American Family Physician;
Oct 14th, 2019 - The incidence of pulmonary complications following major surgery is estimated to be 1% to 23%, with the risk varying based on patient factors and the type of surgery.1 Postoperative pulmonary complications include pneumonia, tracheobronchitis, pulmonary edema, pulmonary embolism, atelectasis, pleural effusion, pneumothorax, bronchospasm, aspiration, respiratory failure, and acute respiratory di...
American Family Physician;
Sep 30th, 2019 - Anticoagulation therapy is recommended for preventing, treating, and reducing the recurrence of venous thromboembolism, and preventing stroke in persons with atrial fibrillation. Direct oral anticoagulants are first-line agents for eligible patients for treating venous thromboembolism and preventing stroke in those with nonvalvular atrial fibrillation. Vitamin K antagonists are recommended for ...
Annals of Internal Medicine;
Sep 9th, 2019 - Background: Whether health outcomes of menopausal estrogen therapy differ between women with and without bilateral salpingo-oophorectomy (BSO) is unknown. Objective: To examine estrogen therapy outcomes by BSO status, with additional stratification by 10-year age groups. Design: Subgroup analyses of the randomized Women's Health Initiative Estrogen-Alone Trial. (ClinicalTrials.gov: NCT...
Aug 29th, 2019 - The European Society of Cardiology (ESC) released five separate guidelines covering dyslipidemias, supraventricular tachycardia, chronic coronary syndrome, acute pulmonary embolism, and diabetes as part of ESC Congress 2019 and published in the European Heart Journal.
The New England Journal of Medicine; van der Pol, L. et. al.
Mar 20th, 2019 - Pulmonary embolism is one of the leading causes of maternal death in the Western world. Because of the low specificity and sensitivity of the d-dimer test, all pregnant women with suspected pulmonary embolism undergo computed tomographic (CT) pulmonary angiography or ventilation–perfusion scanning, both of which involve radiation exposure to the mother and fetus. Whether a pregnancy-adapted alg...
Heller, M.,et al
Nov 27th, 2018 - Thrombolysis, either catheter directed or systemic, is a treatment option in the management of patients with intermediate risk pulmonary embolism and a high likelihood of clinical deterioration. Each method of thrombolysis carries risks and benefits.
Apr 30th, 2017 - Pulmonary embolism (PE) remains a common and important clinical condition that cannot be accurately diagnosed on the basis of signs, symptoms, and history alone. The diagnosis of PE has been facilitated by technical advancements and multidetector CT pulmonary angiography, which is the major diagnostic modality currently used.
Apr 30th, 2017 - Perfusion lung imaging for diagnosing pulmonary embolism (PE) was introduced 50 y ago At that time, it offered a noninvasivealternative to pulmonary angiography in patients with a clinical suspicion of PE. Because there are many causes of diminished regional blood flow in the lungs, particularly redistribution of blood flow away from regions with lung disease, the subsequent introduction of rad.
Bradley E. Barth, Grzegorz Waligora
Mar 19th, 2017 - Based on multiple retrospective and one prospective study, it appears that age-adjusted D-dimer cut-off values (patient age in years x 10 = cut-off in ?g/L) in combination with a non-high clinical probability is safe and effective to essentially rule out pulmonary embolism in emergency department patients. Caution may be advised in patients over 75 years old, as these patients are more likely t.
Dec 31st, 2015 - Embolism from the heart or the thoracic aorta often leads to clinically significant morbidity and mortality due to transient ischemic attack, stroke or occlusion of peripheral arteries. Transthoracic and transesophageal echocardiography are the key diagnostic modalities for evaluation, diagnosis, and management of stroke, systemic and pulmonary embolism.
Ali S. Raja
Nov 2nd, 2015 - Pulmonary embolism (PE) can be a severe disease and is difficult to diagnose, given its nonspecific signs and symptoms. Because of this, testing patients with suspected acute PE has increased dramatically.
Christopher M. Bono
Nov 30th, 2009 - The objective of the North American Spine Society (NASS) Evidence-Based Clinical Guideline on Antithrombotic Therapies in Spine Surgery is to provide evidence-based recommendations to address key clinical questions surrounding the use of antithrombotic therapies in spine surgery. The guideline is intended to address these questions based on the highest quality clinical literature available on t.
