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About 20,525 results

ALLMedicine™ Amyotrophic Lateral Sclerosis Center

Research & Reviews  7,143 results

Activating mitofusins interrupts mitochondrial degeneration and delays disease progress...
https://doi.org/10.1093/hmg/ddac287
Human Molecular Genetics; Dang X, Zhang L et. al.

Nov 24th, 2022 - Mitochondrial involvement in neurodegenerative diseases is widespread and multifactorial. Targeting mitochondrial pathology is therefore of interest. The recent development of bioactive molecules that modulate mitochondrial dynamics (fusion, fissi...

Physical therapy for the management of motor symptoms in amyotrophic lateral sclerosis:...
https://doi.org/10.1136/bmjopen-2022-063689
BMJ Open; Silva ST, Souza AA et. al.

Nov 23rd, 2022 - The prescription of an intervention plan can be challenging for the physical therapist, considering clinical phenotypes, individual prognosis and the rapid, progressive and deteriorating nature of amyotrophic lateral sclerosis (ALS). In this conte...

Postural Facial Deformation of Patients With Bulbar Amyotrophic Lateral Sclerosis and V...
https://doi.org/10.4187/respcare.10055
Respiratory Care; Jung H, Kim SY et. al.

Nov 23rd, 2022 - Postural Facial Deformation of Patients With Bulbar Amyotrophic Lateral Sclerosis and Virtual Fit of Noninvasive Ventilation Mask.|2022|Jung H,Kim SY,Cui X,Lee W,Kwon D,|

A blood-brain penetrant RNA-targeted small molecule triggers elimination of r(G4C2)exp ...
https://doi.org/10.1073/pnas.2210532119
Proceedings of the National Academy of Sciences of the Un... Bush JA, Meyer SM et. al.

Nov 22nd, 2022 - A hexanucleotide repeat expansion in intron 1 of the C9orf72 gene is the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia, or c9ALS/FTD. The RNA transcribed from the expansion, r(G4C2)exp, causes various patho...

Occupational therapy using a robotic-assisted glove ameliorates finger dexterity and mo...
https://doi.org/10.1016/j.jocn.2022.11.004
Journal of Clinical Neuroscience : Official Journal of Th... Yamakawa I, Yamada A et. al.

Nov 22nd, 2022 - Although rehabilitation is recommended for amyotrophic lateral sclerosis (ALS), improvement of functional decline has hardly been achieved. We investigated the effect of occupational therapy that uses a robotic-assisted glove (RAG) on hand dexteri...

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Guidelines  3 results

Provisional best practices guidelines for the evaluation of bulbar dysfunction in amyot...
https://doi.org/10.1002/mus.26408
Muscle & Nerve; Pattee GL, Plowman EK et. al.

Jan 9th, 2019 - Universally established comprehensive clinical bulbar scales objectively assessing disease progression in amyotrophic lateral sclerosis (ALS) are currently lacking. The goal of this working group project is to design a best practice set of provisi...

ESPEN guideline clinical nutrition in neurology.
https://doi.org/10.1016/j.clnu.2017.09.003
Clinical Nutrition (Edinburgh, Scotland); Burgos R, Bretón I et. al.

Dec 25th, 2017 - Neurological diseases are frequently associated with swallowing disorders and malnutrition. Moreover, patients with neurological diseases are at increased risk of micronutrient deficiency and dehydration. On the other hand, nutritional factors may...

Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764728
Neurology Miller RG, Jackson CE et. al.

Oct 14th, 2009 - To systematically review evidence bearing on the management of patients with amyotrophic lateral sclerosis (ALS). The authors analyzed studies from 1998 to 2007 to update the 1999 practice parameter. Topics covered in this section include breaking...

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Drugs  18 results see all →

Clinicaltrials.gov  539 results

Neurodegenerative Alzheimer's Disease and Amyotrophic Lateral Sclerosis (NADALS) Basket Trial
https://clinicaltrials.gov/ct2/show/NCT05189106

Oct 14th, 2022 - Overview of Clinical Trial: Many age-associated neurodegenerative diseases, including Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS), are associated with increased inflammatory signaling in the central nervous system. While there...

Study to Investigate the Efficacy and Safety of FAB122 (Daily Oral Edaravone) in Patients With Amyotrophic Lateral Sclerosis
https://clinicaltrials.gov/ct2/show/NCT05178810

Oct 13th, 2022 - Multicenter, multinational, double-blind, randomized (2:1), placebo-controlled Phase III study to investigate the efficacy and safety of 100 mg FAB122 once daily as oral formulation in ALS patients.

TJ-68 Clinical Trial in Patients With Amyotrophic Lateral Sclerosis (ALS) and Muscle Cramps
https://clinicaltrials.gov/ct2/show/NCT04998305

Oct 13th, 2022 - In Japan, TJ-68 is a common Kampo medicine prescribed by Japanese physicians to manage muscle cramps or pain of diverse origins. In the USA, there are no effective medications to control muscle cramps and no approved medications to specifically tr...

A Study of BIIB067 When Initiated in Clinically Presymptomatic Adults With a Confirmed Superoxide Dismutase 1 Mutation
https://clinicaltrials.gov/ct2/show/NCT04856982

Oct 13th, 2022 - The primary objective of this study is to evaluate the efficacy of BIIB067 when initiated in presymptomatic adult carriers of a superoxide dismutase 1 (SOD1) mutation with elevated neurofilament (NF). The secondary objectives of this study are to ...

A Study of Monepantel in Individuals With Motor Neurone Disease
https://clinicaltrials.gov/ct2/show/NCT04894240

Oct 12th, 2022 - Amyotrophic lateral sclerosis/ Motor Neurone Disease (ALS/MND) is a rare and invariably fatal neurological disease. ALS/MND has a terribly high burden on patients, family and carers, and carries great socioeconomic burden. Current best treatment o...

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News  479 results

Trending Clinical Topic: Vitamin B12
https://www.medscape.com/viewarticle/983670

Nov 11th, 2022 - Each week, we identify one top search term, speculate about what caused its popularity, and provide an infographic on a related condition. If you have thoughts about what's trending and why, share them with us on Twitter or Facebook.  The potentia...

Amyotrophic Lateral Sclerosis (ALS)
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/336726

Learn about this progressive disease attacks the nerve cells that control voluntary movement.

Dementia Prediction and Blood Tests; Paraquat and Parkinson's; NIH Issues CTE Stance
https://www.medpagetoday.com/neurology/generalneurology/101415

Oct 25th, 2022 - Alzheimer's blood biomarkers indicated underlying pathology but added little to current 5-year dementia risk prediction models in people with subjective cognitive complaint or mild cognitive impairment. (Neurology) About one-third of patients spon...

Novel gene-based therapies for neuromuscular diseases
https://www.mdedge.com/neurology/article/258357/rare-diseases/novel-gene-based-therapies-neuromuscular-diseases
Nahomi Yewhalashet, Larry J. Davis, PharmD

Oct 15th, 2022 - Neuromuscular diseases (NMDs) are a broad classification of heterogeneous groups of disorders characterized by progressive muscle weakness resulting from muscle or nerve dysfunction. 1 Diagnosis is based on symptoms and a full medical history, as w.

Amylyx Prices Newly Approved ALS Drug at $158,000 Per Year
https://www.medscape.com/viewarticle/981708

Oct 3rd, 2022 - (Reuters) - Amylyx Pharmaceuticals Inc on Friday set the list price of its newly approved drug to treat amyotrophic lateral sclerosis (ALS) at about $158,000 per year in the United States, a discount to its most recently approved competitor. The d...

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Patient Education  28 results see all →