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About 2,146 results

ALLMedicine™ Orthostatic Hypotension Center - Clinicaltrials.gov

Associations of the systolic and diastolic components of orthostatic hypotension with m...
https://doi.org/10.1111/jch.13996
Journal of Clinical Hypertension (Greenwich, Conn.) References; Gilani A, Ramsay SE et. al.

Nov 24th, 2020 - The mechanisms underlying the association between orthostatic hypotension (OH) and cardiovascular disease are unclear. We investigated whether OH is associated with circulating cardiovascular risk markers. This was a cross-sectional analysis of 3857 older, community-dwelling men. "Consensus OH" was defined as a sitting-to-standing decrease in systolic blood pressure ≥20 mm Hg and/or diastolic b...

Prevalence of Impaired Orthostasis after Concussion Injury.
https://doi.org/10.1212/01.wnl.0000719868.04095.27
Neurology La Fountaine MF, Hohn A et. al.

Nov 17th, 2020 - To determine the prevalence of orthostatic hypotension (OHypo) and hypertension (OHTN), respectively after a concussion in collegiate athletes. Orthostasis causes a gravity-dependent redistribution of blood volume to the lower extremities. The baroreflex coordinates the cardiovascular autonomic nervous system to mitigate aberrant changes in systolic blood pressure (SBP). In autonomic dysfunctio...

What is the role of ascorbic acid in norepinephrine synthesis and orthostatic hypotension?
https://doi.org/10.1212/WNL.0000000000010960
Neurology Benarroch EE

Nov 17th, 2020 - What is the role of ascorbic acid in norepinephrine synthesis and orthostatic hypotension?|2020|Benarroch EE,|

Midodrine hydrochloride - midodrine hydrochloride tablet-NCS HealthCare of KY, Inc dba Vangard Labs
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=01b364d5-1c00-4f77-9adf-a360b70c381d

Nov 16th, 2020 - Midodrine hydrochloride is indicated for the treatment of symptomatic orthostatic hypotension (OH). Because midodrine hydrochloride can cause marked elevation of supine blood pressure (BP>200 mmHg systolic), it should be used in patients whose lives are considerably impaired despite standard clinical care, including non-pharmacologic treatment (such as support stockings), fluid expansion, and l...

Validation of the new index of baroreflex function to identify neurogenic orthostatic h...
https://doi.org/10.1016/j.autneu.2020.102744
Autonomic Neuroscience : Basic & Clinical; Guaraldi P, Baschieri F et. al.

Nov 14th, 2020 - According to expert opinion, orthostatic hypotension (OH) associated to a change in heart rate (ΔHR) less than 15 bpm suggests neurogenic OH (NOH). Recently, the ratio between HR and systolic blood pressure changes at 3 min of tilt test (ΔHR/ΔSBP) has been proposed as a better index than the ΔHR cut-off of 17 bpm. Our aim was to validate these indexes based on HR in an independent cohort of pat...

The Association of Orthostatic Hypotension with Ambulatory Blood Pressure Phenotypes in...
https://doi.org/10.1093/ajh/hpaa184
American Journal of Hypertension; Ghazi L, Drawz PE et. al.

Nov 13th, 2020 - Clinic blood pressure (BP) when measured in the seated position, can miss meaningful BP phenotypes, including low ambulatory BP (white coat effects [WCE]) or high supine BP (nocturnal non-dipping). Orthostatic hypotension (OH) measured via both seated (or supine) and standing BP, could identify phenotypes poorly captured by seated clinic BP alone. We examined the association of OH with WCE and ...

Loss of Pulsatility: Another Cause of Syncope in Patients with Left Ventricular Assist ...
https://doi.org/10.1097/MAT.0000000000001137
ASAIO Journal (American Society for Artificial Internal Organs : 1992); Money JE, Al Danaf J et. al.

Nov 2nd, 2020 - We report a case of a 55-year-old man who presented with recurrent syncope 15 months after HeartWare left ventricular assist device (LVAD) implantation and was found to have diminished LVAD flow and pulsatility on tilt table testing leading to severe orthostatic hypotension (OH). The prevalence of OH is common, but autonomic dysfunction leading to OH has not been well described in patients with...

Orthostatic hypotension: a pragmatic guide to diagnosis and treatment.
https://doi.org/10.1136/dtb.2020.000056
Drug and Therapeutics Bulletin; Gibbon JR, Frith J

Oct 31st, 2020 - Topics for DTB review articles are selected by DTB's editorial board to provide concise overviews of medicines and other treatments to help patients get the best care. Articles include a summary of key points and a brief overview for patients. Articles may also have a series of multiple choice CME questions.

