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About 9,994 results
Gastroesophageal Reflux Disease - StatPearls
https://www.ncbi.nlm.nih.gov/books/NBK441938/
Antunes, C. et. al.

Oct 26th, 2018 - Gastroesophageal reflux disease (GERD) is a condition that develops when there is a retrograde flow of stomach contents causing symptoms or complications. GERD can present as Non-erosive reflux disease (NERD) when typical symptoms of GERD occur in the absence of visible mucosal injury during endoscopy, or as erosive esophagitis (EE) when patients have histopathological changes in esophageal muc...

Asthma as the Underlying Cause of Death | CDC
https://www.cdc.gov/asthma/asthma_stats/asthma_underlying_death.html

Apr 23rd, 2018 - Asthma deaths have decreased over time and varied by demographic characteristics. View the statistics from the Centers for Disease Control and Prevention (CDC) - National Center of Environmental Health (NCEH) - National Asthma Control Program

Esophageal dilation with either bougie or balloon technique as a treatment for eosinoph...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601027
Gastrointestinal Endoscopy; Dougherty M, Runge TM et. al.

May 3rd, 2017 - Esophageal dilation is a now recognized to be an important therapeutic modality in eosinophilic esophagitis (EoE). We aimed to evaluate the safety of esophageal dilation in EoE, especially regarding perforation risk, and to examine perforation risk by dilator type. We conducted a systematic review of the published literature from January 1, 1950 to June 30, 2016 using PubMed, EMBASE, and Web of...

Symptoms Have Modest Accuracy in Detecting Endoscopic and Histologic Remission in Adult...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011000
Gastroenterology Safroneeva E, Straumann A et. al.

Nov 20th, 2015 - It is not clear whether symptoms alone can be used to estimate the biologic activity of eosinophilic esophagitis (EoE). We aimed to evaluate whether symptoms can be used to identify patients with endoscopic and histologic features of remission. Between April 2011 and June 2014, we performed a prospective, observational study and recruited 269 consecutive adults with EoE (67% male; median age, 3...

Eosinophilic esophagitis in adults is associated with IgG4 and not mediated by IgE.
https://doi.org/10.1053/j.gastro.2014.05.036
Gastroenterology Clayton F, Fang JC et. al.

Jun 7th, 2014 - Eosinophilic esophagitis is usually triggered by foods, by unclear mechanisms. We evaluated the roles of IgE and IgG4 in the development of eosinophilic esophagitis. We performed a prospective, randomized, double-blind, placebo-controlled trial of adults with eosinophilic esophagitis given an antibody against IgE (omalizumab, n = 16) or placebo (n = 14) every 2-4 weeks for 16 weeks, based on we...

Pilomatrix carcinoma: 13 new cases and review of the literature with emphasis on predic...
https://doi.org/10.1016/j.jaad.2014.02.042
Journal of the American Academy of Dermatology; Herrmann JL, Allan A et. al.

Apr 17th, 2014 - Pilomatrix carcinoma is a rare cutaneous tumor derived from follicular matrix cells with few cases documented in the literature. We sought to better characterize this tumor by analyzing its epidemiologic, clinical, and histopathologic features in 13 new cases and by reviewing the literature. All cases of pilomatrix carcinoma from a large regional dermatopathology practice were identified and an...

The natural history of steroid-naïve eosinophilic esophagitis in adults treated with en...
https://doi.org/10.1016/j.gie.2014.02.012
Gastrointestinal Endoscopy; Lipka S, Keshishian J et. al.

Apr 7th, 2014 - Despite the vast focus of research in eosinophilic esophagitis (EoE), the natural history of untreated EoE remains undefined. Current expert consensus panels are calling for natural history studies to define long-term risks, adverse events, and progression of the disease. To address the natural course and long-term adverse events of EoE. Retrospective, single-center study. Tertiary-care center....

Efficacy of dietary interventions for inducing histologic remission in patients with eo...
https://doi.org/10.1053/j.gastro.2014.02.006
Gastroenterology Arias A, González-Cervera J et. al.

Feb 18th, 2014 - Various dietary interventions have been used to treat patients with eosinophilic esophagitis (EoE), yielding varied results. This systematic review assesses the efficacy of different dietary therapies in inducing disease remission. We performed a systematic search of the MEDLINE, EMBASE, and SCOPUS databases for studies investigating the efficacy of dietary interventions (reducing infiltration ...

The optimal number of biopsy fragments to establish a morphologic diagnosis of eosinoph...
https://doi.org/10.1038/ajg.2013.463
The American Journal of Gastroenterology; Nielsen JA, Lager DJ et. al.

Jan 21st, 2014 - Eosinophilic esophagitis (EoE) is characterized clinically by dysphagia, chest pain, and food impaction, and morphologically by increased numbers of intraepithelial eosinophils and marked basal hyperplasia of the squamous mucosa. The consensus criteria for a diagnosis of EoE include the presence of ≥15 eosinophils/HPF in biopsies from both proximal and distal esophagus in the absence of other c...

Dietary elimination therapy is an effective option for adults with eosinophilic esophag...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102669
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association; Wolf WA, Jerath MR et. al.

Jan 20th, 2014 - Eosinophilic esophagitis (EoE) is an immune-mediated disorder. Food elimination is an established treatment for children, but data in adults are limited. We aimed to determine the response of adults with EoE to dietary therapy. This was a retrospective cohort study using the University of North Carolina EoE database from 2006 to 2012. Subjects were age 18 and older, had EoE by consensus guideli...

Clinical outcomes of adults with eosinophilic esophagitis with severe stricture.
https://doi.org/10.1016/j.gie.2020.01.015
Gastrointestinal Endoscopy; Kim JP, Weingart G et. al.

Jan 19th, 2020 - Eosinophilic esophagitis (EoE) is an inflammatory disease of the esophagus that has been steadily increasing in prevalence over the past three decades. The prognosis of EoE patients presenting with severe esophageal strictures is poorly understood. The aim of this study is to describe the clinical outcomes of EoE patients with severe stricture and identify factors associated with a greater like...

Efficacy of Budesonide Orodispersible Tablets as Induction Therapy for Eosinophilic Eso...
https://doi.org/10.1053/j.gastro.2019.03.025
Gastroenterology Lucendo AJ, Miehlke S et. al.

Mar 29th, 2019 - Swallowed topical-acting corticosteroids are recommended as first-line therapy for eosinophilic esophagitis (EoE). Asthma medications not optimized for esophageal delivery are sometimes effective, although given off-label. We performed a randomized, placebo-controlled trial to assess the effectiveness and tolerability of a budesonide orodispersible tablet (BOT), which allows the drug to be deli...

Efficacy of Budesonide vs Fluticasone for Initial Treatment of Eosinophilic Esophagitis...
https://doi.org/10.1053/j.gastro.2019.03.014
Gastroenterology Dellon ES, Woosley JT et. al.

