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About 7,978 results

ALLMedicine™ Antiepileptic Drugs Center

Research & Reviews  2,676 results

DRESS Syndrome Associated with Liposomal Amphotericin-B in a Kidney Transplant Patient:...
https://doi.org/10.2174/1574886316666210727145646
Current Drug Safety; Charfi O, Hammamia SB et. al.

Jul 29th, 2021 - Liposomal amphotericin B is a widely used broad-spectrum antifungal drug. It was developed to reduce nephrotoxicity and maximize the therapeutic utility of amphotericin B in the treatment of invasive fungal infections. Drug Rash with Eosinophilia ...

Understanding mechanisms of drug resistance in epilepsy and strategies for overcoming it.
https://doi.org/10.1080/17425255.2021.1959912
Expert Opinion on Drug Metabolism & Toxicology; Łukawski K, Czuczwarb SJ

Jul 27th, 2021 - The present evidence indicates that approximately 70% of patients with epilepsy can be successfully treated with antiepileptic drugs (AEDs). A significant proportion of patients are not under sufficient control and pharmacoresistant epilepsy is cl...

PRRT2 variants and effectiveness of various antiepileptic drugs in self-limited familia...
https://doi.org/10.1016/j.seizure.2021.07.013
Seizure Zhao Q, Hu Y et. al.

Jul 24th, 2021 - Self-limited familial infantile epilepsy (SFIE) is largely associated with variants in proline-rich transmembrane protein 2 (PRRT2). However, the detailed phenotype-genotype correlations are unclear, along with the efficacy of various antiepilepti...

Chicken embryo as animal model to study drug distribution to the developing brain.
https://doi.org/10.1016/j.vascn.2021.107105
Journal of Pharmacological and Toxicological Methods; Zosen D, Hadera MG et. al.

Jul 21st, 2021 - Rodent models are routinely used to assess the safety and developmental toxicity of pharmaceuticals, along with analysis of their distribution. These models require sacrifice of parent females, have challenges in the estimation of the number of em...

Comparison of efficiency between VNS and ANT-DBS therapy in drug-resistant epilepsy: A ...
https://doi.org/10.1016/j.jocn.2021.05.046
Journal of Clinical Neuroscience : Official Journal of Th... Zhu J, Wang X et. al.

Jul 20th, 2021 - Vagus nerve stimulation (VNS) and anterior thalamic deep brain stimulation (ANT-DBS) have both been used for treatments of drug-resistant epilepsy (DRE). However, there is no comparative study on the effectiveness of two methods from one single ce...

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Guidelines  5 results

Practice guideline update summary: Efficacy and tolerability of the new antiepileptic d...
https://doi.org/10.1212/WNL.0000000000005755
Neurology Kanner AM, Ashman E et. al.

Jun 15th, 2018 - To update the 2004 American Academy of Neurology (AAN) guideline for treating new-onset focal or generalized epilepsy with second- and third-generation antiepileptic drugs (AEDs). The 2004 AAN criteria were used to systematically review literature...

Practice guideline update summary: Efficacy and tolerability of the new antiepileptic d...
https://doi.org/10.1212/WNL.0000000000005756
Neurology Kanner AM, Ashman E et. al.

Jun 15th, 2018 - To update the 2004 American Academy of Neurology guideline for managing treatment-resistant (TR) epilepsy with second- and third-generation antiepileptic drugs (AEDs). 2004 criteria were used to systemically review literature (January 2003 to Nove...

European Stroke Organization guideline for the diagnosis and treatment of cerebral veno...
https://doi.org/10.1111/ene.13381
European Journal of Neurology; Ferro JM, Bousser MG et. al.

Aug 24th, 2017 - Current guidelines on cerebral venous thrombosis (CVT) diagnosis and management were issued by the European Federation of Neurological Societies in 2010. We aimed to update the previous European Federation of Neurological Societies guidelines usin...

Management issues for women with epilepsy--focus on pregnancy (an evidence-based review...
https://doi.org/10.1111/j.1528-1167.2009.02130.x
Epilepsia Harden CL, Pennell PB et. al.

Jun 10th, 2009 - A committee assembled by the American Academy of Neurology (AAN) reassessed the evidence related to the care of women with epilepsy (WWE) during pregnancy, including preconceptional folic acid and prenatal vitamin K use and the clinical implicatio...

Practice parameter update: management issues for women with epilepsy--focus on pregnanc...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475195
Neurology Harden CL, Hopp J et. al.

