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About 245 results

ALLMedicine™ Iron Toxicity Center

Research & Reviews  89 results

Reduction of iron toxicity in the heart of iron-overloaded mice with natural compounds.
https://doi.org/10.1016/j.ejphar.2022.174981
European Journal of Pharmacology; Alikhani M, Aalikhani M et. al.

Apr 30th, 2022 - Iron-overload is one of the risk factors in susceptible individuals. Iron-overload causes complications such as diastolic dysfunction, arrhythmias, ventricular dilation, and systolic dysfunction in the heart. Therefore, particular care is needed f...

Preoperative Monoferric for Abdominal Surgery
https://clinicaltrials.gov/ct2/show/NCT05258825

Apr 21st, 2022 - The Food and Drug Administration approved drug Monoferric has a unique structure that allows for a slow, sustained release and bioavailability without free iron toxicity. Efficacy studies demonstrated a faster change in hemoglobin concentration fr...

Red Blood Cell - IMProving trAnsfusions for Chronically Transfused Recipients
https://clinicaltrials.gov/ct2/show/NCT05255445

Mar 21st, 2022 - Sickle cell disease (SCD) and thalassemia are genetic disorders inducing anemia of differing pathophysiology. A primary therapy for preventing certain SCD complications (e.g., stroke) and for thalassemia major is regular red blood cell (RBC) trans...

Porphyromonas gingivalis outer membrane vesicles as the major drivers of and source for...
https://doi.org/10.1002/alz.056458
Alzheimer's & Dementia : the Journal of the Alzheimer's A... Nara PL

Feb 4th, 2022 - Alzheimer's disease (AD) is a progressive neuroinflammatory and neurodegenerative disease of the brain, defined by the accumulation and deposition of beta-amyloid, which has recently been identified as an antimicrobial peptide suggesting an infect...

Suppressed farnesoid X receptor by iron overload in mice and humans potentiates iron-in...
https://doi.org/10.1002/hep.32270
Hepatology (Baltimore, Md.); Xiong H, Zhang C et. al.

Dec 7th, 2021 - Iron overload (IO) is a frequent finding in the general population. As the major iron storage site, the liver is subject to iron toxicity. Farnesoid X receptor (FXR) regulates bile acid metabolism and is implicated in various liver diseases. We ai...

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Clinicaltrials.gov  7 results

Preoperative Monoferric for Abdominal Surgery
https://clinicaltrials.gov/ct2/show/NCT05258825

Apr 21st, 2022 - The Food and Drug Administration approved drug Monoferric has a unique structure that allows for a slow, sustained release and bioavailability without free iron toxicity. Efficacy studies demonstrated a faster change in hemoglobin concentration fr...

Red Blood Cell - IMProving trAnsfusions for Chronically Transfused Recipients
https://clinicaltrials.gov/ct2/show/NCT05255445

Mar 21st, 2022 - Sickle cell disease (SCD) and thalassemia are genetic disorders inducing anemia of differing pathophysiology. A primary therapy for preventing certain SCD complications (e.g., stroke) and for thalassemia major is regular red blood cell (RBC) trans...

Brain Iron Toxicity and Neurodegeneration - A 7T MRI Study
https://clinicaltrials.gov/ct2/show/NCT04992975

Aug 6th, 2021 - This study aims to determine whether high resolution MRI at 7T and Quantitative Susceptibility Mapping (QSM) can demonstrate a specific pattern of iron overload in strategically important areas of brain as a sensitive marker of pathological Alzhei...

Reproductive Capacity and Iron Burden in Thalassemia
https://clinicaltrials.gov/ct2/show/NCT02308904

Dec 23rd, 2020 - The improved long-term survival of thalassemia major (TM) patients has resulted in increased focus on the ability to preserve fertility. While the association of iron toxicity with vital organ dysfunction, heart and liver, has been extensively inv...

Use of Desferal for Prevention of ARDS in Hospitalised Cases Documented With Covid 19 Infection
https://clinicaltrials.gov/ct2/show/NCT04389801

May 15th, 2020 - COVID-19 is a condition caused by a coronavirus (called SARS-CoV-2) that was first identified in late 2019. In 2020, the virus has spread to many countries around the world and neither a vaccine against the virus or specific treatment for COVID-19...

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News  2 results

Will We Make Artificial Blood Soon? (STAT)
https://www.medpagetoday.com/criticalcare/intensivists/63444

Feb 27th, 2017 - Researchers have sought a blood substitute for over 150 years, and they've all failed. Now, one candidate has demonstrated promising early results, while another nears clinical trials again, reported STAT. ErythroMer encloses hemoglobin in a synth...

Excess Iron May Boost Adult Height
https://www.medpagetoday.com/hematologyoncology/hematology/41120

Aug 21st, 2013 - Action Points Patients with hemochromatosis were taller on average than those in a reference population. The deviation in height did not correlate with the type of HFE mutation, serum ferritin level, liver enzyme elevation, liver fibrosis, or clin...

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