Non-pharmacologic management of orthostatic hypotension.
https://doi.org/10.1016/j.autneu.2020.102732
Autonomic Neuroscience : Basic & Clinical; Chelimsky G, Chelimsky T

Oct 30th, 2020 - Orthostatic hypotension (OH), a debilitating disorder characterized by a drop in blood pressure when in the upright position, may be treated through several pharmacologic and lifestyle modifications. The treatment is aimed at decreasing the symptoms, mainly the falls, increase the standing time, and improve the activities of daily life. A recent expert consensus outlined the management of ortho...

Midodrine hydrochloride - midodrine hydrochloride tablet-Major Pharmaceuticals
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=164dce3b-1927-497e-884a-a2c72958beb9

Oct 28th, 2020 - Midodrine hydrochloride is indicated for the treatment of symptomatic orthostatic hypotension (OH). Because midodrine hydrochloride can cause marked elevation of supine blood pressure (BP>200 mmHg systolic), it should be used in patients whose lives are considerably impaired despite standard clinical care, including non-pharmacologic treatment (such as support stockings), fluid expansion, and l...

Orthostatic hypotension (postural hypotension) - Symptoms and causes - Mayo Clinic
https://www.mayoclinic.org/diseases-conditions/orthostatic-hypotension/symptoms-causes/syc-20352548

Oct 26th, 2020 - Overview Orthostatic hypotension — also called postural hypotension — is a form of low blood pressure that happens when you stand up from sitting or lying down. Orthostatic hypotension can make you feel dizzy or lightheaded, and maybe even cause you to faint. Orthostatic hypotension may be mild, and episodes can last for less than a few minutes. However, long-lasting orthostatic hypotension can...

Orthostatic hypotension (postural hypotension) - Diagnosis and treatment - Mayo Clinic
https://www.mayoclinic.org/diseases-conditions/orthostatic-hypotension/diagnosis-treatment/drc-20352553

Oct 26th, 2020 - Diagnosis Tilt table test Open pop-up dialog box Close Tilt table test Tilt table test You begin by lying flat on a table. Straps are put around your body to hold you in place. After lying flat for a while, the table is tilted to raise your body and head — simulating a change in position from lying down to standing up. During this test, your heart rate and blood pressure are monitored to evalua...

Four Hours Postoperative Mobilization is Feasible After Thoracoscopic Anatomical Pulmon...
https://doi.org/10.1007/s00268-020-05836-0
World Journal of Surgery; Nakada T, Shirai S et. al.

Oct 24th, 2020 - We aimed to analyze the feasibility and risk factors associated with early mobilization (EM) within 4 h after thoracoscopic lobectomy and segmentectomy. This study retrospectively evaluated 214 consecutive patients who underwent thoracoscopic anatomical pulmonary resection using our EM protocol between October 2017 and February 2019. We compared the correlations of the patients' characteristics...

Increased Pulse Wave Velocity in Persons with Spinal Cord Injury: The Effect of the Ren...
https://doi.org/10.1152/ajpheart.00544.2020
American Journal of Physiology. Heart and Circulatory Physiology; Katzelnick CG, Weir J et. al.

Oct 23rd, 2020 - Increased pulse wave velocity (PWV), a marker of cardiovascular disease (CVD), has been reported in otherwise healthy individuals with spinal cord injury (SCI) compared to age-matched uninjured controls. Due to decentralized descending sympathetic vascular control, individuals with injuries above T6 are prone to orthostatic hypotension and, as a result, depend on the renin-angiotensin aldostero...

Heart rate and blood pressure response improve the prediction of orthostatic cardiovasc...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575221
Physiological Reports REFERENCES; Wang S, Wecht JM et. al.

Oct 20th, 2020 - Unstable blood pressure after spinal cord injury (SCI) is not routinely examined but rather predicted by level and completeness of injury (i.e., American Spinal Injury Association Impairment Scale AIS classification). Our aim was to investigate hemodynamic response to a sit-up test in a large cohort of individuals with chronic SCI to better understand cardiovascular function in this population....

Management of Orthostatic Hypotension, Postprandial Hypotension, and Supine Hypertension.
https://doi.org/10.1055/s-0040-1713886
Seminars in Neurology; Shibao CA, Biaggioni I

Oct 15th, 2020 - This review provides recommendations for the treatment of neurogenic orthostatic hypotension (nOH), postprandial hypotension, and supine hypertension. It focuses on novel treatment strategies and new insights into the mechanism underlying these conditions. Our goal is to provide practical advice for clinicians on how to screen, diagnose, and treat these conditions with nonpharmacological and ph...