Mar 15th, 2019 - Topical steroid treatments for eosinophilic esophagitis (EoE) include swallowed fluticasone from a multi-dose inhaler (MDI) or oral viscous budesonide (OVB) slurry, but the 2 have never been compared. We assessed whether OVB was more effective than MDI for initial treatment of patients with EoE. In a double-blind, double-dummy trial, patients with a new diagnosis of EoE were randomly assigned t...

Eosinophilic Esophagitis: Relationship of Subepithelial Eosinophilic Inflammation With ...
https://doi.org/10.1038/ajg.2017.493
The American Journal of Gastroenterology; Schoepfer AM, Simko A et. al.

Jan 17th, 2018 - For technical reasons, the histologic characterization of eosinophilic esophagitis (EoE)-specific alterations is almost exclusively based on those found in the esophageal epithelium, whereas little is known about subepithelial abnormalities. In this study, we aimed to systematically assess the nature of subepithelial histologic alterations, and analyze their relationship with epithelial histolo...

Successful Esophageal Dilation of Eosinophilic Esophagitis (EoE) Patients With a Previo...
https://doi.org/10.1097/MCG.0000000000000873
Journal of Clinical Gastroenterology; Lipka S, Kumar A et. al.

Sep 8th, 2017 - Esophageal dilation is an effective and safe treatment option for fibrostenotic eosinophilic esophagitis (EoE). Despite the safety, adverse events occur, yet there is scarce literature on the best treatment postcomplications. Patients with diagnosis of EoE (≥15 eosinophils per high-power field) from 2011 to 2015 treated at our center were included. Thirty patients with fibrostenotic disease had...

Accuracy and Safety of the Cytosponge for Assessing Histologic Activity in Eosinophilic...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848207
The American Journal of Gastroenterology; Katzka DA, Smyrk TC et. al.

Aug 15th, 2017 - Management of eosinophilic esophagitis (EoE) requires repeated endoscopic mucosal sampling to assess disease activity. A less invasive and expensive means of monitoring of EoE is required. The objective of this study was to assess the accuracy, safety, and tolerability of the cytosponge compared to endoscopy and biopsy for histologic assessment of EoE. In this prospective two-center cross-secti...

Toward More Efficient Dietary Elimination Therapy for Eosinophilic Esophagitis: The Fan...
https://doi.org/10.1016/j.cgh.2017.07.022
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association; Eluri S, Dellon ES

Aug 1st, 2017 - Toward More Efficient Dietary Elimination Therapy for Eosinophilic Esophagitis: The Fantastic 4?|2017|Eluri S,Dellon ES,|

Long-Term Treatment of Eosinophilic Esophagitis With Swallowed Topical Corticosteroids:...
https://doi.org/10.1038/ajg.2017.202
The American Journal of Gastroenterology; Greuter T, Bussmann C et. al.

Jul 18th, 2017 - Swallowed topical corticosteroids (STCs) are efficacious in inducing and presumably maintaining remission in patients with active eosinophilic esophagitis (EoE). Hitherto, it has not been evaluated whether long-lasting remission can be achieved, and whether treatment can be stopped once patients have achieved this remission. Since 2007, EoE patients included into a large database at the Swiss E...

Efficacy of a 4-Food Elimination Diet for Children With Eosinophilic Esophagitis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448398
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association; Kagalwalla AF, Wechsler JB et. al.

Jun 12th, 2017 - A 6-food elimination diet induces remission in most children and adults with eosinophilic esophagitis (EoE). The effectiveness of empiric elimination of only 4 foods has not been studied in children. We performed a prospective observational outcome study in children with EoE treated with dietary exclusion of cow's milk, wheat, egg, and soy. The objective was to assess the clinical, endoscopic, ...

Esophageal and Small Intestinal Mucosal Integrity in Eosinophilic Esophagitis and Respo...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527277
The American Journal of Gastroenterology; Warners MJ, Vlieg-Boerstra BJ et. al.

Apr 18th, 2017 - The esophageal mucosal integrity is impaired in eosinophilic esophagitis (EoE) and it has been suggested that the duodenal permeability is increased. The absence of food allergens may restore the integrity. The aims of this study were to assess duodenal permeability in EoE and to evaluate the effect of an elemental diet on the esophageal and duodenal integrity. In this prospective study 17 adul...

Body mass index, height and early-onset basal cell carcinoma in a case-control study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5272867
Cancer Epidemiology; Zhang Y, Cartmel B et. al.

Dec 31st, 2016 - Basal cell carcinoma (BCC) is the most common malignancy in the US. Body mass index (BMI) and height have been associated with a variety of cancer types, yet the evidence regarding BCC is limited. Therefore, we evaluated BMI and height in relation to early-onset BCC (under age 40) and explored the potential role of ultraviolet (UV) radiation exposure and estrogen-related exposures in the BMI-BC...

How I Approach the Management of Eosinophilic Esophagitis in Adults.
https://doi.org/10.1038/ajg.2016.515
The American Journal of Gastroenterology; Hirano I

Nov 15th, 2016 - How I Approach the Management of Eosinophilic Esophagitis in Adults.|2016|Hirano I,|diagnosis,therapy,

The GerdQ questionnaire and high resolution manometry support the hypothesis that proto...
https://doi.org/10.1111/apt.13718
Alimentary Pharmacology & Therapeutics; Savarino EV, Tolone S et. al.

Jul 4th, 2016 - Little is known about the relationship between proton pump inhibitor-responsive oesophageal eosinophilia (PPI-REE), eosinophilic esophagitis (EoE) and gastro-oesophageal reflux disease (GERD). To compare high resolution manometry features and symptom profiles of patients with EoE, PPI-REE and GERD. Consecutive patients diagnosed with EoE or PPI-REE according to international criteria (presence ...

Transfusion reactions: prevention, diagnosis, and treatment.
https://doi.org/10.1016/S0140-6736(15)01313-6
Lancet (London, England); Delaney M, Wendel S et. al.

Apr 16th, 2016 - Blood transfusion is one of the most common procedures in patients in hospital so it is imperative that clinicians are knowledgeable about appropriate blood product administration, as well as the signs, symptoms, and management of transfusion reactions. In this Review, we, an international panel, provide a synopsis of the pathophysiology, treatment, and management of each diagnostic category of...

A Novel CD4+ T Cell-Dependent Murine Model of Pneumocystis-driven Asthma-like Pathology.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074654
American Journal of Respiratory and Critical Care Medicine; Eddens T, Campfield BT et. al.

Mar 23rd, 2016 - Infection with Pneumocystis, an opportunistic fungal pathogen, can result in fulminant pneumonia in the clinical setting of patients with immunosuppression. In murine models, Pneumocystis has previously been shown to induce a CD4+ T cell-dependent eosinophilic response in the lung capable of providing protection. We sought to explore the role of Pneumocystis in generating asthma-like lung patho...

Accuracy of the Eosinophilic Esophagitis Endoscopic Reference Score in Diagnosis and De...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690779
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association; Dellon ES, Cotton CC et. al.