Annals of Internal Medicine; Raja AS, Greenberg JO et. al.
Sep 28th, 2015 - Pulmonary embolism (PE) can be a severe disease and is difficult to diagnose, given its nonspecific signs and symptoms. Because of this, testing patients with suspected acute PE has increased dramatically. However, the overuse of some tests, particularly computed tomography (CT) and plasma d-dimer measurement, may not improve care while potentially leading to patient harm and unnecessary expens...
European Heart Journal; Konstantinides SV, Torbicki A et. al.
Aug 31st, 2014 - 2014 ESC guidelines on the diagnosis and management of acute pulmonary embolism.|2014|Konstantinides SV,Torbicki A,Agnelli G,Danchin N,Fitzmaurice D,|administration & dosage,metabolism,methods,methods,methods,methods,metabolism,therapeutic use,drug therapy,diagnosis,therapy,complications,diagnosis,therapy,diagnosis,etiology,therapy,therapeutic use,therapeutic use,antagonists & inhibitors,
Chest Linkins LA, Dans AL et. al.
Feb 14th, 2012 - Heparin-induced thrombocytopenia (HIT) is an antibody-mediated adverse drug reaction that can lead to devastating thromboembolic complications, including pulmonary embolism, ischemic limb necrosis necessitating limb amputation, acute myocardial infarction, and stroke. The methods of this guideline follow the Methodology for the Development of Antithrombotic Therapy and Prevention of Thrombosis ...
Chest Kearon C, Akl EA et. al.
Feb 14th, 2012 - This article addresses the treatment of VTE disease. We generated strong (Grade 1) and weak (Grade 2) recommendations based on high-quality (Grade A), moderate-quality (Grade B), and low-quality (Grade C) evidence. For acute DVT or pulmonary embolism (PE), we recommend initial parenteral anticoagulant therapy (Grade 1B) or anticoagulation with rivaroxaban. We suggest low-molecular-weight hepari...
Chest Falck-Ytter Y, Francis CW et. al.
Feb 14th, 2012 - VTE is a serious, but decreasing complication following major orthopedic surgery. This guideline focuses on optimal prophylaxis to reduce postoperative pulmonary embolism and DVT. The methods of this guideline follow those described in Methodology for the Development of Antithrombotic Therapy and Prevention of Thrombosis Guidelines: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: A...
Obstetrics and Gynecology; James A,
Aug 23rd, 2011 - Pregnant women have a fourfold to fivefold increased risk of thromboembolism compared with nonpregnant women (1, 2). Approximately 80% of thromboembolic events in pregnancy are venous (3), with a prevalence of 0.5–2.0 per 1,000 pregnant women (4–9). Venous thromboembolism, including pulmonary embolism, accounts for 1.1 deaths per 100,000 deliveries (3), or 9 % of all maternal deaths in the Unit...
Circulation Jaff MR, McMurtry MS et. al.
Mar 22nd, 2011 - Venous thromboembolism (VTE) is responsible for the hospitalization of >250 000 Americans annually and represents a significant risk for morbidity and mortality. Despite the publication of evidence-based clinical practice guidelines to aid in the management of VTE in its acute and chronic forms, the clinician is frequently confronted with manifestations of VTE for which data are sparse and opti...
Obstetrics and Gynecology; Chen MM, Coakley FV et. al.
Aug 1st, 2008 - There has been a substantial increase in the use of computed tomography (CT) and magnetic resonance imaging (MRI) in pregnancy and lactation. Among some physicians and patients, however, there are misperceptions regarding risks, safety, and appropriate use of these modalities in pregnancy. We have developed a set of evidence-based guidelines for the use of CT, MRI, and contrast media during pre...
Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis; Rivera-Lebron B, McDaniel M et. al.
Jun 12th, 2019 - Pulmonary embolism (PE) is a life-threatening condition and a leading cause of morbidity and mortality. There have been many advances in the field of PE in the last few years, requiring a careful assessment of their impact on patient care. However, variations in recommendations by different clinical guidelines, as well as lack of robust clinical trials, make clinical decisions challenging. The ...
