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About 13,970 results

ALLMedicine™ Alzheimer Disease Center

Research & Reviews  4,894 results

Association of Posttraumatic Stress Disorder With Accelerated Cognitive Decline in Midd...
https://doi.org/10.1001/jamanetworkopen.2022.17698
JAMA Network Open; Roberts AL, Liu J et. al.

Jul 1st, 2022 - Posttraumatic stress disorder (PTSD) has been hypothesized to lead to impaired cognitive function. However, no large-scale studies have assessed whether PTSD is prospectively associated with cognitive decline in middle-aged adults. To assess the a...

Amyloid-β (Aβ)-Related Cerebral Amyloid Angiopathy Causing Lobar Hemorrhage Decades Aft...
https://doi.org/10.1161/STROKEAHA.121.038364
Stroke Kellie JF, Campbell BCV et. al.

Jul 1st, 2022 - Recent reports raise the possibility of cerebral amyloid angiopathy (CAA) leading to intracerebral hemorrhage in young adults following childhood neurosurgery, suggesting transmission of amyloid-β (Aβ) through neurosurgical procedures including du...

Cognitive Effects of Theta-burst Stimulation (TBS) in Suspected Non-Alzheimer Disease Pathophysiology (SNAP)
https://clinicaltrials.gov/ct2/show/NCT05440110

Jun 30th, 2022 - We apply the NIA-AA criteria to identify the individuals of biomarker-defined SNAP endophenotype. This is a prospective, randomized controlled clinical trial for the first two weeks, followed by an open-label trial for the next two weeks, and comb...

CSF phosphorylated tau as an indicator of subsequent tau accumulation.
https://doi.org/10.1016/j.neurobiolaging.2022.02.015
Neurobiology of Aging; Cogswell PM, Wiste HJ et. al.

Jun 29th, 2022 - We evaluated the relationship between baseline CSF p-tau181 and the rate of tau PET change in the temporal meta-ROI and entorhinal cortex (ERC) and how it varied by amyloid level (CSF Aβ42 or amyloid PET) among 143 individuals from the Mayo Clinic...

Association of APOE Genotypes and Chronic Traumatic Encephalopathy.
https://doi.org/10.1001/jamaneurol.2022.1634
JAMA Neurology; Atherton K, Han X et. al.

Jun 28th, 2022 - Repetitive head impact (RHI) exposure is the chief risk factor for chronic traumatic encephalopathy (CTE). However, the occurrence and severity of CTE varies widely among those with similar RHI exposure. Limited evidence suggests that the APOEε4 a...

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Guidelines  5 results

ACR Appropriateness Criteria® Dementia.
https://doi.org/10.1016/j.jacr.2020.01.040
Journal of the American College of Radiology : JACR; , Moonis G et. al.

May 7th, 2020 - Degenerative disease of the central nervous system is a growing public health concern. The primary role of neuroimaging in the workup of patients with probable or possible Alzheimer disease has typically been to exclude other significant intracran...

Falls Risk and Alzheimer Disease: A Patient Guide.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252520
Archives of Physical Medicine and Rehabilitation; Kahya M, Sood P et. al.

Mar 3rd, 2020 - Falls Risk and Alzheimer Disease: A Patient Guide.|2020|Kahya M,Sood P,Devos H,Krishnan S,Hirsch MA,|

Update on appropriate use criteria for amyloid PET imaging: dementia experts, mild cogn...
https://doi.org/10.1016/j.jalz.2013.06.001
Alzheimer's & Dementia : the Journal of the Alzheimer's A... Johnson KA, Minoshima S et. al.

Jul 3rd, 2013 - Amyloid PET imaging is a novel diagnostic test that can detect in living humans one of the two defining pathologic lesions of Alzheimer disease, amyloid-β deposition in the brain. The Amyloid Imaging Task Force of the Alzheimer's Association and S...

Genetic counseling and testing for Alzheimer disease: joint practice guidelines of the ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326653
Genetics in Medicine : Official Journal of the American C... Goldman JS, Hahn SE et. al.

May 18th, 2011 - Alzheimer disease is the most common cause of dementia. It occurs worldwide and affects all ethnic groups. The incidence of Alzheimer disease is increasing due, in part, to increased life expectancy and the aging baby boomer generation. The averag...

Responding to requests from adult patients for neuroenhancements: guidance of the Ethic...
https://doi.org/10.1212/WNL.0b013e3181beecfe
Neurology Larriviere D, Williams MA et. al.