Sep 25th, 2015 - Little is known about the diagnostic utility of the Eosinophilic Esophagitis (EoE) Endoscopic Reference Score (EREFS), and how scores change in response to treatment. We investigated the operating characteristics of the EREFS in diagnosis of EoE, how the score changes with treatment, and ways to optimize scoring system. We performed a prospective study of adults undergoing outpatient upper endo...

Unsedated transnasal esophagoscopy for monitoring therapy in pediatric eosinophilic eso...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698253
Gastrointestinal Endoscopy; Friedlander JA, DeBoer EM et. al.

Jul 5th, 2015 - Unsedated transnasal endoscopy (TNE) is safer and less costly than sedated EGD. The aim of this study was to evaluate the performance of TNE with biopsies in monitoring the esophageal mucosa of pediatric patients with eosinophilic esophagitis. Patients between 8 and 17 years of age with eosinophilic esophagitis and their parents were enrolled. Unsedated TNE was performed. A 2.8-mm (1.2-mm chann...

Amyloid burden is associated with self-reported sleep in nondemented late middle-aged a...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523445
Neurobiology of Aging; Sprecher KE, Bendlin BB et. al.

Jun 10th, 2015 - Midlife may be an ideal window for intervention in Alzheimer's disease (AD). To determine whether sleep is associated with early signs of AD neuropathology (amyloid deposition) in late midlife, we imaged brain amyloid deposits using positron emission tomography with [C-11]Pittsburgh Compound B (PiB), and assessed sleep with the Epworth Sleepiness Scale and the Medical Outcomes Study Sleep Scale...

Multicenter prospective cohort study of the incidence of adverse events associated with...
https://doi.org/10.1001/jamadermatol.2014.2494
JAMA Dermatology; Alam M, Kakar R et. al.

Nov 5th, 2014 - Common noninvasive to minimally invasive cosmetic dermatologic procedures are widely believed to be safe given the low incidence of reported adverse events, but reliable incidence data regarding adverse event rates are unavailable to date. To assess the incidence of adverse events associated with noninvasive to minimally invasive cosmetic dermatologic procedures, including those involving laser...

Aspergillosis, eosinophilic esophagitis, and allergic rhinitis in signal transducer and...
https://doi.org/10.1016/j.jaci.2018.05.009
The Journal of Allergy and Clinical Immunology; Natarajan M, Hsu AP et. al.

May 28th, 2018 - Aspergillosis, eosinophilic esophagitis, and allergic rhinitis in signal transducer and activator of transcription 3 haploinsufficiency.|2018|Natarajan M,Hsu AP,Weinreich MA,Zhang Y,Niemela JE,|

Combined and Alternating Topical Steroids and Food Elimination Diet for the Treatment o...
https://doi.org/10.1007/s10620-018-4931-9
Digestive Diseases and Sciences; Reed CC, Safta AM et. al.

Jan 30th, 2018 - Few studies have examined combined or alternating treatment algorithms in eosinophilic esophagitis. We conducted a retrospective cohort study to ascertain the efficacy and adherence to a combined and alternating treatment approach with topical corticosteroids and 2-food elimination diet for pediatric EoE. Patients were prescribed a 2-food elimination diet (milk and soy) and topical corticostero...

Efficacy of Atopy Patch Testing in Directed Dietary Therapy of Eosinophilic Esophagitis...
https://doi.org/10.1007/s10620-018-4928-4
Digestive Diseases and Sciences; Eckmann JD, Ravi K et. al.

Jan 19th, 2018 - Atopy patch testing (APT) has shown potential for predicting dietary food triggers in studies of children and adolescents with eosinophilic esophagitis (EoE). To assess the efficacy of APT in adults with EoE. We conducted a prospective open-label pilot study of patients ≥ 18 years old with diagnosis of EoE at Mayo Clinic in Rochester, Minnesota, from November 2014 to January 2016. All patients ...

A Prospective Study of Eosinophilic Esophagitis and the Expression of Tight Junction Pr...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753681
Gut and Liver; Okimoto K, Arai M et. al.

Oct 16th, 2017 - Eosinophilic esophagitis (EoE) is often erroneously diagnosed as gastroesophageal reflux disease (GERD). The aim of this study is to investigate the prevalence of EoE and the expression of tight junction (TJ) proteins in patients with GERD symptoms. One hundred patients with GERD symptoms and 10 healthy controls were prospectively studied. Sixty-two patients had symptoms refractory to proton pu...

Impact of smoking, alcohol consumption, and NSAID use on risk for and phenotypes of eos...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036648
Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus; Koutlas NT, Eluri S et. al.

Oct 12th, 2017 - There are few data exploring modifiable risk factors for eosinophilic esophagitis (EoE). We aimed to determine if smoking, alcohol consumption, and nonsteroidal anti-inflammatory drug (NSAID) use were risk factors for EoE, and to assess their impact on EoE phenotypes and treatment outcomes. We performed a case-control study analyzing data collected from a prospective cohort of adults undergoing...

Comparison of endoscopy and radiographic imaging for detection of esophageal inflammati...
https://doi.org/10.1016/j.gie.2017.09.037
Gastrointestinal Endoscopy; Nelson MJ, Miller FH et. al.

Oct 10th, 2017 - Eosinophil predominant mucosal inflammation is central to the diagnosis and activity assessment of eosinophilic esophagitis (EoE). Esophageal mural remodeling is an important consequence of EoE that is responsible for adverse events of dysphagia, food impaction, and esophageal stenosis. The aim of this study was to compare upper endoscopy (EGD) with barium upper GI study (UGI) for the detection...

Editorial: Widening the Use of the Functional Lumen Imaging Probe to Kids With Eosinoph...
https://doi.org/10.1038/ajg.2017.237
The American Journal of Gastroenterology; Carlson DA

Sep 6th, 2017 - The functional lumen imaging probe (FLIP) provides objective measurement of esophageal distensibility, thus offering a unique and potentially valuable assessment in eosinophilic esophagitis (EoE). Menard-Katcher and colleagues report the first study evaluating use of FLIP in pediatric patients that demonstrated a reduction in esophageal distensibility in patients with EoE compared to patients w...

Injectable and topical neurotoxins in dermatology: Indications, adverse events, and con...
https://doi.org/10.1016/j.jaad.2016.11.012
Journal of the American Academy of Dermatology; Giordano CN, Matarasso SL et. al.

May 19th, 2017 - The use of neuromodulators for therapeutic and cosmetic indications has proven to be remarkably safe. While aesthetic and functional adverse events are uncommon, each anatomic region has its own set of risks of which the physician and patient must be aware before treatment. The therapeutic usages of botulinum toxins now include multiple specialties and multiple indications. New aesthetic indica...

Injectable and topical neurotoxins in dermatology: Basic science, anatomy, and therapeu...
https://doi.org/10.1016/j.jaad.2016.11.022
Journal of the American Academy of Dermatology; Giordano CN, Matarasso SL et. al.

