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About 25,588 results
Asthma in Adults
https://www.sciencedirect.com/science/article/abs/pii/S0025712519300896?via%3Dihub
Medical Clinics of North America; Nanda A, et al

Oct 27th, 2019 - Asthma affects approximately 300 million people worldwide and approximately 7.5% of adults in the United States. Among adults, asthma results in about 10.5 million physician office visits per year and affects approximately 8.7% of blacks, 7.6% of whites, and 5.8% of Hispanics. Asthma is characterized by inflammation of airways, variable airflow obstruction, and bronchial hyperresponsiveness.3 I...

Nasal High-Flow Therapy for Newborn Infants in Special Care Nurseries.
https://doi.org/10.1056/NEJMoa1812077
The New England Journal of Medicine; Manley BJ, Arnolda GRB et. al.

May 22nd, 2019 - Nasal high-flow therapy is an alternative to nasal continuous positive airway pressure (CPAP) as a means of respiratory support for newborn infants. The efficacy of high-flow therapy in nontertiary special care nurseries is unknown. We performed a multicenter, randomized, noninferiority trial involving newborn infants (<24 hours of age; gestational age, ≥31 weeks) in special care nurseries in A...

Jazz Pharmaceuticals Announces U.S. FDA Approval of Sunosi™ (solriamfetol) for Excessive Daytime Sleepiness Associated with Narcolepsy or Obstructive Sleep Apnea
https://investor.jazzpharma.com/news-releases/news-release-details/jazz-pharmaceuticals-announces-us-fda-approval-sunositm

Mar 19th, 2019 - Jazz Pharmaceuticals plc (Nasdaq: JAZZ) today announced that the U.S. Food and Drug Administration (FDA) approved Sunosi™ (solriamfetol) to improve wakefulness in adult patients with excessive daytime sleepiness associated with narcolepsy or obstructive sleep apnea (OSA). Once-daily Sunosi is approved with doses of 75 mg and 150 mg for patients with narcolepsy and doses of 37.5 mg, 75 mg, and 1...

Treatment of Adult Obstructive Sleep Apnea With Positive Airway Pressure
http://jcsm.aasm.org/ViewAbstract.aspx?pid=31512
Journal of Clinical Sleep Medicine;

Feb 14th, 2019 - Introduction The purpose of this systematic review is to provide supporting evidence for the clinical practice guideline for the treatment of obstructive sleep apnea (OSA) in adults using positive airway pressure (PAP). Methods The American Academy of Sleep Medicine commissioned a task force of experts in sleep medicine. A systematic review was conducted to identify studies that compared t...

The Link Between Obesity and Obstructive Sleep Apnea
https://j2vjt3dnbra3ps7ll1clb4q2-wpengine.netdna-ssl.com/wp-content/uploads/2018/09/ProviderFS_Obesity_18.pdf
American Academy Of Sleep Medicine;

Sep 22nd, 2018 - The Link Between Obesity and Obstructive Sleep Apnea Obstructive sleep apnea (OSA) is a sleep disorder characterized by complete or partial airway closure during sleep. Patients with obesity are at higher risk of OSA. The interrelationships between obesity and OSA are complex and bidirectional. Obesity places patients at higher risk for OSA and patients with OSA are likely to gain more w...

Association of STOP-Bang Questionnaire as a Screening Tool for Sleep Apnea and Postoper...
https://doi.org/10.1213/ANE.0000000000002344
Anesthesia and Analgesia; Nagappa M, Patra J et. al.

Aug 17th, 2017 - The risk of postoperative complications increases with undiagnosed obstructive sleep apnea (OSA). The high-risk OSA (HR-OSA) patients can be easily identified using the STOP-Bang screening tool. The aim of this systematic review and meta-analysis is to determine the association of postoperative complications in patients screened as HR-OSA versus low-risk OSA (LR-OSA). The following data bases w...

Screening for Obesity in Children and Adolescents: US Preventive Services Task Force Re...
https://doi.org/10.1001/jama.2017.6803
JAMA , Grossman DC et. al.

Jun 20th, 2017 - Based on year 2000 Centers for Disease Control and Prevention growth charts, approximately 17% of children and adolescents aged 2 to 19 years in the United States have obesity, and almost 32% of children and adolescents are overweight or have obesity. Obesity in children and adolescents is associated with morbidity such as mental health and psychological issues, asthma, obstructive sleep apnea,...

Screening for Obstructive Sleep Apnea in Adults: Evidence Report and Systematic Review ...
https://doi.org/10.1001/jama.2016.19635
JAMA Jonas DE, Amick HR et. al.

Jan 24th, 2017 - Many adverse health outcomes are associated with obstructive sleep apnea (OSA). To review primary care-relevant evidence on screening adults for OSA, test accuracy, and treatment of OSA, to inform the US Preventive Services Task Force. MEDLINE, Cochrane Library, EMBASE, and trial registries through October 2015, references, and experts, with surveillance of the literature through October 5, 201...

Sleep characteristics and cognitive impairment in the general population: The HypnoLaus...
https://doi.org/10.1212/WNL.0000000000003557
Neurology Haba-Rubio J, Marti-Soler H et. al.

Dec 31st, 2016 - To assess the association between sleep structure and cognitive impairment in the general population. Data stemmed from 580 participants aged >65 years of the population-based CoLaus/PsyCoLaus study (Lausanne, Switzerland) who underwent complete sleep evaluation (HypnoLaus). Evaluations included demographic characteristics, personal and treatment history, sleep complaints and habits (using vali...

Nasal High-Flow Therapy for Primary Respiratory Support in Preterm Infants.
https://doi.org/10.1056/NEJMoa1603694
The New England Journal of Medicine; Roberts CT, Owen LS et. al.

Sep 22nd, 2016 - Treatment with nasal high-flow therapy has efficacy similar to that of nasal continuous positive airway pressure (CPAP) when used as postextubation support in neonates. The efficacy of high-flow therapy as the primary means of respiratory support for preterm infants with respiratory distress has not been proved. In this international, multicenter, randomized, noninferiority trial, we assigned 5...

Adenotonsillectomy Complications: A Meta-analysis.
https://doi.org/10.1542/peds.2015-1283
Pediatrics De Luca Canto G, Pachêco-Pereira C et. al.

Sep 23rd, 2015 - Complications after adenotonsillectomy (AT) in children have been extensively studied, but differences between children with and without obstructive sleep apnea (OSA) have not been systematically reported. Our objective was to identify the most frequent complications after AT, and evaluate if differences between children with and without OSA exist. Several electronic databases were searched. A ...

Bubble continuous positive airway pressure for children with severe pneumonia and hypox...
https://doi.org/10.1016/S0140-6736(15)60249-5
Lancet (London, England); Chisti MJ, Salam MA et. al.

Aug 24th, 2015 - In developing countries, mortality in children with very severe pneumonia is high, even with the provision of appropriate antibiotics, standard oxygen therapy, and other supportive care. We assessed whether oxygen therapy delivered by bubble continuous positive airway pressure (CPAP) improved outcomes compared with standard low-flow and high-flow oxygen therapies. This open, randomised, control...

