rd, 2012 - Botulinum neurotoxins have been shown to be a safe and effective therapeutic option for most forms of focal dystonia, and are now considered to provide the best symptomatic treatment in these disorders. However, only a few papers addressed the long-term efficacy and safety of repeated treatments with this drug. This article reviews the data from clinical trials that have assessed the long-term ...

Does vigorous exercise have a neuroprotective effect in Parkinson disease?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136051
Neurology Ahlskog JE

Jul 19th, 2011 - Parkinson disease (PD) is progressive, with dementia and medication-refractory motor problems common reasons for late-stage nursing-home placement. Increasing evidence suggests that ongoing vigorous exercise/physical fitness may favorably influence this progression. Parkinsonian animal models reveal exercise-related protection from dopaminergic neurotoxins, apparently mediated by brain neurotro...

Narrative review: tetanus-a health threat after natural disasters in developing countries.
https://doi.org/10.7326/0003-4819-154-5-201103010-00007
Annals of Internal Medicine; Afshar M, Raju M et. al.

Mar 1st, 2011 - Tetanus is an expected complication when disasters strike in developing countries, where tetanus immunization coverage is often low or nonexistent. Collapsing structures and swirling debris inflict numerous crush injuries, fractures, and serious wounds. Clostridium tetani infects wounds contaminated with dirt, feces, or saliva and releases neurotoxins that may cause fatal disease. Clusters of i...

Terminology for preparations of botulinum neurotoxins: what a difference a name makes.
https://doi.org/10.1001/jama.2010.1937
JAMA Albanese A

Jan 5th, 2011 - Terminology for preparations of botulinum neurotoxins: what a difference a name makes.|2011|Albanese A,|adverse effects,classification,therapeutic use,adverse effects,classification,therapeutic use,classification,drug therapy,drug therapy,

Paralytic shellfish poisoning: seafood safety and human health perspectives.
https://doi.org/10.1016/j.toxicon.2009.12.013
Toxicon : Official Journal of the International Society on Toxinology; Etheridge SM

Dec 28th, 2009 - Paralytic shellfish poisoning (PSP) is the foodborne illness associated with the consumption of seafood products contaminated with the neurotoxins known collectively as saxitoxins (STXs). This family of neurotoxins binds to voltage-gated sodium channels, thereby attenuating action potentials by preventing the passage of sodium ions across the membrane. Symptoms include tingling, numbness, heada...

Envenomations: an overview of clinical toxinology for the primary care physician.
https://www.ncbi.nlm.nih.gov/pubmed/19835341
American Family Physician; Weinstein S, Dart R et. al.

Oct 19th, 2009 - About 4,000 to 6,000 venomous snakebites occur each year in the United States. Although these envenomations (also known as envenomings) are rarely fatal, about 70 percent require antivenom therapy. Few evidence-based guidelines are available for the management of envenomation. Antivenom therapy is the cornerstone of management for hemorrhagic or coagulopathic envenomation from pit vipers (with ...

Aconite poisoning.
https://doi.org/10.1080/15563650902904407
Clinical Toxicology (Philadelphia, Pa.); Chan TY

Jun 11th, 2009 - Aconitine and related alkaloids found in the Aconitum species are highly toxic cardiotoxins and neurotoxins. The wild plant (especially the roots and root tubers) is extremely toxic. Severe aconite poisoning can occur after accidental ingestion of the wild plant or consumption of an herbal decoction made from aconite roots. In traditional Chinese medicine, aconite roots are used only after proc...

International outbreak of severe botulism with prolonged toxemia caused by commercial c...
https://doi.org/10.1086/592574
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America; Sheth AN, Wiersma P et. al.

Oct 6th, 2008 - On 8 September 2006, 3 Georgia residents presented with symptoms of food-borne botulism, a potentially fatal illness caused by Clostridium botulinum neurotoxins. Investigators reviewed medical records and interviewed patients and family members. Foods from patients' homes and samples of the implicated commercial beverage were tested for botulinum toxin and C. botulinum by standard methods. The ...

Recommendations on the use of botulinum toxin in the treatment of lower urinary tract d...
https://doi.org/10.1016/j.eururo.2008.09.009
European Urology; Apostolidis A, Dasgupta P et. al.

Sep 30th, 2008 - The increasing body of evidence and number of potential indications for the use of botulinum neurotoxins (BoNTs) in the lower urinary tract (LUT) underlines the pressing need for evidence-based guidelines. A European expert panel consensus conference was convened with the main aim of evaluating the evidence and clinical considerations for the use of BoNTs in the treatment of urologic and pelvic...

Neuronal selectivity of botulinum neurotoxins.
https://doi.org/10.1016/j.toxicon.2020.02.006
Toxicon : Official Journal of the International Society on Toxinology; Poulain B, Lemichez E et. al.

Feb 25th, 2020 - Botulinum neurotoxins (BoNTs) are highly potent toxins responsible for a severe disease, called botulism. They are also efficient therapeutic tools with an increasing number of indications ranging from neuromuscular dysfunction to hypersecretion syndrome, pain release, depression as well as cosmetic application. BoNTs are known to mainly target the motor-neurons terminals and to induce flaccid ...

Protective efficacy of recombinant bacterin vaccine against botulism in cattle.
https://doi.org/10.1016/j.vaccine.2020.01.089
Vaccine Moreira C, Ferreira MRA et. al.

Feb 10th, 2020 - Botulism is a paralytic disease caused by the intoxication of neurotoxins produced by Clostridium botulinum. Among the seven immunologically distinct serotypes of neurotoxins (BoNTs A - G), serotypes C and D, or a chimeric fusion termed C/D or D/C, are responsible for animal botulism. The most effective way to prevent botulism in cattle is through vaccination; however, the commercially availabl...

Potency and stability of a trivalent, catalytically inactive vaccine against botulinum ...
https://doi.org/10.1016/j.toxicon.2020.02.001
Toxicon : Official Journal of the International Society on Toxinology; Webb R, Wright PM et. al.

Feb 7th, 2020 - Botulism is an acute neuroparalytic affliction of the motor and autonomic neurons caused by the toxins produced from Clostridium botulinum and related bacterial strains. The botulinum neurotoxins, or BoNTs, consist of a phylogenetically diverse group of highly potent protein toxins. Current medical interventions for confirmed cases of botulism are limited to immediate administration of antitoxi...

Ion channel modulation by scorpion hemolymph and its defensin ingredients highlights or...
https://doi.org/10.1016/j.ijbiomac.2020.01.133
International Journal of Biological Macromolecules; Meng L, Zhao Y et. al.

Jan 18th, 2020 - An increasing number of scorpion fossils indicate that the venomous telson developed from the sharp telson in sea scorpions into the extant scorpion-like telson in aquatic scorpions in the Paleozoic Era and then further evolved into the fetal venom system. This hypothesis led us to evaluate the inhibition of scorpion venom-sensitive potassium channels by hemolymph from the scorpion Mesobuthus m...