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About 155 results

ALLMedicine™ Shigella Infection Center

Research & Reviews  52 results

Shigella CVD 30000: Study of Responses to Vaccination With Shigella Vaccine
https://clinicaltrials.gov/ct2/show/NCT04078022

May 9th, 2022 - The purpose of this study is to determine whether SF2a-TT15 (a monovalent synthetic carbohydrate-based conjugate Shigella vaccine) is safe and effective in the prevention of Shigella infection. This will be a phase 2b, double-blind, placebo-contro...

A Study to Investigate the Safety and Immunogenicity of the SF2a-TT15 Synthetic Carbohydrate-based Conjugate Vaccine Against Shigella Flexneri 2a
https://clinicaltrials.gov/ct2/show/NCT04602975

Dec 9th, 2021 - The purpose of this study is to examine the safety and immunogenicity of two doses of the parenteral synthetic carbohydrate-based conjugate vaccine against Shigella flexneri 2a (Shigella flexneri 2a-Tetanus Toxoid15 (SF2a-TT15)) adjuvanted or not ...

Biofilm Formation and Virulence of Shigella flexneri Are Modulated by pH of Gastrointes...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519285
Infection and Immunity; Chiang IL, Wang Y et. al.

Aug 24th, 2021 - Shigella infection remains a public health problem in much of the world. Classic models of Shigella pathogenesis suggest that microfold epithelial cells in the small intestine are the preferred initial site of invasion. However, recent evidence su...

Au Nanoclusters Ameliorate Shigella Infectious Colitis by Inducing Oxidative Stress.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275169
International Journal of Nanomedicine; Wu X, Chen Y et. al.

Jul 17th, 2021 - Shigella infection has always been a global burden, and it particularly threatens children between the ages of 1 and 5 years. Economically underdeveloped countries are dominated by Shigella flexneri infection. The most effective method to treat Sh...

Shigellosis in young children in low-income and middle-income countries: insights from ...
https://doi.org/10.1097/QCO.0000000000000758
Current Opinion in Infectious Diseases; Platts-Mills JA, Rogawski McQuade ET

Jul 16th, 2021 - To describe the impact of molecular diagnostics on our understanding of the burden and epidemiology of shigellosis in children in low-income and middle-income countries. The incorporation of molecular diagnostics has led to a substantial increase ...

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Clinicaltrials.gov  5 results

Shigella CVD 30000: Study of Responses to Vaccination With Shigella Vaccine
https://clinicaltrials.gov/ct2/show/NCT04078022

May 9th, 2022 - The purpose of this study is to determine whether SF2a-TT15 (a monovalent synthetic carbohydrate-based conjugate Shigella vaccine) is safe and effective in the prevention of Shigella infection. This will be a phase 2b, double-blind, placebo-contro...

A Study to Investigate the Safety and Immunogenicity of the SF2a-TT15 Synthetic Carbohydrate-based Conjugate Vaccine Against Shigella Flexneri 2a
https://clinicaltrials.gov/ct2/show/NCT04602975

Dec 9th, 2021 - The purpose of this study is to examine the safety and immunogenicity of two doses of the parenteral synthetic carbohydrate-based conjugate vaccine against Shigella flexneri 2a (Shigella flexneri 2a-Tetanus Toxoid15 (SF2a-TT15)) adjuvanted or not ...

Safety and Efficacy Study of CVD 1208S, a Live, Attenuated Oral Vaccine to Prevent Shigella Infection Using cGMP
https://clinicaltrials.gov/ct2/show/NCT01531530

Apr 30th, 2021 - There are two purposes for conducting this Vaccine Study to evaluate an experimental vaccine called CVD 1208S (Center for Vaccine Development 1208S): 1) to learn whether CVD 1208S causes side effects, and 2) to learn whether the CVD 1208S gives pe...

Safety and Efficacy Study of CVD 1208S, a Live, Attenuated Oral Vaccine to Prevent Shigella Infection: Phase IIa
https://clinicaltrials.gov/ct2/show/NCT00866476

Apr 29th, 2021 - The study comprises a Phase 2 vaccination study and a Phase 2b challenge study. The primary objectives of the Phase 2 vaccination study are: 1. To evaluate, in healthy volunteers, the safety and clinical acceptability of three spaced doses (one mo...

Multidrug Resistant Shigella Infection in Bangladesh
https://clinicaltrials.gov/ct2/show/NCT03778125

Jan 29th, 2019 - 2000 suspected Shigella cases will be recruited from International Centre for Diarrhoeal Disease Research hospital, Dhaka who are presenting with diarrhea at the hospital. A stool sample will be collected from the participants after consenting by ...

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News  3 results

Rise in Possible Fluoroquinolone-Resistant Shigella Isolates, CDC Warns
https://www.staging.medscape.com/viewarticle/897806

Jun 7th, 2018 - The US Centers for Disease Control and Prevention (CDC) continues to see an increasing number of Shigella isolates that test within the susceptible range for the fluoroquinolone antibiotic ciprofloxacin (minimum inhibitory concentration [MIC] valu...

CDC: Some Shigella strains show reduced ciprofloxacin susceptibility
https://www.mdedge.com/gihepnews/article/136209/antimicrobial-resistant-infections/cdc-some-shigella-strains-show-reduced
Sharon Worcester, MDedge News

Apr 21st, 2017 - The Centers for Disease Control and Prevention has identified an increase in Shigella isolates with reduced susceptibility to ciprofloxacin, and has released an official health advisory outlining new recommendations for clinical diagnosis, managem.

Azithromycin Not Effective Against All Shigella Infections
https://www.medscape.com/viewarticle/820607

Feb 13th, 2014 - A team from the Centers for Disease Control and Prevention has tracked Shigella isolates that show decreased susceptibility to azithromycin (DSA-Shigella), according to a note published in the February 14 issue of the Morbidity and Mortality Weekl...

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Patient Education  2 results see all →