Effects of Oropharyngeal Exercises on Snoring: A Randomized Trial.
https://doi.org/10.1378/chest.14-2953
Chest Ieto V, Kayamori F et. al.

May 7th, 2015 - Snoring is extremely common in the general population and may indicate OSA. However, snoring is not objectively measured during polysomnography, and no standard treatment is available for primary snoring or when snoring is associated with mild forms of OSA. This study determined the effects of oropharyngeal exercises on snoring in minimally symptomatic patients with a primary complaint of snori...

Quality of life and obstructive sleep apnea symptoms after pediatric adenotonsillectomy.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306791
Pediatrics Garetz SL, Mitchell RB et. al.

Jan 20th, 2015 - Data from a randomized, controlled study of adenotonsillectomy for obstructive sleep apnea syndrome (OSAS) were used to test the hypothesis that children undergoing surgery had greater quality of life (QoL) and symptom improvement than control subjects. The objectives were to compare changes in validated QoL and symptom measurements among children randomized to undergo adenotonsillectomy or wat...

Association between asthma and risk of developing obstructive sleep apnea.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334115
JAMA Teodorescu M, Barnet JH et. al.

Jan 14th, 2015 - Obstructive sleep apnea (OSA) is more common among patients with asthma; whether asthma is associated with the development of OSA is unknown. To examine the prospective relationship of asthma with incident OSA. Population-based prospective epidemiologic study (the Wisconsin Sleep Cohort Study) beginning in 1988. Adult participants were recruited from a random sample of Wisconsin state employees...

Growth after adenotonsillectomy for obstructive sleep apnea: an RCT.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187239
Pediatrics Katz ES, Moore RH et. al.

Jul 29th, 2014 - Adenotonsillectomy for obstructive sleep apnea syndrome (OSAS) may lead to weight gain, which can have deleterious health effects when leading to obesity. However, previous data have been from nonrandomized uncontrolled studies, limiting inferences. This study examined the anthropometric changes over a 7-month interval in a randomized controlled trial of adenotonsillectomy for OSAS, the Childho...

CPAP, weight loss, or both for obstructive sleep apnea.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138510
The New England Journal of Medicine; Chirinos JA, Gurubhagavatula I et. al.

Jun 11th, 2014 - Obesity and obstructive sleep apnea tend to coexist and are associated with inflammation, insulin resistance, dyslipidemia, and high blood pressure, but their causal relation to these abnormalities is unclear. We randomly assigned 181 patients with obesity, moderate-to-severe obstructive sleep apnea, and serum levels of C-reactive protein (CRP) greater than 1.0 mg per liter to receive treatment...

CPAP versus oxygen in obstructive sleep apnea.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172401
The New England Journal of Medicine; Gottlieb DJ, Punjabi NM et. al.

Jun 11th, 2014 - Obstructive sleep apnea is associated with hypertension, inflammation, and increased cardiovascular risk. Continuous positive airway pressure (CPAP) reduces blood pressure, but adherence is often suboptimal, and the benefit beyond management of conventional risk factors is uncertain. Since intermittent hypoxemia may underlie cardiovascular sequelae of sleep apnea, we evaluated the effects of no...

A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing d...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104022
The Lancet. Neurology; Sabater L, Gaig C et. al.

Apr 7th, 2014 - Autoimmunity might be associated with or implicated in sleep and neurodegenerative disorders. We aimed to describe the features of a novel neurological syndrome associated with prominent sleep dysfunction and antibodies to a neuronal antigen. In this observational study, we used clinical and video polysomnography to identify a novel sleep disorder in three patients referred to the Sleep Unit of...

Polysomnographic assessment of suvorexant in patients with probable Alzheimer's disease...
https://doi.org/10.1002/alz.12035
Alzheimer's & Dementia : the Journal of the Alzheimer's Association REFERENCES; Herring WJ, Ceesay P et. al.

Jan 16th, 2020 - We evaluated the clinical profile of the orexin receptor antagonist suvorexant for treating insomnia in patients with mild-to-moderate probable Alzheimer's disease (AD) dementia. Randomized, double-blind, 4-week trial of suvorexant 10 mg (could be increased to 20 mg based on clinical response) or placebo in patients who met clinical diagnostic criteria for both probable AD dementia and insomnia...

Cognition After Early Tonsillectomy for Mild OSA.
https://doi.org/10.1542/peds.2019-1450
Pediatrics Waters KA, Chawla J et. al.

Jan 10th, 2020 - It remains uncertain whether treatment with adenotonsillectomy for obstructive sleep apnea in children improves cognitive function. The Preschool Obstructive Sleep Apnea Tonsillectomy and Adenoidectomy study was a prospective randomized controlled study in which researchers evaluated outcomes 12 months after adenotonsillectomy compared with no surgery in preschool children symptomatic for obstr...

Evolution of prodromal Parkinson's disease and dementia with Lewy bodies: a prospective...
https://doi.org/10.1093/brain/awz111
Brain : a Journal of Neurology; Fereshtehnejad SM, Yao C et. al.

May 21st, 2019 - Parkinson's disease has a long prodromal stage with various subclinical motor and non-motor manifestations; however, their evolution in the years before Parkinson's disease is diagnosed is unclear. We traced the evolution of early motor and non-motor manifestations of synucleinopathy from the stage of idiopathic rapid eye movement (REM) sleep behaviour disorder until defined neurodegenerative d...

Non-invasive positive pressure ventilation (CPAP or bilevel NPPV) for cardiogenic pulmo...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449889
The Cochrane Database of Systematic Reviews; Berbenetz N, Wang Y et. al.

Apr 5th, 2019 - Non-invasive positive pressure ventilation (NPPV) has been used to treat respiratory distress due to acute cardiogenic pulmonary oedema (ACPE). We performed a systematic review and meta-analysis update on NPPV for adults presenting with ACPE. To evaluate the safety and effectiveness of NPPV compared to standard medical care (SMC) for adults with ACPE. The primary outcome was hospital mortality....

Sleep deficiency and motor vehicle crash risk in the general population: a prospective ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859531
BMC Medicine; Gottlieb DJ, Ellenbogen JM et. al.

Mar 20th, 2018 - Insufficient sleep duration and obstructive sleep apnea, two common causes of sleep deficiency in adults, can result in excessive sleepiness, a well-recognized cause of motor vehicle crashes, although their contribution to crash risk in the general population remains uncertain. The objective of this study was to evaluate the relation of sleep apnea, sleep duration, and excessive sleepiness to c...

Onabotulinum toxin-A injections for sleep bruxism: A double-blind, placebo-controlled s...
https://doi.org/10.1212/WNL.0000000000004951
Neurology Ondo WG, Simmons JH et. al.

Jan 18th, 2018 - To test the safety and efficacy of onabotulinum toxin-A (BoNT-A) injections into the masseter and temporalis muscles in patients with symptomatic sleep bruxism. Participants 18 to 85 years old with clinically diagnosed sleep bruxism confirmed by polysomnography were enrolled in this randomized, placebo-controlled, 1:1, parallel-design trial with open-label extension. Participants were injected ...

Pharmacotherapy of Apnea by Cannabimimetic Enhancement, the PACE Clinical Trial: Effect...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806568
Sleep Carley DW, Prasad B et. al.