May 19th, 2017 - Botulinum toxin is a potentially deadly anaerobic bacterial toxin that acts by inhibiting release of acetylcholine at the neuromuscular junction, thereby inhibiting contraction of the exposed striated muscle. There are currently 4 botulinum toxin preparations approved by the US Food and Drug Administration (FDA): onabotulinumtoxin, abobotulinumtoxin, incobotulinumtoxin and rimabotulinumtoxin. W...

Differentiating pulmonary transfusion reactions using recipient and transfusion factors.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758383
Transfusion Roubinian NH, Looney MR et. al.

May 4th, 2017 - It is increasingly recognized that recipient risk factors play a prominent role in possible transfusion-related acute lung injury (pTRALI) and transfusion-associated circulatory overload (TACO). We hypothesized that both transfusion and recipient factors including natriuretic peptides could be used to distinguish TRALI from TACO and pTRALI. We performed a post hoc analysis of a case-control stu...

Feeling the burn: the significant burden of febrile nonhemolytic transfusion reactions.
https://doi.org/10.1111/trf.14099
Transfusion Cohen R, Escorcia A et. al.

Apr 3rd, 2017 - Febrile nonhemolytic transfusion reactions (FNHTRs) are characterized by a post-transfusion temperature rise (of ≥ 1°C, to ≥ 38°C) or chills/rigors unrelated to the underlying condition. FNHTRs are provoked by inflammatory cytokines in the product or by host antileukocyte antibodies against residual donor leukocytes. FNHTRs are among the most commonly reported transfusion disturbances and are g...

Genetics of eosinophilic esophagitis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600523
Mucosal Immunology; Kottyan LC, Rothenberg ME

Feb 22nd, 2017 - Eosinophilic esophagitis (EoE) is a chronic, allergic disease associated with marked mucosal eosinophil accumulation. EoE disease risk is multifactorial and includes environmental and genetic factors. This review will focus on the contribution of genetic variation to EoE risk, as well as the experimental tools and statistical methodology used to identify EoE risk loci. Specific disease-risk loc...

Calpain-14 and its association with eosinophilic esophagitis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461191
The Journal of Allergy and Clinical Immunology; Litosh VA, Rochman M et. al.

Jan 30th, 2017 - Calpains are a family of intracellular, calcium-dependent cysteine proteases involved in a variety of regulatory processes, including cytoskeletal dynamics, cell-cycle progression, signal transduction, gene expression, and apoptosis. These enzymes have been implicated in a number of disease processes, notably for this review involving eosinophilic tissue inflammation, such as eosinophilic esoph...

Budesonide Oral Suspension Improves Symptomatic, Endoscopic, and Histologic Parameters ...
https://doi.org/10.1053/j.gastro.2016.11.021
Gastroenterology Dellon ES, Katzka DA et. al.

Nov 27th, 2016 - Pharmacologic treatment of eosinophilic esophagitis (EoE) is limited to off-label use of corticosteroids not optimized for esophageal delivery. We performed a randomized, controlled phase 2 trial to assess the ability of budesonide oral suspension (BOS), a novel muco-adherent topical steroid formulation, to reduce symptoms and esophageal eosinophilia in adolescents and adults with EoE. In this ...

Root cause analysis of limitations of virtual crossmatch for kidney allocation to highl...
https://doi.org/10.1016/j.humimm.2016.11.003
Human Immunology; Jani V, Ingulli E et. al.

Nov 19th, 2016 - Efficient allocation of deceased donor organs depends upon effective prediction of immunologic compatibility based on donor HLA genotype and recipient alloantibody profile, referred to as virtual crossmatching (VCXM). VCXM has demonstrated utility in predicting compatibility, though there is reduced efficacy for patients highly sensitized against allogeneic HLA antigens. The recently revised de...

Association of eosinophilic esophagitis and food pollen allergy syndrome.
https://doi.org/10.1016/j.anai.2016.10.012
Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology; Mahdavinia M, Bishehsari F et. al.

Nov 19th, 2016 - Association of eosinophilic esophagitis and food pollen allergy syndrome.|2016|Mahdavinia M,Bishehsari F,Hayat W,Elhassan A,Tobin MC,|etiology,immunology,complications,immunology,immunology,

Measurement of haemolysis markers following transfusion of uncrossmatched, low-titre, g...
https://doi.org/10.1111/tme.12372
Transfusion Medicine (Oxford, England); Seheult JN, Triulzi DJ et. al.

Oct 29th, 2016 - The safety of administering uncrossmatched, group O, cold-stored, whole blood (cWB) during civilian trauma resuscitation was evaluated. Male trauma patients with haemorrhage-induced hypotension who received leuko-reduced uncrossmatched group O+, low titre (<50) anti-A and -B, platelet-replete cWB during initial resuscitation were included. The biochemical markers of haemolysis (lactate dehydrog...

Stillbirth and intrauterine fetal death: factors affecting determination of cause of de...
https://doi.org/10.1002/uog.16016
Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology; Man J, Hutchinson JC et. al.

Oct 26th, 2016 - There have been several attempts to classify cause of death (CoD) in stillbirth; however, all such systems are subjective, allowing for observer bias and making comparisons between systems challenging. This study aimed to examine factors relating to determination of CoD using a large dataset from two specialist centers in which observer bias had been reduced by classifying findings objectively ...

Eosinophilic esophagitis in an octogenarian: A case report and review of the literature.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072977
Medicine Trifan A, Stoica O et. al.

Oct 15th, 2016 - Eosinophilic esophagitis (EoE) is a chronic, immune/antigen-mediated disease characterized clinically by symptoms related to esophageal dysfunction and histologically by a marked eosinophilic infiltrate in the esophageal mucosa. What was once considered a rare disease has nowadays become one of the most frequent esophageal diseases in the Western countries, occupying a place just next to the ga...

The association of anti-platelet factor 4/heparin antibodies with early and delayed thr...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5280211
Journal of Thrombosis and Haemostasis : JTH; Welsby IJ, Krakow EF et. al.

Oct 7th, 2016 - Essentials We evaluated antibody status, thromboembolism and survival after cardiac surgery. Positive antibody tests are common - over 50% are seropositive at 30 days. Seropositivity did not increase thromboembolism or impair survival after cardiac surgery. Results show heparin induced thrombocytopenia antibody screening after surgery is not warranted. Background Heparin-induced thrombocytopeni...

Montelukast Does not Maintain Symptom Remission After Topical Steroid Therapy for Eosin...
https://doi.org/10.1016/j.cgh.2016.09.013
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association; Alexander JA, Ravi K et. al.

Sep 21st, 2016 - Montelukast, a cysteinyl leukotriene type-1 receptor blocker, has been shown in small retrospective studies to reduce symptoms in patients with eosinophilic esophagitis (EoE). We performed a randomized, placebo-controlled, double-blind trial to determine whether montelukast maintains symptomatic remission induced by topical steroid therapy in patients with EoE. We performed a prospective study ...

