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About 14,673 results

ALLMedicine™ Alzheimer Disease Center

Research & Reviews  5,138 results

Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives c...
https://doi.org/10.1038/s41467-022-34679-7
Nature Communications; Lordén G, Wozniak JM et. al.

Nov 24th, 2022 - Exquisitely tuned activity of protein kinase C (PKC) isozymes is essential to maintaining cellular homeostasis. Whereas loss-of-function mutations are generally associated with cancer, gain-of-function variants in one isozyme, PKCα, are associated...

One Minute of EEG Data Provides Sufficient and Reliable Data for Identifying Lewy Body ...
https://doi.org/10.1097/WAD.0000000000000536
Alzheimer Disease and Associated Disorders; Jin L, Nawaz H et. al.

Nov 23rd, 2022 - To determine the minimum duration of electroencephalography (EEG) data necessary to differentiate EEG features of Lewy body dementia (LBD), that is, dementia with Lewy bodies and Parkinson disease dementia, from non-LBD patients, that is, Alzheime...

Association of Klotho Protein Levels and KL-VS Heterozygosity With Alzheimer Disease an...
https://doi.org/10.1001/jamanetworkopen.2022.43232
JAMA Network Open; Grøntvedt GR, Sando SB et. al.

Nov 23rd, 2022 - Identification of proteins and genetic factors that reduce Alzheimer disease (AD) pathology is of importance when searching for novel AD treatments. Heterozygosity of the KL-VS haplotype has been associated with reduced amyloid and tau burden. Whe...

Genetic evidence for causal relationships between age at natural menopause and the risk...
https://doi.org/10.1093/ije/dyac215
International Journal of Epidemiology; Lankester J, Li J et. al.

Nov 22nd, 2022 - A later age at natural menopause (ANM) has been linked to several ageing-associated traits including an increased risk of breast and endometrial cancer and a decreased risk of lung cancer, osteoporosis and Alzheimer disease. However, ANM is also r...

Inhibition of circ_0004381 improves cognitive function via miR-647/PSEN1 axis in an Alz...
https://doi.org/10.1093/jnen/nlac108
Journal of Neuropathology and Experimental Neurology; Li N, Zhang D et. al.

Nov 22nd, 2022 - Circ_0004381 promotes neuronal damage in Parkinson disease, but its role in Alzheimer disease (AD) is unreported. The goal of this study was to investigate the role and potential mechanisms of circ_0004381 effects in AD models. Primary hippocampal...

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Guidelines  5 results

ACR Appropriateness Criteria® Dementia.
https://doi.org/10.1016/j.jacr.2020.01.040
Journal of the American College of Radiology : JACR; , Moonis G et. al.

May 7th, 2020 - Degenerative disease of the central nervous system is a growing public health concern. The primary role of neuroimaging in the workup of patients with probable or possible Alzheimer disease has typically been to exclude other significant intracran...

Falls Risk and Alzheimer Disease: A Patient Guide.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252520
Archives of Physical Medicine and Rehabilitation; Kahya M, Sood P et. al.

Mar 3rd, 2020 - Falls Risk and Alzheimer Disease: A Patient Guide.|2020|Kahya M,Sood P,Devos H,Krishnan S,Hirsch MA,|

Update on appropriate use criteria for amyloid PET imaging: dementia experts, mild cogn...
https://doi.org/10.1016/j.jalz.2013.06.001
Alzheimer's & Dementia : the Journal of the Alzheimer's A... Johnson KA, Minoshima S et. al.

Jul 3rd, 2013 - Amyloid PET imaging is a novel diagnostic test that can detect in living humans one of the two defining pathologic lesions of Alzheimer disease, amyloid-β deposition in the brain. The Amyloid Imaging Task Force of the Alzheimer's Association and S...

Genetic counseling and testing for Alzheimer disease: joint practice guidelines of the ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326653
Genetics in Medicine : Official Journal of the American C... Goldman JS, Hahn SE et. al.

May 18th, 2011 - Alzheimer disease is the most common cause of dementia. It occurs worldwide and affects all ethnic groups. The incidence of Alzheimer disease is increasing due, in part, to increased life expectancy and the aging baby boomer generation. The averag...

Responding to requests from adult patients for neuroenhancements: guidance of the Ethic...
https://doi.org/10.1212/WNL.0b013e3181beecfe
Neurology Larriviere D, Williams MA et. al.

