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About 1,752 results

ALLMedicine™ Paget Disease Center

Research & Reviews  841 results

A p97/valosin-containing protein inhibitor drug CB-5083 has a potent but reversible off...
https://doi.org/10.1124/jpet.120.000486
The Journal of Pharmacology and Experimental Therapeutics; Leinonen H, Cheng C et. al.

May 1st, 2021 - CB-5083 is an inhibitor of p97/valosin-containing protein (VCP), for which Phase I trials for cancer were terminated due to adverse effects on vision, such as photophobia and dyschromatopsia. Lower dose CB-5083 could combat inclusion body myopathy...

Anogenital syringocystadenocarcinoma papilliferum in situ or anaplastic extramammary Pa...
https://doi.org/10.1111/cup.14029
Journal of Cutaneous Pathology; Sheldon JD, Buckley K et. al.

Apr 24th, 2021 - Extramammary Paget disease (EMPD) is a rare cutaneous malignancy that typically involves the genital skin and can be primary or associated with an underlying internal malignancy. The typical histopathological appearance of EMPD consists of single ...

Ectopic extramammary Paget disease in thoracic location.
https://www.ncbi.nlm.nih.gov/pubmed/33865280
Dermatology Online Journal; Stevens J, Manubens-Vargas V et. al.

Apr 18th, 2021 - Extramammary Paget disease (EMPD) is a rare skin cancer that affects areas with a high concentration of apocrine glands including genital, axillary, and anal skin. When it affects other locations it is called ectopic extramammary Paget disease (E-...

High-Frequency Ultrasound for Evaluation of the Pathological Invasion Level of Extramam...
https://doi.org/10.1002/jum.15716
Journal of Ultrasound in Medicine : Official Journal of T... Ma YY, Gong XH et. al.

Apr 15th, 2021 - Pathological invasion level of extramammary Paget disease (EMPD) is strongly related with its risk staging, treatment, and prognosis. However, the current evaluation before treatments fails to evaluate pathological invasion level of EMPD. High-fre...

Aberrant Melan-A Expression in Extramammary Paget Disease.
https://doi.org/10.1097/DAD.0000000000001943
The American Journal of Dermatopathology; Weston GK, Murphy MJ

Apr 2nd, 2021 - Aberrant Melan-A Expression in Extramammary Paget Disease.|2021|Weston GK,Murphy MJ,|

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Guidelines  1 results

Paget's Disease of Bone: An Endocrine Society Clinical Practice Guideline
https://academic.oup.com/jcem/article/99/12/4408/2833929
Frederick R. Singer

Nov 30th, 2014 - We recommend that plain radiographs be obtained of the pertinent regions of the skeleton in patients with suspected Paget's disease. If the diagnosis is confirmed, we suggest that a radionucleotide bone scan be done to determine the extent of the.

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Clinicaltrials.gov  857 results

A p97/valosin-containing protein inhibitor drug CB-5083 has a potent but reversible off...
https://doi.org/10.1124/jpet.120.000486
The Journal of Pharmacology and Experimental Therapeutics; Leinonen H, Cheng C et. al.

May 1st, 2021 - CB-5083 is an inhibitor of p97/valosin-containing protein (VCP), for which Phase I trials for cancer were terminated due to adverse effects on vision, such as photophobia and dyschromatopsia. Lower dose CB-5083 could combat inclusion body myopathy...

Anogenital syringocystadenocarcinoma papilliferum in situ or anaplastic extramammary Pa...
https://doi.org/10.1111/cup.14029
Journal of Cutaneous Pathology; Sheldon JD, Buckley K et. al.

Apr 24th, 2021 - Extramammary Paget disease (EMPD) is a rare cutaneous malignancy that typically involves the genital skin and can be primary or associated with an underlying internal malignancy. The typical histopathological appearance of EMPD consists of single ...

Ectopic extramammary Paget disease in thoracic location.
https://www.ncbi.nlm.nih.gov/pubmed/33865280
Dermatology Online Journal; Stevens J, Manubens-Vargas V et. al.

Apr 18th, 2021 - Extramammary Paget disease (EMPD) is a rare skin cancer that affects areas with a high concentration of apocrine glands including genital, axillary, and anal skin. When it affects other locations it is called ectopic extramammary Paget disease (E-...

High-Frequency Ultrasound for Evaluation of the Pathological Invasion Level of Extramam...
https://doi.org/10.1002/jum.15716
Journal of Ultrasound in Medicine : Official Journal of T... Ma YY, Gong XH et. al.

Apr 15th, 2021 - Pathological invasion level of extramammary Paget disease (EMPD) is strongly related with its risk staging, treatment, and prognosis. However, the current evaluation before treatments fails to evaluate pathological invasion level of EMPD. High-fre...

Aberrant Melan-A Expression in Extramammary Paget Disease.
https://doi.org/10.1097/DAD.0000000000001943
The American Journal of Dermatopathology; Weston GK, Murphy MJ

Apr 2nd, 2021 - Aberrant Melan-A Expression in Extramammary Paget Disease.|2021|Weston GK,Murphy MJ,|

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News  51 results

Fast Five Quiz: Test Your Knowledge on Key Aspects of Heart Failure
https://reference.medscape.com/viewarticle/893861_2

Feb 6th, 2020 - Because of increased myocardial oxygen consumption and demand beyond a critical level, the following high-output states can precipitate the clinical presentation of heart failure: Profound anemia Thyrotoxicosis Myxedema Paget disease of bone Albri...

Fast Five Quiz: Advanced and Metastatic Prostate Cancer Presentation and Diagnosis
https://reference.medscape.com/viewarticle/921119_4

Dec 29th, 2019 - Answer 3/5 Which of the following are important considerations in the differential diagnosis of advanced prostate cancer? Your peers chose: The lower the free-to-total PSA ratio, the lower the likelihood of cancer 0% Radiologic findings of bony me...

Acantholytic Anaplastic Extramammary Paget Disease
https://www.mdedge.com/dermatology/article/209263/mixed-topics/acantholytic-anaplastic-extramammary-paget-disease/page/0/2?channel=27442

Oct 2nd, 2019 - Acantholytic dyskeratosis of the genitocrural area is a rare lesion included in the spectrum of focal acantholytic dyskeratoses described by Ackerman. 19 It also has been referred to as papular acantholytic dyskeratosis of the vulva, though histolo.

Paget Disease: Osmosis Study Video
https://www.medscape.com/viewarticle/916385

Aug 29th, 2019 - What is Paget disease? Paget disease is a localized disorder of bone remodeling that typically begins with excessive bone resorption followed by an increase in bone formation. This video provides an illustrated overview of the condition, including...

Don’t Just Look at the Lesion
https://www.mdedge.com/clinicianreviews/article/201295/oncology/dont-just-look-lesion/page/0/1?channel=203

May 23rd, 2019 - DISCUSSION The biopsy results confirmed the impression of superficial squamous cell carcinoma (SSC) with focal areas of invasion. One thinks of skin cancer as being “a thing,” a papule or nodule, and that’s usually true.

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Patient Education  2 results see all →