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About 1,004 results
Emphysema in active farmer's lung disease.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470683
PloS One; Soumagne T, Chardon ML et. al.

Jun 14th, 2017 - Farmer's lung (FL) is a common type of hypersensitivity pneumonitis. It is often considered that fibrosis is the most frequent finding in chronic FL. Nevertheless, three cohort studies have suggested that some patients with chronic FL may develop emphysema. We aimed to evaluate the current prevalence of emphysema in active FL, to describe the radiological and functional features of emphysema in...

Identification of Antigenic Proteins from Lichtheimia corymbifera for Farmer's Lung Dis...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973876
PloS One; Rognon B, Barrera C et. al.

Aug 4th, 2016 - The use of recombinant antigens has been shown to improve both the sensitivity and the standardization of the serological diagnosis of Farmer's lung disease (FLD). The aim of this study was to complete the panel of recombinant antigens available for FLD serodiagnosis with antigens of Lichtheimia corymbifera, known to be involved in FLD. L. corymbifera proteins were thus separated by 2D electrop...

The latency period of mesothelioma among a cohort of British asbestos workers (1978-2005).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790169
British Journal of Cancer; Frost G

Aug 30th, 2013 - The Great Britain (GB) Asbestos Survey is a prospective cohort of asbestos workers in GB. The objective of this study was to investigate determinants of mesothelioma latency, paying particular attention to indicators of intensity of asbestos exposure such as occupation, sex, and presence of asbestosis. The analysis included members of the cohort who died with mesothelioma between 1978 and 2005....

Epigenetics, asthma, and allergic diseases: a review of the latest advancements.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358775
Current Allergy and Asthma Reports; Lovinsky-Desir S, Miller RL

Mar 27th, 2012 - Environmental epigenetic regulation in asthma and allergic disease is an exciting area that has gained a great deal of scientific momentum in recent years. Environmental exposures, including prenatal maternal smoking, have been associated with asthma-related outcomes that may be explained by epigenetic regulation. In addition, several known allergy and asthma genes have been found to be suscept...

Pro/Con debate: Is occupational asthma induced by isocyanates an immunoglobulin E-media...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121887
Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology; Wisnewski AV, Jones M

Jun 15th, 2010 - Isocyanates, low-molecular weight chemicals essential to polyurethane production, are one of the most common causes of occupational asthma, yet the mechanisms by which exposure leads to disease remain unclear. While isocyanate asthma closely mirrors other Type I Immune Hypersensitivity (Allergic) disorders, one important characteristic of hypersensitivity ('allergen'-specific IgE) is reportedly...

Occupational lung disease.
https://doi.org/10.1097/RTI.0b013e3181c1a9b3
Journal of Thoracic Imaging; Sirajuddin A, Kanne JP

Nov 25th, 2009 - Despite federally mandated safety standards, occupational lung disease remains one of the most common work-related injuries. Inhaled dust can result in a range of tissue injury in the lung and can lead to significant respiratory insufficiency causing death. Although silicosis and coal worker's pneumoconiosis are becoming less common, hypersensitivity pneumonitis is increasingly recognized as an...

Bronchiectasis.
https://doi.org/10.1016/j.rcl.2008.11.006
Radiologic Clinics of North America; Javidan-Nejad C, Bhalla S

Mar 2nd, 2009 - Bronchiectasis is defined as irreversible bronchial dilatation, leading to chronic cough, sputum formation, and recurrent infections. HRCT plays a major role in diagnosis of bronchiectasis. Most bronchiectasis is either idiopathic or a result of prior infections. Cystic fibrosis, allergic bronchopulmonary aspergillosis, and traction bronchiectasis caused by prior tuberculosis, sarcoidosis, and ...

Triple Overlap Between Silicosis, Dermatomyositis, and Systemic Sclerosis: Opening Up a...
https://doi.org/10.1097/RHU.0000000000001371
Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases; Jain S, Samanta J et. al.

Mar 16th, 2020 - Triple Overlap Between Silicosis, Dermatomyositis, and Systemic Sclerosis: Opening Up a Pandora's Box.|2020|Jain S,Samanta J,Vyas S,Mahajan S,Suri V,|

Silicosis in artificial stone workers: Spectrum of radiological high-resolution CT ches...
https://doi.org/10.1111/1754-9485.13015
Journal of Medical Imaging and Radiation Oncology References; Jones CM, Pasricha SS et. al.

Mar 9th, 2020 - Silicosis in artificial stone workers has become increasingly recognised in Australia over the last two years, with a large proportion of screened workers showing imaging features of the disease. The spectrum of findings has differed from the classical silicosis previously described, with many features of accelerated disease, including ground-glass opacities and progressive massive fibrosis. Th...

Asbestosis Treatment & Management
https://emedicine.medscape.com/article/295966-treatment

Mar 4th, 2020 - Approach Considerations Remain aware of the complications of asbestosis to expedite detection and treatment. Inform patients about the work-related causation of the disease (potentially compensable) and report it to appropriate state or federal agencies. Additionally, advise smokers to quit smoking, and provide referral to a smoking cessation clinic. Assessment of disease severity and functiona...

Silica particles disorganize the polarization of pulmonary macrophages in mice.
https://doi.org/10.1016/j.ecoenv.2020.110364
Ecotoxicology and Environmental Safety; Zhao Y, Hao C et. al.

Mar 2nd, 2020 - Silicosis is a fatal fibrotic lung disease caused by long-term silica particle exposure, in which pulmonary macrophages play an important role. However, the relationship between macrophage polarization and silicosis remains unclear. We established an experimental silicosis mouse model to investigate macrophage polarization during silicosis development. C57BL/c mice were exposed to silica by int...

Exosomal miR-125a-5p derived from silica-exposed macrophages induces fibroblast transdi...
https://doi.org/10.1016/j.ecoenv.2020.110253
Ecotoxicology and Environmental Safety; Wang D, Hao C et. al.

Feb 14th, 2020 - Silica particles can cause a systemic disease in workers termed lung silicosis, characterized by diffuse fibrosis. The development of lung silicosis involves various signaling pathway networks comprising numerous cell types and cytokines. As an important medium for communication between cells, exosomes have emerged as a hot research topic; however, the role of exosomal microRNAs (miRNAs) in sil...

Silica Perturbs Primary Cilia and Causes Myofibroblast Differentiation during Silicosis...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993221
Theranostics Li S, Wei Z et. al.

Feb 11th, 2020 - The purpose of this study was to determine the effects of Kinesin family member 3A (KIF3A) on primary cilia and myofibroblast differentiation during silicosis by regulating Sonic hedgehog (SHH) signalling. Methods: Changes in primary cilia during silicosis and myofibroblast differentiation were detected in silicotic patients, experimental silicotic rats, and a myofibroblast differentiation mode...

