Antunes, C. et. al.
Oct 26th, 2018 - Gastroesophageal reflux disease (GERD) is a condition that develops when there is a retrograde flow of stomach contents causing symptoms or complications. GERD can present as Non-erosive reflux disease (NERD) when typical symptoms of GERD occur in the absence of visible mucosal injury during endoscopy, or as erosive esophagitis (EE) when patients have histopathological changes in esophageal muc...
Apr 23rd, 2018 - Asthma deaths have decreased over time and varied by demographic characteristics. View the statistics from the Centers for Disease Control and Prevention (CDC) - National Center of Environmental Health (NCEH) - National Asthma Control Program
Jul 31st, 2017 - Since first characterized in 2 small case series in the early 1990s, eosinophilic esophagitis (EoE) has emerged as a commonly identified cause of esophageal symptoms in children and adults. 1, 2 Although several highly effectively dietary, pharmacologic, and endoscopic therapies have been reported, none is currently approved by either the US Food and Drug Administration (FDA) or European regulat.
Dec 20th, 2016 - This work group report addresses the potential challenges of implementing an elimination diet for the management of EoE and provides instructions and tools for physicians, dietitians, and other allied health professionals to help guide them in planning elimination diets for both children and adult.
Gastrointestinal Endoscopy; Dougherty M, Runge TM et. al.
May 3rd, 2017 - Esophageal dilation is a now recognized to be an important therapeutic modality in eosinophilic esophagitis (EoE). We aimed to evaluate the safety of esophageal dilation in EoE, especially regarding perforation risk, and to examine perforation risk by dilator type. We conducted a systematic review of the published literature from January 1, 1950 to June 30, 2016 using PubMed, EMBASE, and Web of...
Gastroenterology Safroneeva E, Straumann A et. al.
Nov 20th, 2015 - It is not clear whether symptoms alone can be used to estimate the biologic activity of eosinophilic esophagitis (EoE). We aimed to evaluate whether symptoms can be used to identify patients with endoscopic and histologic features of remission. Between April 2011 and June 2014, we performed a prospective, observational study and recruited 269 consecutive adults with EoE (67% male; median age, 3...
Gastroenterology Clayton F, Fang JC et. al.
Jun 7th, 2014 - Eosinophilic esophagitis is usually triggered by foods, by unclear mechanisms. We evaluated the roles of IgE and IgG4 in the development of eosinophilic esophagitis. We performed a prospective, randomized, double-blind, placebo-controlled trial of adults with eosinophilic esophagitis given an antibody against IgE (omalizumab, n = 16) or placebo (n = 14) every 2-4 weeks for 16 weeks, based on we...
Journal of the American Academy of Dermatology; Herrmann JL, Allan A et. al.
Apr 17th, 2014 - Pilomatrix carcinoma is a rare cutaneous tumor derived from follicular matrix cells with few cases documented in the literature. We sought to better characterize this tumor by analyzing its epidemiologic, clinical, and histopathologic features in 13 new cases and by reviewing the literature. All cases of pilomatrix carcinoma from a large regional dermatopathology practice were identified and an...
Gastrointestinal Endoscopy; Lipka S, Keshishian J et. al.
Apr 7th, 2014 - Despite the vast focus of research in eosinophilic esophagitis (EoE), the natural history of untreated EoE remains undefined. Current expert consensus panels are calling for natural history studies to define long-term risks, adverse events, and progression of the disease. To address the natural course and long-term adverse events of EoE. Retrospective, single-center study. Tertiary-care center....
Gastroenterology Arias A, González-Cervera J et. al.
Feb 18th, 2014 - Various dietary interventions have been used to treat patients with eosinophilic esophagitis (EoE), yielding varied results. This systematic review assesses the efficacy of different dietary therapies in inducing disease remission. We performed a systematic search of the MEDLINE, EMBASE, and SCOPUS databases for studies investigating the efficacy of dietary interventions (reducing infiltration ...
The American Journal of Gastroenterology; Nielsen JA, Lager DJ et. al.