Nov 9th, 2017 - There remains an important and unmet need for fully effective and acceptable treatments in obstructive sleep apnea (OSA). At present, there are no approved drug treatments. Dronabinol has shown promise for OSA pharmacotherapy in a small dose-escalation pilot study. Here, we present initial findings of the Phase II PACE (Pharmacotherapy of Apnea by Cannabimimetic Enhancement) trial, a fully blin...

Sleep architecture and the risk of incident dementia in the community.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606917
Neurology Pase MP, Himali JJ et. al.

Aug 24th, 2017 - Sleep disturbance is common in dementia, although it is unclear whether differences in sleep architecture precede dementia onset. We examined the associations between sleep architecture and the prospective risk of incident dementia in the community-based Framingham Heart Study (FHS). Our sample comprised a subset of 321 FHS Offspring participants who participated in the Sleep Heart Health Study...

Association of Positive Airway Pressure With Cardiovascular Events and Death in Adults ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541330
JAMA Yu J, Zhou Z et. al.

Jul 11th, 2017 - Sleep apnea (obstructive and central) is associated with adverse cardiovascular risk factors and increased risks of cardiovascular disease. Positive airway pressure (PAP) provides symptomatic relief, whether delivered continuously (CPAP) or as adaptive servo-ventilation (ASV), but the associations with cardiovascular outcomes and death are unclear. To assess the association of PAP vs control wi...

Conventional Polysomnography Is Not Necessary for the Management of Most Patients with ...
https://doi.org/10.1164/rccm.201612-2497OC
American Journal of Respiratory and Critical Care Medicine; Corral J, Sánchez-Quiroga MÁ et. al.

Jun 21st, 2017 - Home respiratory polygraphy may be a simpler alternative to in-laboratory polysomnography for the management of more symptomatic patients with obstructive sleep apnea, but its effectiveness has not been evaluated across a broad clinical spectrum. To compare the long-term effectiveness (6 mo) of home respiratory polygraphy and polysomnography management protocols in patients with intermediate-to...

Screening for Obstructive Sleep Apnea in Adults: US Preventive Services Task Force Reco...
https://doi.org/10.1001/jama.2016.20325
JAMA , Bibbins-Domingo K et. al.

Jan 24th, 2017 - Based on data from the 1990s, estimated prevalence of obstructive sleep apnea (OSA) in the United States is 10% for mild OSA and 3.8% to 6.5% for moderate to severe OSA; current prevalence may be higher, given the increasing prevalence of obesity. Severe OSA is associated with increased all-cause mortality, cardiovascular disease and cerebrovascular events, diabetes, cognitive impairment, decre...

Physician Decision Making and Clinical Outcomes With Laboratory Polysomnography or Limi...
https://doi.org/10.7326/M16-1301
Annals of Internal Medicine; Chai-Coetzer CL, Antic NA et. al.

Jan 23rd, 2017 - The clinical utility of limited-channel sleep studies (which are increasingly conducted at home) versus laboratory polysomnography (PSG) for diagnosing obstructive sleep apnea (OSA) is unclear. To compare patient outcomes after PSG versus limited-channel studies. Multicenter, randomized, noninferiority study. (Australian New Zealand Clinical Trials Registry: ACTRN12611000926932). 7 academic sle...

Association of Noninvasive Ventilation Strategies With Mortality and Bronchopulmonary D...
https://doi.org/10.1001/jama.2016.10708
JAMA Isayama T, Iwami H et. al.

Aug 17th, 2016 - Various noninvasive ventilation strategies are used to prevent bronchopulmonary dysplasia (BPD) of preterm infants; however, the best mode is uncertain. To compare 7 ventilation strategies for preterm infants including nasal continuous positive airway pressure (CPAP) alone, intubation and surfactant administration followed by immediate extubation (INSURE), less invasive surfactant administratio...

Effect of Positive Airway Pressure on Cardiovascular Outcomes in Coronary Artery Diseas...
https://doi.org/10.1164/rccm.201601-0088OC
American Journal of Respiratory and Critical Care Medicine; Peker Y, Glantz H et. al.

Feb 25th, 2016 - Obstructive sleep apnea (OSA) is common in patients with coronary artery disease (CAD), many of whom do not report daytime sleepiness. First-line treatment for symptomatic OSA is continuous positive airway pressure (CPAP), but its value in patients without daytime sleepiness is uncertain. To determine the effects of CPAP on long-term adverse cardiovascular outcome risk in patients with CAD with...

Sleep disturbances compared to traditional risk factors for diabetes development: Syste...
https://doi.org/10.1016/j.smrv.2015.10.002
Sleep Medicine Reviews; Anothaisintawee T, Reutrakul S et. al.

Dec 21st, 2015 - Sleep disturbances [short (<6 h) and long (>8 h) sleeping time, insomnia (initiating or maintaining sleep), obstructive sleep apnea (OSA) and abnormal sleep timing] have been associated with increased diabetes risk but the effect size relative to that of traditional risk factors is unknown. We conducted a systematic review and meta-analysis to compare the risk associated with sleep disturbances...

CPAP vs Mandibular Advancement Devices and Blood Pressure in Patients With Obstructive ...
https://doi.org/10.1001/jama.2015.16303
JAMA Bratton DJ, Gaisl T et. al.

Dec 1st, 2015 - Obstructive sleep apnea is associated with higher levels of blood pressure (BP), which can lead to increased cardiovascular risk. To compare the association of continuous positive airway pressure (CPAP), mandibular advancement devices (MADs), and inactive control groups (placebo or no treatment) with changes in systolic BP (SBP) and diastolic BP (DBP) in patients with obstructive sleep apnea. T...

Maxillomandibular Advancement for Treatment of Obstructive Sleep Apnea: A Meta-analysis.
https://doi.org/10.1001/jamaoto.2015.2678
JAMA Otolaryngology-- Head & Neck Surgery; Zaghi S, Holty JE et. al.

Nov 25th, 2015 - Maxillomandibular advancement (MMA) is an invasive yet effective surgical option for obstructive sleep apnea (OSA) that achieves enlargement of the upper airway by physically expanding the facial skeletal framework. To identify criteria associated with surgical outcomes of MMA using aggregated individual patient data from multiple studies. The Cochrane Library, Scopus, Web of Science, and MEDLI...

Mechanism of Gastroesophageal Reflux in Obstructive Sleep Apnea: Airway Obstruction or ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702204
Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine; Shepherd K, Orr W

Oct 8th, 2015 - This is the first study to compare reflux events during wake and sleep in obese and non-obese individuals with obstructive sleep apnea (OSA) and obese individuals without OSA. The primary aim of the study was to investigate any additive effect of OSA on gastroesophageal reflux (GER) above that of obesity. Twenty obese individuals (body mass index, BMI > 30 kg/m(2)), 9 non-obese individuals (BMI...

Quality of Life in Patients With Chronic Rhinosinusitis and Sleep Dysfunction Undergoin...
https://doi.org/10.1001/jamaoto.2015.1673
JAMA Otolaryngology-- Head & Neck Surgery; Alt JA, DeConde AS et. al.