Journal of the American College of Radiology : JACR; , Hanley M et. al.
Nov 5th, 2018 - Suspected lower extremity deep venous thrombosis is a common clinical scenario which providers seek a reliable test to guide management. The importance of confidently making this diagnosis lies in the 50% to 60% risk of pulmonary embolism with untreated deep vein thrombosis and subsequent mortality of 25% to 30%, balanced with the risks of anticoagulation. The ACR Appropriateness Criteria Exper...
Neurosurgery Raksin PB, Harrop JS et. al.
Sep 11th, 2018 - Does routine screening for deep venous thrombosis prevent pulmonary embolism (or venous thromboembolism (VTE)-associated morbidity and mortality) in patients with thoracic and lumbar fractures? There is insufficient evidence to recommend for or against routine screening for deep venous thrombosis in preventing pulmonary embolism (or VTE-associated morbidity and mortality) in patients with thora...
Thorax Howard LSGE, Barden S et. al.
Jun 14th, 2018 - British Thoracic Society Guideline for the initial outpatient management of pulmonary embolism (PE).|2018|Howard LSGE,Barden S,Condliffe R,Connolly V,Davies CWH,|standards,adverse effects,therapeutic use,therapeutic use,chemically induced,complications,drug therapy,blood,complications,diagnostic imaging,drug therapy,therapeutic use,therapeutic use,therapeutic use,therapeutic use,complications,t...
Journal of Vascular and Interventional Radiology : JVIR; Kuo WT, Sista AK et. al.
Feb 9th, 2018 - Society of Interventional Radiology Position Statement on Catheter-Directed Therapy for Acute Pulmonary Embolism.|2018|Kuo WT,Sista AK,Faintuch S,Dariushnia SR,Baerlocher MO,|diagnostic imaging,therapy,methods,methods,
Journal of the American College of Radiology : JACR; , Kirsch J et. al.
May 5th, 2017 - Pulmonary embolism (PE) remains a common and important clinical condition that cannot be accurately diagnosed on the basis of signs, symptoms, and history alone. The diagnosis of PE has been facilitated by technical advancements and multidetector CT pulmonary angiography, which is the major diagnostic modality currently used. Ventilation and perfusion scans remain largely accurate and useful in...
Journal of ObstEtrics and Gynaecology Canada : JOGC = Journal D'obstEtrique Et Gynecologie Du Canada : JOGC; Chan WS, Rey E et. al.
Jun 13th, 2014 - To present an approach, based on current evidence, for the diagnosis, treatment, and thromboprophylaxis of venous thromboembolism in pregnancy and postpartum. Published literature was retrieved through searches of PubMed, Medline, CINAHL, and The Cochrane Library from November 2011 to July 2013 using appropriate controlled vocabulary (e.g. pregnancy, venous thromboembolism, deep vein thrombosis...
American Journal of Respiratory and Critical Care Medicine; Leung AN, Bull TM et. al.
Nov 16th, 2011 - Pulmonary embolism (PE) is a leading cause of maternal mortality in the developed world. Along with appropriate prophylaxis and therapy, prevention of death from PE in pregnancy requires a high index of clinical suspicion followed by a timely and accurate diagnostic approach. To provide guidance on this important health issue, a multidisciplinary panel of major medical stakeholders was convened...
Journal of Vascular and Interventional Radiology : JVIR; Caplin DM, Nikolic B et. al.
Sep 5th, 2011 - Quality improvement guidelines for the performance of inferior vena cava filter placement for the prevention of pulmonary embolism.|2011|Caplin DM,Nikolic B,Kalva SP,Ganguli S,Saad WE,|prevention & control,standards,adverse effects,standards,standards,standards,adverse effects,standards,
Journal of Thrombosis and Haemostasis : JTH; Mitchell LG, Goldenberg NA et. al.
Sep 2nd, 2011 - Definition of clinical efficacy and safety outcomes for clinical trials in deep venous thrombosis and pulmonary embolism in children.|2011|Mitchell LG,Goldenberg NA,Male C,Kenet G,Monagle P,|standards,standards,pharmacology,drug therapy,prevention & control,drug therapy,prevention & control,
Annals of Emergency Medicine; Fesmire FM, Brown MD et. al.