Jan 21st, 2014 - Eosinophilic esophagitis (EoE) is characterized clinically by dysphagia, chest pain, and food impaction, and morphologically by increased numbers of intraepithelial eosinophils and marked basal hyperplasia of the squamous mucosa. The consensus criteria for a diagnosis of EoE include the presence of ≥15 eosinophils/HPF in biopsies from both proximal and distal esophagus in the absence of other c...
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association; Wolf WA, Jerath MR et. al.
Jan 20th, 2014 - Eosinophilic esophagitis (EoE) is an immune-mediated disorder. Food elimination is an established treatment for children, but data in adults are limited. We aimed to determine the response of adults with EoE to dietary therapy. This was a retrospective cohort study using the University of North Carolina EoE database from 2006 to 2012. Subjects were age 18 and older, had EoE by consensus guideli...
Gastroenterology Lucendo AJ, Miehlke S et. al.
Mar 24th, 2019 - Swallowed topical-acting corticosteroids are recommended as first-line therapy for eosinophilic esophagitis (EoE). Asthma medications not optimized for esophageal delivery are sometimes effective, although given off label. We performed a randomized, placebo-controlled trial to assess the effectiveness and tolerability of a budesonide orodispersible tablet (BOT) that allows the drug to be delive...
Gastroenterology Dellon ES, Woosley JT et. al.
Mar 15th, 2019 - Topical steroid treatments for eosinophilic esophagitis (EoE) include swallowed fluticasone from a multi-dose inhaler (MDI) or oral viscous budesonide (OVB) slurry, but the two have never been compared. We assessed whether OVB was more effective than MDI for initial treatment of patients with EoE. In a double-blind, double-dummy trial, patients with a new diagnosis of EoE were randomly assigned...
The American Journal of Gastroenterology; Schoepfer AM, Simko A et. al.
Jan 17th, 2018 - For technical reasons, the histologic characterization of eosinophilic esophagitis (EoE)-specific alterations is almost exclusively based on those found in the esophageal epithelium, whereas little is known about subepithelial abnormalities. In this study, we aimed to systematically assess the nature of subepithelial histologic alterations, and analyze their relationship with epithelial histolo...
Journal of Clinical Gastroenterology; Lipka S, Kumar A et. al.
Sep 8th, 2017 - Esophageal dilation is an effective and safe treatment option for fibrostenotic eosinophilic esophagitis (EoE). Despite the safety, adverse events occur, yet there is scarce literature on the best treatment postcomplications. Patients with diagnosis of EoE (≥15 eosinophils per high-power field) from 2011 to 2015 treated at our center were included. Thirty patients with fibrostenotic disease had...
The American Journal of Gastroenterology; Katzka DA, Smyrk TC et. al.
Aug 15th, 2017 - Management of eosinophilic esophagitis (EoE) requires repeated endoscopic mucosal sampling to assess disease activity. A less invasive and expensive means of monitoring of EoE is required. The objective of this study was to assess the accuracy, safety, and tolerability of the cytosponge compared to endoscopy and biopsy for histologic assessment of EoE. In this prospective two-center cross-secti...
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association; Eluri S, Dellon ES
Aug 1st, 2017 - Toward More Efficient Dietary Elimination Therapy for Eosinophilic Esophagitis: The Fantastic 4?|2017|Eluri S,Dellon ES,|
The American Journal of Gastroenterology; Greuter T, Bussmann C et. al.
Jul 18th, 2017 - Swallowed topical corticosteroids (STCs) are efficacious in inducing and presumably maintaining remission in patients with active eosinophilic esophagitis (EoE). Hitherto, it has not been evaluated whether long-lasting remission can be achieved, and whether treatment can be stopped once patients have achieved this remission. Since 2007, EoE patients included into a large database at the Swiss E...
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association; Kagalwalla AF, Wechsler JB et. al.
Jun 12th, 2017 - A 6-food elimination diet induces remission in most children and adults with eosinophilic esophagitis (EoE). The effectiveness of empiric elimination of only 4 foods has not been studied in children. We performed a prospective observational outcome study in children with EoE treated with dietary exclusion of cow's milk, wheat, egg, and soy. The objective was to assess the clinical, endoscopic, ...