Sep 11th, 2015 - Patients with chronic rhinosinusitis (CRS) have reduced sleep quality linked to their overall well-being and disease-specific quality of life (QOL). Other primary sleep disorders also affect QOL. To determine the impact of comorbid obstructive sleep apnea (OSA) on CRS disease-specific QOL and sleep dysfunction in patients with CRS following functional endoscopic sinus surgery. Prospective multi...

Precision Medicine in Patients With Resistant Hypertension and Obstructive Sleep Apnea:...
https://doi.org/10.1016/j.jacc.2015.06.1315
Journal of the American College of Cardiology; Sánchez-de-la-Torre M, Khalyfa A et. al.

Aug 31st, 2015 - In patients with resistant hypertension (RH) and obstructive sleep apnea (OSA), the blood pressure response to continuous positive airway pressure (CPAP) treatment is highly variable and could be associated with differential micro-ribonucleic acid (miRNA) profiles. Currently, no available methods exist to identify patients who will respond favorably to CPAP treatment. The aim of this study was ...

Depressive Symptoms before and after Treatment of Obstructive Sleep Apnea in Men and Wo...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543247
Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine; Edwards C, Mukherjee S et. al.

Apr 23rd, 2015 - To determine prevalence of depressive symptoms in obstructive sleep apnea (OSA) and the impact of OSA treatment on depression scores. Consecutive new patients referred for investigation of suspected OSA were approached. Consenting patients completed a patient health questionnaire (PHQ-9) for depressive symptoms when attending for laboratory polysomnography. Those with moderate/severe (apneahypo...

Orexinergic system dysregulation, sleep impairment, and cognitive decline in Alzheimer ...
https://doi.org/10.1001/jamaneurol.2014.2510
JAMA Neurology; Liguori C, Romigi A et. al.

Oct 16th, 2014 - Nocturnal sleep disruption develops in Alzheimer disease (AD) owing to the derangement of the sleep-wake cycle regulation pathways. Orexin contributes to the regulation of the sleep-wake cycle by increasing arousal levels and maintaining wakefulness. To study cerebrospinal fluid levels of orexin in patients with AD, to evaluate the relationship of orexin cerebrospinal fluid levels with the degr...

Diagnosis of obstructive sleep apnea in adults: a clinical practice guideline from theA...
https://doi.org/10.7326/M12-3187
Annals of Internal Medicine; Qaseem A, Dallas P et. al.

Aug 4th, 2014 - The American College of Physicians (ACP) developed this guideline to present the evidence and provide clinical recommendations on the diagnosis of obstructive sleep apnea in adults. This guideline is based on published literature on this topic that was identified by using MEDLINE (1966 through May 2013), the Cochrane Central Register of Controlled Trials, and the Cochrane Database of Systematic...

The efficacy of a brief motivational enhancement education program on CPAP adherence in...
https://doi.org/10.1378/chest.13-2228
Chest Lai AYK, Fong DYT et. al.

May 8th, 2014 - Poor adherence to CPAP treatment in OSA adversely affects the effectiveness of this therapy. This randomized controlled trial (RCT) examined the efficacy of a brief motivational enhancement education program in improving adherence to CPAP treatment in subjects with OSA. Subjects with newly diagnosed OSA were recruited into this RCT. The control group received usual advice on the importance of C...

Sleep on the ward in intensive care unit survivors: a case series of polysomnography.
https://doi.org/10.1111/imj.13791
Internal Medicine Journal; Wilcox ME, Lim AS et. al.

Mar 9th, 2018 - Few studies have investigated sleep in patients after intensive care despite the possibility that inadequate sleep might further complicate an acute illness impeding recovery. To assess the quality and quantity of a patient's sleep on the ward by polysomnography (PSG) within a week of intensive care unit (ICU) discharge and to explore the prevalence of key in-ICU risk factors for persistent sle...

Sleep endoscopy findings in children with persistent obstructive sleep apnea after aden...
https://doi.org/10.1016/j.ijporl.2018.01.029
International Journal of Pediatric Otorhinolaryngology; Coutras SW, Limjuco A et. al.

Mar 4th, 2018 - Describe the patterns of obstruction in persistent pediatric OSA and their relationship with patient weight. Retrospective review. All pediatric DISE procedures performed at a tertiary care hospital between October 2010 and October 2015 were reviewed. Patients had polysomnography after adenotonsillectomy that confirmed persistent obstructive sleep apnea (OSA). Variables included age, gender, co...

Impact of earplugs and eye mask on sleep in critically ill patients: a prospective rand...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696771
Critical Care (London, England); Demoule A, Carreira S et. al.

Nov 21st, 2017 - Poor sleep is common in intensive care unit (ICU) patients, where environmental factors contribute to reduce and fragment sleep. The objective of this study was to evaluate the impact of earplugs and eye mask on sleep architecture in ICU patients. A single-center randomized controlled trial of 64 ICU patients was conducted from July 2012 to December 2013. Patients were randomly assigned to slee...

Impaired memory consolidation in children with obstructive sleep disordered breathing.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667754
PloS One; Maski K, Steinhart E et. al.

Nov 2nd, 2017 - Memory consolidation is stabilized and even enhanced by sleep (and particularly by 12-15 Hz sleep spindles in NREM stage 2 sleep) in healthy children but it is unclear what happens to these processes when sleep is disturbed by obstructive sleep disordered breathing. This cross-sectional study investigates differences in declarative memory consolidation among children with primary snoring (PS) a...

Obstructive sleep apnea in pregnancy is associated with adverse maternal outcomes: a na...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677512
Sleep Medicine; Bourjeily G, Danilack VA et. al.

Oct 16th, 2017 - Pregnancy and the obesity epidemic impacting women of reproductive age appear to predispose women to obstructive sleep apnea (OSA) in pregnancy. The aim of this study is to examine the association between OSA and adverse maternal outcomes in a national cohort. The National Perinatal Information Center in the US was used to identify women with a delivery discharge diagnosis of OSA from 2010 to 2...

The urge to move and breathe - the impact of obstructive sleep apnea syndrome treatment...
https://doi.org/10.1016/j.sleep.2017.06.023
Sleep Medicine; Silva C, Peralta AR et. al.

Oct 16th, 2017 - The association between restless legs syndrome (RLS) and obstructive sleep apnea syndrome (OSAS) has seldom been reported. There is one study reporting improvement of RLS symptoms severity in patients naive of treatment after initiation of continuous positive airway pressure (CPAP) for OSAS. The aim of this study was to evaluate the impact of the OSAS treatment in patients with previously diagn...

Risk of glucose intolerance and gestational diabetes mellitus in relation to maternal h...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605003
PloS One; Qiu C, Lawrence W et. al.

Sep 19th, 2017 - Obstructive sleep apnea (OSA) or habitual snoring is known to be associated with impaired glucose tolerance and type 2 diabetes among both men and non-pregnant women. We examined the association of habitual snoring during early pregnancy with risk of impaired glucose tolerance (IGT) and gestational diabetes mellitus (GDM). A cohort of 1,579 women was interviewed during early pregnancy. We colle...

Effectiveness of Adenotonsillectomy and Risk of Velopharyngeal Insufficiency in Childre...
https://doi.org/10.1177/0003489417729834
The Annals of Otology, Rhinology, and Laryngology; Padia R, Muntz H et. al.