Silica-related diseases in the modern world.
https://doi.org/10.1111/all.14202
Allergy REFERENCES; Hoy RF, Chambers DC

Jan 28th, 2020 - Silicosis is an ancient and potentially fatal pneumoconiosis caused by exposure to respirable crystalline silica. Silicosis is historically a disease of miners; however, failure to recognize and control the risk associated with silica exposure in contemporary work practices such as sandblasting denim jeans and manufacturing of artificial stone benchtops has led to re-emergence of silicosis arou...

Inflammatory and oxidative stress biomarkers induced by silica exposure in crystal craf...
https://doi.org/10.1002/ajim.23088
American Journal of Industrial Medicine REFERENCES; Scalia Carneiro AP, Algranti E et. al.

Jan 18th, 2020 - Identification of biomarkers associated with the diagnosis and prognosis of silicosis would be highly advantageous in the clinical setting. The aim of this study is to evaluate inflammatory and oxidative stress biomarkers in subjects exposed to silica. A cross-sectional study of crystal craftsmen currently (n = 34) or formerly (n = 35) exposed and a group of nonexposed subjects (n = 12) was per...

Occupational lung diseases in the 21st century: the changing landscape and future chall...
https://doi.org/10.1097/MCP.0000000000000658
Current Opinion in Pulmonary Medicine; Fazen LE, Linde B et. al.

Jan 2nd, 2020 - Occupational exposures remain an underrecognized and preventable cause of lung disease in high-income countries. The present review highlights the emergence of cleaning-related respiratory disease and the re-emergence of silicosis as examples of trends in occupational lung diseases in the 21st century. Employment trends, such as the shift from large-scale manufacturing to a service economy, the...

Superior mediastinal lymphadenopathy by silicosis mimicking metastasis of papillary thy...
https://doi.org/10.1016/j.anl.2019.12.003
Auris, Nasus, Larynx; Tsukatani T, Niwa H et. al.

Dec 30th, 2019 - Silicosis is caused by inhalation of silica dust and is the most common type of pneumoconiosis. The characteristics of silicosis are inflammation of lung tissue and calcified lymphadenopathy of pulmonary hilum, mediastinum and paratrachea. We present a papillary thyroid carcinoma (PTC) case with paratracheal and superior mediastinal calcified lymphadenopathy caused by silicosis. The patient did...

Chemical Worker's Lung
https://emedicine.medscape.com/article/297248-overview

Dec 23rd, 2019 - Practice Essentials Occupational lung diseases refers to the development of lung diseases from inhalational exposure that occurs at the work place. However, these lung diseases may also occur in environments other than work, even home. Occupational lung disease can result from inhalational exposure to minerals and dusts, microbes, animal and insect proteins, and chemicals and can have long-last...

Chemical Worker's Lung 
https://emedicine.medscape.com/article/297248-print

Dec 23rd, 2019 - Practice Essentials Occupational lung diseases refers to the development of lung diseases from inhalational exposure that occurs at the work place. However, these lung diseases may also occur in environments other than work, even home. Occupational lung disease can result from inhalational exposure to minerals and dusts, microbes, animal and insect proteins, and chemicals and can have long-last...

Accelerated silicosis with bone marrow, hepatic and splenic involvement in a patient wi...
https://doi.org/10.1136/bcr-2019-230781
BMJ Case Reports; Carreño Hernández MC, Garrido Paniagua S et. al.

Dec 10th, 2019 - Chronic silicosis is an entity widely described in literature. However, other types such as accelerated, acute, complicated and extrapulmonary silicosis are little documented. We present a case of accelerated extrapulmonary silicosis in a lung transplant patient in whom the diagnosis of systemic silicosis was made incidental to non-respiratory complications that occurred during follow-up. The a...

Renal involvement in a silicosis patient - case report and literature review.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913658
Renal Failure; Chen FF, Tang HY et. al.

Dec 6th, 2019 - A 43-year-old Chinese man with a silicosis history was admitted to our hospital due to bilateral lower extremity edema for 1 year, exacerbating with hematuria for 2 months. He started working as a coal miner 30 years ago, and was diagnosed as silicosis 3 months ago. Lab tests revealed hematuria 3+, proteinuria 3+, and a serum creatinine value 2.47 mg/dl on routine check. He was diagnosed with f...

Silicosis 
https://emedicine.medscape.com/article/302027-print

Dec 4th, 2019 - Background Silicosis is a primary pneumoconiosis involving fibronodular lung disease caused by inhalation of silica dust.​ Quartz, the most common form of crystalline silica, is abundantly present in granite, slate, and sandstone.[1]  Although silicosis has been recognized for many centuries, its prevalence increased markedly with the introduction of mechanized mining. The clinical picture of s...

Silicosis
https://emedicine.medscape.com/article/302027-overview

Dec 4th, 2019 - Background Silicosis is a primary pneumoconiosis involving fibronodular lung disease caused by inhalation of silica dust.​ Quartz, the most common form of crystalline silica, is abundantly present in granite, slate, and sandstone. [1]  Although silicosis has been recognized for many centuries, its prevalence increased markedly with the introduction of mechanized mining. The clinical picture of ...

Assessment of silica dust exposure profile in relation to prevalence of silicosis among...
https://doi.org/10.1002/ajim.23077
American Journal of Industrial Medicine REFERENCES; Dhatrak S, Nandi S

Nov 27th, 2019 - In Indian mines, the prescribed exposure limit (PEL) for free silica dust is 0.15 mg/m3 which is much higher than those of OSHA and the ACGIH. Because of the reporting of high numbers of silicosis cases among Indian sandstone mine workers, the present study was designed to assess the dust exposure profile of the workers and to substantiate correlation of silica exposure with radiographic findin...

Preventive tuberculosis treatment effect on QuantiFERON TB-Gold in-tube testing in a hi...
https://doi.org/10.1016/j.ijid.2019.11.023
International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases; Yang Q, Ruan Q et. al.

Nov 26th, 2019 - Whether T-cell interferon-γ responses to Mycobacterium tuberculosis-specific antigens can be influenced by tuberculosis preventive treatment in a high-endemic country is uncertain. In this prospective, open-label, controlled study, 513 individuals with silicosis were randomly selected for TB preventive treatment with rifapentine and isoniazid or for observation. QuantiFERON-TB Gold in-tube (QFT...

