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About 30,873 results

ALLMedicine™ Immunosuppression Center

Research & Reviews  10,991 results

An Immunogenic and Slow-Growing Cryptococcal Strain Induces a Chronic Granulomatous Inf...
https://doi.org/10.1128/iai.00580-21
Infection and Immunity; Telzrow CL, Esher Righi S et. al.

May 20th, 2022 - Many successful pathogens cause latent infections, remaining dormant within the host for years but retaining the ability to reactivate to cause symptomatic disease. The human opportunistic fungal pathogen Cryptococcus neoformans establishes latent...

Novel immunotherapies in multiple myeloma.
https://doi.org/10.1007/s12185-022-03365-1 10.1007/s12185-020-02828-7 10.1007/s12185-020-02828-7 10.1016/j.pathol.2021.02.003 10.1158/1078-0432.CCR-10-1822 10.3324/haematol.2017.163766 10.1056/NEJMoa1709974 10.3390/cancers13092018 10.1046/j.1365-2141.1998.00525.x 10.1016/S0145-2126(01)00192-8 10.1016/j.leukres.2004.06.003 10.1182/blood-2005-09-3671 10.1182/blood.V100.1.230 10.1111/j.1365-2249.2006.03037.x 10.4049/jimmunol.1203373 10.1002/jcp.27172 10.3390/cancers12040924 10.1200/JCO.2015.65.9789 10.1158/1078-0432.CCR-15-0200 10.1016/S2352-3026(19)30110-3 10.1016/S2352-3026(19)30109-7 10.1093/annonc/mdv383 10.1200/JCO.2017.35.15_suppl.TPS8051 10.1016/j.jtct.2020.12.026 10.1158/1078-0432.CCR-15-0304 10.3324/haematol.2013.103085 10.1016/j.immuni.2020.04.011 10.3390/cancers12020305 10.1158/1535-7163.MCT-19-1079 10.4049/jimmunol.2001019 10.1200/JCO.2020.38.15_suppl.3064 10.1158/1078-0432.CCR-06-1603 10.4149/neo_2010_05_455 10.1111/bjh.12943 10.1182/blood.V97.5.1508 10.1182/blood-2007-03-082529 10.1007/s00262-011-1009-3 10.1158/0008-5472.CAN-05-1383 10.1073/pnas.90.8.3539 10.1586/14760584.4.3.259 10.1158/1078-0432.CCR-21-1916 10.1158/1078-0432.CCR-13-0282 10.1056/NEJM198812223192527 10.1093/jnci/86.15.1159 10.1007/s12185-016-2039-6 10.1056/NEJMoa1707447 10.1056/NEJMoa1804980 10.1056/NEJMoa1709866 10.1016/S0140-6736(14)61403-3 10.1126/scitranslmed.3005930 10.1172/JCI85309 10.1158/1078-0432.CCR-12-2422 10.1016/j.smim.2006.04.006 10.1056/NEJMoa1817226 10.1056/NEJMoa2024850 10.1186/s13045-018-0681-6 10.1016/S0140-6736(21)00933-8 10.1182/blood-2021-146200 10.1182/blood-2021-146072 10.1038/s41591-021-01497-1 10.1158/2159-8290.CD-15-1020 10.1182/blood-2015-08-665547 10.1038/s41591-018-0201-9 10.1038/leu.2016.211 10.1200/JCO2101676 10.1182/blood-2017-05-781351 10.1182/bloodadvances.2019000703 10.1038/ncomms8333 10.1182/blood-2021-154170 10.1182/blood-2019-130340 10.1038/s41467-020-16160-5 10.1158/2326-6066.CIR-18-0307 10.1172/JCI86000 10.3390/cells9122666 10.3389/fimmu.2018.02551 10.1016/S2152-2650(21)02229-1 10.1182/blood-2010-06-292243 10.1182/blood-2010-06-292243 10.1038/nm.4431 10.1016/j.bbmt.2019.08.015 10.3324/haematol.2019.229781 10.1111/ejh.13380 10.1038/s41409-019-0451-2 10.1038/nrclinonc.2017.148 10.1038/s41591-021-01564-7 10.1038/nrc3670 10.1182/blood-2004-09-3707 10.1038/nm.3910 10.1182/bloodadvances.2019000194 10.1126/science.aba7365 10.1182/blood-2016-09-737536 10.1016/j.ymthe.2021.08.010 10.1182/blood-2010-04-279893 10.1038/sj.leu.2404444 10.1016/j.imlet.2018.04.005 10.3324/haematol.2018.202200 10.1038/s41375-018-0153-6 10.1038/s41591-018-0010-1 10.1038/s41591-020-1061-7 10.3389/fimmu.2021.732135 10.1093/intimm/dxab091
International Journal of Hematology; Ohmine K, Uchibori R