Midodrine hydrochloride - midodrine hydrochloride tablet-Bryant Ranch Prepack
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2be17e48-8258-4f29-914b-7f0fe9ace7a1

Oct 15th, 2020 - Midodrine hydrochloride tablets are indicated for the treatment of symptomatic orthostatic hypotension (OH). Because midodrine hydrochloride tablets can cause marked elevation of supine blood pressure (BP > 200 mmHg systolic), it should be used in patients whose lives are considerably impaired despite standard clinical care, including non-pharmacologic treatment (such as support stockings), flu...

The absence of orthostatic heart rate increase is associated with cognitive impairment ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7561175
PloS One; Tanaka R, Yamashiro K et. al.

Oct 15th, 2020 - Orthostatic hypotension (OH) frequently accompanies autonomic dysfunction and is an important risk factor for cognitive impairment in Parkinson's disease (PD). While OH is usually diagnosed based on an orthostatic blood pressure drop, the association between the heart rate response and cognitive impairment remains unclear. We retrospectively analyzed 143 cases of clinically diagnosed PD to dete...

Midodrine hydrochloride - midodrine hydrochloride tablet-Xiromed, LLC
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a4332a41-2a0a-a14a-9ce5-1465f39ff725

Oct 14th, 2020 - Midodrine hydrochloride tablets are indicated for the treatment of symptomatic orthostatic hypotension (OH). Because midodrine hydrochloride tablets can cause marked elevation of supine blood pressure (BP > 200 mmHg systolic), it should be used in patients whose lives are considerably impaired despite standard clinical care, including non-pharmacologic treatment (such as support stockings), flu...

Clinical presentation and long-term follow-up of dopamine beta hydroxylase deficiency.
https://doi.org/10.1002/jimd.12321
Journal of Inherited Metabolic Disease REFERENCES; Wassenberg T, Deinum J et. al.

Oct 9th, 2020 - Dopamine beta hydroxylase (DBH) deficiency is an extremely rare autosomal recessive disorder with severe orthostatic hypotension, that can be treated with L-threo-3,4-dihydroxyphenylserine (L-DOPS). We aimed to summarize clinical, biochemical, and genetic data of all world-wide reported patients with DBH-deficiency, and to present detailed new data on long-term follow-up of a relatively large D...

Rivastigmine in Parkinson's Disease Dementia with Orthostatic Hypotension.
https://doi.org/10.1002/ana.25923
Annals of Neurology References; Espay AJ, Marsili L et. al.

Oct 5th, 2020 - The purpose of this study was to evaluate if the cognitive benefit of rivastigmine is affected by the presence of orthostatic hypotension (OH) in patients with Parkinson's disease dementia (PDD). We conducted a post hoc analysis on 1,047 patients with PDD from 2 randomized controlled trials comparing rivastigmine versus placebo at week 24 (n = 501) and rivastigmine patch versus capsule at week ...

Risk of orthostatic hypotension associated with sodium-glucose cotransporter-2 inhibito...
https://doi.org/10.1177/1479164120953625
Diabetes & Vascular Disease Research; Rong X, Li X et. al.

Sep 28th, 2020 - The aim of this study was to assess the association between sodium-glucose cotransporter-2 (SGLT2) inhibitors and the risk of orthostatic hypotension (OH) in patients with type 2 diabetes mellitus (T2DM). A systematic literature retrieval was performed using PubMed, Embase, and the Cochrane Central Register of Controlled Trials (CENTRAL) from inception up to 16 October 2019. Data for study char...

Pharmacologic treatment of orthostatic hypotension.
https://doi.org/10.1016/j.autneu.2020.102721
Autonomic Neuroscience : Basic & Clinical; Park JW, Okamoto LE et. al.

Sep 26th, 2020 - Neurogenic orthostatic hypotension (OH) is a disabling disorder caused by impairment of the normal autonomic compensatory mechanisms that maintain upright blood pressure. Nonpharmacologic treatment is always the first step in the management of this condition, but a considerable number of patients will require pharmacologic therapies. Denervation hypersensitivity and impairment of baroreflex buf...

Orthostatic Hypotension: A Prodromal Marker of Parkinson's Disease?
https://doi.org/10.1002/mds.28303
Movement Disorders : Official Journal of the Movement Disorder Society References; Dommershuijsen LJ, Heshmatollah A et. al.

Sep 23rd, 2020 - Orthostatic hypotension is common in patients with Parkinson's disease (PD). However, it remains unknown whether orthostatic hypotension is a marker of prodromal PD or more advanced disease. The objectives of this study were to assess whether orthostatic hypotension is a prodromal marker of PD in the general population. This study was embedded in the Rotterdam Study, a large prospective populat...