The potential of mesenchymal stem cell therapy for chronic lung disease.
https://doi.org/10.1080/17476348.2020.1679628
Expert Review of Respiratory Medicine; Cruz FF, Rocco PRM

Oct 14th, 2019 - Introduction: Mesenchymal stem/stromal cells (MSCs) have been shown to improve lung function and survival in chronic inflammatory lung diseases, including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), pulmonary arterial hypertension (PAH), and silicosis.Areas covered: This review covers rationale for the use of MSC therapy, along with preclinical stu...

Allergic and Environmental Asthma
https://emedicine.medscape.com/article/137501-overview

Oct 6th, 2019 - Overview Asthma is a clinical syndrome characterized by episodic reversible airway obstruction, increased bronchial reactivity, and airway inflammation. Asthma results from complex interactions among inflammatory cells, their mediators, airway epithelium and smooth muscle, and the nervous system. In genetically susceptible individuals, these interactions can lead the patient with asthma to symp...

Severe Silicosis in Engineered Stone Fabrication Workers - California, Colorado, Texas,...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6762184
MMWR. Morbidity and Mortality Weekly Report; Rose C, Heinzerling A et. al.

Sep 26th, 2019 - Silicosis is an incurable occupational lung disease caused by inhaling particles of respirable crystalline silica. These particles trigger inflammation and fibrosis in the lungs, leading to progressive, irreversible, and potentially disabling disease. Silica exposure is also associated with increased risk for lung infection (notably, tuberculosis), lung cancer, emphysema, autoimmune diseases, a...

Prevention of crystalline silica-induced inflammation by the anti-malarial hydroxychlor...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813911
Inhalation Toxicology; Burmeister R, Rhoderick JF et. al.

Sep 26th, 2019 - Objectives: Inhalation of crystalline silica (cSiO2) remains a significant occupational hazard and may lead to the development of silicosis. When cSiO2 particles are phagocytized by alveolar macrophages, they cause disruption of the lysosomal membrane which results in cell death. There are currently no pharmaceutical treatments directed at this mechanism of disease; however, many existing pharm...

Does exposure to bentonite dust during tunnel hyperbaric interventions increase health ...
https://www.ncbi.nlm.nih.gov/pubmed/31509901
Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc; O'Neill OJ, Costello J et. al.

Sep 11th, 2019 - The mining and tunneling industries are historically associated with hazardous exposures that result in significant occupational health concerns. Occupational respiratory exposures causing pneumoconiosis and silicosis are of great concern, silicosis being non-curable. This work demonstrates that compressed-air workers (CAWs) performing tunnel hyperbaric interventions (HIs) may be at risk for ha...

Silicosis in rhinestone-manufacturing workers in South China.
https://doi.org/10.1093/occmed/kqz107
Occupational Medicine (Oxford, England); Wen C, Wen X et. al.

Sep 10th, 2019 - Silicosis is caused by long-term exposure to silica dust. Crystal rhinestone workers can be exposed to high levels of silica dust and are at risk of silicosis. To explore silicosis cases, silica dust exposure and control measures in a rhinestone factory in South China. We extracted and analysed data on new silicosis cases reported to China's occupational disease and occupational health informat...

Targeting Mechanics-Induced Fibroblast Activation through CD44-RhoA-YAP Pathway Amelior...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691376
Theranostics Li S, Li C et. al.

Aug 14th, 2019 - Silicosis is pneumoconiosis of the lung, usually resulting from prolonged exposure to crystalline silica (CS). The hallmark of silicosis is excessive extracellular matrix (ECM) deposition produced by activated fibroblasts. Recent work demonstrated that excessive ECM-forming mechanical cues play an essential role in promoting fibroblast activation and perpetuating fibrotic pathologies. However, ...

Bronchoalveolar cell differential count and the number of asbestos bodies correlate wit...
https://doi.org/10.1136/oemed-2018-105606
Occupational and Environmental Medicine; Keskitalo E, Varis L et. al.

Jul 24th, 2019 - To determine cell differential counts and the number of asbestos bodies (ABs) in bronchoalveolar lavage (BAL) fluid obtained from patients with asbestosis, and to correlate the results with their survival. The BAL cell differential counts and ABs from 91 patients with asbestosis were determined. The BAL cell differential counts were analysed in relation to smoking status. BAL cell differential ...

CD3+, CD4+, and CD8+ Expression in Cells in Peripheral Blood of Silicosis Patients and ...
https://www.ncbi.nlm.nih.gov/pubmed/31308037
Annals of Clinical and Laboratory Science; Xiong W, Liu ZG et. al.

Jul 16th, 2019 - This study aims to investigate the changes in CD3+, CD4+ and CD8+ expression in cells in peripheral blood of silicosis patients, and observe the immunoregulatory effect of thymalfasin. A total of 80 silicosis patients were enrolled in the study, randomly divided into two groups: treatment group and control group (n=40, each group). In addition, 40 healthy adults, who underwent physical examinat...

The natural course of lung function decline in asbestos exposed subjects with pleural p...
https://doi.org/10.1016/j.rmed.2019.06.013
Respiratory Medicine; Barnikel M, Million PM et. al.

Jun 21st, 2019 - While there is a good knowledge of the natural course of lung function in interstitial lung diseases (ILD) like idiopathic lung fibrosis (IPF), many ambiguities remain in patients with asbestosis. Therefore, we evaluated the change in lung function in asbestos exposed subjects with pleural plaques and asbestosis and analysed corresponding morphology of computer tomography of the thorax. 93 asbe...

Silicotuberculosis as an occupational infection: rate, risk factors and control strateg...
https://doi.org/10.1080/19338244.2019.1619505
Archives of Environmental & Occupational Health; Ghasemian A, Nojoomi F et. al.

Jun 16th, 2019 - Silicotuberculosis is critical in the community places among workers and employees exposing to silica dust. Older age of entry (>30 years), male sex, infection with HIV, exposure duration, smoking, chronic obstructive pulmonary disease, migration, the severity of the silicosis, and the intensity of the exposure are potential risk factors. Lack of on time diagnosis and treatment for tuberculosis...

Characterizing environmental asthma triggers and healthcare use patterns in Puerto Rico.
https://doi.org/10.1080/02770903.2019.1612907
The Journal of Asthma : Official Journal of the Association for the Care of Asthma; Lewis LM, Mirabelli MC et. al.

Jun 11th, 2019 - Objective: Asthma carries a high burden of disease for residents of Puerto Rico. We conducted this study to better understand asthma-related healthcare use and to examine potential asthma triggers. Methods: We characterized asthma-related healthcare use in 2013 by demographics, region, and date using outpatient, hospital, and emergency department (ED) insurance claims with a primary diagnostic ...