Sep 25th, 2009 - In the last decade, persons who have no diagnosed medical or mental health condition are increasingly seeking and utilizing, for the ostensible purpose of enhancing their memory or cognitive skills, prescription drugs that were originally develope...

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Drugs  5 results see all →

Clinicaltrials.gov  233 results

Cognitive Effects of Theta-burst Stimulation (TBS) in Suspected Non-Alzheimer Disease Pathophysiology (SNAP)
https://clinicaltrials.gov/ct2/show/NCT05440110

Jun 30th, 2022 - We apply the NIA-AA criteria to identify the individuals of biomarker-defined SNAP endophenotype. This is a prospective, randomized controlled clinical trial for the first two weeks, followed by an open-label trial for the next two weeks, and comb...

Renji Alzheimer's Disease Neuroimaging Cohort Study
https://clinicaltrials.gov/ct2/show/NCT05433363

Jun 27th, 2022 - Alzheimer disease (AD) is the most common cognitive impairment disease, which is mainly manifested in memory loss, language function and logical thinking disorder, and ultimately leads to the loss of independent living ability of patients. China h...

Evaluating the Relationship Between Tau PET Imaging and CSF Biomarkers of AD (Alzheimer Disease) in Humans
https://clinicaltrials.gov/ct2/show/NCT03287765

Jun 21st, 2022 - The purpose of this research study is to evaluate a new radioactive compound used in positron emission tomography (PET) scans in identifying tau tangles (a certain protein that might be associated with Alzheimer's disease) in the brain, and if the...

A Study of Gantenerumab in Participants With Mild Alzheimer Disease
https://clinicaltrials.gov/ct2/show/NCT02051608

Jun 16th, 2022 - Part 1 is a multicenter, randomized, double-blind, placebo-controlled, parallel-group study will evaluate the efficacy and safety of gantenerumab in participants with mild Alzheimer disease. Participants will be randomized to receive either ganten...

The Analysis of Gene Variants Related to POCD in Elderly Patients
https://clinicaltrials.gov/ct2/show/NCT05419596

Jun 15th, 2022 - The pathophysiology of postoperative cognitive dysfunction (POCD) following surgery may be related to Alzheimer's disease. Different studies show that; low levels of glial cell line-derived growth factor are found in both POCD and Alzheimer, and b...

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News  451 results

An Imminent Risk Factor for Alzheimer's Disease?
https://www.medscape.com/viewarticle/974596

May 25th, 2022 - The study covered in this summary was published in medRxiv.org as a preprint and has not yet been peer reviewed. Key Takeaways The clinical value of biologic criteria ― global amyloid burden (A), composite of temporal region of tau PET uptake (T),...

Risk of developing dementia is similar with tofacitinib, tocilizumab, or TNFi vs. abatacept in RA
https://www.mdedge.com/rheumatology/article/254915/rheumatoid-arthritis/risk-developing-dementia-similar-tofacitinib

May 24th, 2022 - Key clinical point: Treatment with tofacitinib, tocilizumab, or tumor necrosis factor inhibitors (TNFi) vs. abatacept did not reduce the risk of developing Alzheimer disease and related dementia (ADRD) in patients with rheumatoid arthritis (RA).

Patients asking about APOE gene test results? Here’s what to tell them
https://www.mdedge.com/familymedicine/article/254542/preventive-care/patients-asking-about-apoe-gene-test-results-heres
MDedge Family Medicine; Shana D. Stites, PsyD, MS, MA, Nicholas M. Vogt, MD, PhD et. al.

May 11th, 2022 - Advances in Alzheimer disease (AD) genes and biomarkers now allow older adults to undergo testing and learn about their risk for AD. 1 Current routes for doing so include testing in cardiology, screening for enrollment in secondary prevention trial.

Lipid Measurements: Noninvasive Biomarkers for Alzheimer Disease?
https://www.medscape.com/viewarticle/973486

May 5th, 2022 - The study covered in this summary was published on medRxiv.org as a preprint and has not yet been peer reviewed. Key Takeaways Higher expression and upregulation of fatty acid pathways and the phospholipids phosphatidylethanolamine (PE) and diacyl...

Neurotransmitter-based diagnosis and treatment: A hypothesis (Part 1)
https://www.mdedge.com/psychiatry/article/254209/neurotransmitter-based-diagnosis-and-treatment-hypothesis-part-1
Dmitry M. Arbuck, MD, José Miguel Salmerón, MD et. al.

Apr 28th, 2022 - It is unfortunate that, in some clinical areas, medical conditions are still treated by name and not based on the underlying pathological process. It would be odd in 2022 to treat “dropsy” instead of heart or kidney disease (2 very different cause.

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