Clinical Pattern in Hypotensive Transfusion Reactions.
https://doi.org/10.1213/ANE.0000000000001387
Anesthesia and Analgesia; Metcalf RA, Bakhtary S et. al.

Jun 10th, 2016 - Hypotensive transfusion reactions (HyTRs) may be underreported and have been associated with patients taking angiotensin-converting enzyme inhibitors (ACEIs) receiving poststorage leukoreduced blood products through negatively charged filters. Although bedside leukoreduction is no longer commonplace, HyTRs still occur and are insufficiently characterized in the prestorage leukoreduction era. We...

Association of Acute Gastroesophageal Reflux Disease With Esophageal Histologic Changes.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030713
JAMA Dunbar KB, Agoston AT et. al.

May 17th, 2016 - The histologic changes associated with acute gastroesophageal reflux disease (GERD) have not been studied prospectively in humans. Recent studies in animals have challenged the traditional notion that reflux esophagitis develops when esophageal surface epithelial cells are exposed to lethal chemical injury from refluxed acid. To evaluate histologic features of esophageal inflammation in acute G...

Functional Esophageal Disorders.
https://doi.org/10.1053/j.gastro.2016.02.012
Gastroenterology Aziz Q, Fass R et. al.

May 4th, 2016 - Functional esophageal disorders consist of a disease category that present with esophageal symptoms (heartburn, chest pain, dysphagia, globus) not explained by mechanical obstruction (stricture, tumor, eosinophilic esophagitis), major motor disorders (achalasia, EGJ outflow obstruction, absent contractility, distal esophageal spasm, jackhammer esophagus), or gastroesophageal reflux disease (GER...

Newly developed and validated eosinophilic esophagitis histology scoring system and evi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373936
Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus; Collins MH, Martin LJ et. al.

Feb 9th, 2016 - Eosinophilic esophagitis (EoE) is diagnosed by symptoms, and at least 15 intraepithelial eosinophils per high power field in an esophageal biopsy. Other pathologic features have not been emphasized. We developed a histology scoring system for esophageal biopsies that evaluates eight features: eosinophil density, basal zone hyperplasia, eosinophil abscesses, eosinophil surface layering, dilated ...

Key Issues Associated with Helicobacter pylori Eradication.
https://doi.org/10.1159/000441667
Digestion Kawai T, Moriyasu F et. al.

Jan 20th, 2016 - Eradication of Helicobacter pylori causes improvement of gastric atrophy and intestinal metaplasia. Gastric acid secretion levels in corpus predominant gastritis increase after eradication. These changes can increase the risk of reflux esophagitis and low-dosage aspirin ulcers. Although eradication may reduce the overall risk of gastric cancer, a certain degree of risk remains, related to the e...

Should wheat, barley, rye, and/or gluten be avoided in a 6-food elimination diet?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826834
The Journal of Allergy and Clinical Immunology; Kliewer KL, Venter C et. al.

Jan 4th, 2016 - Eosinophilic esophagitis (EoE), a food antigen-mediated disease, is effectively treated with the dietary elimination of 6 foods commonly associated with food allergies (milk, wheat, egg, soy, tree nuts/peanuts, and fish/shellfish). Because wheat shares homologous proteins (including gluten) with barley and rye and can also be processed with these grains, some clinicians have suggested that barl...

Adrenal Insufficiency after Chronic Swallowed Glucocorticoid Therapy for Eosinophilic E...
https://doi.org/10.1016/j.jpeds.2015.11.026
The Journal of Pediatrics; Golekoh MC, Hornung LN et. al.

Dec 21st, 2015 - To establish the prevalence of adrenal insufficiency (AI) in children with eosinophilic esophagitis treated with swallowed fluticasone propionate (FP) or budesonide. Children treated with FP or budesonide for ≥ 6 months underwent a low-dose adrenocorticotropin stimulation test. Patients using systemic, inhaled, intranasal, or topical glucocorticoids were excluded. The primary outcome is AI, def...

Eosinophilic esophagitis strongly linked to chronic rhinosinusitis.
https://doi.org/10.1002/lary.25798
The Laryngoscope; Padia R, Curtin K et. al.

Nov 26th, 2015 - To determine the relative risk of having eosinophilic esophagitis (EoE) coexist with chronic rhinosinusitis (CRS) in probands and their families using the Utah Population Database (UPDB). This retrospective observational cohort study with population-based matched controls utilized the UPDB, a genealogical database linked to medical records. It was used to identify CRS and EoE patients diagnosed...

Indication for resuscitative thoracotomy in thoracic injuries-Adherence to the ATLS gui...
https://doi.org/10.1016/j.injury.2015.10.034
Injury Ohrt-Nissen S, Colville-Ebeling B et. al.

Nov 13th, 2015 - The appropriate indications for Resuscitative Thoracotomy (RT) are still debated in the literature and various guidelines have been proposed. This study aimed to evaluate whether Advanced Trauma Life Support (ATLS) guidelines for RT were applied correctly and to evaluate the proportion of deceased patients with potentially reversible thoracic lesions (PRTL). The database at the Department of Fo...

Esophageal dilation in eosinophilic esophagitis.
https://doi.org/10.1016/j.bpg.2015.06.015
Best Practice & Research. Clinical Gastroenterology; Richter JE

Nov 10th, 2015 - Tissue remodeling with scaring is common in adult EoE patients with long standing disease. This is the major factor contributing to their complaints of solid food dysphagia and recurrent food impactions. The best tests to define the degree of remodeling are barium esophagram, high resolution manometry and endoscopy. Many physicians are fearful to dilate EoE patients because of concerns about mu...

Eosinophilic Esophagitis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905697
The New England Journal of Medicine; Furuta GT, Katzka DA

Oct 21st, 2015 - Eosinophilic Esophagitis.|2015|Furuta GT,Katzka DA,|diagnosis,diet therapy,etiology,therapy,pathology,physiopathology,therapeutic use,therapeutic use,

Lung Pathology in Pediatric Pulmonary Vein Stenosis.
https://doi.org/10.2350/15-07-1670-OA.1
Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society; Pogoriler JE, Kulik TJ et. al.

Oct 12th, 2015 - Pulmonary vein stenosis is a rare progressive narrowing of the extrapulmonary pulmonary veins, presenting predominantly in infancy and virtually always lethal. It typically arises following repair of congenital heart disease, particularly anomalous pulmonary venous return. Histologic characterization of pediatric pulmonary vein stenosis, not previously well described, may provide insight into t...

Recent research advances in eosinophilic esophagitis.
https://doi.org/10.1097/MOP.0000000000000284
Current Opinion in Pediatrics; Oyoshi MK

Sep 29th, 2015 - Eosinophilic esophagitis (EoE) is a chronic allergic disease triggered by food allergens with an increasing prevalence. This review highlights recent research advances in EoE with a focus on the literature of the past 18 months. The incidence of EoE in the black population is higher than previously suggested. A novel locus spanning CAPN14 is associated with EoE. Diagnostic tests utilizing an an...