Chronic Silicosis with Progressive Massive Fibrosis.
https://doi.org/10.1056/NEJMicm1809675
The New England Journal of Medicine; Riley L, Urbine D

Jun 5th, 2019 - Chronic Silicosis with Progressive Massive Fibrosis.|2019|Riley L,Urbine D,|etiology,diagnostic imaging,complications,diagnostic imaging,complications,diagnostic imaging,

Silicosis and pulmonary tuberculosis in deceased female South African miners.
https://doi.org/10.1093/occmed/kqz067
Occupational Medicine (Oxford, England); Ndlovu N, Richards G et. al.

May 23rd, 2019 - Implementation of South Africa's 2002 Mining Charter increased women's participation in underground mining. However, occupational lung diseases (OLDs) in female gold miners have not been studied. To compare autopsy-diagnosed pulmonary silicosis, lymph gland silicosis (a precursor of pulmonary silicosis) and active pulmonary tuberculosis (PTB) in South African gold miners. The law allows for aut...

Crystalline silica activates the T-cell and the B-cell antigen receptor complexes and i...
https://doi.org/10.1080/08916934.2019.1614171
Autoimmunity Eleftheriadis T, Pissas G et. al.

May 23rd, 2019 - Silicosis is an occupational fibrotic lung disease, which is associated with an increased incidence of autoimmune diseases. The effect of crystalline silica on the immune system is thought to be mediated by the antigen presenting cells. However, the direct effect of silica on T-cells and B-cells has not been evaluated adequately. For this purpose, CD4(+)T-cells and B-cells from 10 healthy indiv...

Beyond silicosis, is the world failing on silica hazards?
https://doi.org/10.1016/S2213-2600(19)30174-2
The Lancet. Respiratory Medicine; Cavalin C, Lescoat A et. al.

May 21st, 2019 - Beyond silicosis, is the world failing on silica hazards?|2019|Cavalin C,Lescoat A,Ballerie A,Belhomme N,Jégo P,|

Radiological progression and lung function decrements among silica-exposed ceramic work...
https://doi.org/10.1080/08958378.2019.1613459
Inhalation Toxicology; Karataş M, Gündüzöz M et. al.

May 10th, 2019 - Objectives: This follow-up study set out to evaluate the natural course and radiographic progression of silicosis among ceramic workers and describe the risk factors related with disease progression. Materials and methods: We retrospectively analyzed the data of ceramic workers with silicosis who were referred to our hospital between February 2010 and March 2018. A total of 165 ceramic workers ...

Dioscin Alleviates Crystalline Silica-Induced Pulmonary Inflammation and Fibrosis throu...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485284
Theranostics Du S, Li C et. al.

Apr 30th, 2019 - Occupational exposure to crystalline silica (CS) particles leads to silicosis, which is characterized by chronic inflammation and abnormal tissue repair. Alveolar macrophages (AMs) play a crucial role in the process of silicosis. Previously, we demonstrated positive effect of dioscin on silicosis through modulating macrophage-elicited innate immune response. However, the concrete molecular mech...

Continued increase in prevalence of r-type opacities among underground coal miners in t...
https://doi.org/10.1136/oemed-2019-105691
Occupational and Environmental Medicine; Hall NB, Blackley DJ et. al.

Apr 26th, 2019 - Respirable crystalline silica exposure has been implicated in the resurgence of coal workers' pneumoconiosis (CWP) in the USA. A 2010 report found an increasing prevalence of r-type opacities, which are associated with silicosis lung pathology, on the radiographs of working underground coal miners in central Appalachia. This analysis updates that report by assessing the prevalence of r-type opa...

Synthetic secoisolariciresinol diglucoside (LGM2605) inhibits Libby amphibole fiber-ind...
https://doi.org/10.1016/j.taap.2019.04.018
Toxicology and Applied Pharmacology; Christofidou-Solomidou M, Pietrofesa RA et. al.

Apr 25th, 2019 - Exposure to the Libby Amphibole (LA) asbestos-like fibers found in Libby, Montana, is associated with inflammatory responses in mice and humans, and an increased risk of developing mesothelioma, asbestosis, pleural disease, and systemic autoimmune disease. Flaxseed-derived secoisolariciresinol diglucoside (SDG) has anti-inflammatory, anti-fibrotic, and antioxidant properties. We have previously...

Accelerated Silicosis-An Emerging Epidemic Associated with Engineered Stone. Comment on...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480259
International Journal of Environmental Research and Public Health; Edwards G

Apr 16th, 2019 - The systematic review by Leso et al. (16 February 2019) is a timely contribution to the body of knowledge concerning silicosis. It highlights the lack of quality data necessary to inform both occupational health risk management and the clinical management of workers exposed to respirable crystalline silica. This communication highlights current activity being undertaken in Queensland, Australia...

Reply to Accelerated Silicosis-An Emerging Epidemic Associated with Engineered Stone. C...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526474
International Journal of Environmental Research and Public Health; Leso V, Fontana L et. al.

Apr 16th, 2019 - China is world's largest market of machine-made cigarettes. In 2015, more than 315 million or around 26.9% of the adult population in China were smokers-50.6% among men and 2.2% among women. Growing affordability of cigarettes led to increased cigarette consumption in China to the detriment of public health. This study investigated whether the level and growth in cigarette affordability in Chin...

Asbestosis Imaging 
https://emedicine.medscape.com/article/352900-overview

Apr 10th, 2019 - Practice Essentials Pneumoconiosis is a lung disease that is caused by the inhalation and deposition of mineral dust, with asbestosis being a form of pneumoconiosis that is specifically caused by inhalation of asbestos fibers. Asbestos is the generic term used for the group of fibrous mineral silicates of magnesium and iron whose chemical and physical properties make it ideal for a variety of c...

Asbestosis Imaging 
https://emedicine.medscape.com/article/352900-print

Apr 10th, 2019 - Pneumoconiosis is a lung disease that is caused by the inhalation and deposition of mineral dust, with asbestosis being a form of pneumoconiosis that is specifically caused by inhalation of asbestos fibers. Asbestos is the generic term used for the group of fibrous mineral silicates of magnesium and iron whose chemical and physical properties make it ideal for a variety of commercial and indust...

CircRNA-012091/PPP1R13B-mediated Lung Fibrotic Response in Silicosis via Endoplasmic Re...
https://doi.org/10.1165/rcmb.2019-0017OC
American Journal of Respiratory Cell and Molecular Biology; Cheng Y, Luo W et. al.

Mar 25th, 2019 - Silicosis is a progressive fibrotic disease of lung tissue caused by long-term inhalation of SiO2. However, relatively few studies of the direct effects of SiO2 on lung fibroblasts have been performed. PPP1R13B is a major member of the apoptosis-stimulating proteins of the p53 family, but its role in pulmonary fibrosis is unclear. To elucidate the role of PPP1R13B in the pathological process of...