Sep 12th, 2017 - (1) Review effectiveness of adenotonsillectomy (T&A) for obstructive sleep apnea (OSA) in children with Prader-Willi syndrome (PW). (2) Examine the incidence of velopharyngeal insufficiency (VPI) after T&A in this population. (3) Compare outcomes of T&A in PW and Trisomy 21 (T21) patients. Outcomes after T&A in a PW cohort were retrospectively reviewed and compared to those in patients with T21...

American Academy of Sleep Medicine Position Paper for the Use of a Home Sleep Apnea Tes...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612636
Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine; Kirk V, Baughn J et. al.

Sep 7th, 2017 - The purpose of this position paper is to establish the American Academy of Sleep Medicine's (AASM) position on the use of a home sleep apnea test (HSAT) for the diagnosis of obstructive sleep apnea (OSA) in children (birth to 18 years of age). The AASM commissioned a task force of 8 experts in sleep medicine to review the available literature on the use of an HSAT to diagnose OSA in children. T...

Dopamine transporter imaging deficit predicts early transition to synucleinopathy in id...
https://doi.org/10.1002/ana.25026
Annals of Neurology; Iranzo A, Santamaría J et. al.

Aug 23rd, 2017 - To determine the usefulness of dopamine transporter (DAT) imaging to identify idiopathic rapid eye movement sleep behavior disorder (IRBD) patients at risk for short-term development of clinically defined synucleinopathy. Eighty-seven patients with polysomnography-confirmed IRBD underwent 123 I-FP-CIT DAT-SPECT. Results were compared to 20 matched controls without RBD who underwent DAT-SPECT. I...

Sleep-Wake Disorders of Childhood.
https://doi.org/10.1212/CON.0000000000000504
Continuum (Minneapolis, Minn.); Kotagal S

Aug 4th, 2017 - Sleep-wake disorders occur in 10% to 28% of children and differ somewhat in pathophysiology and management from sleep-wake disorders in adults. This article discusses the diagnosis and management of key childhood sleep disorders. The role of sleep in memory consolidation and in the facilitation of learning has been increasingly recognized, even at the toddler stage. Cataplexy, a key feature of ...

Success of Tonsillectomy for Obstructive Sleep Apnea in Children With Down Syndrome.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529134
Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine; Ingram DG, Ruiz AG et. al.

Jul 21st, 2017 - Obstructive sleep apnea (OSA) is common in children with Down syndrome (DS) and associated with significant morbidity. In the current study we examined polysomnographic outcomes of children with DS who underwent tonsillectomy. A retrospective chart review of children with DS who underwent a tonsillectomy between 2009-2015 was performed. All children had either a concurrent adenoidectomy or had ...

Preoperatively Screened Obstructive Sleep Apnea Is Associated With Worse Postoperative ...
https://doi.org/10.1213/ANE.0000000000002241
Anesthesia and Analgesia; Fernandez-Bustamante A, Bartels K et. al.

Jul 6th, 2017 - Obstructive sleep apnea (OSA) affects up to 26% of US adults, is often undiagnosed, and increases perioperative morbidity. We hypothesized that patients screened on the day of surgery as moderate/high risk for OSA (S-OSA) present similar perioperative respiratory complications, hospital use, and mortality than patients with previously diagnosed OSA (D-OSA). Second, we hypothesized that both OSA...

Obstructive and Central Sleep Apnea and the Risk of Incident Atrial Fibrillation in a C...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586257
Journal of the American Heart Association; Tung P, Levitzky YS et. al.

Jul 2nd, 2017 - Previous studies have documented a high prevalence of atrial fibrillation (AF) in individuals with obstructive sleep apnea (OSA). Central sleep apnea (CSA) has been associated with AF in patients with heart failure. However, data from prospective cohorts are sparse and few studies have distinguished the associations of obstructive sleep apnea from CSA with AF in population studies. We assessed ...

Perioperative management of obstructive sleep apnea in bariatric surgery: a consensus g...
https://doi.org/10.1016/j.soard.2017.03.022
Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery; de Raaff CAL, Gorter-Stam MAW et. al.

Jul 1st, 2017 - The frequency of metabolic and bariatric surgery (MBS) is increasing worldwide, with over 500,000 cases performed every year. Obstructive sleep apnea (OSA) is present in 35%-94% of MBS patients. Nevertheless, consensus regarding the perioperative management of OSA in MBS patients is not established. To provide consensus based guidelines utilizing current literature and, when in the absence of s...

REM Sleep Behavior Disorder and Cognitive Impairment in Parkinson's Disease.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806543
Sleep Jozwiak N, Postuma RB et. al.

Jun 24th, 2017 - REM sleep behavior disorder (RBD) is a parasomnia affecting 33% to 46% of patients with Parkinson's disease (PD). The existence of a unique and specific impaired cognitive profile in PD patients with RBD is still controversial. We extensively assessed cognitive functions to identify whether RBD is associated with more severe cognitive deficits in nondemented patients with PD. One hundred sixty-...

Amyloid Burden in Obstructive Sleep Apnea.
https://doi.org/10.3233/JAD-161047
Journal of Alzheimer's Disease : JAD; Yun CH, Lee HY et. al.

May 27th, 2017 - To test the hypothesis that excessive amyloid deposition is a biological link between obstructive sleep apnea (OSA) and Alzheimer's disease, we determined whether OSA increases cerebral amyloid burden, relative to controls, using Pittsburgh Compound B (PiB) PET imaging. The subjects were adult participants (age 50-65 years) from the Korean Genome and Epidemiology Study. Polysomnography, brain M...

Sleep disturbances in fibromyalgia: A meta-analysis of case-control studies.
https://doi.org/10.1016/j.jpsychores.2017.03.011
Journal of Psychosomatic Research; Wu YL, Chang LY et. al.

May 26th, 2017 - Sleep disturbances are common in fibromyalgia, but the features of sleep disturbances are not well understood. We performed a systematic review and meta-analysis of case-control studies to compare the sleep outcomes of individuals with fibromyalgia and healthy controls. We systematically searched eight databases (PubMed, Ovid MEDLINE, Embase, CINAHL, PsycINFO, Web of Science, Airiti Library and...

A randomized, controlled trial of positional therapy versus oral appliance therapy for ...
https://doi.org/10.1016/j.sleep.2017.01.024
Sleep Medicine; Benoist L, de Ruiter M et. al.

May 19th, 2017 - To compare the effectiveness of positional therapy (PT) with the sleep position trainer (SPT) to oral appliance therapy (OAT) in patients with mild-to-moderate positional obstructive sleep apnea (POSA). Multicenter, prospective, randomized, controlled trial. Patients with mild-to-moderate POSA (apnea-hypopnea index (AHI) ≥5 ≤ 30/hour sleep) were randomized for PT or OAT. Polysomnography was rep...

Recognition and Treatment of Sleep-Disordered Breathing in Obese Hospitalized Patients ...
https://doi.org/10.1016/j.amjmed.2017.03.055
The American Journal of Medicine; Sharma S, Mukhtar U et. al.

