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About 23,374 results

ALLMedicine™ Alzheimer Disease Center

Research & Reviews  11,099 results

Age-Related Macular Degeneration: From Epigenetics to Therapeutic Implications.
https://doi.org/10.1007/978-3-030-66014-7_9 10.1038/ng.3448 10.1093/hmg/ddx228 10.1097/ICU.0000000000000657 10.1016/S0169-328X(98)00044-8 10.1159/000485503 10.1016/S0197-4580(01)00216-0 10.1016/S0140-6736(05)63300-4 10.1001/archgenpsychiatry.2011.76 10.1038/s41593-020-0599-5 10.1016/S0161-6420(01)01049-1 10.1001/archopht.123.3.321 10.1001/archopht.122.4.575 10.1016/j.visres.2009.09.016 10.1016/j.jfo.2018.09.001 10.1016/j.preteyeres.2018.03.002 10.1007/s00018-019-03421-w 10.1167/iovs.18-24254 10.1038/s41467-019-11262-1 10.5966/sctm.2016-0037 10.1016/j.stem.2016.12.015 10.1186/s12974-016-0776-3 10.1167/iovs.02-1120 10.1007/s10561-008-9067-2 10.1111/bcpt.12875 10.3389/fgene.2015.00182 10.1158/0008-5472.CAN-15-2125 10.1016/j.cell.2012.06.013 10.1186/s13148-019-0650-0 10.1007/978-1-4939-7481-8_21 10.1038/s41467-017-02088-w 10.1186/s13148-018-0564-2 10.3390/cancers11101598 10.1007/s11060-018-03016-8 10.1016/j.neuron.2017.04.022 10.1016/j.survophthal.2014.01.001 10.3390/molecules24122283 10.1016/j.plefa.2015.04.007 10.2217/epi-2019-0066 10.1098/rstb.2018.0120 10.1186/s13148-018-0443-x 10.1186/s12931-018-0850-8 10.1007/s10654-019-00555-w 10.1186/s13148-015-0148-3 10.3390/jcm8020159 10.1080/15592294.2015.1060388 10.1167/iovs.11-8449 10.1016/j.celrep.2013.11.042 10.1097/MD.0000000000015083 10.1186/s13148-019-0608-2 10.1016/j.celrep.2012.10.013 10.3109/02713683.2014.1002044 10.1371/journal.pone.0126592 10.1159/000362814 10.1093/hmg/ddu114 10.1523/JNEUROSCI.5657-12.2013 10.1002/cmdc.201900174 10.3389/fnagi.2017.00366 10.1016/j.mad.2017.08.008 10.2174/1871527317666181004155136 10.1007/s11064-016-2110-y 10.1186/s13024-020-0358-9 10.1523/JNEUROSCI.2006-14.2016 10.3389/fnagi.2019.00342 10.3389/fphar.2020.00537 10.1016/j.trsl.2018.10.002 10.1074/jbc.M116.756643 10.1073/pnas.1001702107 10.1126/science.1166226 10.1186/1471-213X-7-78 10.3389/fnagi.2012.00008 10.1016/j.tibs.2013.12.002 10.1038/nature08197 10.1167/iovs.08-2817 10.1016/j.cmet.2010.06.009 10.1371/journal.pone.0098831 10.2217/rme.16.5 10.1007/s12015-016-9680-6 10.1007/s11899-019-00528-6 10.1098/rstb.2014.0367 10.3390/cells8050403 10.4103/2542-3975.260958 10.1038/nbt.4114 10.1007/978-3-030-05222-5_13 10.1038/s41598-020-64657-2 10.1016/j.bbamcr.2016.03.003 10.1007/978-3-030-20047-3_2 10.1002/stem.531 10.1016/j.stem.2015.05.015 10.1007/s00441-016-2369-y 10.1038/nature09342 10.2174/15680096113139990077 10.1371/journal.pone.0176139
Advances in Experimental Medicine and Biology; Farkas MH, DeAngelis MM

Apr 13th, 2021 - Aberrant regulation of epigenetic mechanisms, including the two most common types; DNA methylation and histone modification have been implicated in common chronic progressive conditions, including Alzheimer disease, cardiovascular disease, and age...