The world is failing on silicosis.
https://doi.org/10.1016/S2213-2600(19)30078-5
The Lancet. Respiratory Medicine; The Lancet Respiratory Medicine

Mar 15th, 2019 - The world is failing on silicosis.|2019|The Lancet Respiratory Medicine ,|

Female workers' silicosis diagnosis delayed due to gender bias.
https://doi.org/10.1093/occmed/kqz019
Occupational Medicine (Oxford, England); Kerget B, Araz O et. al.

Mar 14th, 2019 - After excluding alternative explanations, a silicosis diagnosis is based on the combination of appropriate silica exposure history and compatible clinical, radiological and occasionally pathological findings. Not taking appropriate occupational history by a physician may cause a misdiagnosis or underdiagnosis of silicosis. Herein, we present a female worker in a small-scale sandblasting factory...

Australia reports on audit of silicosis for stonecutters.
https://doi.org/10.1016/S0140-6736(19)30478-7
Lancet (London, England); Kirby T

Mar 6th, 2019 - Australia reports on audit of silicosis for stonecutters.|2019|Kirby T,|

Hypersensitivity pneumonitis: A new strategy for serodiagnosis and environmental surveys.
https://doi.org/10.1016/j.rmed.2019.02.019
Respiratory Medicine; Bellanger AP, Reboux G et. al.

Mar 4th, 2019 - We propose a strategy for serodiagnosis of hypersensitivity pneumonitis (HP): 1) question patients about their private or occupational activity, or visit him on site; 2) select panels of six somatic specific antigens appropriate for each type of exposure; 3) and use ELISA to test concomitantly two recombinant antigens highly specific to Farmer's lung, Metalworking-fluid HP, and for Bird fancier...

Ac-SDKP increases α-TAT 1 and promotes the apoptosis in lung fibroblasts and epithelial...
https://doi.org/10.1016/j.taap.2019.02.015
Toxicology and Applied Pharmacology; Shifeng L, Hong X et. al.

Mar 3rd, 2019 - Crystalline silica (SiO2) particles have very strong toxicity to the lungs, and silicosis is an excessive pulmonary interstitial remodeling disease that follows persistent SiO2 injury. We showed here that DNA double strand breaks (DSBs) and apoptosis were aggravated during rat silicosis induced by SiO2 exposure. Ac-SDKP attenuates lung parenchymal distortion and collagen deposition, and decreas...

Carvedilol attenuates experimentally induced silicosis in rats via modulation of P-AKT/...
https://doi.org/10.1016/j.intimp.2019.02.011
International Immunopharmacology; Helal MG, Said E

Feb 20th, 2019 - Silicosis is a well acknowledged occupational lung disorder with considerable negative impact on the patients' quality of life. Various signaling pathways have been reported to interplay in the pathogenesis of pulmonary fibro-proliferative disorders; of which, P-AKT/mTOR signaling pathway. The current study highlights the potential pulmonary protective effect of carvedilol; a non-selective α/β ...

Artificial Stone Associated Silicosis: A Systematic Review.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406954
International Journal of Environmental Research and Public Health; Leso V, Fontana L et. al.

Feb 19th, 2019 - Silicosis is a progressive fibrotic lung disease that is caused by the inhalation of respirable crystalline silica. Due to its high silica content, artificial stone (AS) can become a possible source of hazardous dust exposure for workers that are employed in the manufacturing, finishing, and installing of AS countertops. Therefore, the aim of this review was to verify the association between AS...

Interstitial Lung Diseases in Developing Countries.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052338
Annals of Global Health; Rivera-Ortega P, Molina-Molina M

Feb 11th, 2019 - More than 100 different conditions are grouped under the term interstitial lung disease (ILD). A diagnosis of an ILD primarily relies on a combination of clinical, radiological, and pathological criteria, which should be evaluated by a multidisciplinary team of specialists. Multiple factors, such as environmental and occupational exposures, infections, drugs, radiation, and genetic predispositi...

Aluminum in the lungs of Ontario hardrock miners.
https://doi.org/10.1080/19338244.2019.1574703
Archives of Environmental & Occupational Health; Verma DK

Feb 11th, 2019 - The objective of this study was to determine the concentration of aluminum in the autopsied lungs of eight hardrock miners. These miners had inhaled McIntyre Powder (a mixture of aluminum and aluminum oxide) as a prophylaxis against silicosis. The study involved chemical analysis of lungs, where each whole lung was divided horizontally into three sections and analyzed by atomic absorption spect...

Characteristics and Trends of Pneumoconiosis in the Jiangsu Province, China, 2006⁻2017.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388371
International Journal of Environmental Research and Public Health; Han L, Yao W et. al.

Feb 5th, 2019 - This study aims to describe the characteristics and trends of pneumoconiosis in the Jiangsu Province, China, and provide information for the occupational diseases control. We collected and analyzed the data of pneumoconiosis cases reported annually from 2006 to 2017. The information of the cases mainly includes case distributions, clinical types and stages, enterprise types and scales, as well ...

Functional variant of the carboxypeptidase M (CPM) gene may affect silica-related pneum...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581105
Occupational and Environmental Medicine; Chu M, Wu S et. al.

Jan 24th, 2019 - In a genome-wide association study, we discovered chromosome 12q15 (defined as rs73329476) as a silica-related pneumoconiosis susceptibility region. However, the causal variants in this region have not yet been reported. We systematically screened eight potentially functional single-neucleotide polymorphism (SNPs) in the genes near rs73329476 (carboxypeptidase M (CPM) and cleavage and polyadeny...

Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio as haematological indic...
https://doi.org/10.1111/crj.12997
The Clinical Respiratory Journal; Karataş M, Gündüzöz M et. al.

Jan 21st, 2019 - Occupational exposure to crystalline silica over time may result in silicosis: a fatal, irreversible occupational disease leading to lung function impairment. A complex inflammatory process, excessive accumulation of mesenchymal cells and collagen production are the primary mechanisms underlying silicosis. Neutrophil to lymphocyte ratio (NLR) and the platelet to lymphocyte ratio (PLR) have emer...

Aberrant expression of miR-125a-3p promotes fibroblast activation via Fyn/STAT3 pathway...
https://doi.org/10.1016/j.tox.2019.01.007
Toxicology Xu Q, Liu Y et. al.

Jan 18th, 2019 - Various miRNAs are dysregulated during initiation and progression of pulmonary fibrosis. However, their function remains limited in silicosis. Here, we observed that miR-125a-3p was downregulated in silica-induced fibrotic murine lung tissues. Ectopic miR-125a-3p expression with chemotherapy attenuated silica-induced pulmonary fibrosis. Further in vitro experiments revealed that TGF-β1 effectiv...