Family history of skin cancer is associated with early-onset basal cell carcinoma indep...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679454
Cancer Epidemiology; Berlin NL, Cartmel B et. al.

Sep 18th, 2015 - As a marker of genetic susceptibility and shared lifestyle characteristics, family history of cancer is often used to evaluate an individual's risk for developing a particular malignancy. With comprehensive data on pigment characteristics, lifestyle factors, and melanocortin 1 receptor (MC1R) gene sequence, we sought to clarify the role of family history of skin cancer in early-onset basal cell...

A Clinical Prediction Tool Identifies Cases of Eosinophilic Esophagitis Without Endosco...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586067
The American Journal of Gastroenterology; Dellon ES, Rusin S et. al.

Aug 25th, 2015 - Eosinophilic esophagitis (EoE) is difficult to distinguish from gastroesophageal reflux (GERD) and other causes of dysphagia. We assessed the utility of a set of clinical and endoscopic features for predicting EoE without obtaining esophageal biopsies. We prospectively enrolled consecutive adults undergoing outpatient upper endoscopy at the University of North Carolina from July 2011 through De...

Meta-Analysis-Based Guidance for Dietary Management in Eosinophilic Esophagitis.
https://doi.org/10.1007/s11894-015-0464-y
Current Gastroenterology Reports; Lucendo AJ

Aug 21st, 2015 - Eosinophilic esophagitis (EoE) is a prevalent chronic esophageal disorder, triggered and maintained by immunologically mediated responses against dietary antigens. EoE represents the most recent form of food allergy, and its control by avoiding offending foods has increasingly appeared as a therapeutic alternative to achieve and maintain remission. Dietary therapies have proved equally effectiv...

Pain typology and incident endometriosis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573450
Human Reproduction (Oxford, England); Schliep KC, Mumford SL et. al.

Aug 13th, 2015 - What are the pain characteristics among women, with no prior endometriosis diagnosis, undergoing laparoscopy or laparotomy regardless of clinical indication? Women with surgically visualized endometriosis reported the highest chronic/cyclic pain and significantly greater dyspareunia, dysmenorrhea, and dyschezia compared with women with other gynecologic pathology (including uterine fibroids, pe...

Seasonal exacerbation of esophageal eosinophilia in children with eosinophilic esophagi...
https://doi.org/10.1016/j.anai.2015.07.004
Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology; Ram G, Lee J et. al.

Aug 3rd, 2015 - Evidence supports a possible link between eosinophilic esophagitis (EoE) and environmental aeroallergens, which can manifest as seasonal exacerbation of esophageal eosinophilia. Few studies have examined this link in pediatric patients with EoE. To identify the proportion of patients with seasonal induced esophageal eosinophilia. A retrospective chart review was conducted of all patients diagno...

Contribution of Esophagram to the Evaluation of Complicated Pediatric Eosinophilic Esop...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623947
Journal of Pediatric Gastroenterology and Nutrition; Menard-Katcher C, Swerdlow MP et. al.

May 19th, 2015 - In contrast to peptic strictures, clinically significant strictures in patients with eosinophilic esophagitis (EoE) may be subtle and go unrecognized at the time of endoscopy. We aimed to identify how often stricture was identified by endoscopy as compared with contrast esophagram. We retrospectively reviewed esophagram and endoscopy examinations of all of the patients with EoE with esophageal ...

Spitzoid tumors in children and adults: a comparative clinical, pathological, and cytog...
https://doi.org/10.1097/CMR.0000000000000160
Melanoma Research; Dika E, Fanti PA et. al.

May 1st, 2015 - Spitzoid neoplasms may represent a difficult diagnosis in the practice of dermatopathology. We evaluated the concordance of the fluorescence in-situ hybridization (FISH) assay, histopathology, and dermoscopy in a group of adults and in a group of children with spitzoid neoplasms. The FISH assay, designed to detect the copy number of the RREB1 (6p25), MYB (6q23), and CCND1 (11q13) genes and of c...

The role of endoscopy in the management of GERD.
https://doi.org/10.1016/j.gie.2015.02.021
Gastrointestinal Endoscopy; , Muthusamy VR et. al.

Apr 12th, 2015 - We recommend that uncomplicated GERD be diagnosed on the basis of typical symptoms without the use of diagnostic testing, including EGD. We recommend EGD for patients who have symptoms suggesting complicated GERD or alarm symptoms. We recommend that EGD not be routinely performed solely for the assessment of extraesophageal GERD symptoms. We recommend that endoscopic findings of reflux esophagi...

Allergy-test-driven elimination diet is useful in children with eosinophilic esophagiti...
https://doi.org/10.1111/pai.12389
Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology; Syrigou E, Angelakopoulou A et. al.

Apr 7th, 2015 - A combination of PPIs and corticosteroids is the pharmacotherapy mostly used to treat eosinophilic esophagitis (EoE), while dietetic manipulations consist also an efficient option. The aim of this study was to compare the efficacy of allergy-test-driven elimination diet in children with mild symptoms of EoE to a group of children with moderate/severe symptoms. Thirty-five children, aged 7 month...

Delayed haemolytic transfusion reaction in adults with sickle cell disease: a 5-year ex...
https://doi.org/10.1111/bjh.13339
British Journal of Haematology; Vidler JB, Gardner K et. al.

Mar 10th, 2015 - Delayed haemolytic transfusion reactions (DHTR) are potentially life-threatening complications in patients with sickle cell disease (SCD). Between 1 August 2008 and 31 December 2013, 220 of 637 adult patients in our centre had at least one red blood cell (RBC) transfusion in 2158 separate transfusion episodes. Twenty-three DHTR events occurred in 17 patients (13 female) including 15 HbSS, one H...

Prospective, comparative effectiveness trial of cow's milk elimination and swallowed fl...
https://doi.org/10.1111/dote.12339
Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus; Kruszewski PG, Russo JM et. al.

Feb 27th, 2015 - Eosinophilic esophagitis (EoE) is a chronic, immune-mediated disease in which food antigens play a key role. Current therapeutic options are limited to long-term steroid medication and dietary elimination of multiple foods, each of which is challenging. Our objective was to compare single food elimination of cow's milk to swallowed fluticasone in pediatric EoE patients. This is a prospective, c...

Impact of Diagnostic Delay and Other Risk Factors on Eosinophilic Esophagitis Phenotype...
https://doi.org/10.1097/MCG.0000000000000297
Journal of Clinical Gastroenterology; Lipka S, Kumar A et. al.

Feb 24th, 2015 - Endoscopic features of eosinophilic esophagitis (EoE) are variable with at least 2 phenotypes. The goal of this study was to classify adult EoE patients based on esophageal phenotype and diameter, and assess an association between demographical and clinical histories to define EoE phenotypes and overall disease progression. All consecutive patients with a confirmed diagnosis of EoE from 1988 to...