Apr 29th, 2009 - To reassess the evidence for management issues related to the care of women with epilepsy (WWE) during pregnancy, including the risk of pregnancy complications or other medical problems during pregnancy in WWE compared to other women, change in se...

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Drugs  42 results see all →

Clinicaltrials.gov  79 results

A Study to Assess the Safety and Efficacy of Lacosamide Versus Placebo (a Pill Without Active Medication) in Patients With Idiopathic Generalised Epilepsy Who Are Already Taking Anti-epileptic Medi...
https://clinicaltrials.gov/ct2/show/NCT02408523

Apr 16th, 2020 - Evaluating efficacy & safety of lacosamide versus Placebo in a blinded fashion as add-on Therapy for Primary Generalized Tonic-clonic (PGTC) seizures in subject 4 years of age or greater with idiopathic generalized epilepsy currently taking 1 to 3...

A Multicentre Clinical Investigation of a Decision Support Algorithm for Neonatal Seizure Detection
https://clinicaltrials.gov/ct2/show/NCT02431780

Jan 10th, 2020 - This will be an open, two arm, parallel group, randomised, controlled investigation of the ANSeR Software System as a stand-alone neonatal seizure recognition decision support tool. Term neonates requiring EEG monitoring will be stratified by recr...

Open-Label Extension Study of Rufinamide Given as Adjunctive Therapy in Patients With Refractory Partial Seizures
https://clinicaltrials.gov/ct2/show/NCT00448539

Nov 22nd, 2019 - This was an open-label extension study in adolescent and adult (between 12 and 80 years old) participants who had completed their participation in Study E2080-A001-301. The main objective of this study was to evaluate the safety and efficacy of lo...

Low vs. Standard Daily Doses of Antiepileptic Drugs in Newly Diagnosed, Previously Untreated Epilepsy(STANDLOW)
https://clinicaltrials.gov/ct2/show/NCT03689114

Sep 27th, 2019 - There are no guidelines on the first maintenance daily dose of antiepileptic drugs (AEDs) in newly diagnosed, previously untreated epilepsy. Original trials and Cochrane reviews show that seizure remission can be achieved with differing daily dose...

Counseling on the Interaction of Hormonal Contraceptives and Antiepileptics
https://clinicaltrials.gov/ct2/show/NCT02485756

Jun 7th, 2019 - Previous studies have shown that women on anti-seizure medications are not informed about the pharmaceutical drug interactions between anti-seizure medications (antiepileptic drugs, AEDs) and certain hormonal contraceptive. The goal of this propos...

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News  389 results

More Evidence Epilepsy Tied to Risk for Major Cardiovascular Events
https://www.medscape.com/viewarticle/954347

Jul 7th, 2021 - More data link epilepsy to a significantly increased risk for major cardiovascular events, including stroke or arrhythmia. In a large retrospective cohort study, risk for cardiovascular events was 58% greater among patients with epilepsy who under...

Cannabidiol Cleared for Tuberous Sclerosis Complex in Europe
https://www.medscape.com/viewarticle/949596

Apr 20th, 2021 - The European Commission (EC) has approved cannabidiol (Epidyolex) oral solution as adjunctive treatment of seizures associated with tuberous sclerosis complex (TSC) in patients aged 2 years and older. It's the third indication for the drug in Euro...

Prenatal Dietary Folate Not Enough to Offset AEDs' Effect on Kids' Cognition
https://www.medscape.com/viewarticle/947829

Mar 22nd, 2021 - New research underscores the importance of folic acid supplementation for pregnant women with epilepsy who are taking antiepileptic drugs (AEDs). Dietary folate alone, even in the United States, where food is fortified with folic acid, is "not suf...

More Reassurance for Certain Antiseizure Drugs in Pregnancy
https://www.medscape.com/viewarticle/947241

Mar 10th, 2021 - Further evidence supporting the safety of two antiseizure medications in pregnancy has come from a new study. The Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs (MONEAD) study found no difference in neurobehavioral develop...

Psychiatrists Report Rare Case of Woman Who Thinks She’s a Chicken 
https://www.medscape.com/viewarticle/934961

Jul 31st, 2020 - LEUVEN, Belgium—A 54-year-old woman has suffered the delusion of thinking she is a chicken for 24 hours. This very rare condition, known as zoanthropy, in which people think they are an animal is often not recognised, say researchers from the Univ...

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