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About 4,313 results

ALLMedicine™ Rickets Center

Research & Reviews  1,949 results

Clinical, biochemical, and echocardiographic evaluation of neonates with vitamin D defi...
https://doi.org/10.1017/S1047951121001633
Cardiology in the Young; Cayir A, Akyigit A et. al.

May 4th, 2021 - There are a few number of case reports and small-scale case series reporting dilated cardiomyopathy due to vitamin D-deficient rickets. The present study evaluates the clinical, biochemical, and echocardiographic features of neonates with vitamin ...

Influence of maternal use of tenofovir disoproxil fumarate or zidovudine in Vietnamese ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084453
PloS One; Kinai E, Nguyen HDT et. al.

Apr 29th, 2021 - Tenofovir disoproxil fumarate (TDF) is still widely prescribed for human immunodeficiency virus (HIV)-infected pregnant women, despite its renal and bone toxicity. Although TDF-exposed infants often show transient growth impairment, it is not clea...

A mosaic mutation of phosphate-regulating gene with homologies to endopeptidases on the...
https://doi.org/10.1507/endocrj.EJ20-0809
Endocrine Journal; Asano S, Sako S et. al.

Apr 28th, 2021 - X-linked hypophosphatemic rickets (XLH) is primarily characterized by renal phosphate wasting with hypophosphatemia, short stature, and bone deformity of the leg. Here we present a male case of XLH with relatively mild bone deformity caused by a m...

Effects of Active Vitamin D or FGF23 Antibody on Hyp Mice Dentoalveolar Tissues.
https://doi.org/10.1177/00220345211011041
Journal of Dental Research; Lira Dos Santos EJ, Chavez MB et. al.

Apr 28th, 2021 - Mutations in the PHEX gene lead to X-linked hypophosphatemia (XLH), a form of inherited rickets featuring elevated fibroblast growth factor 23 (FGF23), reduced 1,25-dihydroxyvitamin D (1,25D), and hypophosphatemia. Hyp mutant mice replicate the XL...

INZ-701 Prevents Ectopic Tissue Calcification and Restores Bone Architecture and Growth...
https://doi.org/10.1002/jbmr.4315
Journal of Bone and Mineral Research : the Official Journ... Cheng Z, O'Brien K et. al.

Apr 26th, 2021 - Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is the major enzyme that cleaves extracellular adenosine triphosphate (ATP) to generate pyrophosphate (PPi), an inorganic metabolite with potent anticalcification activity. Loss-of-functio...

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Guidelines  4 results

Vitamin D in European children-statement from the European Academy of Paediatrics (EAP).
https://doi.org/10.1007/s00431-017-2903-2
European Journal of Pediatrics; Grossman Z, Hadjipanayis A et. al.

Apr 12th, 2017 - Vitamin D is synthesized in human skin upon sun exposure and is also a nutrient. It regulates calcium and phosphate metabolism and is essential for the maintenance of bone health. Vitamin D supplementation during infancy, in order to prevent ricke...

Pathogenesis and diagnostic criteria for rickets and osteomalacia - proposal by an expe...
https://doi.org/10.1507/endocrj.EJ15-0289
Endocrine Journal; Fukumoto S, Ozono K et. al.

Jul 14th, 2015 - Rickets and osteomalacia are diseases characterized by impaired mineralization of bone matrix. Recent investigations revealed that the causes for rickets and osteomalacia are quite variable. While these diseases can severely impair the quality of ...

A.S.P.E.N. clinical guidelines: nutrition support of neonatal patients at risk for meta...
https://doi.org/10.1177/0148607113487216
JPEN. Journal of ParEnteral and Enteral Nutrition; Nehra D, Carlson SJ et. al.

May 20th, 2013 - Premature infants are at increased risk for metabolic bone disease, with resulting delayed bone growth, osteopenia, and rickets. A systematic review of the best available evidence to answer a series of questions regarding neonatal patients at risk...

ACOG Committee Opinion No. 495: Vitamin D: Screening and supplementation during pregnancy.
https://doi.org/10.1097/AOG.0b013e318227f06b
Obstetrics and Gynecology;

Jun 21st, 2011 - During pregnancy, severe maternal vitamin D deficiency has been associated with biochemical evidence of disordered skeletal homeostasis, congenital rickets, and fractures in the newborn. At this time, there is insufficient evidence to support a re...