Association of transient orthostatic hypotension with falls and syncope in patients wit...
https://doi.org/10.1212/WNL.0000000000010749
Neurology Fanciulli A, Campese N et. al.

Sep 17th, 2020 - To assess the frequency of transient orthostatic hypotension (tOH) and its clinical impact in Parkinson disease (PD), we retrospectively studied 173 patients with PD and 173 age- and sex-matched controls with orthostatic intolerance, who underwent cardiovascular autonomic function testing under continuous noninvasive blood pressure (BP) monitoring. We screened for tOH (systolic BP fall ≥20 mm H...

Delayed orthostatic hypotension.
https://doi.org/10.1016/j.autneu.2020.102724
Autonomic Neuroscience : Basic & Clinical; Gibbons CH, Freeman R

Sep 17th, 2020 - Delayed orthostatic hypotension is a fall in blood pressure beyond 3 min of standing or upright tilt table testing. The prevalence, clinical features and pathophysiology are reviewed. To date, there is little data to support a standardized or recommended treatment. However, the 10-year mortality rates of individuals with delayed orthostatic hypotension are approximately 50%. Despite the fact th...

GBE1 Adult Polyglucosan Body Disease - GeneReviews® - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/n/gene/apbd/

Sep 16th, 2020 - Most individuals with classic GBE1 adult polyglucosan body disease (GBE1-APBD) present after age 40 years with unexplained progressive neurogenic bladder, gait difficulties (i.e., spasticity and weakness) from mixed upper and lower motor neuron involvement, sensory loss predominantly in the distal lower extremities, autonomic dysfunction (associated with orthostatic hypotension and constipation...

Does arterial stiffness affect orthostatic hypotension among high-altitude Tibetans?
https://doi.org/10.1080/00325481.2020.1823683
Postgraduate Medicine; Li X, Shi R et. al.

Sep 14th, 2020 - This study aimed to investigate the association between arterial stiffness and orthostatic hypotension (OH) and orthostatic blood pressure (BP) changes among Tibetans living at high altitude. A total of 630 high-altitude Tibetans were included (56.53 ± 10.16 years; 246 men). Arterial stiffness was assessed by brachial-ankle pulse wave velocity (baPWV). OH was defined as a decrease in systolic B...

Respiratory and sleep-related complications of multiple system atrophy.
https://doi.org/10.1097/MCP.0000000000000725
Current Opinion in Pulmonary Medicine; Ralls F, Cutchen L

Sep 14th, 2020 - The purpose of this article is to provide a contemporary review of sleep issues affecting patients with multiple system atrophy (MSA). Prodromal symptoms of MSA may occur years prior to diagnosis, including autonomic dysfunction such as orthostatic hypotension, urogenital dysfunction, rapid eye movement (REM) sleep behavior disorder (RBD), and stridor. Patients may also develop sleep-related re...

Does Vitamin D Deficiency Increase Orthostatic Hypotension Risk in Older Men?
https://www.medscape.com/viewarticle/937154

Sep 13th, 2020 - Takeaway Vitamin D deficiency (<25 nmol/L) was associated with an increased risk of orthostatic hypotension (OH) that occurred within 1 minute of standing (OH-1) in older men.

Effects of Intensive Blood Pressure Treatment on Orthostatic Hypotension : A Systematic...
https://doi.org/10.7326/M20-4298
Annals of Internal Medicine; Juraschek SP, Hu JR et. al.

Sep 10th, 2020 - Although intensive blood pressure (BP)-lowering treatment reduces risk for cardiovascular disease, there are concerns that it might cause orthostatic hypotension (OH). To examine the effects of intensive BP-lowering treatment on OH in hypertensive adults. (PROSPERO: CRD42020153753). MEDLINE, EMBASE, and Cochrane CENTRAL from inception through 7 October 2019, without language restrictions. Rando...

Intensive Hypertension Treatment Lowers Orthostatic Hypotension
https://www.staging.medscape.com/viewarticle/937189

Sep 9th, 2020 - For most patients with hypertension, more aggressive blood pressure (BP) lowering does not increase risk for orthostatic hypotension (OH); on the contrary, it appears to lower the risk, a new meta-analysis suggests. In addition, OH prior to treatment was not associated with more OH from aggressive treatment, principal investigator Stephen Juraschek, MD, PhD, of Beth Israel Deaconess Medical Cen...