Silicosis prevalence and incidence among Medicare beneficiaries.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492239
American Journal of Industrial Medicine; Casey ML, Mazurek JM

Jan 18th, 2019 - Existing epidemiologic information on silicosis relies on mortality data. We analyzed health insurance claims and enrollment information from 49 923 987 fee-for-service (FFS) Medicare beneficiaries aged ≥65 from 1999 to 2014. Three different definitions were developed to identify silicosis cases and results are presented as ranges of values for the three definitions. Among FFS beneficiaries, 10...

Exposure to Respirable Crystalline Silica in the GB Brick Manufacturing and Stone Worki...
https://doi.org/10.1093/annweh/wxy103
Annals of Work Exposures and Health; Baldwin PEJ, Yates T et. al.

Jan 9th, 2019 - The aim of this work was to benchmark respirable crystalline silica (RCS) exposures in brick manufacturing and stone working sectors in Great Britain. This will contribute to a larger programme of work, which will be used to better understand the role of health surveillance in preventing the development of further cases of silicosis and chronic obstructive pulmonary disease. This work was under...

Severe Silicosis in Engineered Stone Fabrication Workers — California, Colorado, Texas, and Washington, 2017–2019
https://WWW.CDC.GOV/mmwr/volumes/68/wr/mm6838a1.htm?s_cid=mm6838a1_w

Dec 31st, 2018 - Eighteen cases of silicosis among workers in the stone fabrication industry are reported in California, Colorado, Texas, and Washington.

Severe Silicosis in Engineered Stone Fabrication Workers — California, Colorado, Texas, and Washington, 2017–2019
https://www.cdc.gov/mmwr/volumes/68/wr/mm6838a1.htm?s_cid=mm6838a1_w

Dec 31st, 2018 - Eighteen cases of silicosis among workers in the stone fabrication industry are reported in California, Colorado, Texas, and Washington.

Metachronous Pulmonary Neoplasms in Lung Transplantation-When They Arise in the Donor L...
https://doi.org/10.1016/j.transproceed.2018.08.051
Transplantation Proceedings; Rodrigues D, Borro JM et. al.

Dec 23rd, 2018 - Lung cancer (LC) is uncommon among lung transplant recipients, being most often described in the native lung of single-lung transplant recipients. Its appearance in the transplanted lung is a very uncommon phenomenon, in which donor and recipient factors appear to be involved. We present a case of 2 distinct metachronous lung neoplasms diagnosed in the transplanted lung of a non-smoker patient ...

Evaluation of the Bioavailability and Translocation of Selected Heavy Metals by Brassic...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313626
International Journal of Environmental Research and Public Health; Mashau AS, Gitari MW et. al.

Dec 15th, 2018 - This study evaluated the physicochemical and mineralogical properties, mobile chemical species bioavailability and translocation in Brassica juncea and Spinacea oleracea L. plants of a South African coal-fired power utility. Coal-fly-ash (CFA) disposal is associated with various environmental and health risks, including air, soil, surface, and groundwater pollution due to the leaching of toxic ...

STING-dependent sensing of self-DNA drives silica-induced lung inflammation.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283886
Nature Communications; Benmerzoug S, Rose S et. al.

Dec 12th, 2018 - Silica particles induce lung inflammation and fibrosis. Here we show that stimulator of interferon genes (STING) is essential for silica-induced lung inflammation. In mice, silica induces lung cell death and self-dsDNA release in the bronchoalveolar space that activates STING pathway. Degradation of extracellular self-dsDNA by DNase I inhibits silica-induced STING activation and the downstream ...

Outcomes after lung transplantation for patients with occupational lung diseases.
https://doi.org/10.1111/ctr.13460
Clinical Transplantation; Joubert KD, Awori Hayanga J et. al.

Dec 6th, 2018 - Occupational lung diseases (OLD) including silicosis, asbestosis, and pneumoconiosis progress to end stage lung disease requiring lung transplantation (LT). Prognosis and treatment of OLDs are poorly understood and a paucity of data exists regarding LT outcomes. Additionally, transplant operative complexity for patients with OLD is high. A single center retrospective review of all single and bi...

Multiorgan accelerated silicosis misdiagnosed as sarcoidosis in two workers exposed to ...
https://doi.org/10.1136/oemed-2018-105462
Occupational and Environmental Medicine; Guarnieri G, Bizzotto R et. al.

Dec 5th, 2018 - Clusters of silicosis cases have been reported in the fabrication of quartz conglomerate, a new high-silica-content artificial stone for kitchen and bathroom benchtops (countertops). We describe two cases of accelerated-type silicosis with hepatic granulomas arising in workers exposed to artificial quartz conglomerates. A confident diagnosis of multiorgan silicosis was based on high level of re...

Focusing on Coal Workers' Lung Diseases: A Comparative Analysis of China, Australia, an...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266950
International Journal of Environmental Research and Public Health; Han S, Chen H et. al.

Nov 20th, 2018 - China has high and increasing annual rates of occupational lung diseases such as pneumoconiosis and silicosis. In contrast, Australia and the United States of America (USA) have greatly lowered their annual rates of lung diseases since the 1970s. This paper systematically compared and analysed the multi-elements of coal dust management and health management in these three countries to provide a...

Role of SOD3 in silica-related lung fibrosis and pulmonary vascular remodeling.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245633
Respiratory Research; Zelko IN, Zhu J et. al.

Nov 20th, 2018 - Work-place exposure to silica dust may lead to progressive lung inflammation culminating in the development of silicosis, an irreversible condition that can be complicated by onset of pulmonary hypertension (PH). The molecular mechanisms leading to the development of PH and lung fibrosis in response to silica are not well understood. Oxidant/antioxidant imbalance in the lung may promote fibropr...

Epidemiology of silicosis: reports from the SWORD scheme in the UK from 1996 to 2017.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327866
Occupational and Environmental Medicine; Barber CM, Fishwick D et. al.

Nov 11th, 2018 - To document the demographic risk factors of workers reported to have silicosis in the UK. All cases of silicosis reported to the Surveillance of Work-related and Occupational Respiratory Disease (SWORD) scheme between January 1996 and December 2017 were classified into one of eight industry categories, and one of five age groups. In addition, to investigate whether there had been any temporal c...

