ALLMedicine™ Pertussis Center

May 4th, 2021 - The prevalent resurgence of pertussis has recently become a critical public health problem worldwide. To understand pertussis pathogenesis and the host response to both the pathogen and vaccines, a suitable pertussis animal model, particularly a n...

May 3rd, 2021 - A comprehensive review of observational pertussis vaccine effectiveness (VE) studies is needed to update gaps from previous reviews. We conducted a systematic review of VE and duration of protection studies for the whole-cell (wP) and acellular (a...

Apr 28th, 2021 - Necrotizing crescentic glomerulonephritis (GN) associated with anti-neutrophil cytoplasmic antibodies (ANCA) against myeloperoxidase (MPO) is a devastating disease that quickly progresses to kidney failure. Current therapies are broadly immunosupp...

Apr 26th, 2021 - RTX toxin action often defines the outcome of bacterial infections. Here, we discuss the progress in understanding the impacts of RTX toxin activities on host immunity. Bordetella pertussis CyaA activity paralyzes sentinel phagocytic cells by elev...

Apr 26th, 2021 - Pertussis, mainly caused by Bordetella pertussis, is a severe respiratory disease that can be fatal, especially in young infants. Vaccines, massively implemented since the middle of the last century, have substantially reduced the pertussis incide...

Feb 6th, 2020 - On December 21, 2018 the Food and Drug Administration (FDA) licensed a hexavalent combined diphtheria and tetanus toxoids and acellular pertussis (DTaP) adsorbed, inactivated poliovirus (IPV), Haemophilus influenzae type b (Hib) conjugate (meningo...

Jan 23rd, 2020 - Since 2005, a single dose of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine has been recommended by the Advisory Committee on Immunization Practices (ACIP) for adolescents and adults (1,2). After receipt of Tdap,...

Mar 12th, 2019 - We characterized 170 complete genome assemblies from clinical Bordetella pertussis isolates representing geographic and temporal diversity in the United States. These data capture genotypic shifts, including increased pertactin deficiency, occurri...

Apr 27th, 2018 - This report compiles and summarizes all recommendations from CDC's Advisory Committee on Immunization Practices (ACIP) regarding prevention and control of tetanus, diphtheria, and pertussis in the United States. As a comprehensive summary of previ...

Aug 23rd, 2017 - The overwhelming majority of morbidity and mortality attributable to pertussis infection occurs in infants who are 3 months and younger. Infants do not begin their own vaccine series against pertussis until approximately 2 months of age. This leav...

May 4th, 2021 - The prevalent resurgence of pertussis has recently become a critical public health problem worldwide. To understand pertussis pathogenesis and the host response to both the pathogen and vaccines, a suitable pertussis animal model, particularly a n...

May 3rd, 2021 - A comprehensive review of observational pertussis vaccine effectiveness (VE) studies is needed to update gaps from previous reviews. We conducted a systematic review of VE and duration of protection studies for the whole-cell (wP) and acellular (a...

Apr 28th, 2021 - Necrotizing crescentic glomerulonephritis (GN) associated with anti-neutrophil cytoplasmic antibodies (ANCA) against myeloperoxidase (MPO) is a devastating disease that quickly progresses to kidney failure. Current therapies are broadly immunosupp...

Apr 26th, 2021 - RTX toxin action often defines the outcome of bacterial infections. Here, we discuss the progress in understanding the impacts of RTX toxin activities on host immunity. Bordetella pertussis CyaA activity paralyzes sentinel phagocytic cells by elev...

Apr 26th, 2021 - Pertussis, mainly caused by Bordetella pertussis, is a severe respiratory disease that can be fatal, especially in young infants. Vaccines, massively implemented since the middle of the last century, have substantially reduced the pertussis incide...

Apr 20th, 2021 - (Reuters Health) - Maternal tetanus, diphtheria, and acellular pertussis (Tdap) vaccination during pregnancy isn't associated with adverse outcomes for offspring through early childhood, a new study suggests. Researchers examined data on 625,643 l...

Jan 27th, 2021 - Vaccination series against diphtheria, tetanus, and pertussis (DTaP); tetanus, diphtheria, and pertussis (Tdap); and tetanus and diphtheria (Td) provide necessary protection against these diseases and their associated complications. It is importan...

Oct 22nd, 2020 - Only 30.6% of American adolescents complete three routinely recommended vaccinations, new research has found, but that number varies widely by state. The Advisory Committee on Immunization Practices recommends that by age 17, adolescents complete ...

Oct 22nd, 2020 - Only 30.6% of American adolescents complete three routinely recommended vaccinations, new research has found, but that number varies widely by state. The Advisory Committee on Immunization Practices recommends that by age 17, adolescents complete ...

Aug 4th, 2020 - NEW YORK (Reuters Health) - Health providers should pay extra attention to infants with signs of pertussis given the potential interaction between maternal vaccination for the disease and the baby's responses to diphtheria, tetanus, and whole-cell...