Clinical Trials for Neurogenic Orthostatic Hypotension: A Comprehensive Review of Endpo...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606619
Seminars in Neurology; Palma JA, Kaufmann H

Sep 9th, 2020 - Neurogenic orthostatic hypotension (nOH) is among the most debilitating nonmotor features of patients with Parkinson's disease (PD) and other synucleinopathies. Patients with PD and nOH generate more hospitalizations, make more emergency room visits, create more telephone calls/mails to doctors, and have earlier mortality than those with PD but without nOH. Overall, the health-related cost in p...

Vitamin D deficiency is associated with orthostatic hypotension in older men: a cross-s...
https://doi.org/10.1093/ageing/afaa146
Age and Ageing; Gilani A, Ramsay SE et. al.

Sep 9th, 2020 - orthostatic hypotension (OH) that occurs within, or at, 1 minute of standing is associated with higher risk of falls, myocardial infarction, syncope and mortality, compared to OH that occurs after 1 minute of standing. Whether vitamin D deficiency increases the risk of OH is controversial. this was a cross-sectional analysis of 3,620 older, community-dwelling men. Multinomial, multiple logistic...

Intensive Hypertension Treatment Lowers Orthostatic Hypotension
https://www.medscape.com/viewarticle/937189

Sep 9th, 2020 - For most patients with hypertension, more aggressive blood pressure (BP) lowering does not increase risk for orthostatic hypotension (OH); on the contrary, it appears to lower the risk, a new meta-analysis suggests. In addition, OH prior to treatment was not associated with more OH from aggressive treatment, principal investigator Stephen Juraschek, MD, PhD, of Beth Israel Deaconess Medical Cen...

Morbidity and mortality in orthostatic hypotension.
https://doi.org/10.1016/j.autneu.2020.102717
Autonomic Neuroscience : Basic & Clinical; Farrell MC, Shibao CA

Sep 8th, 2020 - This review summarizes the current literature on the epidemiology of orthostatic hypotension (OH) in the elderly and in patients with autonomic impairment also known as neurogenic OH (nOH); these two conditions have distinct pathophysiologies and affect different patient populations. The prevalence of OH in the elderly varies depending on the study population. In community dwellers, OH prevalen...

Clinical clustering of eight orthostatic haemodynamic patterns in The Irish Longitudina...
https://doi.org/10.1093/ageing/afaa174
Age and Ageing; Moloney D, O'Connor J et. al.

Sep 7th, 2020 - Orthostatic hypotension (OH) can be assessed with non-invasive continuous beat-to-beat haemodynamic monitoring during active stand (AS) testing; this yields large volumes of data outside the scope of the traditional OH definition. We explored clinical associations of different AS patterns in participants from Wave 1 of the Irish Longitudinal Study on Ageing. AS patterns were generated based on ...

Drug-Related Orthostatic Hypotension: Beyond Anti-Hypertensive Medications.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524811
Drugs & Aging; Rivasi G, Rafanelli M et. al.

Sep 7th, 2020 - Orthostatic hypotension (OH) is an abnormal blood pressure response to standing, which is associated with an increased risk of adverse outcomes such as syncope, falls, cognitive impairment, and mortality. Medical therapy is one the most common causes of OH, since numerous cardiovascular and psychoactive medications may interfere with the blood pressure response to standing, leading to drug-rela...

Midodrine hydrochloride - midodrine hydrochloride tablet-Zydus Pharmaceuticals (USA) Inc.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3bc97210-fa2f-4979-abdf-d92e5973e6e3

Sep 6th, 2020 - Midodrine hydrochloride tablets are indicated for the treatment of symptomatic orthostatic hypotension (OH). Because midodrine hydrochloride tablets can cause marked elevation of supine blood pressure (BP > 200 mmHg systolic), it should be used in patients whose lives are considerably impaired despite standard clinical care, including non-pharmacologic treatment (such as support stockings), flu...

Orthostatic hypotension, arterial stiffness and home blood pressure variability: an opp...
https://doi.org/10.1097/HJH.0000000000002557
Journal of Hypertension; Barochiner J

Sep 5th, 2020 - Orthostatic hypotension, arterial stiffness and home blood pressure variability: an opportunity for looking beyond the horizon.|2020|Barochiner J,|

Midodrine hydrochloride - midodrine hydrochloride tablet-Cadila Healthcare Limited
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b4c4417e-d8fd-46c8-b82f-ffbc8f201752

Sep 4th, 2020 - Midodrine hydrochloride tablets are indicated for the treatment of symptomatic orthostatic hypotension (OH). Because midodrine hydrochloride tablets can cause marked elevation of supine blood pressure (BP > 200 mmHg systolic), it should be used in patients whose lives are considerably impaired despite standard clinical care, including non-pharmacologic treatment (such as support stockings), flu...