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Drugs  115 results see all →

Clinicaltrials.gov  2,147 results

Clinical, biochemical, and echocardiographic evaluation of neonates with vitamin D defi...
https://doi.org/10.1017/S1047951121001633
Cardiology in the Young; Cayir A, Akyigit A et. al.

May 4th, 2021 - There are a few number of case reports and small-scale case series reporting dilated cardiomyopathy due to vitamin D-deficient rickets. The present study evaluates the clinical, biochemical, and echocardiographic features of neonates with vitamin ...

Influence of maternal use of tenofovir disoproxil fumarate or zidovudine in Vietnamese ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084453
PloS One; Kinai E, Nguyen HDT et. al.

Apr 29th, 2021 - Tenofovir disoproxil fumarate (TDF) is still widely prescribed for human immunodeficiency virus (HIV)-infected pregnant women, despite its renal and bone toxicity. Although TDF-exposed infants often show transient growth impairment, it is not clea...

A mosaic mutation of phosphate-regulating gene with homologies to endopeptidases on the...
https://doi.org/10.1507/endocrj.EJ20-0809
Endocrine Journal; Asano S, Sako S et. al.

Apr 28th, 2021 - X-linked hypophosphatemic rickets (XLH) is primarily characterized by renal phosphate wasting with hypophosphatemia, short stature, and bone deformity of the leg. Here we present a male case of XLH with relatively mild bone deformity caused by a m...

Effects of Active Vitamin D or FGF23 Antibody on Hyp Mice Dentoalveolar Tissues.
https://doi.org/10.1177/00220345211011041
Journal of Dental Research; Lira Dos Santos EJ, Chavez MB et. al.

Apr 28th, 2021 - Mutations in the PHEX gene lead to X-linked hypophosphatemia (XLH), a form of inherited rickets featuring elevated fibroblast growth factor 23 (FGF23), reduced 1,25-dihydroxyvitamin D (1,25D), and hypophosphatemia. Hyp mutant mice replicate the XL...

INZ-701 Prevents Ectopic Tissue Calcification and Restores Bone Architecture and Growth...
https://doi.org/10.1002/jbmr.4315
Journal of Bone and Mineral Research : the Official Journ... Cheng Z, O'Brien K et. al.

Apr 26th, 2021 - Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is the major enzyme that cleaves extracellular adenosine triphosphate (ATP) to generate pyrophosphate (PPi), an inorganic metabolite with potent anticalcification activity. Loss-of-functio...

see more →

News  91 results

Vitamin D Supplements Don't Impact Growth or Rickets in Stunted Children
https://www.medscape.com/viewarticle/943692

Jan 6th, 2021 - (Reuters Health) - Children with stunted growth do not experience improved growth or a reduction in rickets risk by taking vitamin D supplements, a clinical trial suggests. Researchers randomly assigned 3,046 children in Kabul, Afghanistan, rangin...

Burosumab Is a 'Game Changer,' Effective in All Subgroups of XLH
https://www.medscape.com/viewarticle/937820

Sep 21st, 2020 - A recently approved agent, burosumab (Crysvita), was better than placebo across a range of efficacy outcomes for 14 predefined subgroups of adults with X-linked hypophosphatemia (XLH), new research shows. The authors analyzed data from the initial...

Burosumab Is a 'Game Changer,' Effective in All Subgroups of XLH
https://www.staging.medscape.com/viewarticle/937820

Sep 21st, 2020 - A recently approved agent, burosumab (Crysvita), was better than placebo across a range of efficacy outcomes for 14 predefined subgroups of adults with X-linked hypophosphatemia (XLH), new research shows. The authors analyzed data from the initial...

Fast Five Quiz: Vitamin D
https://reference.staging.medscape.com/viewarticle/934164

Jul 20th, 2020 - Vitamin D is a vitamin obtained from sun exposure, a few foods, and many dietary supplements. In proper amounts, vitamin D plays a role in the prevention of osteomalacia and osteoporosis in adults and rickets in children. Vitamin D deficiency can ...

Fast Five Quiz: Vitamin D
https://reference.medscape.com/viewarticle/934164

Jul 20th, 2020 - Vitamin D is a vitamin obtained from sun exposure, a few foods, and many dietary supplements. In proper amounts, vitamin D plays a role in the prevention of osteomalacia and osteoporosis in adults and rickets in children. Vitamin D deficiency can ...

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Patient Education  7 results see all →