May 9th, 2017 - Sleep-disordered breathing is a common sleep disorder. Recent studies have shown that hospitalized obese patients have a high likelihood of unrecognized sleep-disordered breathing. However, no systematic large study has so far evaluated the outcomes of a screening program. This study provides demographic, clinical, and outcome data from a screening program at a tertiary care academic center. Su...

The Efficacy of Adenotonsillectomy for Obstructive Sleep Apnea in Children with Down Sy...
https://doi.org/10.1177/0194599817703921
Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery; Nation J, Brigger M

May 9th, 2017 - Objective Determine the efficacy of adenotonsillectomy in children with Down syndrome. Data Sources Databases included PubMed, EMBASE, CINAHL, and Google Scholar. The search was inclusive of all references available through January 5, 2017. Review Methods A systematic review of the medical literature addressing adenotonsillectomy in treating obstructive sleep apnea in children with Down syndrom...

Sleep-Related Breathing Disorders in Chiari Malformation Type 1: A Prospective Study of...
https://doi.org/10.1093/sleep/zsx069
Sleep Ferré Á, Poca MA et. al.

Apr 29th, 2017 - The aim of the present study is to describe the prevalence of sleep disorders in a large group of patients with Chiari malformation type 1 (CM-1) and determine the presence of risk factors associated with these abnormalities. Prospective study with consecutive patient selection. We included 90 adult patients with CM-1, defined by the presence of a cerebellar tonsillar descent (TD) ≥3 mm. Clinic...

Can Intracapsular Tonsillectomy Be an Alternative to Classical Tonsillectomy? A Meta-an...
https://doi.org/10.1177/0194599817700374
Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery; Kim JS, Kwon SH et. al.

Apr 18th, 2017 - Objective Tonsillectomy is the most common operation performed in the otolaryngologic fields. Efforts have been made to reduce postoperative complications, and one of these is intracapsular tonsillectomy and adenoidectomy (ICTA), which leaves the tonsillar tissue with tonsillar capsule. This study aimed to evaluate intracapsular tonsillectomy compared with classical extracapsular tonsillectomy ...

Feasibility and physiological effects of noninvasive neurally adjusted ventilatory assi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605676
Pediatric Research; Gibu CK, Cheng PY et. al.

Apr 11th, 2017 - BackgroundNoninvasive neurally adjusted ventilator assist (NIV-NAVA) was introduced to our clinical practice via a pilot and a randomized observational study to assess its safety, feasibility, and short-term physiological effects.MethodsThe pilot protocol applied NIV-NAVA to 11 infants on nasal CPAP, high-flow nasal cannula, or nasal intermittent mandatory ventilation (NIMV), in multiple 2- to ...

The effect of fluid overload on sleep apnoea severity in haemodialysis patients.
https://doi.org/10.1183/13993003.01789-2016
The European Respiratory Journal; Lyons OD, Inami T et. al.

Apr 6th, 2017 - As in heart failure, obstructive and central sleep apnoea (OSA and CSA, respectively) are common in end-stage renal disease. Fluid overload characterises end-stage renal disease and heart failure, and in heart failure plays a role in the pathogenesis of OSA and CSA. We postulated that in end-stage renal disease patients, those with sleep apnoea would have greater fluid volume overload than thos...

Noninvasive positive pressure ventilation in the immediate post-bariatric surgery care ...
https://doi.org/10.1016/j.soard.2017.02.009
Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery; Tong S, Gower J et. al.

Apr 4th, 2017 - Obstructive sleep apnea is common in morbidly obese patients, and noninvasive positive pressure ventilation (NIPPV) is the standard treatment. Postoperatively, NIPPV is highly effective in preventing hypoxia and apneic episodes; however, the concern of gastric distention leading to increased risk of an anastomotic dehiscence limits universal acceptance. To perform a systematic review of the lit...

The Impact of Subthalamic Deep Brain Stimulation on Sleep-Wake Behavior: A Prospective ...
https://doi.org/10.1093/sleep/zsx033
Sleep Baumann-Vogel H, Imbach LL et. al.

Apr 3rd, 2017 - This prospective observational study was designed to systematically examine the effect of subthalamic deep brain stimulation (DBS) on subjective and objective sleep-wake parameters in Parkinson patients. In 50 consecutive Parkinson patients undergoing subthalamic DBS, we assessed motor symptoms, medication, the position of DBS electrodes within the subthalamic nucleus (STN), subjective sleep-wa...

The Efficacy of Low-Level Continuous Positive Airway Pressure for the Treatment of Snor...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406953
Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine; Guzman MA, Sgambati FP et. al.

Mar 30th, 2017 - To assess effects of low-level continuous positive airway pressure (CPAP) on snoring in habitual snorers without obstructive sleep apnea (OSA). A multicenter prospective in-laboratory reversal crossover intervention trial was conducted between September 2013 and August 2014. Habitual snorers were included if they snored (inspiratory sound pressure level ≥ 40 dBA) for ≥ 30% all sleep breaths on ...

Adenotonsillotomy Versus Adenotonsillectomy in Pediatric Obstructive Sleep Apnea: An RCT.
https://doi.org/10.1542/peds.2016-3314
Pediatrics Borgström A, Nerfeldt P et. al.

Mar 22nd, 2017 - Adenotonsillectomy (ATE) is a well-established and effective treatment of pediatric obstructive sleep apnea (OSA). In recent years, a more conservative method, adenotonsillotomy (ATT), has gained popularity because it is associated with less postoperative morbidity. Yet no previous randomized study has compared these 2 methods regarding their effectiveness in treating pediatric OSA in terms of ...

Codeine and opioid metabolism: implications and alternatives for pediatric pain managem...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482206
Current Opinion in Anaesthesiology; Chidambaran V, Sadhasivam S et. al.

Mar 22nd, 2017 - Use of perioperative opioids for surgical pain management of children presents clinical challenges because of concerns of serious adverse effects including life-threatening respiratory depression. This is especially true for children with history of obstructive sleep apnea. This review will explore current knowledge of clinically relevant factors and genetic polymorphisms that affect opioid met...

Obstructive Sleep Apnea is Associated With Early but Possibly Modifiable Alzheimer's Di...
https://doi.org/10.1093/sleep/zsx011
Sleep Liguori C, Mercuri NB et. al.

Mar 22nd, 2017 - Obstructive sleep apnea (OSA) is a common sleep disorder. The, literature lacks studies examining sleep, cognition, and Alzheimer's Disease (AD) cerebrospinal fluid (CSF) biomarkers in OSA patients. Therefore, we first studied cognitive performances, polysomnographic sleep, and CSF β-amyloid42, tau proteins, and lactate levels in patients affected by subjective cognitive impairment (SCI) divide...

Periodic limb movements and restless legs syndrome in children with a history of premat...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321628
Sleep Medicine; Cielo CM, DelRosso LM et. al.

Feb 21st, 2017 - Little is known about the pediatric population at an increased risk of restless legs syndrome (RLS) and periodic limb movement disorder (PLMD). Polysomnographic data from the Caffeine for Apnea of Prematurity-Sleep (CAPS) study showed a high prevalence of elevated periodic limb movement index (PLMI) in a cohort of ex-preterm children, but the clinical importance of this finding, such as associa...

