ALLMedicine™ Crossmatching Center

Mar 4th, 2023 - Although rare, infection and vaccination can result in antibodies to human leukocyte antigens (HLA). We analyzed the effect of SARS-CoV-2 infection or vaccination on HLA antibodies in waitlisted renal transplant candidates. Specificities were coll...

Feb 16th, 2023 - Twenty patients with ESKD listed for kidney allotransplantation at UAB will be enrolled to receive either one or two porcine kidney xenotransplants from a 10-GE pig donor, contingent on the pig's overall size at the time of procurement. Recruitmen...

Dec 20th, 2022 - Patients undergoing recurrent platelet transfusions can become refractory to these transfusions. Platelet antibody screens (Immucor), platelet crossmatching assays (Immucor), and HLA antibody testing are commonly used to test these patients. The r...

Dec 3rd, 2022 - Red blood cell (RBC) alloimmunization can occur secondary to transfusion or pregnancy. It is observed most frequently among patients with hemoglobinopathies and myeloid neoplasms. Although previous antigen exposure is generally required for alloim...

Nov 20th, 2022 - Candidates for combined liver-kidney transplant frequently present pretransplant HLA sensitization in most cases related to elevated prior transfusion requirements. The urgency criterion and the evidence of the protective effect at the immunologic...

Apr 27th, 2018 - Red blood cell (RBC) transfusions remain essential in the treatment of patients with sickle cell disease (SCD) and β-thalassemia. Alloimmunization, a well-documented complication of transfusion, increases the risk of delayed hemolytic transfusion ...

Jul 31st, 2010 - Ongoing technological developments in antibody detection and characterisation allowing relative quantitation of HLA-specific antibody levels, combined with crossmatch results, now allow a graded assessment of patient potential donor immunological ...

Feb 16th, 2023 - Twenty patients with ESKD listed for kidney allotransplantation at UAB will be enrolled to receive either one or two porcine kidney xenotransplants from a 10-GE pig donor, contingent on the pig's overall size at the time of procurement. Recruitmen...

Jun 15th, 2018 - We hypothesize that the following improvements to islet transplantation will increase the islet mass successfully isolated and allow for engraftment from a single pancreas. The improvements are: Using Two-Layer method preservation to improve pancr...

Sep 17th, 2009 - Approximately 20 percent of corneal transplant patients, about 6,000 per year, face donor tissue rejection at rates of up to 60 percent because of corneal vascularization or prior graft rejection. Histocompatibility antigen matching and/or crossma...

Dec 5th, 2020 - David R. Gandara, MD Each morning, David R. Gandara, MD, wakes up energized to spend another day as an oncologist in lung cancer practice and research, a field in which advances have been more rapid than anything previously seen in oncology. As ...

Dec 4th, 2020 - Peter F. Lebowitz, MD, PhD Adding daratumumab (Darzalex) to standard bortezomib (Velcade) and dexamethasone improved progression-free survival (PFS) in patients with relapsed/refractory multiple myeloma enrolled in the phase III CASTOR (MMY3004) ...

Dec 4th, 2020 - Richard Pazdur, MD Acting 4 months ahead of schedule, the FDA has granted an accelerated approval to the CD38-targeted monoclonal antibody daratumumab (Darzalex) as a monotherapy for patients with multiple myeloma following at least 3 prior thera...

Nov 13th, 2018 - Photo by Graham Colm Blood samples The U. S.

Jun 30th, 2018 - David R. Gandara, MD Each morning, David R. Gandara, MD, wakes up energized to spend another day as an oncologist in lung cancer practice and research, a field in which advances have been more rapid than anything previously seen in oncology. As th...