ALLMedicine™ Pediatric Sepsis Center

Jun 28th, 2022 - Sepsis is the leading cause of death in hospitalized children worldwide. Despite its hypothesized immune-mediated mechanism, targeted immunotherapy for sepsis is not available for clinical use. To determine the association between longitudinal cyt...

Jun 23rd, 2022 - Sepsis represents the most common cause of childhood mortality worldwide. In the United States alone, 200 cases of pediatric sepsis are diagnosed each day, with an associated hospital mortality rate of 5-10% and health care expenditures now approa...

Jun 16th, 2022 - To investigate the association between increased monocyte distribution width (MDW) and pediatric sepsis in the emergency department (ED). Retrospective cohort study. A single academic hospital study. Patients from birth to the age of 18 years who ...

Jun 14th, 2022 - Corticosteroids are commonly used in the treatment of pediatric septic shock without clear evidence of the potential benefits or risks. This study examined the association of early corticosteroid therapy with patient-centered clinically meaningful...

Jun 14th, 2022 - Early recognition of sepsis remains a critical goal in the pediatric emergency department (ED). Although this has led to the development of best practice alerts (BPAs) to facilitate screening and bundled care, research on how individual physicians...

Jun 23rd, 2022 - Sepsis represents the most common cause of childhood mortality worldwide. In the United States alone, 200 cases of pediatric sepsis are diagnosed each day, with an associated hospital mortality rate of 5-10% and health care expenditures now approa...

May 10th, 2022 - The GRACE-2 study is a is a prospective, multi-center, double-blind, randomized controlled trial of the drug GM-CSF vs placebo in children with sepsis-induced multiple organ dysfunction syndrome (MODS) who have immunoparalysis with mild to moderat...

May 10th, 2022 - The TRIPS study is a prospective, multi-center, double-blind, adaptively randomized, placebo-controlled clinical trial of the drug anakinra for reversal of moderate to severe hyperinflammation in children with sepsis-induced multiple organ dysfunc...

May 9th, 2022 - a single blinded randomized controlled clinical trial that was conducted to evaluate the role of zinc supplementation in improving the outcome of infants and children with sepsis in pediatric intensive care unit. The study included 72 cases that w...

Apr 5th, 2022 - Background and Rationale Existing automated pediatric sepsis screening tools (PSCT) based on consensus criteria currently used in emergency departments do not improve early recognition and/or inform personalized therapeutic decisions leading to im...

Feb 4th, 2021 - Interim results from a 40-hospital pediatric sepsis quality improvement study support lengthening the initial window for giving fluids and antibiotics. They also suggest better outcomes when providers adhere to optimal care bundles. Raina Paul, MD...

Nov 14th, 2019 - The prediction of septic shock outcomes and the selection of early optimal treatment may become more precise, thanks to a new biomarker-based tool. The investigative Pediatric Sepsis Biomarker Risk Model (PERSEVERE) assay is a rapid blood test tha...

Aug 19th, 2019 - LJUBLJANA, SLOVENIA – During their first 4 days in the pediatric ICU, critically ill children have significantly reduced human leukocyte antigen (HLA)–DR expression within all three major subsets of monocytes. The reductions are seen regardless of.

Aug 19th, 2019 - LJUBLJANA, SLOVENIA – During their first 4 days in the pediatric ICU, critically ill children have significantly reduced human leukocyte antigen (HLA)–DR expression within all three major subsets of monocytes. The reductions are seen regardless of.

Jun 26th, 2019 - The current Pediatric Sepsis Consensus Conference definition dates back to 2005. A comprehensive revision is getting underway.