Metastatic atypical fibroxanthoma: a series of 11 cases including with minimal and no s...
https://doi.org/10.1097/DAD.0000000000000237
The American Journal of Dermatopathology; Wang WL, Torres-Cabala C et. al.

Jan 15th, 2015 - Atypical fibroxanthoma (AFX) is a dermal mesenchymal neoplasm arising in sun-damaged skin, primarily of the head and neck region of older men. Conservative excision cures most. However, varying degrees of subcutaneous involvement can lead to a more aggressive course and rare metastases. Thus, AFX involving the subcutis are termed pleomorphic dermal sarcomas or other monikers by some to recogniz...

Twin and family studies reveal strong environmental and weaker genetic cues explaining ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253562
The Journal of Allergy and Clinical Immunology; Alexander ES, Martin LJ et. al.

Sep 26th, 2014 - Eosinophilic esophagitis (EoE) is a chronic antigen-driven allergic inflammatory disease, likely involving the interplay of genetic and environmental factors, yet their respective contributions to heritability are unknown. To quantify the risk associated with genes and environment on familial clustering of EoE. Family history was obtained from a hospital-based cohort of 914 EoE probands (n = 21...

Intravenous anti-IL-13 mAb QAX576 for the treatment of eosinophilic esophagitis.
https://doi.org/10.1016/j.jaci.2014.07.049
The Journal of Allergy and Clinical Immunology; Rothenberg ME, Wen T et. al.

Sep 17th, 2014 - Eosinophilic esophagitis (EoE) is a chronic allergic disease with limited treatment options. We evaluated QAX576, an mAb against IL-13, in the treatment of patients with EoE. Patients (18-50 years) with proton pump inhibitor-resistant esophageal eosinophilia received intravenous QAX576 (6 mg/kg) or placebo (2:1) at weeks 0, 4, and 8 and were followed for 6 months. The primary end point was the ...

Relation between eosinophilic esophagitis and oral immunotherapy for food allergy: a sy...
https://doi.org/10.1016/j.anai.2014.08.004
Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology; Lucendo AJ, Arias A et. al.

Sep 13th, 2014 - The onset of eosinophilic esophagitis (EoE) after oral immunotherapy (OIT) has been repeatedly described in patients with immunoglobulin E (IgE)-mediated food allergy in recent years, but the relation between the 2 conditions has not been fully assessed and quantified. To provide a systematic review of the evidence for an association between OIT and EoE. Electronic searches were performed with ...

Evaluating the endoscopic reference score for eosinophilic esophagitis: moderate to sub...
https://doi.org/10.1055/s-0034-1377781
Endoscopy van Rhijn BD, Warners MJ et. al.

Sep 10th, 2014 - Recently the Endoscopic Reference Score (EREFS) for endoscopic assessment of eosinophilic esophagitis was introduced, with good interobserver agreement for most signs. The EREFS has not yet been evaluated by other investigators and intraobserver agreement has not been assessed. The aim of this study was to further validate the EREFS by assessing interobserver and intraobserver agreement of endo...

Four-food group elimination diet for adult eosinophilic esophagitis: A prospective mult...
https://doi.org/10.1016/j.jaci.2014.07.023
The Journal of Allergy and Clinical Immunology; Molina-Infante J, Arias A et. al.

Sep 1st, 2014 - Eosinophilic esophagitis (EoE) is an esophageal disorder predominantly triggered by food antigens. A six-food group elimination diet (SFGED) achieves remission in more than 70% of adult patients with EoE. After individual food reintroduction, just 1 or 2 food triggers for EoE can be identified in 65% to 85% of the patients, so some dietary restrictions and endoscopies after food challenge may b...

Development and validation of a symptom-based activity index for adults with eosinophil...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425255
Gastroenterology Schoepfer AM, Straumann A et. al.

Aug 27th, 2014 - Standardized instruments are needed to assess the activity of eosinophilic esophagitis (EoE) and to provide end points for clinical trials and observational studies. We aimed to develop and validate a patient-reported outcome (PRO) instrument and score, based on items that could account for variations in patient assessments of disease severity. We also evaluated relationships between patient as...

Transfusion reactions in pediatric compared with adult patients: a look at rate, reacti...
https://doi.org/10.1111/trf.12827
Transfusion Oakley FD, Woods M et. al.

Aug 25th, 2014 - The majority of reports on transfusion reactions address adult patients. Less is known about the types, incidence, and other clinical details of transfusion reactions in pediatric populations. Furthermore, to our knowledge, there have been no previous reports directly comparing these aspects between adults and pediatric patient populations to assess if there are differences. Between the period ...

Vulvar inflammatory dermatoses: an update and review.
https://doi.org/10.1097/DAD.0000000000000149
The American Journal of Dermatopathology; Hoang MP, Reutter J et. al.

Aug 25th, 2014 - Currently, urogenital complaints are among the most common problems encountered by family practitioners, gynecologists, and dermatologists. In response to the intricacy of vulvar disorders, the International Society for the Study of Vulvovaginal Disease was created to facilitate the exchange between clinicians and pathologists involved in the care of these patients. Recent classifications for i...

Novel platelet storage conditions: additive solutions, gas, and cold.
https://doi.org/10.1097/MOH.0000000000000081
Current Opinion in Hematology; Capocelli KE, Dumont LJ

Aug 21st, 2014 - Platelets are a frequently requested blood product today and are often in limited supply because of a shelf life of 5-7 days, depending on the country. Room temperature storage is associated with an increased risk of transfusion-transmitted infection. Plasma used for platelet storage is unavailable for other uses, and allogeneic plasma carries with it risks for adverse transfusion reactions. Th...

Predictors of response to steroid therapy for eosinophilic esophagitis and treatment of...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312270
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association; Wolf WA, Cotton CC et. al.

Aug 2nd, 2014 - Eosinophilic esophagitis (EoE) is commonly treated with swallowed (topical) corticosteroids (tCS). However, few factors have been described that predict outcomes of steroid therapy. We aimed to identify factors associated with nonresponse to tCS and report outcomes of second-line treatment for patients with steroid-refractory EoE. We performed a retrospective cohort study by using the Universit...

Genome-wide association analysis of eosinophilic esophagitis provides insight into the ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121957
Nature Genetics; Kottyan LC, Davis BP et. al.

Jul 15th, 2014 - Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder associated with allergic hypersensitivity to food. We interrogated >1.5 million genetic variants in EoE cases of European ancestry and subsequently in a multi-site cohort with local and out-of-study control subjects. In addition to replicating association of the 5q22 locus (meta-analysis P=1.9×10(-16)), we identified an associati...

Acquired hypothyroidism due to iodine deficiency in an American child.
https://doi.org/10.1515/jpem-2014-0226
Journal of Pediatric Endocrinology & Metabolism : JPEM; Brooks MJ, Post EM

Jul 8th, 2014 - Acquired hypothyroidism secondary to iodine deficiency is rarely reported in iodine-replete environments. The case of a 9-year-old patient with severe acquired hypothyroidism due to iodine deficiency is presented. His deficiency occurred because of a restrictive diet used to control eosinophilic esophagitis. Hypothyroidism and iodine deficiency were quickly corrected with a kelp supplement.