Comparative efficacy of CPAP, MADs, exercise-training, and dietary weight loss for slee...
https://doi.org/10.1016/j.sleep.2016.06.001
Sleep Medicine; Iftikhar IH, Bittencourt L et. al.

Feb 21st, 2017 - To synthesize evidence from available studies on the relative efficacies of continuous positive airway pressure (CPAP), mandibular advancement device (MAD), supervised aerobic exercise training, and dietary weight loss in patients with obstructive sleep apnea (OSA). Network meta-analysis of 80 randomized controlled trials (RCTs) short-listed from PubMed, SCOPUS, Web of science, and Cochrane reg...

Effects of Adenotonsillectomy on Parent-Reported Behavior in Children With Obstructive ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806563
Sleep Thomas NH, Xanthopoulos MS et. al.

Feb 15th, 2017 - The childhood obstructive sleep apnea syndrome (OSAS) is associated with behavioral abnormalities. Studies on the effects of OSAS treatment on behavior are conflicting, with few studies using a randomized design. Further, studies may be confounded by the inclusion of behavioral outcome measures directly related to sleep. The objective of this study was to determine the effect of adenotonsillect...

Associations of Incident Cardiovascular Events With Restless Legs Syndrome and Periodic...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806566
Sleep Winkelman JW, Blackwell T et. al.

Feb 15th, 2017 - Both restless legs syndrome (RLS) and periodic leg movements in sleep (PLMS) may be associated with incident cardiovascular disease (CVD). However, the individual contributions of these factors to adverse CVD outcomes are unknown. During the MrOS Sleep Study, 2823 men (mean age = 76.3 years) participated in a comprehensive sleep assessment from 2000 to 2002. RLS was identified by self-report of...

Clinical Practice Guideline for Diagnostic Testing for Adult Obstructive Sleep Apnea: A...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337595
Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine; Kapur VK, Auckley DH et. al.

Feb 6th, 2017 - This guideline establishes clinical practice recommendations for the diagnosis of obstructive sleep apnea (OSA) in adults and is intended for use in conjunction with other American Academy of Sleep Medicine (AASM) guidelines on the evaluation and treatment of sleep-disordered breathing in adults. The AASM commissioned a task force of experts in sleep medicine. A systematic review was conducted ...

A predictive model for obstructive sleep apnea and Down syndrome.
https://doi.org/10.1002/ajmg.a.38137
American Journal of Medical Genetics. Part A; Skotko BG, Macklin EA et. al.

Jan 26th, 2017 - Obstructive sleep apnea (OSA) occurs frequently in people with Down syndrome (DS) with reported prevalences ranging between 55% and 97%, compared to 1-4% in the neurotypical pediatric population. Sleep studies are often uncomfortable, costly, and poorly tolerated by individuals with DS. The objective of this study was to construct a tool to identify individuals with DS unlikely to have moderate...

Risk of failure of adenotonsillectomy for obstructive sleep apnea in obese pediatric pa...
https://doi.org/10.1016/j.ijporl.2016.09.026
International Journal of Pediatric Otorhinolaryngology; Lennon CJ, Wang RY et. al.

Dec 25th, 2016 - Pediatric obesity is a leading risk factor for obstructive sleep apnea (OSA), a condition commonly treated with adenotonsillectomy (T&A). It has been hypothesized that obesity increases a child's risk of failing T&A for OSA, however this relationship has not yet been quantified. The primary objective of this study was to investigate the relationship between obesity as measured by perioperative ...

Postoperative Oxygen Therapy in Patients With OSA: A Randomized Controlled Trial.
https://doi.org/10.1016/j.chest.2016.12.005
Chest Liao P, Wong J et. al.

Dec 22nd, 2016 - Surgical patients with OSA are at increased risk for perioperative complications. Postoperative supplemental oxygen is commonly used, but it may contribute to respiratory depression in patients with OSA receiving opioids. The objective of the study is to investigate the effect of postoperative supplemental oxygen on arterial oxygen saturation (Sao2), sleep respiratory events, and CO2 level in p...

Performance of screening questionnaires for obstructive sleep apnea during pregnancy: A...
https://doi.org/10.1016/j.smrv.2016.11.003
Sleep Medicine Reviews; Tantrakul V, Numthavaj P et. al.

Dec 22nd, 2016 - This review aims to evaluate the performance of obstructive sleep apnea (OSA) screening questionnaires during pregnancy. A systematic review and meta-analysis was performed using MEDLINE Scopus, CINAHL, and the Cochrane library. A bivariate meta-analysis was applied for pooling of diagnostic parameters. Six of the total 4719 articles met the inclusion criteria. The Berlin questionnaire (BQ, N =...

The Accuracy of Portable Monitoring in Diagnosing Significant Sleep Disordered Breathin...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167272
PloS One; Nagubadi S, Mehta R et. al.

Dec 19th, 2016 - Polysomnograms are not always feasible when sleep disordered breathing (SDB) is suspected in hospitalized patients. Portable monitoring is a practical alternative; however, it has not been recommended in patients with comorbidities. We evaluated the accuracy of portable monitoring in hospitalized patients suspected of having SDB. Prospective observational study. Large, public, urban, teaching h...

Comparisons of Office and 24-Hour Ambulatory Blood Pressure Monitoring in Children with...
https://doi.org/10.1016/j.jpeds.2016.11.032
The Journal of Pediatrics; Kang KT, Chiu SN et. al.

Dec 12th, 2016 - To compare office blood pressure (BP) and 24-hour ambulatory BP (ABP) monitoring to facilitate the diagnosis and management of hypertension in children with obstructive sleep apnea (OSA). Children aged 4-16 years with OSA-related symptoms were recruited from a tertiary referral medical center. All children underwent overnight polysomnography, office BP, and 24-hour ABP studies. Multiple linear ...

An update on the various practical applications of the STOP-Bang questionnaire in anest...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214142
Current Opinion in Anaesthesiology; Nagappa M, Wong J et. al.

Nov 29th, 2016 - The present review aims to provide an update on the various practical applications of the STOP-Bang questionnaire in anesthesia, surgery, and perioperative medicine. The STOP-Bang questionnaire was originally validated as a screening tool to identify surgical patients who are at high-risk of obstructive sleep apnea (OSA). A recent meta-analysis confirmed that STOP-Bang is validated for use in t...

Central apneas in children with obstructive sleep apnea syndrome: prevalence and effect...
https://doi.org/10.1016/j.sleep.2016.05.018
Sleep Medicine; Boudewyns A, Van de Heyning P et. al.

Nov 8th, 2016 - The aim of this study is to investigate the prevalence of central sleep apneas syndrome (CSAS) in children with obstructive sleep apnea syndrome (OSAS) and the effect of adenotonsillectomy (A)TE on CSAS. Retrospective analysis of polysomnographic data in children diagnosed with OSAS and without comorbidity. A central apnea index (CAI) ≥1/h is considered abnormal and central sleep apnea syndrome...

Effect of sodium oxybate on disrupted nighttime sleep in patients with narcolepsy.
https://doi.org/10.1111/jsr.12468
Journal of Sleep Research; Roth T, Dauvilliers Y et. al.

