About 11,933 results

ALLMedicine™ Alzheimer Disease Center

Research & Reviews  4,296 results

Alzheimer disease and neuroplasticity.
Handbook of Clinical Neurology; Koch G, Spampinato D

Jan 18th, 2022 - Alzheimer's disease (AD) is considered the most harmful form of dementia in the elderly population. At present, there are no effective treatments and this is likely due to the incomplete understanding of the pathophysiology. Recent data indicate t...

Sharper in the morning: Cognitive time of day effects revealed with high-frequency smar...
Journal of Clinical and Experimental Neuropsychology; Wilks H, Aschenbrenner AJ et. al.

Jan 18th, 2022 - Decades of research has established a shift from an "eveningness" preference to a "morningness" preference with increasing age. Accordingly, older adults typically have better cognition in morning hours compared to evening hours. We present the fi...

Murine roseolovirus does not accelerate amyloid-β pathology and human roseoloviruses ar...
https://doi.org/10.1186/s13024-021-00514-8 10.1016/j.cell.2019.09.001 10.3233/JAD-160517 10.1126/scitranslmed.aaf1059 10.1016/j.tins.2018.07.001 10.1177/1352458517737392 10.1084/jem.20201503 10.1002/jmv.20271 10.1002/path.2449 10.1371/journal.pone.0003637 10.3233/JAD-161305 10.1371/journal.ppat.1008575 10.1128/CMR.00143-20 10.1002/path.1127 10.1016/j.neuron.2019.11.009 10.1016/j.medmal.2016.09.004 10.1002/jmv.1890430203 10.1128/JVI.01851-19 10.1128/JVI.01556-13 10.1128/JVI.03763-13 10.1128/JVI.02463-16 10.1258/002367707780378203 10.1128/iai.26.3.1186-1195.1979 10.4049/jimmunol.1700982 10.1128/jvi.19.2.594-609.1976 10.1128/JVI.00505-11 10.1007/978-1-60761-744-0_2 10.1126/scitranslmed.abd7522 10.1038/s41593-019-0501-5 10.1186/s13073-018-0551-4 10.1186/s13024-019-0319-3 10.1007/s00401-019-02066-0 10.1021/bi7015553 10.1016/j.jalz.2018.06.3040 10.1016/j.bbadis.2019.165647 10.3233/JAD-2009-0963 10.1002/ana.10662 10.1099/0022-1317-68-4-1173 10.1371/journal.ppat.1007617 10.1016/S0140-6736(89)93019-5 10.1016/S0140-6736(89)90754-X 10.1093/infdis/162.3.634 10.4049/jimmunol.1302326 10.3389/fmicb.2017.02143 10.3390/microorganisms8010039 10.3389/fnmol.2018.00340 10.1007/s11908-008-0048-1
Molecular Neurodegeneration; Bigley TM, Xiong M et. al.

Jan 17th, 2022 - The role of viral infection in Alzheimer Disease (AD) pathogenesis is an area of great interest in recent years. Several studies have suggested an association between the human roseoloviruses, HHV-6 and HHV-7, and AD. Amyloid-β (Aβ) plaques are a ...

PrecivityAD for Diagnosis of Alzheimer Disease.
American Family Physician; Anderson J, Pierce C

Jan 15th, 2022 - PrecivityAD for Diagnosis of Alzheimer Disease.|2022|Anderson J,Pierce C,|

Association of serum 25-hydroxyvitamin D concentrations with risk of dementia among ind...
PLoS Medicine; Geng T, Lu Q et. al.

Jan 14th, 2022 - Several epidemiological studies have suggested that vitamin D status is associated with risk of dementia in general populations. However, due to the synergistic effect between diabetic pathology and neuroinflammation, and the prothrombotic profile...

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Guidelines  6 results

ACR Appropriateness Criteria® Dementia.
Journal of the American College of Radiology : JACR; , Moonis G et. al.

May 7th, 2020 - Degenerative disease of the central nervous system is a growing public health concern. The primary role of neuroimaging in the workup of patients with probable or possible Alzheimer disease has typically been to exclude other significant intracran...

Falls Risk and Alzheimer Disease: A Patient Guide.
Archives of Physical Medicine and Rehabilitation; Kahya M, Sood P et. al.

Mar 3rd, 2020 - Falls Risk and Alzheimer Disease: A Patient Guide.|2020|Kahya M,Sood P,Devos H,Krishnan S,Hirsch MA,|

Diagnostic criteria for vascular cognitive disorders: a VASCOG statement.
Alzheimer Disease and Associated Disorders; Sachdev P, Kalaria R et. al.