May 30th, 2011 - This clinical policy from the American College of Emergency Physicians is the revision of a 2003 clinical policy on the evaluation and management of adult patients presenting with suspected pulmonary embolism (PE).(1) A writing subcommittee reviewed the literature to derive evidence-based recommendations to help clinicians answer the following critical questions: (1) Do objective criteria provi...
Maturitas Tremollieres F, Brincat M et. al.
Apr 14th, 2011 - Venous thromboembolism (VTE), including deep venous thrombosis (DVT) and pulmonary embolism (PE), is a serious cardiovascular event whose incidence rises with increasing age. To formulate a position statement on the management of the menopause in women with a personal or family history of VTE. Literature review and consensus of expert opinion. Randomized controlled trials have shown an increase...
Canadian Respiratory Journal; Mehta S, Helmersen D et. al.
Dec 17th, 2010 - Pulmonary embolism is a common condition. Some patients subsequently develop chronic thromboembolic pulmonary hypertension (CTEPH). Many care gaps exist in the diagnosis and management of CTEPH patients including lack of awareness, incomplete diagnostic assessment, and inconsistent use of surgical and medical therapies. A representative interdisciplinary panel of medical experts undertook a for...
British Journal of Haematology; Watson HG, Baglin TP
Nov 18th, 2010 - Long duration travel is a weak risk factor for the development of venous thromboembolism (VTE). The incidence of VTE after flights of >4 h is 1 in 4656 and for flights of more than 8 h in low and intermediate risk flyers is around 0.5%. Severe symptomatic pulmonary embolism in the period immediately after travel is extremely rare after flights of <8 h. In flights over 12 h the rate is 5 per mil...
Orthopedics Colwell CW
Mar 17th, 2010 - The 1986 National Institutes of Health consensus conference Prevention of Venous Thrombosis and Pulmonary Embolism emphasized the high rates of venous thromboembolic disease (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), associated with orthopedic surgery of the lower extremity when performed without thromboprophylaxis. Total joint arthroplasty patients treated with pl...
European Journal of Nuclear Medicine and Molecular Imaging; Bajc M, Neilly JB et. al.
Jul 24th, 2009 - As emphasized in Part 1 of these guidelines, the diagnosis of pulmonary embolism (PE) is confirmed or refuted using ventilation/perfusion scintigraphy (V/P(SCAN)) or multidetector computed tomography of the pulmonary arteries (MDCT). To reduce the costs, the risks associated with false-negative and false-positive diagnoses, and unnecessary radiation exposure, preimaging assessment of clinical p...
European Journal of Nuclear Medicine and Molecular Imaging; Bajc M, Neilly JB et. al.
Jun 29th, 2009 - Pulmonary embolism (PE) can only be diagnosed with imaging techniques, which in practice is performed using ventilation/perfusion scintigraphy (V/P(SCAN)) or multidetector computed tomography of the pulmonary arteries (MDCT). The epidemiology, natural history, pathophysiology and clinical presentation of PE are briefly reviewed. The primary objective of Part 1 of the Task Group's report was to ...
Chest Eikelboom JW, Karthikeyan G et. al.
Feb 9th, 2009 - The recently published American Association of Orthopedic Surgeons (AAOS) guidelines for the prevention of venous thromboembolism (VTE) in patients undergoing hip or knee surgery conflict with long-established and widely used American College of Chest Physicians (ACCP) guidelines. Both guidelines accepted that the most important goal of thromboprophylaxis in patients undergoing hip or knee repl...
European Heart Journal; Torbicki A, Perrier A et. al.
Sep 1st, 2008 - Non-thrombotic PE does not represent a distinct clinical syndrome. It may be due to a variety of embolic materials and result in a wide spectrum of clinical presentations, making the diagnosis difficult. With the exception of severe air and fat embolism, the haemodynamic consequences of non-thrombotic emboli are usually mild. Treatment is mostly supportive but may differ according to the type o...