Nov 3rd, 2016 - This post hoc analysis evaluated the dose-related effects of sodium oxybate on sleep continuity and nocturnal sleep quality in patients with narcolepsy-cataplexy. Polysomnography data, including shifts to Stage N1/Wake, were from a randomized, placebo-controlled trial of sodium oxybate. Patients were ≥16 years old with a diagnosis of narcolepsy including symptoms of cataplexy and excessive dayt...

Obesity hypoventilation syndrome, sleep apnea, overlap syndrome: perioperative manageme...
https://doi.org/10.1097/ACO.0000000000000421
Current Opinion in Anaesthesiology; Raveendran R, Wong J et. al.

Oct 29th, 2016 - The prevalence of sleep disordered breathing (SDB) is increasing proportional to the prevalence of obesity. Although anesthesiologists are familiar with obstructive sleep apnea (OSA) - the most common SDB, anesthesiologists may not be aware of other SDB such as obesity hypoventilation syndrome (OHS) and overlap syndrome (combination of OSA and chronic obstructive pulmonary disease). The present...

Validation of the pediatric sleep questionnaire in children with asthma.
https://doi.org/10.1002/ppul.23568
Pediatric Pulmonology; Ehsan Z, Kercsmar CM et. al.

Oct 27th, 2016 - The prevalence of obstructive sleep apnea (OSA) is higher in children with poorly controlled asthma. We aimed to determine the validity of the Pediatric Sleep Questionnaire (PSQ) to screen for OSA in children with asthma. This retrospective review encompassed sleep studies and medical records of asthmatic children evaluated in the sleep center at CCHMC over 13 years. Measures of validity were c...

Risk factors for residual obstructive sleep apnea after adenotonsillectomy in children.
https://doi.org/10.1002/lary.25979
The Laryngoscope; Imanguli M, Ulualp SO

Oct 24th, 2016 - To determine the prevalence of residual obstructive sleep apnea (OSA) in children who had adenotonsillectomy (AT) and to identify the risk factors for residual OSA after AT. Retrospective chart review. Children with OSA who had AT at a tertiary care children's hospital were reviewed. Data pertaining to demographics, past medical history, body mass index, tonsil and adenoid size, and polysomnogr...

Surfactant instillation in spontaneously breathing preterm infants: a systematic review...
https://doi.org/10.1007/s00431-016-2789-4
European Journal of Pediatrics; Rigo V, Lefebvre C et. al.

Sep 29th, 2016 - Less invasive surfactant therapies (LIST) use surfactant instillation through a thin tracheal catheter in spontaneously breathing infants. This review and meta-analysis investigates respiratory outcomes for preterm infants with respiratory distress syndrome treated with LIST rather than administration of surfactant through an endotracheal tube. Randomised controlled trial (RCT) full texts provi...

Early stridor onset and stridor treatment predict survival in 136 patients with MSA.
https://doi.org/10.1212/WNL.0000000000003156
Neurology Giannini G, Calandra-Buonaura G et. al.

Aug 27th, 2016 - To evaluate the predictive value of stridor and its latency of onset and to investigate the role of stridor treatment in a cohort of patients with multiple system atrophy (MSA) referred to a tertiary center. We retrospectively identified patients diagnosed with MSA referred to our department beginning in 1991 and evaluated at least yearly during the disease course. Stridor was defined as presen...

The Impact of Residual Neuromuscular Blockade, Oversedation, and Hypothermia on Adverse...
https://doi.org/10.1213/ANE.0000000000001513
Anesthesia and Analgesia; Stewart PA, Liang SS et. al.

Aug 18th, 2016 - Residual neuromuscular blockade (RNMB) has been linked to adverse respiratory events (AREs) in the postanesthetic care unit (PACU). However, these events are often not attributed to RNMB by anesthesiologists because they may also be precipitated by other factors including obstructive sleep apnea, opioids, or hypnotic agents. Many anesthesiologists believe RNMB occurs infrequently and is rarely ...

Cognitive Effects of Adenotonsillectomy for Obstructive Sleep Apnea.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960728
Pediatrics Taylor HG, Bowen SR et. al.

Jul 28th, 2016 - Research reveals mixed evidence for the effects of adenotonsillectomy (AT) on cognitive tests in children with obstructive sleep apnea syndrome (OSAS). The primary aim of the study was to investigate effects of AT on cognitive test scores in the randomized Childhood Adenotonsillectomy Trial. Children ages 5 to 9 years with OSAS without prolonged oxyhemoglobin desaturation were randomly assigned...

Society of Anesthesia and Sleep Medicine Guidelines on Preoperative Screening and Asses...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956681
Anesthesia and Analgesia; Chung F, Memtsoudis SG et. al.

Jul 21st, 2016 - The purpose of the Society of Anesthesia and Sleep Medicine guideline on preoperative screening and assessment of adult patients with obstructive sleep apnea (OSA) is to present recommendations based on the available clinical evidence on the topic where possible. As very few well-performed randomized studies in this field of perioperative care are available, most of the recommendations were dev...

Incidence and Outcome of CPAP Failure in Preterm Infants.
https://doi.org/10.1542/peds.2015-3985
Pediatrics Dargaville PA, Gerber A et. al.

Jul 1st, 2016 - Data from clinical trials support the use of continuous positive airway pressure (CPAP) for initial respiratory management in preterm infants, but there is concern regarding the potential failure of CPAP support. We aimed to examine the incidence and explore the outcomes of CPAP failure in Australian and New Zealand Neonatal Network data from 2007 to 2013. Data from inborn preterm infants manag...

Effect of CPAP Therapy on Symptoms of Nocturnal Gastroesophageal Reflux among Patients ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990948
Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine; Tamanna S, Campbell D et. al.

Jun 16th, 2016 - Nocturnal gastroesophageal reflux (nGER) is common among patients with obstructive sleep apnea (OSA). Previous studies demonstrated that continuous positive airway pressure (CPAP) reduces symptoms of nGER. However, improvement in nGER symptoms based on objective CPAP compliance has not been documented. We have examined the polysomnographic characteristics of patients with nGER and OSA and looke...

Objective Outcomes of Supraglottoplasty for Children With Laryngomalacia and Obstructiv...
https://doi.org/10.1001/jamaoto.2016.0830
JAMA Otolaryngology-- Head & Neck Surgery; Farhood Z, Ong AA et. al.

Jun 3rd, 2016 - Surgical intervention is the main treatment alternative for patients with severe laryngomalacia. Supraglottoplasty offers effective treatment results not only for laryngomalacia but also for concurrent obstructive sleep apnea (OSA). To quantify the objective outcomes of supraglottoplasty for laryngomalacia with OSA via polysomnography data in the pediatric population. A comprehensive literature...

Severity of self-reported insomnia in adults with epilepsy is related to comorbid medic...
https://doi.org/10.1016/j.yebeh.2016.03.023
Epilepsy & Behavior : E&B; Yang KI, Grigg-Damberger M et. al.

May 13th, 2016 - Few studies have systematically investigated insomnia in adults with epilepsy. We performed a prospective cross-sectional investigation of the prevalence, severity, and comorbidities of insomnia in 90 adults with epilepsy using a battery of self-reported instruments and polysomnography. We quantified insomnia severity using the Insomnia Severity Index (ISI). Fifty-nine of 90 (65.5%) adults with...