Signs of Chronic Hypoxia Suggest a Novel Pathophysiological Event in α-Synucleinopathies.
https://doi.org/10.1002/mds.28229
Movement Disorders : Official Journal of the Movement Disorder Society References; Heras-Garvin A, Danninger C et. al.

Sep 3rd, 2020 - Multiple system atrophy (MSA) and Parkinson's disease (PD) patients develop respiratory and cardiovascular disturbances including obstructive sleep apnea, orthostatic hypotension, and nocturnal stridor. We hypothesized that, associated with these respiratory and cardiovascular disturbances, hypoxic events may occur in MSA and PD brains that may play a role in disease progression. The objective ...

Hypertension and orthostatic hypotension with venlafaxine treatment in depressed older ...
https://doi.org/10.1177/0269881120944154
Journal of Psychopharmacology (Oxford, England); Wathra R, Mulsant BH et. al.

Aug 27th, 2020 - Venlafaxine, a serotonin-norepinephrine reuptake inhibitor, is often used as first- or second-line therapy for depression in older adults. It can be associated with adverse blood pressure (BP) effects. Adults ⩾60 years of age in a current major depressive episode were treated in a protocolized manner with venlafaxine XR; 429 participants were treated for 8-16 weeks with a daily dose up to 300 m...

Pharmacokinetics of Ampreloxetine, a Norepinephrine Reuptake Inhibitor, in Healthy Subj...
https://doi.org/10.1007/s40262-020-00918-7
Clinical Pharmacokinetics; Kanodia J, Lo A et. al.

Aug 26th, 2020 - Ampreloxetine is a novel norepinephrine reuptake inhibitor in development for the treatment of symptomatic neurogenic orthostatic hypotension. The objectives of this analysis were to define the pharmacokinetics of once-daily oral ampreloxetine and provide dose recommendations for clinical development. We fitted a population pharmacokinetic model to ampreloxetine plasma concentrations from singl...

Systolic Orthostatic Hypotension Tied to Dementia Risk
https://www.staging.medscape.com/viewarticle/936079

Aug 19th, 2020 - Systolic, but not diastolic, orthostatic hypotension is associated with a 40% increase in risk for incident dementia ― and the risk is not affected by demographic variables or medical comorbidities, new research suggests. Data from the prospective Health, Aging, and Body Composition (Health ABC) study also showed that variability over time in postural changes in systolic blood pressure (BP) was...

Systolic Orthostatic Hypotension Tied to Dementia Risk
https://www.medscape.com/viewarticle/936079

Aug 19th, 2020 - Systolic, but not diastolic, orthostatic hypotension is associated with a 40% increase in risk for incident dementia ― and the risk is not affected by demographic variables or medical comorbidities, new research suggests. Data from the prospective Health, Aging, and Body Composition (Health ABC) study also showed that variability over time in postural changes in systolic blood pressure (BP) was...

Differential diagnosis of orthostatic hypotension.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502506
Autonomic Neuroscience : Basic & Clinical; Lei LY, Chew DS et. al.

Aug 17th, 2020 - Orthostatic hypotension (OH) is a common clinical manifestation characterized by a significant fall in blood pressure with postural change and is frequently accompanied by debilitating symptoms of orthostatic intolerance. The reported prevalence of OH ranges between 5 and 10% in middle-aged adults with a burden that increases concomitantly with age; in those over 60 years of age, the prevalence...

Autonomic Dysfunction in Parkinson's Disease.
https://doi.org/10.1007/s13311-020-00897-4
Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics; Pfeiffer RF

Aug 12th, 2020 - Recognition of the importance of nonmotor dysfunction as a component of Parkinson's disease has exploded over the past three decades. Autonomic dysfunction is a frequent and particularly important nonmotor feature because of the broad clinical spectrum it covers. Cardiovascular, gastrointestinal, urinary, sexual, and thermoregulatory abnormalities all can appear in the setting of Parkinson's di...

Orthostatic blood pressure recovery associates with physical performance, frailty and n...
https://doi.org/10.1097/HJH.0000000000002617
Journal of Hypertension; Mol A, Slangen LRN et. al.

Aug 10th, 2020 - Blood pressure (BP) recovery after orthostatic hypotension might be important to prevent cerebral hypoperfusion episodes in older adults, and be related to better clinical outcome. The objective was to study the relationship between BP recovery and clinical outcome, that is physical and cognitive performance, frailty and falls, in geriatric outpatients. One hundred and sixty-eight geriatric out...

