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ALLMedicine™ Alpha1-antitrypsin Deficiency Center

Research & Reviews  38 results

Alpha1-antitrypsin deficiency: New therapies on the horizon.
https://doi.org/10.1016/j.coph.2021.06.001
Current Opinion in Pharmacology; Remih K, Amzou S et. al.

Jul 14th, 2021 - Alpha1-antitrypsin deficiency (AATD) is caused by mutations in the SERPINA1 gene, coding for alpha1-antitrypsin (AAT). AAT is synthesised mainly in the liver and is released into bloodstream to protect tissues (particularly lung) with its antiprot...

SARS-CoV-2 infection in alpha1-antitrypsin deficiency.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116136
Respiratory Medicine; Schneider CV, Strnad P

May 20th, 2021 - Alpha1-antitrypsin deficiency arises due to mutations in alpha1-antitrypsin (AAT) gene and represents the most prominent genetic predisposition to chronic obstructive pulmonary disease and emphysema. Since AAT plays important immunomodulatory and ...

FOOTPRINTS study protocol: rationale and methodology of a 3-year longitudinal observati...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7986686
BMJ Open; Crapo J, Gupta A et. al.

Mar 24th, 2021 - A better understanding is needed of the different phenotypes that exist for patients with chronic obstructive pulmonary disease (COPD), their relationship with the pathogenesis of COPD and how they may affect disease progression. Biomarkers, inclu...

Comparison of different algorithms in laboratory diagnosis of alpha1-antitrypsin defici...
https://doi.org/10.1515/cclm-2020-1881
Clinical Chemistry and Laboratory Medicine; Balderacchi AM, Barzon V et. al.

Mar 7th, 2021 - Alpha1-antitrypsin deficiency (AATD) is an inherited condition that predisposes individuals to an increased risk of developing lung and liver disease. Even though AATD is one of the most widespread inherited diseases in Caucasian populations, only...

Alpha1-antitrypsin deficiency and asthma.
https://doi.org/10.1097/ACI.0000000000000711
Current Opinion in Allergy and Clinical Immunology; Pini L, Paoletti G et. al.

Dec 8th, 2020 - The aim of the article is to highlight the association between α1-antitrypsin deficiency (AATD) and asthma. AATD is one of the most common and underrecognized autosomal disorders associated with an increased risk of developing liver and lung disea...

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Drugs  3 results see all →

News  4 results

Fast Five Quiz: How Much Do You Know About COPD?
https://reference.medscape.com/viewarticle/865477_5

May 27th, 2020 - ABG analysis provides the best clues as to acuteness and severity of disease exacerbation. Renal compensation generally occurs even in chronic CO2 retainers (ie, those with bronchitis); thus, pH usually is near normal. Any pH below 7.3 is typicall...

Older Lung Donors Raise Mortality Risk Only Slightly
https://www.medscape.com/viewarticle/862727

May 2nd, 2016 - WASHINGTON, DC — For people who undergo lung transplantation, mortality risk is only slightly higher when donors are 55 to 64 years of age than when they are younger than 55 years, the current age recommendation, according to an analysis of the wo...

Alpha1-Antitrypsin Deficiency Significantly Increases Risk for Lung Cancer
https://www.medscape.com/viewarticle/575125

May 27th, 2008 - May 27, 2008 — Alpha1-antitrypsin deficiency (AATD) can greatly increase the risk for lung cancer, researchers report. AATD carriers might have a risk of developing lung cancer that is 70% higher than that for noncarriers, according to new data pu...

Alpha1-Antitrypsin Deficiency Significantly Increases Risk for Lung Cancer
https://www.staging.medscape.com/viewarticle/575125

May 27th, 2008 - May 27, 2008 — Alpha1-antitrypsin deficiency (AATD) can greatly increase the risk for lung cancer, researchers report. AATD carriers might have a risk of developing lung cancer that is 70% higher than that for noncarriers, according to new data pu...

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