ALLMedicine™ Rickets Center

May 4th, 2021 - There are a few number of case reports and small-scale case series reporting dilated cardiomyopathy due to vitamin D-deficient rickets. The present study evaluates the clinical, biochemical, and echocardiographic features of neonates with vitamin ...

Apr 29th, 2021 - Tenofovir disoproxil fumarate (TDF) is still widely prescribed for human immunodeficiency virus (HIV)-infected pregnant women, despite its renal and bone toxicity. Although TDF-exposed infants often show transient growth impairment, it is not clea...

Apr 28th, 2021 - X-linked hypophosphatemic rickets (XLH) is primarily characterized by renal phosphate wasting with hypophosphatemia, short stature, and bone deformity of the leg. Here we present a male case of XLH with relatively mild bone deformity caused by a m...

Apr 28th, 2021 - Mutations in the PHEX gene lead to X-linked hypophosphatemia (XLH), a form of inherited rickets featuring elevated fibroblast growth factor 23 (FGF23), reduced 1,25-dihydroxyvitamin D (1,25D), and hypophosphatemia. Hyp mutant mice replicate the XL...

Apr 26th, 2021 - Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is the major enzyme that cleaves extracellular adenosine triphosphate (ATP) to generate pyrophosphate (PPi), an inorganic metabolite with potent anticalcification activity. Loss-of-functio...

Apr 12th, 2017 - Vitamin D is synthesized in human skin upon sun exposure and is also a nutrient. It regulates calcium and phosphate metabolism and is essential for the maintenance of bone health. Vitamin D supplementation during infancy, in order to prevent ricke...

Jul 14th, 2015 - Rickets and osteomalacia are diseases characterized by impaired mineralization of bone matrix. Recent investigations revealed that the causes for rickets and osteomalacia are quite variable. While these diseases can severely impair the quality of ...

May 20th, 2013 - Premature infants are at increased risk for metabolic bone disease, with resulting delayed bone growth, osteopenia, and rickets. A systematic review of the best available evidence to answer a series of questions regarding neonatal patients at risk...

Jun 21st, 2011 - During pregnancy, severe maternal vitamin D deficiency has been associated with biochemical evidence of disordered skeletal homeostasis, congenital rickets, and fractures in the newborn. At this time, there is insufficient evidence to support a re...

May 4th, 2021 - There are a few number of case reports and small-scale case series reporting dilated cardiomyopathy due to vitamin D-deficient rickets. The present study evaluates the clinical, biochemical, and echocardiographic features of neonates with vitamin ...

Apr 29th, 2021 - Tenofovir disoproxil fumarate (TDF) is still widely prescribed for human immunodeficiency virus (HIV)-infected pregnant women, despite its renal and bone toxicity. Although TDF-exposed infants often show transient growth impairment, it is not clea...

Apr 28th, 2021 - X-linked hypophosphatemic rickets (XLH) is primarily characterized by renal phosphate wasting with hypophosphatemia, short stature, and bone deformity of the leg. Here we present a male case of XLH with relatively mild bone deformity caused by a m...

Apr 28th, 2021 - Mutations in the PHEX gene lead to X-linked hypophosphatemia (XLH), a form of inherited rickets featuring elevated fibroblast growth factor 23 (FGF23), reduced 1,25-dihydroxyvitamin D (1,25D), and hypophosphatemia. Hyp mutant mice replicate the XL...

Apr 26th, 2021 - Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is the major enzyme that cleaves extracellular adenosine triphosphate (ATP) to generate pyrophosphate (PPi), an inorganic metabolite with potent anticalcification activity. Loss-of-functio...

Jan 6th, 2021 - (Reuters Health) - Children with stunted growth do not experience improved growth or a reduction in rickets risk by taking vitamin D supplements, a clinical trial suggests. Researchers randomly assigned 3,046 children in Kabul, Afghanistan, rangin...

Sep 21st, 2020 - A recently approved agent, burosumab (Crysvita), was better than placebo across a range of efficacy outcomes for 14 predefined subgroups of adults with X-linked hypophosphatemia (XLH), new research shows. The authors analyzed data from the initial...

Sep 21st, 2020 - A recently approved agent, burosumab (Crysvita), was better than placebo across a range of efficacy outcomes for 14 predefined subgroups of adults with X-linked hypophosphatemia (XLH), new research shows. The authors analyzed data from the initial...

Jul 20th, 2020 - Vitamin D is a vitamin obtained from sun exposure, a few foods, and many dietary supplements. In proper amounts, vitamin D plays a role in the prevention of osteomalacia and osteoporosis in adults and rickets in children. Vitamin D deficiency can ...

Jul 20th, 2020 - Vitamin D is a vitamin obtained from sun exposure, a few foods, and many dietary supplements. In proper amounts, vitamin D plays a role in the prevention of osteomalacia and osteoporosis in adults and rickets in children. Vitamin D deficiency can ...