May 19th, 2022 - For a substantial period, options for the treatment of multiple myeloma (MM) were limited; however, the advent of novel therapies into clinical practice in the 1990s resulted in dramatic changes in the prognosis of the disease. Subsequently, new p...

Impact of solid organ transplant status on outcomes of hospitalized patients with COVID...
https://doi.org/10.1111/tid.13853
Transplant Infectious Disease : an Official Journal of Th... Schaenman J, Byford H et. al.

May 18th, 2022 - The COVID-19 pandemic has caused significant morbidity and mortality in solid organ transplant (SOT) recipients. However, it remains unclear whether the risk factor for SOT patients is the immunosuppression inherent to transplantation versus patie...

Claudin-12 deficiency inhibits tumor growth by impairing transendothelial migration of ...
https://doi.org/10.1158/0008-5472.CAN-21-3896
Cancer Research; Qin Z, Cao H et. al.

May 18th, 2022 - Migration of myeloid-derived suppressor cells (MDSCs) out of the circulation, across vascular walls, and into tumor is crucial for their immunosuppressive activity. A deeper understanding of critical junctional molecules and the regulatory mechani...

Visual Outcomes of Patients With Peripheral Ulcerative Keratitis and the Effect of Immu...
https://doi.org/10.1097/ICL.0000000000000906
Eye & Contact Lens; Li Y, McKelvie J et. al.

May 18th, 2022 - Peripheral ulcerative keratitis (PUK) can cause significant ocular morbidity and mortality. This study aimed to review the effects of systemic immunosuppression on visual outcomes. A state-wide, retrospective case series based in Queensland, Austr...

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Guidelines  17 results

Primary prophylaxis of bacterial infections and Pneumocystis jirovecii pneumonia in pat...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116237
Annals of Hematology; Classen AY, Henze L et. al.

Apr 14th, 2021 - Hematologic and oncologic patients with chemo- or immunotherapy-related immunosuppression are at substantial risk for bacterial infections and Pneumocystis jirovecii pneumonia (PcP). As bacterial resistances are increasing worldwide and new resear...

Cancer immunotherapy in special challenging populations: recommendations of the Advisor...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009216
Journal for Immunotherapy of Cancer; Gonzalez-Cao M, Puertolas T et. al.

Mar 31st, 2021 - Cancer immunotherapy based on the use of antibodies targeting the so-called checkpoint inhibitors, such as programmed cell death-1 receptor, its ligand, or CTLA-4, has shown durable clinical benefit and survival improvement in melanoma and other t...

Clinical Practice Guideline for Systemic Antifungal Prophylaxis in Pediatric Patients W...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499615
Journal of Clinical Oncology : Official Journal of the Am... Lehrnbecher T, Fisher BT et. al.

May 28th, 2020 - To develop a clinical practice guideline for systemic antifungal prophylaxis in pediatric patients with cancer and hematopoietic stem-cell transplantation (HSCT) recipients. Recommendations were developed by an international multidisciplinary pane...

2019 Update of the Joint European League Against Rheumatism and European Renal Associat...
https://doi.org/10.1136/annrheumdis-2020-216924
Annals of the Rheumatic Diseases; Fanouriakis A, Kostopoulou M et. al.

Mar 30th, 2020 - To update the 2012 EULAR/ERA-EDTA recommendations for the management of lupus nephritis (LN). Following the EULAR standardised operating procedures, a systematic literature review was performed. Members of a multidisciplinary Task Force voted inde...