Sep 25th, 2009 - In the last decade, persons who have no diagnosed medical or mental health condition are increasingly seeking and utilizing, for the ostensible purpose of enhancing their memory or cognitive skills, prescription drugs that were originally develope...

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Drugs  5 results see all →

Clinicaltrials.gov  238 results

Cognitive Decline in AD
https://clinicaltrials.gov/ct2/show/NCT03946930

Oct 7th, 2022 - There is lack of information on the risk factors of accelerated cognitive decline in older people with Alzheimer disease (AD). The extent of neurodegeneration and white matter disease has been reported to be important factors. In addition there ma...

Mindfulness Meditation and Insomnia in Alzheimer Disease Caregivers
https://clinicaltrials.gov/ct2/show/NCT03538574

Oct 4th, 2022 - This randomized controlled trial aims to evaluate the non-inferiority of Mindful Awareness Practices for Insomnia (MAP-I ) vs. Cognitive Behavioral Therapy for Insomnia (CBT-I) on outcomes of insomnia, cellular and genomic markers of inflammation,...

A Comparison of Two Approaches to Developing Brain Health Programs
https://clinicaltrials.gov/ct2/show/NCT04822129

Sep 27th, 2022 - Overview: Participants will complete a baseline battery of self-report and cognitive measures before and after 12 weeks of weekly videoconferences and diaries of brain health-related activities completed during weeks 1, 6, and 12. They will be ran...

Neuroinflammation and Cognitive Decline in Alzheimer Disease
https://clinicaltrials.gov/ct2/show/NCT02377206

Sep 14th, 2022 - The purpose of this study is to assess the level of neuroinflammation in Alzheimer Disease subject (mild to moderate) estimated with Binding Potential (BP) of [18F]DPA-714 , and its relationship with the kinetics of cognitive decline over a 24-mon...

TDCS to Improve Post-Stroke Cognitive Impairment
https://clinicaltrials.gov/ct2/show/NCT05195398

Sep 13th, 2022 - Vascular cognitive impairment, ranging from vascular mild cognitive impairment to vascular dementia, is a leading cause of progressive cognitive dysfunction second only to Alzheimer Disease. While the accumulation of ischemic infarcts or a large c...

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News  483 results

Defining Clinical Benefit in Oncology Trials Is Not as Simple as Some May Believe
https://www.onclive.com/view/defining-clinical-benefit-in-oncology-trials-is-not-as-simple-as-some-may-believe

Nov 14th, 2022 - A core component of any type of therapeutic research is to enhance clinical benefit.In appropriately designed, comparative, randomized studies another goal is to determine the superiority or potential equivalence of one therapeutic strategy vs ano...

Brain Aging in Black Adults Shows Accelerated Pattern Starting in Midlife
https://www.medpagetoday.com/neurology/dementia/101731

Nov 14th, 2022 - Black individuals showed an accelerated pattern of brain aging beginning in midlife, a cross-sectional analysis of two community-based cohorts showed. Brain aging -- the association of age with cortical thickness and white matter hyperintensity (W...

Daily Aspirin No Help for Fracture Prevention in Seniors, Raises Risk of Falls
https://www.medpagetoday.com/geriatrics/generalgeriatrics/101629

Nov 7th, 2022 - Low-dose aspirin did not reduce risks of fracture in healthy older adults, but was associated with an increased risk of serious falls, a substudy of the randomized ASPREE trial showed. Over a median follow-up of 4.6 years, there was no difference ...

Exercise Strengthens Cognitive Function in Stroke Patients
https://www.medscape.com/viewarticle/982715

Oct 19th, 2022 - Exercise appears to significantly improve cognitive function following a stroke, bringing patients with mild to moderate cognitive impairment back to near normal cognition. Results of a new proof-of-concept trial suggest exercise had a positive ef...

Deprescribing in Older Adults in Community and Nursing Home Settings
https://www.mdedge.com/jcomjournal/article/257897/geriatrics/deprescribing-older-adults-community-and-nursing-home-settings
William W. Hung, MD, MPH

Sep 16th, 2022 - Study 1 Overview (Bayliss et al) Objective: To examine the effect of a deprescribing educational intervention on medication use in older adults with cognitive impairment. Design: This was a pragmatic, cluster randomized trial conducted in 8 primar.

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