Oct 23rd, 2019 - Allergan plc (NYSE: AGN) today announced that the U.S. Food and Drug Administration (FDA) approved the company's supplemental Biologics License Application (sBLA) for BOTOX® for the treatment of pediatric patients (2 to 17 years of age) with lower limb spasticity, excluding spasticity caused by cerebral palsy (CP). This marks the 11th BOTOX® therapeutic indication, having been approved for pedi...
Jul 21st, 2019 - Based on new evidence assessing benefits and risks, the WHO recommends the use of the HIV drug dolutegravir (DTG) as the preferred first-line and second-line treatment for all populations, including pregnant women and those of childbearing potential. Initial studies had highlighted a possible link between DTG and neural tube defects (birth defects of the brain and spinal cord that cause co...
American Family Physician; Kelly, R. et. al.
Jul 14th, 2019 - Acupuncture has been increasingly used as an integrative or complementary therapy for pain. It is well-tolerated with little risk of serious adverse effects. Traditional acupuncture and nontraditional techniques, such as electroacupuncture and dry needling, often result in reported pain improvement. Multiple factors may contribute to variability in acupuncture's therapeutic effects, including n...
Jun 26th, 2019 - View overall prevalence of arthritis and rheumatic diseases as well as prevalence among specific racial and ethnic groups.
Munakomi, S. et. al.
Jun 3rd, 2019 - Approximately 90% of the population will present with low back pain at some point in their lifetime. Spinal stenosis is a condition that is caused by the narrowing of the central canal, the lateral recess, or neural foramen. This is a condition that can cause significant discomfort, interfere with activities of daily living, and may result in progressive disability.With increasing longevity of...
Thomas, R. et. al.
May 11th, 2019 - Cardiac rehabilitation (CR) is an evidence-based intervention that uses patient education, health behavior modification, and exercise training to improve secondary prevention outcomes in patients with cardiovascular disease. CR programs reduce morbidity and mortality rates in adults with ischemic heart disease, heart failure, or cardiac surgery but are significantly underused, with only a minor...
May 8th, 2019 - Safety Review of DEET (chemical name, N,N-diethyl-meta-toluamide) is the active ingredient in many repellent products. It is widely used to repel biting pests such as mosquitoes and ticks. Every year, an estimated one-third of the U.S. population use DEET to protect them from mosquito-borne illnesses like West Nile Virus, the Zika virus or malaria and tick-borne illnesses like Lyme disease and ...
Apr 14th, 2019 - Cardiovascular disease is a competing cause of death in patients with cancer with early-stage disease. This elevated cardiovascular disease risk is thought to derive from both the direct effects of cancer therapies and the accumulation of risk factors such as hypertension, weight gain, cigarette smoking, and loss of cardiorespiratory fitness. Effective and viable strategies are needed to ...
Vandvik, P.,et al
Feb 5th, 2019 - Clinical question: Do adults with atraumatic shoulder pain for more than 3 months diagnosed as subacromial pain syndrome (SAPS), also labelled as rotator cuff disease, benefit from subacromial decompression surgery? This guideline builds on to two recent high quality trials of shoulder surgery. Current practice: SAPS is the common diagnosis for shoulder pain with several first line treatment op.
Feb 4th, 2019 - The International Stroke Conference 2019 provides unique opportunities to meet and network with colleagues from around the world with wide-ranging research interests and expertise in stroke prevention, diagnosis, treatment and rehabilitation. For 2019, we anticipate more than 4,500 professional attendees, as well as exhibitors displaying exciting new stroke products and services. We are truly d...
Stein, M. et. al.
Jan 29th, 2019 - Question Who is at greatest risk for developing mental health problems such as posttraumatic stress disorder (PTSD) or major depression after sustaining a mild traumatic brain injury (mTBI)? Findings In this cohort study of 1155 patients with mTBI and 230 patients with orthopedic injuries not involving the head, patients with mTBI were more likely to report PTSD and/or major depressive sympto...
Zeng, C. et. al.
Jan 27th, 2019 - Objective A recent randomized clinical trial reported that repeated intra-articular corticosteroids (IACs) were associated with a greater cartilage loss. This study aimed to examine the relation of IACs to knee radiographic osteoarthritis (ROA) progression in a real-world setting. Design A cohort that initiated IACs and a comparison cohort without IACs from participants with mild to moderate kn...
Kancherla, V.,et al
Dec 18th, 2018 - In this position statement, the Teratology Society acknowledges the value of accurate measurement of total prevalence of neural tube defects (NTDs) in the population to support prevention, and advocates for rigorous surveillance world‐wide. NTDs, include anencephaly and spina bifida and are some of the more common types of structural birth defects affecting pregnancies worldwide.
Dec 9th, 2018 - One in 4 Americans >40 years of age takes a statin to reduce the risk of myocardial infarction, ischemic stroke, and other complications of atherosclerotic disease. The most effective statins produce a mean reduction in low-density lipoprotein cholesterol of 55% to 60% at the maximum dosage, and 6 of the 7 marketed statins are available in generic form, which makes them affordable for most pati.
Major Extremity Trauma and Rehabilitation Consortium
Dec 6th, 2018 - This clinical practice guideline is based on a formal systematic review of published studies with regard to the management of acute compartment syndrome of the upper or lower extremity in adults. In addition to providing clinical practice recommendations, this guideline also highlights limitations of the current literature and areas that require future research.
Sep 30th, 2018 - This systematic review is an update of an earlier report published in 2013 which evaluated questions related to stroke prevention in patients with atrial fibrillation (AF) and atrial flutter. Given evidence that has emerged since the publication of the 2013 report, this review focuses on updating and expanding the earlier work in three key areas: (1) evaluating the accuracy and utility of c...
Sep 3rd, 2018 - Clinical guidance for health care professionals is critical to improving health and safety of this vulnerable population, the recommendations represent current best practices and comprise the first evidence-based clinical guideline to date for diagnosing and managing pediatric mTBI in the United States.
Zaninotto, G.,et al.
Aug 31st, 2018 - Achalasia is a relatively rare primary motor esophageal disorder, characterized by absence of relaxations of the lower esophageal sphincter and of peristalsis along the esophageal body. As a result, patients typically present with dysphagia, regurgitation and occasionally chest pain, pulmonary complication and malnutrition.
Aug 26th, 2018 - Cardiac rehabilitation (CR) is a comprehensive secondary prevention program designed to improve cardiovascular health following a cardiac-related event or procedure. While there are some instances of inpatient (Phase 1) CR, the vast majority of CR is delivered in an outpatient (Phase 2) setting and, therefore, is the focus of this publication.
Pain and Therapy; Vitoula, K. et. al.
May 15th, 2018 - Low back pain is one of the most common causes for seeking medical treatment and it is estimated that one in two people will experience low back pain at some point during their lifetimes. Management of low back pain includes pharmacological and non-pharmacological approaches. Non-pharmaceutical treatments include interventions such as acupuncture, spinal manipulation, and psychotherapy. The lat...