Accuracy, safety, and tolerability of tissue collection by Cytosponge vs endoscopy for ...
https://doi.org/10.1016/j.cgh.2014.06.026
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association; Katzka DA, Geno DM et. al.

Jul 5th, 2014 - Management of eosinophilic esophagitis (EoE) requires repeated endoscopic collection of mucosal samples to assess disease activity and response to therapy. An easier and less expensive means of monitoring of EoE is required. We compared the accuracy, safety, and tolerability of sample collection via Cytosponge (an ingestible gelatin capsule comprising compressed mesh attached to a string) with ...

Markers of eosinophilic inflammation for diagnosis of eosinophilic esophagitis and prot...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252508
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association; Dellon ES, Speck O et. al.

Jul 5th, 2014 - Distinguishing between eosinophilic esophagitis (EoE), gastroesophageal reflux disease, and proton pump inhibitor-responsive esophageal eosinophilia (PPI-REE) is challenging. We assessed whether immunohistochemical analysis of esophageal tissues for major basic protein (MBP), eotaxin-3, and tryptase can be used for diagnosis of EoE and to differentiate EoE from PPI-REE. We conducted a prospecti...

Analysis and expansion of the eosinophilic esophagitis transcriptome by RNA sequencing.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156528
Genes and Immunity; Sherrill JD, Kiran KC et. al.

Jun 12th, 2014 - Eosinophilic esophagitis (EoE) is an allergic inflammatory disorder of the esophagus that is compounded by genetic predisposition and hypersensitivity to environmental antigens. Using high-density oligonucleotide expression chips, a disease-specific esophageal transcript signature was identified and was shown to be largely reversible with therapy. In an effort to expand the molecular signature ...

Tea, coffee, and caffeine and early-onset basal cell carcinoma in a case-control study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059399
European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP); Ferrucci LM, Cartmel B et. al.

May 20th, 2014 - Tea and coffee are hypothesized to play a protective role in skin carcinogenesis through bioactive components, such as caffeine, yet the epidemiologic evidence is mixed. Existing data support an inverse association with basal cell carcinoma (BCC), more so than for melanoma or squamous cell carcinoma. To understand whether tea, coffee, and caffeine are related to early-onset BCC, we evaluated da...

Genetic and epigenetic underpinnings of eosinophilic esophagitis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019933
Gastroenterology Clinics of North America; Sherrill JD, Rothenberg ME

May 12th, 2014 - Eosinophilic esophagitis (EoE) is a complex, polygenic disorder caused by genetic predisposition and environmental exposures. Because of the recent emergence of EoE as a bona fide global health concern, a paucity of available therapeutic and diagnostic options exists. However, rapid progress has been made in an effort to rectify this lack and to improve understanding of the factors that cause E...

A comparison of adverse reaction rates for PAS C versus plasma platelet units.
https://doi.org/10.1111/trf.12597
Transfusion Cohn CS, Stubbs J et. al.

Apr 16th, 2014 - Plasma constituents have been implicated in some types of platelet (PLT) transfusion reactions. Leukoreduced apheresis PLTs stored in InterSol have 65% less plasma than apheresis PLTs stored in 100% plasma (PPs). This study compared transfusion reaction rates in InterSol PLTs (PLT additive solution [PAS] C) versus PPs. The study design was an open-label, nonrandomized retrospective review. Stat...

Esophageal eosinophilia is increased in rural areas with low population density: result...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594850
The American Journal of Gastroenterology; Jensen ET, Hoffman K et. al.

Mar 28th, 2014 - Eosinophilic esophagitis (EoE) is an increasingly prevalent chronic disease arising from an allergy/immune-mediated process. Generally, the risk of atopic disease differs in rural and urban environments. The relationship between population density and EoE is unknown. Our aim was to assess the relationship between EoE and population density. We conducted a cross-sectional, case-control study of ...

Cardiovascular disease in transsexual persons treated with cross-sex hormones: reversal...
https://doi.org/10.1530/EJE-14-0011
European Journal of Endocrinology; Gooren LJ, Wierckx K et. al.

Mar 12th, 2014 - The incidence of heart disease increases with age, but is lower in women than in men up to 75 years. A protective effect of female sex hormones or, alternatively, acceleration in male heart disease by testosterone at younger ages, could explain this sex difference. In contrast with the above, male-to-female transsexual subjects (MtoF) treated with estrogens (+anti-androgens) show more cardiovas...

Addition of prokinetics to PPI therapy in gastroesophageal reflux disease: a meta-analy...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942846
World Journal of Gastroenterology; Ren LH, Chen WX et. al.

Mar 7th, 2014 - To investigate the efficacy of adding prokinetics to proton pump inhibitors (PPIs) for the treatment of gastroesophageal reflux disease (GERD). PubMed, Cochrane Library, and Web of Knowledge databases (prior to October 2013) were systematically searched for randomized controlled trials (RCTs) that compared therapeutic efficacy of PPI alone (single therapy) or PPI plus prokinetics (combined ther...

Clinical and imaging features predictive of orbital granulomatosis with polyangiitis an...
https://doi.org/10.1016/j.ophtha.2013.12.003
Ophthalmology Tan LT, Davagnanam I et. al.

Feb 24th, 2014 - Granulomatosis with polyangiitis (GPA), previously Wegener's granulomatosis, requires prompt diagnosis and systemic review to exclude life-threatening disease. However, early diagnosis of orbital GPA may be difficult because anti-neutrophil cytoplasmic antibody (ANCA) and anti-PR3 antibody screening can be negative at presentation and orbital biopsies taken for diagnosis may not show the classi...

Mortality among persons in care with hepatitis C virus infection: the Chronic Hepatitis...
https://doi.org/10.1093/cid/ciu077
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America; Mahajan R, Xing J et. al.

Feb 13th, 2014 - The number of deaths in hepatitis C virus (HCV)-infected persons recorded on US death certificates has been increasing, but actual rates and causes of death in these individuals have not been well elucidated. Disease-specific, liver-related, and non-liver-related mortality data for HCV-infected patients in an observational cohort study, the Chronic Hepatitis Cohort Study (CHeCS) at 4 US healthc...

Electron microscopy elucidates eosinophil degranulation patterns in patients with eosin...
https://doi.org/10.1016/j.jaci.2013.11.024
The Journal of Allergy and Clinical Immunology; Saffari H, Hoffman LH et. al.

Jan 20th, 2014 - In patients with eosinophilic esophagitis (EoE), eosinophils accumulate and release granule proteins onto esophageal epithelium. However, little is understood about the mechanism of eosinophil degranulation. To determine and quantify eosinophil degranulation patterns, we studied esophageal biopsy specimens from both the proximal and distal esophagi of 9 randomly selected patients with EoE. The ...