Sep 4th, 2019 - For non–status 1 patients with cirrhosis who are awaiting liver transplantation, type of renal dysfunction may be a key determinant of mortality risk, based on a retrospective analysis of more than 22,000 patients. Risk of death was greatest for patients with acute on chronic kidney disease (AKI on CKD), followed by AKI alone, then CKD alone, reported lead author Giuseppe Cullaro, MD, of the Un.
Aug 9th, 2019 - Transplant Hepatitis C-positive donor organs and lung transplantation: Are we there yet? The field of lung transplantation continues to be encumbered by the mismatch between organ supply and demand. Only approximately 15% of potential donor lungs are currently being used for transplantation, resulting in unacceptably high wait list mortality (17.
Jul 30th, 2019 - Administering a statin via nasogastric tube to brain-dead heart donors resulted in transplant recipients showing less myocardial injury after heart transplantation. (Circulation) The FDA is developing a digital tool to reduce the need for animal and human testing in cardiovascular drug and medical device development. To do this, it will be using a simulated 3D heart model from Dassault Systèmes...
Jul 1st, 2019 - As previously mentioned, patients in GOLD categories B, C, and D should be offered pulmonary rehabilitation as part of their treatment. 23 The ideal patient is one who is not too sick to undergo rehabilitation and is motivated to improve his or her quality of life.
Jun 12th, 2019 - Comment GVHD Subtypes The 2 types of GVHD are humoral and cellular. 5 The humoral type results from ABO blood type incompatibility between donor and recipient and causes mild hemolytic anemia and fever.
May 29th, 2019 - Switching heart transplantation patients from calcineurin inhibitor (CNI)-based to sirolimus-based immunosuppression was associated with an almost doubling of the malignancy-free survival rate in a retrospective cohort analysis. Over a median of 10 years, de novo (nonskin) malignancies were seen in 13% of patients converted early to sirolimus compared with 31% of patients maintained on CNI-base...
May 20th, 2019 - Hepatitis A Outbreaks Multiple states across the country have reported hepatitis A virus (HAV) outbreaks, primarily among people who use drugs, people experiencing homelessness, and men who have sex with men. Since outbreaks of hepatitis A were first identified in 2016, more than 17,000 cases have been reported. More than half of these cases (57%) resulted in hospitalization, a higher rate than...
May 20th, 2019 - Liver transplantation (LT) is “one of the most resource-intense procedures despite significant improvements in procedures and protocols,” say researchers from Seoul National University Hospital in South Korea. But little is known about the “practical aspects of life after liver transplantation,” such as unplanned visits to the emergency department (ED) or readmission for complications.
Apr 8th, 2019 - VIENNA — More than 1000 living-donor liver transplants are performed each year in Turkey, compared with about 300 in the United States, which makes the country straddling Eastern Europe and Western Asia an unpredictably ideal location for surgeons to learn more about the procedure. In fact, Nabil Dagher, MD, from NYU Langone Health in New York City, went to Turkey for nearly 3 months to learn a...
Apr 7th, 2019 - NEW YORK (Reuters Health) - Heart transplantation with organs donated after circulatory death (DCD) can yield "excellent" outcomes, researchers from Australia report. "The fact that these DCD hearts, which otherwise would have been discarded, actually can be reanimated and used for successful transplants was not a surprise," said Dr. Kumud Dhital from St. Vincent's Hospital and the University o...
Mar 13th, 2019 - Cardiac MRI provided an effective, non-invasive means of monitoring for acute rejection episodes after heart transplantation in a prospective study. A model combining age and the MRI parameters of global T2 and global extracellular volume fraction (ECV) was predictive of acute cardiac allograft rejection (ACAR) with an area under the curve of 0.84, according to Ryan Dolan, MD, and colleagues of...
Mar 6th, 2019 - Sensitization in heart transplantation — the expression of circulating antibodies against a potential donor — presents challenges for heart transplant recipients and physicians, concludes a scientific statement from the American Heart Association (AHA) summarizing emerging knowledge in the field. Sensitization in transplantation "remains a limitation to access to heart transplant, increases w...
Mar 1st, 2019 - Elective cholecystectomy should be avoided, and required cases should be performed in experienced centers. “The gallbladder wall may appear thickened on imaging, which may lead to the erroneous diagnosis of acute cholecystitis,” the experts noted.
Feb 5th, 2019 - Nonalcoholic steatohepatitis may soon supplant chronic hepatitis C as the leading cause of hepatocellular carcinoma among patients awaiting liver transplantation, according to the findings of a national longitudinal registry study. Dr.
Jan 31st, 2019 - NEW YORK (Reuters Health) - Rates of de novo skin cancer after lung or heart transplantation are higher when donor and recipient HLA antigens are well matched, a large retrospective study suggests. Lung and heart recipients with HLA mismatches "actually had less skin cancer than those with a closer match," Dr. Sarah T. Arron told Reuters Health by email. "This suggests that the immune system of...
Jan 22nd, 2019 - In recent years, the proportion of patients undergoing liver transplantation for alcohol-associated liver disease (ALD) has doubled, suggesting a major shift in attitudes related to transplant indication, according to an analysis of registry data. VILevi/Thinkstock “The findings suggest that early liver transplant for alcoholic hepatitis may be leading to broader acceptance of ALD for liver tra.
Jan 11th, 2019 - NEW YORK (Reuters Health) - In selected patients with light chain (AL) amyloidosis who are reaching end-stage renal disease (ESRD), kidney transplantation is a worthwhile approach, according to Boston-based researchers. "Renal transplantation in patients with AL amyloidosis has been controversial due to lack of long-term outcome data and appropriate and validated eligibility criteria," Dr. Andr...
Michael Fuchs, MD, PhD, FAASLD, AGAF, FEBG
Jan 10th, 2019 - For many years, viral hepatitis and particularly hepatitis C have been the bread and butter for clinicians dealing with chronic liver diseases. Over the past few years the Veterans Health Administration (VHA) has been incredibly successful in identifying, treating, and curing a significant proportion of veterans of this viral disease.
Dec 28th, 2018 - Action Points Investigators found that waitlist mortality peaked for patients with acute-on-chronic liver failure ACLF category 3 and a MELD score <25. And for this group, liver transplantation increases the odds of survival, especially if performed within 30 days of placement on the waitlist. Intubated patients had the strongest association with reduced post-transplant survival. CME Author: Ze...
Nov 28th, 2018 - SAN FRANCISCO – Using normothermic machine perfusion (NMP) to preserve steatotic livers may result in more successful transplantation of these organs, especially when used concomitantly with lipid apheresis filtration and defatting agents, results from a small trial showed. Doug Brunk/MDedge News Dr.