Midodrine hydrochloride - midodrine hydrochloride tablet-Aurobindo Pharma Limited
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=771b3e81-f15b-4d32-a1d8-c43b104d1f7b

Aug 9th, 2020 - Midodrine hydrochloride tablets are indicated for the treatment of symptomatic orthostatic hypotension (OH). Because midodrine hydrochloride tablets can cause marked elevation of supine blood pressure (BP>200 mmHg systolic), it should be used in patients whose lives are considerably impaired despite standard clinical care, including non-pharmacologic treatment (such as support stockings), fluid...

Older adults' drop in cerebral oxygenation on standing correlates with postural instabi...
https://doi.org/10.1093/gerona/glaa194
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences; Fitzgibbon-Collins LK, Heckman GA et. al.

Aug 6th, 2020 - Impaired blood pressure (BP) recovery with orthostatic hypotension on standing occurs in 20% of older adults. Low BP is associated with low cerebral blood flow but mechanistic links to postural instability and falls are not established. We investigated whether posture-related reductions in cerebral tissue oxygenation (tSO2) in older adults impaired stability upon standing, if a brief sit before...

Serum Activity Against G Protein-Coupled Receptors and Severity of Orthostatic Symptoms...
https://doi.org/10.1161/JAHA.120.015989
Journal of the American Heart Association; Kharraziha I, Axelsson J et. al.

Aug 4th, 2020 - Background Postural orthostatic tachycardia syndrome (POTS) is characterized by excessive heart rate increase on standing and orthostatic intolerance. Previous data indicate autoimmune involvement. We studied serum activity against G protein-coupled receptors in relation to symptoms in patients with POTS and controls using a commercial cell-based assay. Methods and Results Forty-eight patients ...

Addressing Orthostatic Hypotension in Heart Failure: Pathophysiology, Clinical Implicat...
https://doi.org/10.1007/s12265-020-10044-1
Journal of Cardiovascular Translational Research; Soloveva A, Fedorova D et. al.

Aug 4th, 2020 - Heart failure (HF)is a condition at high risk for orthostatic hypotension (OH)given the large proportion of patients at an advanced age and high burden of comorbidities contributing to OH, as well as a high prevalence of medications with neurovascular and volume modulating properties. Early identification of OH in HF seems to be crucial as OH can have an impact on patient symptoms, activity lev...

Orthostatic hypotension, dizziness, neurology outcomes, and death in older adults.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682840
Neurology Juraschek SP, Longstreth WT et. al.

Jul 31st, 2020 - To test the hypothesis that orthostatic hypotension (OH) might cause cerebral hypoperfusion and injury, we examined the longitudinal relationship between OH or orthostatic symptoms and incident neurologic outcomes in a community population of older adults. Cardiovascular Health Study participants (≥65 years) without dementia or stroke had blood pressure (BP) measured after lying down for 20 min...

An Adrenal Incidentaloma Diagnosed as Dopamine-Secreting Pheochromocytoma: A Case Report.
https://doi.org/10.1016/j.jnma.2020.07.005
Journal of the National Medical Association; Jing J, Yu M et. al.

Jul 29th, 2020 - Dopamine-secreting pheochromocytomas are exceedingly rare. A 28-year-old woman, who was admitted due to 4 hours of acute-onset abdominal pain, detected an adrenal mass incidentally. She was almost asymptomatic without a known family history. Laboratory assessments showed significant increases in dopamine levels of serum and 24-h urinary. By using preoperative a-adrenergic receptor blockers, she...

Management of Orthostatic Hypotension in Parkinson's Disease.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592655
Journal of Parkinson's Disease; Fanciulli A, Leys F et. al.

Jul 27th, 2020 - Orthostatic hypotension (OH) is a common non-motor feature of Parkinson's disease that may cause unexplained falls, syncope, lightheadedness, cognitive impairment, dyspnea, fatigue, blurred vision, shoulder, neck, or low-back pain upon standing. Blood pressure (BP) measurements supine and after 3 minutes upon standing screen for OH at bedside. The medical history and cardiovascular autonomic fu...

Systolic blood pressure postural changes variability is associated with greater dementi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682838
Neurology Rouch L, Vidal JS et. al.

Jul 21st, 2020 - To determine whether orthostatic hypotension (OHYPO) and visit-to-visit blood pressure (BP) postural changes variability are associated with incident dementia. We studied 2,131 older adults from the Health, Aging, and Body Composition cohort study. Orthostatic BP was repeatedly assessed over a 5-year baseline period. OHYPO was defined as a fall ≥15 mm Hg in systolic or ≥7 mm Hg in diastolic BP ...

Postural blood pressure changes in the elderly: orthostatic hypotension and hypertension.
https://doi.org/10.1097/MBP.0000000000000466
Blood Pressure Monitoring; Kocyigit SE, Erken N et. al.