European interdisciplinary guideline on invasive squamous cell carcinoma of the skin: P...
https://doi.org/10.1016/j.ejca.2020.01.007
European Journal of Cancer (Oxford, England : 1990); Stratigos AJ, Garbe C et. al.

Mar 3rd, 2020 - Invasive cutaneous squamous cell carcinoma (cSCC) is one of the most common cancers in the white populations, accounting for 20% of all cutaneous malignancies. Factors implicated in cSCC etiopathogenesis include ultraviolet radiation exposure and ...

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Drugs  20 results see all →

Clinicaltrials.gov  480 results

Retrospective Study of Immunotherapy Related Toxicities in Children and Adults With Cancer
https://clinicaltrials.gov/ct2/show/NCT03827343

May 13th, 2022 - Immunotherapy is changing the landscape of cancer therapy. Particularly unique to immunotherapy is the toxicity profile, which differs from chemotherapy-based strategies and can be associated with inflammatory responses and/or autoimmune type reac...

Optimizing PTCy Dose and Timing
https://clinicaltrials.gov/ct2/show/NCT03983850

May 13th, 2022 - Background: Post-transplantation cyclophosphamide (PTCy) reduces rates of severe acute and chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation (HCT) and safely facilitates human leukocyte antigen (HLA)-hapl...

T Cell Receptor Immunotherapy for Patients With Metastatic Non-Small Cell Lung Cancer
https://clinicaltrials.gov/ct2/show/NCT02133196

May 13th, 2022 - Background: Patients with metastatic non-small cell lung cancer (NSCLC) have few approved therapeutic options and those that exist are of transient benefit. Recent clinical experiences with experimental agents that release checkpoints on the host ...

Pediatric cGVHD Symptom Scale
https://clinicaltrials.gov/ct2/show/NCT04044365

May 13th, 2022 - Background: Hematopoietic stem cell transplantation (HSCT) is a curative option for many children with cancer and certain genetic disorders. However, recipients of stem cell transplant must deal with years of disfigurement and symptoms arising fro...

Influenza in People With Normal and Weakened Immune Systems
https://clinicaltrials.gov/ct2/show/NCT00533182

May 13th, 2022 - Influenza viruses cause significant morbidity each year, and past epidemics and pandemics have caused significant mortality. The impact influenza has or could have on the increasing number of patients who are immunocompromised due to acute and chr...

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News  841 results

Durvalumab Combinations Push the Response Envelope in Unresectable NSCLC
https://www.medpagetoday.com/hematologyoncology/lungcancer/98513

May 2nd, 2022 - Patients with unresectable stage III non-small cell lung cancer (NSCLC) had a higher response rate and better progression-free survival when novel targeted agents were added to treatment with durvalumab (Imfinzi), a phase II randomized trial showe...

COVID-19 Outcomes in Atopic Dermatitis Patients: Registry Data Reported
https://www.medscape.com/viewarticle/971247

Mar 30th, 2022 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. BOSTON – Among atopic dermatitis (AD) patients infected with COVID-19, those who received topical treatments were nearly five times more likely to...

Plasma Exchange Works for ANCA-Associated Vasculitis
https://www.medscape.com/viewarticle/969671

Mar 8th, 2022 - NEW YORK (Reuters Health) - Plasma exchange can be an effective treatment for anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV), according to an updated systematic review and meta-analysis. Granulomatosis with polyangiitis and ...

p53 mRNA Nanotherapy Plus Anti-PD-1 Therapy Reverse Immunosuppression in a Liver Cancer Model
https://www.medscape.com/viewarticle/969039

Feb 24th, 2022 - NEW YORK (Reuters Health) - Combining p53 nanotherapy with anti-PD-1 immunotherapy reversed immunosuppression and improved anti-tumor activity compared to either therapy alone in a mouse model of liver cancer, a proof-of-concept study shows. "Our....

Turk Sets Unenviable COVID Record by Testing Positive for 14 Straight Months
https://www.medscape.com/viewarticle/968425

Feb 15th, 2022 - ISTANBUL (Reuters) - When Muzaffer Kayasan first caught COVID-19, he thought he was destined to die since he was already suffering from leukemia. Fourteen months and 78 straight positive tests later, he is still alive - and still battling to shake...

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