ALLMedicine™ Iron Toxicity Center

Apr 30th, 2022 - Iron-overload is one of the risk factors in susceptible individuals. Iron-overload causes complications such as diastolic dysfunction, arrhythmias, ventricular dilation, and systolic dysfunction in the heart. Therefore, particular care is needed f...

Apr 21st, 2022 - The Food and Drug Administration approved drug Monoferric has a unique structure that allows for a slow, sustained release and bioavailability without free iron toxicity. Efficacy studies demonstrated a faster change in hemoglobin concentration fr...

Mar 21st, 2022 - Sickle cell disease (SCD) and thalassemia are genetic disorders inducing anemia of differing pathophysiology. A primary therapy for preventing certain SCD complications (e.g., stroke) and for thalassemia major is regular red blood cell (RBC) trans...

Feb 4th, 2022 - Alzheimer's disease (AD) is a progressive neuroinflammatory and neurodegenerative disease of the brain, defined by the accumulation and deposition of beta-amyloid, which has recently been identified as an antimicrobial peptide suggesting an infect...

Dec 7th, 2021 - Iron overload (IO) is a frequent finding in the general population. As the major iron storage site, the liver is subject to iron toxicity. Farnesoid X receptor (FXR) regulates bile acid metabolism and is implicated in various liver diseases. We ai...

Apr 21st, 2022 - The Food and Drug Administration approved drug Monoferric has a unique structure that allows for a slow, sustained release and bioavailability without free iron toxicity. Efficacy studies demonstrated a faster change in hemoglobin concentration fr...

Mar 21st, 2022 - Sickle cell disease (SCD) and thalassemia are genetic disorders inducing anemia of differing pathophysiology. A primary therapy for preventing certain SCD complications (e.g., stroke) and for thalassemia major is regular red blood cell (RBC) trans...

Aug 6th, 2021 - This study aims to determine whether high resolution MRI at 7T and Quantitative Susceptibility Mapping (QSM) can demonstrate a specific pattern of iron overload in strategically important areas of brain as a sensitive marker of pathological Alzhei...

Dec 23rd, 2020 - The improved long-term survival of thalassemia major (TM) patients has resulted in increased focus on the ability to preserve fertility. While the association of iron toxicity with vital organ dysfunction, heart and liver, has been extensively inv...

May 15th, 2020 - COVID-19 is a condition caused by a coronavirus (called SARS-CoV-2) that was first identified in late 2019. In 2020, the virus has spread to many countries around the world and neither a vaccine against the virus or specific treatment for COVID-19...

Feb 27th, 2017 - Researchers have sought a blood substitute for over 150 years, and they've all failed. Now, one candidate has demonstrated promising early results, while another nears clinical trials again, reported STAT. ErythroMer encloses hemoglobin in a synth...

Aug 21st, 2013 - Action Points Patients with hemochromatosis were taller on average than those in a reference population. The deviation in height did not correlate with the type of HFE mutation, serum ferritin level, liver enzyme elevation, liver fibrosis, or clin...