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About 750 results

ALLMedicine™ Pediatric Sepsis Center

Research & Reviews  259 results

Impaired Lymphocyte Responses in Pediatric Sepsis Vary by Pathogen Type and are Associa...
https://doi.org/10.1097/SHK.0000000000001943
Shock (Augusta, Ga.); Lindell RB, Zhang D et. al.

Jun 28th, 2022 - Sepsis is the leading cause of death in hospitalized children worldwide. Despite its hypothesized immune-mediated mechanism, targeted immunotherapy for sepsis is not available for clinical use. To determine the association between longitudinal cyt...

Stress Hydrocortisone In Pediatric Septic Shock
https://clinicaltrials.gov/ct2/show/NCT03401398

Jun 23rd, 2022 - Sepsis represents the most common cause of childhood mortality worldwide. In the United States alone, 200 cases of pediatric sepsis are diagnosed each day, with an associated hospital mortality rate of 5-10% and health care expenditures now approa...

Monocyte Distribution Width in Children With Systemic Inflammatory Response: Retrospect...
https://doi.org/10.1097/PCC.0000000000003019
Pediatric Critical Care Medicine : a Journal of the Socie... Hou SK, Lin HA et. al.

Jun 16th, 2022 - To investigate the association between increased monocyte distribution width (MDW) and pediatric sepsis in the emergency department (ED). Retrospective cohort study. A single academic hospital study. Patients from birth to the age of 18 years who ...

The Association of Early Corticosteroid Therapy With Clinical and Health-Related Qualit...
https://doi.org/10.1097/PCC.0000000000003009
Pediatric Critical Care Medicine : a Journal of the Socie... Kamps NN, Banks R et. al.

Jun 14th, 2022 - Corticosteroids are commonly used in the treatment of pediatric septic shock without clear evidence of the potential benefits or risks. This study examined the association of early corticosteroid therapy with patient-centered clinically meaningful...

Physician-Specific Utilization of an Electronic Best Practice Alert for Pediatric Sepsi...
https://doi.org/10.1097/PEC.0000000000002778
Pediatric Emergency Care; Souganidis ES, Patel B et. al.

Jun 14th, 2022 - Early recognition of sepsis remains a critical goal in the pediatric emergency department (ED). Although this has led to the development of best practice alerts (BPAs) to facilitate screening and bundled care, research on how individual physicians...

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Clinicaltrials.gov  19 results

Stress Hydrocortisone In Pediatric Septic Shock
https://clinicaltrials.gov/ct2/show/NCT03401398

Jun 23rd, 2022 - Sepsis represents the most common cause of childhood mortality worldwide. In the United States alone, 200 cases of pediatric sepsis are diagnosed each day, with an associated hospital mortality rate of 5-10% and health care expenditures now approa...

GM-CSF for Reversal of Immunoparalysis in Pediatric Sepsis-induced MODS
https://clinicaltrials.gov/ct2/show/NCT05266001

May 10th, 2022 - The GRACE-2 study is a is a prospective, multi-center, double-blind, randomized controlled trial of the drug GM-CSF vs placebo in children with sepsis-induced multiple organ dysfunction syndrome (MODS) who have immunoparalysis with mild to moderat...

Targeted Reversal of Inflammation in Pediatric Sepsis-induced MODS
https://clinicaltrials.gov/ct2/show/NCT05267821

May 10th, 2022 - The TRIPS study is a prospective, multi-center, double-blind, adaptively randomized, placebo-controlled clinical trial of the drug anakinra for reversal of moderate to severe hyperinflammation in children with sepsis-induced multiple organ dysfunc...

Zinc Supplementation in Pediatric Sepsis
https://clinicaltrials.gov/ct2/show/NCT05366595

May 9th, 2022 - a single blinded randomized controlled clinical trial that was conducted to evaluate the role of zinc supplementation in improving the outcome of infants and children with sepsis in pediatric intensive care unit. The study included 72 cases that w...

Biomarker-enhanced Artificial Intelligence Based Pediatric Sepsis Screening Tool
https://clinicaltrials.gov/ct2/show/NCT05311046

Apr 5th, 2022 - Background and Rationale Existing automated pediatric sepsis screening tools (PSCT) based on consensus criteria currently used in emergency departments do not improve early recognition and/or inform personalized therapeutic decisions leading to im...

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News  22 results

Bundle Adherence Helps Improve Pediatric Sepsis Outcomes
https://www.medscape.com/viewarticle/945330

Feb 4th, 2021 - Interim results from a 40-hospital pediatric sepsis quality improvement study support lengthening the initial window for giving fluids and antibiotics. They also suggest better outcomes when providers adhere to optimal care bundles. Raina Paul, MD...

Prognostic Biomarker Test Identifies High-Risk Sepsis in Kids
https://www.medscape.com/viewarticle/921333

Nov 14th, 2019 - The prediction of septic shock outcomes and the selection of early optimal treatment may become more precise, thanks to a new biomarker-based tool. The investigative Pediatric Sepsis Biomarker Risk Model (PERSEVERE) assay is a rapid blood test tha...

Differential monocytic HLA-DR expression prognostically useful in PICU
https://www.mdedge.com/jcomjournal/article/206634/infectious-diseases/differential-monocytic-hla-dr-expression?channel=302
Bruce Jancin

Aug 19th, 2019 - LJUBLJANA, SLOVENIA – During their first 4 days in the pediatric ICU, critically ill children have significantly reduced human leukocyte antigen (HLA)–DR expression within all three major subsets of monocytes. The reductions are seen regardless of.

Differential monocytic HLA-DR expression prognostically useful in PICU
https://www.mdedge.com/pediatrics/article/206634/infectious-diseases/differential-monocytic-hla-dr-expression
Bruce Jancin

Aug 19th, 2019 - LJUBLJANA, SLOVENIA – During their first 4 days in the pediatric ICU, critically ill children have significantly reduced human leukocyte antigen (HLA)–DR expression within all three major subsets of monocytes. The reductions are seen regardless of.

What’s new in pediatric sepsis
https://www.mdedge.com/jcomjournal/article/203587/infectious-diseases/whats-new-pediatric-sepsis/page/0/1?channel=325

Jun 26th, 2019 - The current Pediatric Sepsis Consensus Conference definition dates back to 2005. A comprehensive revision is getting underway.

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