Antunes, C. et. al.
Oct 26th, 2018 - Gastroesophageal reflux disease (GERD) is a condition that develops when there is a retrograde flow of stomach contents causing symptoms or complications. GERD can present as Non-erosive reflux disease (NERD) when typical symptoms of GERD occur in the absence of visible mucosal injury during endoscopy, or as erosive esophagitis (EE) when patients have histopathological changes in esophageal muc...
Apr 23rd, 2018 - Asthma deaths have decreased over time and varied by demographic characteristics. View the statistics from the Centers for Disease Control and Prevention (CDC) - National Center of Environmental Health (NCEH) - National Asthma Control Program
Jan 11th, 2020 - For children with milk-induced eosinophilic esophagitis (EoE), 9 months of epicutaneous immunotherapy (EPIT) with Viaskin Milk did not significantly improve eosinophil counts or symptoms, compared with placebo, according to the results of an intention-to-treat analysis of a randomized, double-blinded pilot study. Average maximum eosinophil counts were 50.
Bruce Jancin, MDedge News
Nov 1st, 2019 - SAN ANTONIO – An investigational muco-adherent swallowed formulation of budesonide developed specifically for treatment of eosinophilic esophagitis aced all primary and secondary endpoints in a pivotal, phase 3, double-blind, placebo-controlled randomized trial, Ikuo Hirano, MD, reported at the annual scientific meeting of the American College of Gastroenterology. Dr.
Oct 30th, 2019 - SAN ANTONIO — A new option for eosinophilic esophagitis met its primary and key secondary end points in the pivotal phase 3 ORBIT study, the largest trial to date in a therapeutic area with limited treatment choices. Findings from the induction-phase trial of budesonide oral suspension (Takeda) were presented here at the American College of Gastroenterology (ACG) 2019 Annual Scientific Meeting....
Andrew D. Bowser, MDedge News
Oct 15th, 2019 - Dupilumab (Dupixent) significantly reduced patient-reported dysphagia among adults with eosinophilic esophagitis enrolled in a randomized trial, investigators reported. Treatment with this monoclonal antibody also improved histologic disease features and abnormal endoscopic features, compared with placebo, according to investigators in the phase 2 trial, which included 47 patients enrolled at 1.
Michele G. Sullivan
Oct 8th, 2019 - Children with eosinophilic esophagitis often experience respiratory and motor disturbances during sleep, which appear related to dysregulated sleep architecture, Rasintra Siriwat, MD, and colleagues have ascertained. ©Alex Vasilev/Fotolia.
Oct 2nd, 2019 - Lung injuries from vaping probably result from direct toxicity or tissue damage caused by noxious chemical fumes, rather than from an accumulation of lipids in the lungs, pathology data suggest. "We were not surprised by what we found, regarding toxicity," Brandon T. Larsen, MD, PhD, a surgical pathologist at the Mayo Clinic, Scottsdale, Arizona, and a national expert in lung pathology, said in...
Sep 14th, 2019 - During initial dose escalation and up-dosing combined, 6. 1% of patients in the active group and 3.
David A. Katzka, MD
Aug 12th, 2019 - In the upper GI section of the Postgraduate course program, Ikuo Hirano, MD, educated us on the refractory patient with eosinophilic esophagitis, reinforcing the need for chronic maintenance treatment and the complementary role of dilation. Gregory Ginsberg, MD, elucidated the specific strategies needed for gastric polyps with advice on which to leave and which to resect.
Aug 2nd, 2019 - Women with preeclampsia were found to be at the highest risk for transfusion reactions when receiving a blood transfusion post partum, according to results from a retrospective study. Additionally, all women who received a transfusion postpartum were twice as likely to experience a procedure-related complication, compared with nonpregnant controls who received identical care.
Aug 2nd, 2019 - The risk of transfusion reactions was twice as high for women requiring blood to treat postpartum hemorrhage compared with nonpregnant women who also required a blood transfusion during the same time period, a Swedish retrospective study showed. Moreover, said Lars Thurn, MD, of Karolinska University Hospital in Stockholm, Sweden, and colleagues, the reactions somewhat paradoxically were more l...
Andrew D. Bowser
Jul 22nd, 2019 - In patients with previously untreated achalasia, peroral endoscopic myotomy had a high procedural success rate as compared to pneumatic dilation, results of a randomized clinical trial show. Peroral endoscopic myotomy (POEM) had a success rate exceeding 90%, versus just about 50% for standard balloon dilation in what investigators say is, to their knowledge, the first-ever randomized trial to e.
Jul 9th, 2019 - NEW YORK (Reuters Health) - For the swallowing disorder achalasia, peroral endoscopic myotomy (POEM) provided better symptom control than pneumatic dilation but was associated with more reflux esophagitis in a multicenter randomized controlled trial. "These findings support consideration of POEM as an initial treatment option for patients with achalasia," researchers write in a paper online tod...
Jun 25th, 2019 - Budesonide orodispersible tablets (BOTs) are highly effective in inducing disease remission in adults with active eosinophilic esophagitis (EOE), according to a study of the tablets versus placebo in European patients. “A 6-week treatment with 1 mg budesonide twice daily was highly superior over placebo with regard to all predefined primary and secondary outcomes,” wrote Alfredo J.
Mar 27th, 2019 - Orodispersible budesonide delivered specifically to the esophagus as a tablet was effective in inducing clinical and histological remission in patients with eosinophilic esophagitis (EoE), according to a European randomized, controlled trial. At 6 weeks of treatment, the new topical-acting formulation of the corticosteroid (Jorveza) induced complete clinical/histological remission in about 58% ...
Amy Karon, MDedge News
Mar 27th, 2019 - A balloon catheter system that measures mucosal impedance contour immediately distinguished gastroesophageal reflux disease (GERD), eosinophilic esophagitis, and non-GERD (normal findings), according to the findings of a prospective study of 69 adults. Source: American Gastroenterological Association Each group showed a significantly different (P less than.
Mar 21st, 2019 - Among the new operator and institutional requirements for patent foramen ovale (PFO) closure by the Society for Cardiovascular Angiography and Interventions and the American Academy of Neurology: operators should maintain a volume of at least 30 septal interventions (or 15 PFO device placements specifically) every 2 years. (Catheterization and Cardiovascular Interventions) Coating separation in...
Mitchel L. Zoler, MDedge News
Mar 7th, 2019 - SAN FRANCISCO – Clinicians safely used epicutaneous immunotherapy to resolve eosinophilic esophagitis in children and teens secondary to milk consumption in a placebo-controlled, pilot study that included 20 patients. Mitchel L.
Feb 4th, 2019 - Treatment with budesonide oral suspension (BOS) was generally well tolerated and maintained a histologic response in some patients with eosinophilic esophagitis (EoE), according to the results of the 24-week, open-label extension phase of a multicenter, randomized, placebo-controlled, industry-sponsored trial. Rates of histologic response (up to 6 eosinophils per high-power field) were “modest”.