Mar 19th, 2014 - Several sets of diagnostic criteria have been published for vascular dementia since the 1960s. The continuing ambiguity in vascular dementia definition warrants a critical reexamination. Participants at a special symposium of the International Soc...

Update on appropriate use criteria for amyloid PET imaging: dementia experts, mild cogn...
Alzheimer's & Dementia : the Journal of the Alzheimer's A... Johnson KA, Minoshima S et. al.

Jul 3rd, 2013 - Amyloid PET imaging is a novel diagnostic test that can detect in living humans one of the two defining pathologic lesions of Alzheimer disease, amyloid-β deposition in the brain. The Amyloid Imaging Task Force of the Alzheimer's Association and S...

Genetic counseling and testing for Alzheimer disease: joint practice guidelines of the ...
Genetics in Medicine : Official Journal of the American C... Goldman JS, Hahn SE et. al.

May 18th, 2011 - Alzheimer disease is the most common cause of dementia. It occurs worldwide and affects all ethnic groups. The incidence of Alzheimer disease is increasing due, in part, to increased life expectancy and the aging baby boomer generation. The averag...

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Drugs  5 results see all →

Clinicaltrials.gov  71 results

In Vivo Alzheimer Proteomics

Dec 28th, 2021 - In France, an estimated 860 000 patients are affected by Alzheimer Disease (AD) which represents, as in other developed countries, a major public health issue. In many cases, AD diagnosis is uncertain and its clinical evolution unpredictable. The ...

Validation of the Stability of Diagnostic Biomarkers on Healthy Volunteers

Dec 16th, 2021 - Firalis SA and its affiliate Amoneta Diagnostics SAS are developing novel in-vitro diagnostic (IVD) tests for diverse diagnostic applications for major human diseases, including cardiovascular, and neurodegenerative disorders. These tests measure ...

A Study to Investigate the Regional Brain Kinetics of Brain Drug Transporters Using P-glycoprotein and Breast Cancer Resistance Protein Substrates and by Using the Positron Emission Tomography Liga...

Dec 9th, 2021 - The purpose of this study is to investigate the total body biodistribution and radiation dosimetry of 11C-JNJ-63779586 by Positron Emission Tomography (PET) in healthy young adult males (Part A); to estimate and compare the uptake, distribution, a...

Study of Phosphorylated Metabolism Profile as Predictive Biomarker of Cognitive Decline in Memory Complaint.

Nov 29th, 2021 - Alzheimer disease is a frequent disease in the late ages that results in global alteration of cognitive functions. In which memory complaint can be isolated in the early stages. Physiopathology of neuronal degenerescence in Alzheimer disease is co...

Resilience and Brain Health of Older Adults During the COVID-19 Pandemic (MEDEX-2)

Nov 17th, 2021 - This project capitalizes on a natural experiment imposed by the COVID-19 pandemic in conjunction with an extensive set of cognitive, emotional, biological, and neuroimaging variables already collected at multiple time points in older adults partic...

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News  395 results

Concussion Sequelae Boost Alzheimer's Risk

Jan 17th, 2022 - Post-traumatic amnesia (PTA) and chronic vascular lesions caused by traumatic brain injury (TBI) is tied to an increased risk of subsequent Alzheimer's disease (AD), new research suggests. Results from a case-controlled retrospective study showed ...

Implications of FDA Approval of Alzheimer Drug May Extend to Novel Anticancer Therapies

Jan 10th, 2022 - It is difficult to know where exactly to begin this commentary regarding the FDA approval to permit commer-cial sales of the Alzheimer disease drug aducanumab-avwa (Aduhelm). There are so many disturbing features of this story, with likely more to...

Cataract Surgery Seen Protective Against Dementia

Dec 10th, 2021 - Older patients who undergo cataract surgery may reduce their risk of developing dementia by roughly 30%, new research shows. Dr Cecilia Lee Although previous studies have linked sensory impairment to dementia, whether correcting vision problems in...

Verubecestat Promising for Glioblastoma

Dec 3rd, 2021 - NEW YORK (Reuters Health) - Verubecestat, a beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1) inhibitor originally developed to treat Alzheimer's disease, showed promise against glioblastoma in a preclinical study. "Because BACE1 inhib...

Biden Seeks to Return Califf as FDA Chief

Nov 12th, 2021 - President Joe Biden on Friday said he will nominate Robert Califf, MD, to return as the top US regulator of drugs and medical devices, selecting a cardiologist with extensive experience in clinical trials. Califf served as the commissioner of the ...

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