Monsanto, PCBs, and the creation of a "world-wide ecological problem".
https://doi.org/10.1057/s41271-018-0146-8
Journal of Public Health Policy; Markowitz G, Rosner D

Nov 7th, 2018 - For the past three decades, we have written on the history of occupational and environmental health, authoring books and articles on lead poisoning, silicosis, asbestosis, and angiosarcoma of the liver, among other diseases. One book, Deceit and Denial, focused specifically on the chemical and lead industries. Because of the rarity of historians who study this history, we have been asked to tes...

Linkage to Care, Antiretroviral Treatment Initiation, and Viral Suppression of Acute HI...
https://doi.org/10.1016/j.annemergmed.2018.07.001
Annals of Emergency Medicine; , Negoita S et. al.

Oct 21st, 2018 - To investigate the influence of the anti-tumor necrosis factor-α infliximab (IFX) in the case of rats with silicosis. Forty-eight Wistar rats were randomly divided into 3 groups. The study group (N = 16) - silicosis was induced by intratracheal instillation of 50 mg silica on day 1, and IFX was subcutaneously administered at a dose of 15 mg/kg of body weight from day 2 to day 6, the vehicle gro...

Children With Asthma in New Orleans After Hurricane Katrina
https://clinicaltrials.gov/ct2/show/NCT00426634

Oct 8th, 2018 - This document presents the protocol for conducting the Head-off Environmental Asthma in Louisiana (HEAL) study in New Orleans, Louisiana. The goal of the HEAL study is to implement and test an Asthma Counselor (AC) intervention program that addresses the multidimensional impact of hurricane Katrina on children with asthma in New Orleans. HEAL is a prospective, controlled trial in which children...

Computed tomography findings of arc-welders' pneumoconiosis: Comparison with silicosis.
https://doi.org/10.1016/j.ejrad.2018.08.020
European Journal of Radiology; Takahashi M, Nitta N et. al.

Oct 7th, 2018 - Arc-welders' pneumoconiosis (AWP) is a less fibrogenic pneumoconiosis with radiographic shadows that can improve after isolation from dusty environments. Therefore, early diagnosis is important. However, the exact role of chest radiograph and computed tomography (CT) for diagnosing AWP is not fully understood. This study was performed to assess the CT appearance of AWP using semi-quantitative m...

Association between tumor necrosis factor-α -308 Gauss/A polymorphism and risk of silic...
https://doi.org/10.1080/08958378.2018.1494766
Inhalation Toxicology; Yang LT, Liu X et. al.

Sep 26th, 2018 - Many studies have attempted to clarify the association between TNF-a -308G/A polymorphism and pneumoconiosis, but there has been no definite consensus to date. To further assess the effects of TNF-a -308G/A polymorphism on the risk of pneumoconiosis, a meta-analysis was performed in Chinese population. We searched the related literature in PubMed and Chinese databases through June 2018. The str...

Subradiological silicosis.
https://doi.org/10.1002/ajim.22909
American Journal of Industrial Medicine; Ehrlich R, Murray J et. al.

Sep 21st, 2018 - The purpose of this commentary is to bring the neglected phenomenon of subradiological silicosis and its implications to the attention of readers. We define subradiological silicosis as silicosis detectable on pathological examination of lung tissue but not visible radiologically. For extent of the phenomenon, we draw on a study using a large South African autopsy database of deceased miners an...

Nicorandil ameliorates pulmonary inflammation and fibrosis in a rat model of silicosis.
https://doi.org/10.1016/j.intimp.2018.09.017
International Immunopharmacology; El-Kashef DH

Sep 17th, 2018 - Nicorandil, an antianginal and potassium channel opener agent, has different useful impacts on cardiovascular and respiratory systems. Its effect against silicosis has not been discussed yet, therefore, this is an attempt to decide whether nicorandil can reduce silica-induced lung injury in rats. Silica model was induced by intranasal instillation of silica dust once. Rats were given nicorandil...

Silica Exposure, Silicosis, and the New Occupational Safety and Health Administration S...
https://doi.org/10.1513/AnnalsATS.201809-589ED
Annals of the American Thoracic Society; Deslauriers JR, Redlich CA

Sep 13th, 2018 - Silica Exposure, Silicosis, and the New Occupational Safety and Health Administration Silica Standard. What Pulmonologists Need to Know.|2018|Deslauriers JR,Redlich CA,|

It's Not JUST Idiopathic Pulmonary Fibrosis Study
https://clinicaltrials.gov/ct2/show/NCT03670576

Sep 12th, 2018 - The overall aims of this study are Identify biomarkers and gene expression profiles that determine progressive fibrotic lung disease regardless of aetiology To prospectively assess biomarkers which predict progressive fibrosis in patients with fibrosing lung disease of alternate aetiology, including RA-UIP, Asbestosis, Chronic Hypersensitivity Pneumonitis and Unclassifiable fibrotic lung diseas...

The CDR1as/miR-7/TGFBR2 Axis Modulates EMT in Silica-Induced Pulmonary Fibrosis.
https://doi.org/10.1093/toxsci/kfy221
Toxicological Sciences : an Official Journal of the Society of Toxicology; Yao W, Li Y et. al.

Sep 11th, 2018 - Silicosis is one of the typical forms of pneumoconiosis characterized by abnormal proliferation of fibroblasts and deposition of extracellular matrix. Recent findings have shown that microRNAs and circular RNAs (circRNAs) are implicated in many diseases. However, the function of noncoding RNAs in pulmonary fibrosis remain to be elucidated. Here, miR-7 was found significantly decreased in silica...

The Burden of Silicosis in Michigan: 1988-2016.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787555
Annals of the American Thoracic Society; Reilly MJ, Timmer SJ et. al.

Sep 6th, 2018 - Exposure to respirable crystalline silica causes silicosis, a preventable, progressive occupational lung disease. A more rigorous occupational health standard for silica could help protect silica-exposed workers. To describe trends over 29 years of silicosis surveillance in Michigan. Michigan law requires the reporting of silicosis. We confirmed the diagnosis of silicosis in reported cases usin...

Time trends and future prediction of coal worker's pneumoconiosis in opencast coal mine...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092848
BMC Public Health; Li Y, Xian W et. al.

Aug 15th, 2018 - The opencast coal mine is a specific mine differing from the underground mine. There are differences in the way into the ore body, the organization of production, transport technology and other aspects. This study aimed to describe the prevalence of CWP among ex-dust miners in opencast coal mines and estimate the incidence trend of CWP by APC model in the future. All opencast miners who had bee...

Regulatory role of heme oxygenase-1 in silica-induced lung injury.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090697
Respiratory Research; Nakashima K, Sato T et. al.

Aug 2nd, 2018 - Silicosis, a progressive inflammatory lung disease attributed mainly to occupational exposure to silica dust, shows loss of lung function even after cessation of exposure. In addition to conventional evaluation methods such as chest X-ray, computed tomography, and spirometry, we identified heme oxygenase (HO)-1, an inducible antioxidant, as a potential biomarker to identify at-risk patients. We...