In Vivo Diagnosis of Synucleinopathies: A Comparative Study of Skin Biopsy and RT-QuIC.
https://doi.org/10.1212/WNL.0000000000011935
Neurology Donadio V, Wang Z et. al.

Apr 10th, 2021 - To determine whether: 1) the immunofluorescence (IF) is a reproducible technique in detecting misfolded α-synuclein (α-syn) in skin nerves; and subsequently 2) IF and RT-QuIC (both in skin and CSF) show a comparable in vivo diagnostic accuracy in ...

Demographic Characteristics Driving Disparities in Receipt of Long-Term Services and Su...
https://doi.org/10.1097/MLR.0000000000001544
Medical Care; Travers JL, Naylor MD et. al.

Apr 7th, 2021 - Research suggests that growth in Black and Hispanic (minority) older adults' nursing home (NH) use may be the result of disparities in access to community-based and alternative long-term services and supports (LTSS). We aimed to determine whether ...

Age, sex, and cerebral microbleeds in EFAD Alzheimer disease mice.
https://doi.org/10.1016/j.neurobiolaging.2021.02.020
Neurobiology of Aging; Cacciottolo M, Morgan TE et. al.

Apr 4th, 2021 - Cerebral microbleeds (MBs) increase at later ages in association with increased cognitive decline and Alzheimer Disease (AD). MB prevalence is also increased by APOE4 and hypertension. In EFAD mice (5XFAD+/-/human APOE+/+), cerebral cortex MBs are...

Low-degree trisomy 21 mosaicism promotes early-onset Alzheimer disease.
https://doi.org/10.1016/j.neurobiolaging.2021.02.021
Neurobiology of Aging; Nuebling GS, Prix C et. al.

Apr 1st, 2021 - Trisomy-21 mosaicism (mT21) with subclinical intellectual development disorder or physical phenotype has very rarely been associated with early-onset cognitive decline. Notably, early-onset Alzheimer's disease (EOAD) patients' family histories fre...

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Guidelines  59 results

Sex Differences in Cognitive Decline Among US Adults
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2776902
JAMA Network Open; Levine DA, Gross AL et. al.

Feb 24th, 2021 - Sex differences in dementia risk are unclear. It is known that women have a greater prevalence of Alzheimer disease (AD) than men, at least partly because women live longer.1-3 Some, but not all, studies suggest that women have higher incidence of...

ACR Appropriateness Criteria® Dementia.
https://doi.org/10.1016/j.jacr.2020.01.040
Journal of the American College of Radiology : JACR; , Moonis G et. al.

May 6th, 2020 - Degenerative disease of the central nervous system is a growing public health concern. The primary role of neuroimaging in the workup of patients with probable or possible Alzheimer disease has typically been to exclude other significant intracran...

Falls Risk and Alzheimer Disease: A Patient Guide.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252520
Archives of Physical Medicine and Rehabilitation; Kahya M, Sood P et. al.

Mar 2nd, 2020 - Falls Risk and Alzheimer Disease: A Patient Guide.|2020|Kahya M,Sood P,Devos H,Krishnan S,Hirsch MA,|

In Alzheimer Research, Glucose Metabolism Moves to Center Stage
https://jamanetwork.com/journals/jama/fullarticle/2758712
JAMA Kuehn BM

Jan 7th, 2020 - Areas or patterns of reduced glucose metabolism are often seen in brain scans of patients with Alzheimer disease and other dementias. Now, a growing body of evidence suggests that glucose hypometabolism may be more than just a biomarker on brain s...

Risk of rhabdomyolysis with donepezil compared with rivastigmine or galantamine: a population-based cohort study
http://www.cmaj.ca/content/191/37/E1018
CMAJ

Sep 15th, 2019 - BACKGROUND: Donepezil, rivastigmine and galantamine are popular cholinesterase inhibitors used to manage the symptoms of Alzheimer disease and other dementias; regulatory agencies in several countries warn about a possible risk of rhabdomyolysis w...