A case of accelerated silicosis.
https://doi.org/10.1093/occmed/kqy106
Occupational Medicine (Oxford, England); Nakládalová M, Štepánek L et. al.

Jul 27th, 2018 - Silicosis, caused by inhaling dust containing free crystalline silica, typically has a chronic course, with the numbers of silicosis patients declining globally. Much rarer are the acute and subacute forms. Presented is a case of severe subacute (accelerated) silicosis. The condition resulted from ~2 years of very intense exposure without appropriate personal protective equipment while sandblas...

A Study on Pneumoconiosis Treated With Whole-lung Lavage Combined With Mesenchymal Stem Cells
https://clinicaltrials.gov/ct2/show/NCT02668068

Jul 17th, 2018 - Pneumoconiosis is a kind of lung disease due to inhalation of dust such as silica(common named Silicosis), coal and rock dust, characterized by inflammation, coughing, and fibrosis. Currently there is no effective drug treatment. The whole-lung lavage(WLL) can effectively clear the protein-like substances and inhaled dust deposited in the alveoli and bronchioles, as well as the pulmonary alveol...

Regulation of TLR4 in silica-induced inflammation: An underlying mechanism of silicosis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036162
International Journal of Medical Sciences; Chan JYW, Tsui JCC et. al.

Jul 17th, 2018 - Silicosis is an incurable lung disease affecting millions of workers in hazardous occupations. It is caused by chronic exposure to the dust that contains free crystalline silica. Silica-induced lung damage occurs by several main mechanisms including cell death by apoptosis, fibrosis and production of cytokines. However, the signal pathways involved in these mechanisms are not fully characterize...

Retrospective Assessment of Respirable Quartz Exposure for a Silicosis Study of the Ind...
https://doi.org/10.1093/annweh/wxy064
Annals of Work Exposures and Health; Rando RJ, Vacek PM et. al.

Jul 17th, 2018 - In 2016, the OSHA PEL for crystalline silica was reduced, renewing interest in evaluating risk of silicosis from occupational exposures. The industrial sand industry, which deals with high-purity quartz sands, is the setting for a current epidemiologic investigation of silicosis risk and progression. In support of that investigation, respirable quartz (RQ) exposures were retrospectively estimat...

Precarious transition: a mortality study of South African ex-miners.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042385
BMC Public Health; Bloch K, Johnson LF et. al.

Jul 12th, 2018 - Despite their burden of a triple epidemic of silicosis, tuberculosis and HIV infection, little is known about the mortality experience of miners from the South African mining industry once they leave employment. Such information is important because of the size and dispersion of this population across a number of countries and the progressive nature of these diseases. This study included 306,29...

Comprehensive Risk Assessment of People With Silicosis: A Population-based Study
https://clinicaltrials.gov/ct2/show/NCT02794701

Jul 5th, 2018 - Objectives: This study aims to explore the risk profiles among people with silicosis in Hong Kong underpinned by the Pittsburgh Mind-Body Center model. Design and subjects: This study will adopt a cross-sectional study design with sampling stratified by participants' degree of incapability. 320 Chinese people diagnosed with silicosis and registered with the Pneumoconiosis Compensation Fund Boar...

Pulmonary tuberculosis in a male with silicosis.
https://doi.org/10.5603/ARM.2018.0019
Advances in Respiratory Medicine; Skowroński M, Halicka A et. al.

Jun 30th, 2018 - Silicosis, a preventable occupational lung disease, is associated with various diseases, including tuberculosis (TB). There is an increased lifelong risk for lung tuberculosis even if exposure to silica dust ceases. That association contributes in a large extent to very high rates of tuberculosis in countries with poor TB and silica exposure control. We report a case of a male with a prior diag...

Measuring EMPs in the lung what can be measured in the lung: Asbestiform minerals and c...
https://doi.org/10.1016/j.taap.2018.06.026
Toxicology and Applied Pharmacology; Roggli VL

Jun 30th, 2018 - Asbestos mineral fibers have been associated with the development of a variety of diseases in humans and experimental animals, including asbestosis, lung cancer, and mesothelioma. Asbestos includes several mineral types divided into two mineral groups, serpentine and amphibole forms. Chrysotile is the serpentine mineral classified as asbestos, whereas the amphiboles include amosite, crocidolite...

Four decades of pulmonary tuberculosis in deceased South African miners: trends and det...
https://doi.org/10.1136/oemed-2017-104806
Occupational and Environmental Medicine; Ndlovu N, Musenge E et. al.

Jun 23rd, 2018 - We investigated trends and determinants of pulmonary tuberculosis (PTB) in deceased South African miners. Statutory autopsies are performed on miners for occupational lung disease compensation, irrespective of cause of death. Data were extracted from the PATHAUT (Pathology Automation System) autopsy database. PTB trends were analysed and explanatory variables (year of autopsy, age at death, gol...

A 47-Year-Old Man With Fever, Dry Cough, and a Lung Mass After Redo Lung Transplantation.
https://doi.org/10.1016/j.chest.2017.09.025
Chest Chaddha U, Patil PD et. al.

Jun 9th, 2018 - A 47-year-old man who was a redo double lung transplant recipient (cytomegalovirus [CMV] status: donor positive/recipient positive; Epstein-Barr virus status: donor positive/recipient positive) presented to the hospital with 1 week of generalized malaise, low-grade fevers, and dry cough. His redo lung transplantation was necessitated by bronchiolitis obliterans syndrome, and his previous lung t...

Bone formation transcripts dominate the differential gene expression profile in an equi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983561
PloS One; Zavodovskaya R, Stover SM et. al.

Jun 1st, 2018 - Osteoporosis has been associated with pulmonary silicosis in California horses exposed to soils rich in cytotoxic silica dioxide crystals, a syndrome termed silicate associated osteoporosis (SAO). The causal mechanism for the development of osteoporosis is unknown. Osteoporotic lesions are primarily located in bone marrow-rich sites such as ribs, scapula and pelvis. Gene transcription patterns ...

Therapeutic effects of adipose-tissue-derived mesenchymal stromal cells and their extra...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975461
Respiratory Research; Bandeira E, Oliveira H et. al.

May 30th, 2018 - Silicosis is an occupational disease that affects workers who inhale silica particles, leading to extensive lung fibrosis and ultimately causing respiratory failure. Mesenchymal stromal cells (MSCs) have been shown to exert therapeutic effects in lung diseases and represent an alternative treatment for silicosis. Recently, it has been suggested that similar effects can be achieved by the therap...