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Drugs  5 results see all →

Clinicaltrials.gov  11,601 results

Age-Related Macular Degeneration: From Epigenetics to Therapeutic Implications.
https://doi.org/10.1007/978-3-030-66014-7_9 10.1038/ng.3448 10.1093/hmg/ddx228 10.1097/ICU.0000000000000657 10.1016/S0169-328X(98)00044-8 10.1159/000485503 10.1016/S0197-4580(01)00216-0 10.1016/S0140-6736(05)63300-4 10.1001/archgenpsychiatry.2011.76 10.1038/s41593-020-0599-5 10.1016/S0161-6420(01)01049-1 10.1001/archopht.123.3.321 10.1001/archopht.122.4.575 10.1016/j.visres.2009.09.016 10.1016/j.jfo.2018.09.001 10.1016/j.preteyeres.2018.03.002 10.1007/s00018-019-03421-w 10.1167/iovs.18-24254 10.1038/s41467-019-11262-1 10.5966/sctm.2016-0037 10.1016/j.stem.2016.12.015 10.1186/s12974-016-0776-3 10.1167/iovs.02-1120 10.1007/s10561-008-9067-2 10.1111/bcpt.12875 10.3389/fgene.2015.00182 10.1158/0008-5472.CAN-15-2125 10.1016/j.cell.2012.06.013 10.1186/s13148-019-0650-0 10.1007/978-1-4939-7481-8_21 10.1038/s41467-017-02088-w 10.1186/s13148-018-0564-2 10.3390/cancers11101598 10.1007/s11060-018-03016-8 10.1016/j.neuron.2017.04.022 10.1016/j.survophthal.2014.01.001 10.3390/molecules24122283 10.1016/j.plefa.2015.04.007 10.2217/epi-2019-0066 10.1098/rstb.2018.0120 10.1186/s13148-018-0443-x 10.1186/s12931-018-0850-8 10.1007/s10654-019-00555-w 10.1186/s13148-015-0148-3 10.3390/jcm8020159 10.1080/15592294.2015.1060388 10.1167/iovs.11-8449 10.1016/j.celrep.2013.11.042 10.1097/MD.0000000000015083 10.1186/s13148-019-0608-2 10.1016/j.celrep.2012.10.013 10.3109/02713683.2014.1002044 10.1371/journal.pone.0126592 10.1159/000362814 10.1093/hmg/ddu114 10.1523/JNEUROSCI.5657-12.2013 10.1002/cmdc.201900174 10.3389/fnagi.2017.00366 10.1016/j.mad.2017.08.008 10.2174/1871527317666181004155136 10.1007/s11064-016-2110-y 10.1186/s13024-020-0358-9 10.1523/JNEUROSCI.2006-14.2016 10.3389/fnagi.2019.00342 10.3389/fphar.2020.00537 10.1016/j.trsl.2018.10.002 10.1074/jbc.M116.756643 10.1073/pnas.1001702107 10.1126/science.1166226 10.1186/1471-213X-7-78 10.3389/fnagi.2012.00008 10.1016/j.tibs.2013.12.002 10.1038/nature08197 10.1167/iovs.08-2817 10.1016/j.cmet.2010.06.009 10.1371/journal.pone.0098831 10.2217/rme.16.5 10.1007/s12015-016-9680-6 10.1007/s11899-019-00528-6 10.1098/rstb.2014.0367 10.3390/cells8050403 10.4103/2542-3975.260958 10.1038/nbt.4114 10.1007/978-3-030-05222-5_13 10.1038/s41598-020-64657-2 10.1016/j.bbamcr.2016.03.003 10.1007/978-3-030-20047-3_2 10.1002/stem.531 10.1016/j.stem.2015.05.015 10.1007/s00441-016-2369-y 10.1038/nature09342 10.2174/15680096113139990077 10.1371/journal.pone.0176139
Advances in Experimental Medicine and Biology; Farkas MH, DeAngelis MM

Apr 13th, 2021 - Aberrant regulation of epigenetic mechanisms, including the two most common types; DNA methylation and histone modification have been implicated in common chronic progressive conditions, including Alzheimer disease, cardiovascular disease, and age...

In Vivo Diagnosis of Synucleinopathies: A Comparative Study of Skin Biopsy and RT-QuIC.
https://doi.org/10.1212/WNL.0000000000011935
Neurology Donadio V, Wang Z et. al.

Apr 10th, 2021 - To determine whether: 1) the immunofluorescence (IF) is a reproducible technique in detecting misfolded α-synuclein (α-syn) in skin nerves; and subsequently 2) IF and RT-QuIC (both in skin and CSF) show a comparable in vivo diagnostic accuracy in ...

Demographic Characteristics Driving Disparities in Receipt of Long-Term Services and Su...
https://doi.org/10.1097/MLR.0000000000001544
Medical Care; Travers JL, Naylor MD et. al.

Apr 7th, 2021 - Research suggests that growth in Black and Hispanic (minority) older adults' nursing home (NH) use may be the result of disparities in access to community-based and alternative long-term services and supports (LTSS). We aimed to determine whether ...

Age, sex, and cerebral microbleeds in EFAD Alzheimer disease mice.
https://doi.org/10.1016/j.neurobiolaging.2021.02.020
Neurobiology of Aging; Cacciottolo M, Morgan TE et. al.

Apr 4th, 2021 - Cerebral microbleeds (MBs) increase at later ages in association with increased cognitive decline and Alzheimer Disease (AD). MB prevalence is also increased by APOE4 and hypertension. In EFAD mice (5XFAD+/-/human APOE+/+), cerebral cortex MBs are...

Low-degree trisomy 21 mosaicism promotes early-onset Alzheimer disease.
https://doi.org/10.1016/j.neurobiolaging.2021.02.021
Neurobiology of Aging; Nuebling GS, Prix C et. al.

Apr 1st, 2021 - Trisomy-21 mosaicism (mT21) with subclinical intellectual development disorder or physical phenotype has very rarely been associated with early-onset cognitive decline. Notably, early-onset Alzheimer's disease (EOAD) patients' family histories fre...

see more →

News  609 results

Sex Differences in Cognitive Decline Among US Adults
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2776902
JAMA Network Open; Levine DA, Gross AL et. al.

Feb 24th, 2021 - Sex differences in dementia risk are unclear. It is known that women have a greater prevalence of Alzheimer disease (AD) than men, at least partly because women live longer.1-3 Some, but not all, studies suggest that women have higher incidence of...

Fast Five Quiz: Alzheimer Disease Management
https://reference.staging.medscape.com/viewarticle/912045_2

Aug 18th, 2020 - Answer 1/5 Which of the following is the current standard pharmacologic treatment for Alzheimer disease in the United States and Europe? Your peers chose: Carbidopa/levodopa/entacapone 0% Cholinesterase inhibitors (ChEIs) and partial N-methyl-D-as...

Fast Five Quiz: Alzheimer Disease Management
https://reference.staging.medscape.com/viewarticle/912045

Aug 18th, 2020 - Alzheimer disease is a chronic, neurodegenerative disorder of the aging population that results in progressive cognitive and behavioral dysfunction. Afflicting more than 6 million Americans and more than 8 million Europeans, Alzheimer disease is t...

Fast Five Quiz: Alzheimer Disease Management
https://reference.staging.medscape.com/viewarticle/912045_5

Aug 18th, 2020 - In addition to the medications approved for Alzheimer disease, regular physical and cognitive exercise routines are strategies to prevent and slow disease progression. Increased cardiorespiratory fitness levels are associated with higher hippocamp...

Fast Five Quiz: Alzheimer Disease Management
https://reference.medscape.com/viewarticle/912045_3

Aug 18th, 2020 - Answer 2/5 Which of the following has been shown to achieve the highest levels of cognitive and functional abilities in patients with Alzheimer disease? Your peers chose: Early diagnosis and treatment 0% Antidepressants 0% Loop diuretics and CCBs ...

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Patient Education  1 results see all →