Jul 17th, 2020 - Orthostatic hypotension is a well-known disorder, but orthostatic hypertension (OHT) still remains unclear in older adults. The aim of this study was to determine the comparison orthostatic hypotension with OHT according to fall risk and geriatric assessment parameters. A total of 741 patients who were admitted to the geriatric clinic and underwent comprehensive geriatric assessment were review...

Antidepressant use and orthostatic hypotension in older adults living with mild-to-mode...
https://doi.org/10.1002/gps.5377
International Journal of Geriatric Psychiatry REFERENCES; Dyer AH, Murphy C et. al.

Jul 15th, 2020 - Antidepressant use is often reported as a risk factor for Orthostatic Hypotension (OH), however this relationship has never been explored in those with mild/moderate Alzheimer Disease (AD), who may represent a particularly vulnerable cohort. We performed a cross-sectional analysis of baseline data from the NILVAD study. Participants with mild-moderate AD were recruited from 23 centres in nine c...

Neurogenic Orthostatic Hypotension: An Underrecognized Complication of Parkinson Disease.
https://doi.org/10.1097/JNN.0000000000000528
The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses; Sin MK, Khemani P

Jul 10th, 2020 - Neurogenic orthostatic hypotension (nOH) is a common source of disability but is an often untreated nonmotor symptom of Parkinson disease. The key manifestations of nOH include lightheadedness, dizziness, weakness, and fatigue when standing and engaging in activities in the upright position and result in falls, impaired activities of living, decreased quality of life, and short-term cognitive i...

Time point of blood pressure drop in patients with orthostatic hypotension in the emerg...
https://doi.org/10.1097/HJH.0000000000002554
Journal of Hypertension; Jang K, Park M et. al.

Jul 10th, 2020 - The purpose of this study was to identify the time of blood pressure (BP) drop in the orthostatic hypotension test, and to propose a realistic and appropriate duration in the orthostatic hypotension test. A total of 879 consecutive patients (61-year-old and 44% women) with positive on the orthostatic hypotension test in the emergency department were retrospectively reviewed. Orthostatic hypoten...

Midodrine hydrochloride - midodrine hydrochloride tablet-Upsher-Smith laboratories, LLC
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4c3517f3-1c68-4ade-b5f1-c488a3a335c1

Jul 8th, 2020 - Midodrine hydrochloride tablets are indicated for the treatment of symptomatic orthostatic hypotension (OH). Because midodrine hydrochloride tablets can cause marked elevation of supine blood pressure (BP>200 mmHg systolic), it should be used in patients whose lives are considerably impaired despite standard clinical care, including non-pharmacologic treatment (such as support stockings), fluid...

Relationship between sarcopenia and orthostatic hypotension.
https://doi.org/10.1093/ageing/afaa077
Age and Ageing; Soysal P, Kocyigit SE et. al.

Jul 2nd, 2020 - The relationship between sarcopenia and orthostatic hypotension (OH) is unclear. The aim of the present study was to investigate associations between sarcopenia/sarcopenia severity and OH. A total of 511 patients attending a geriatric outpatient clinic were included. OH was defined as a decrease in systolic and/or diastolic blood pressure of ≥ 20 mmHg and/or ≥ 10 mmHg, respectively, when one tr...

Increased Salt Intake for Orthostatic Intolerance Syndromes: A Systematic Review and Me...
https://doi.org/10.1016/j.amjmed.2020.05.028
The American Journal of Medicine; Loughlin EA, Judge CS et. al.

Jun 30th, 2020 - Guidelines recommend increased salt intake as a first-line recommendation in the management of symptomatic orthostatic hypotension and recurrent syncope. There have been no systematic reviews of this intervention. We sought to summarize the evidence for increased salt intake in patients with orthostatic intolerance syndromes. We conducted a systematic review and meta-analysis of studies in PubM...

4th A in a triple A syndrome - A rare case report.
https://doi.org/10.1515/jbcpp-2019-0293
Journal of Basic and Clinical Physiology and Pharmacology; MaheshKumar K, Mahadevan S et. al.

Jun 26th, 2020 - Objectives AAA (Allgrove) syndrome is a rare genetic disorder characterized by cardinal features of adrenal insufficiency, achalasia, and alacrimia. Case presentation A 21 year girl of known case of Triple A syndrome was referred for the evaluation of autonomic function. She was born full term with developmental delay and abnormal gait. Esophageal manometry study by pneumatic balloon dilatation...

Droxidopa as an effective treatment for refractory neurogenic orthostatic hypotension a...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305628
Journal of Medical Case Reports; Ho AH, Kinter CW et. al.

Jun 20th, 2020 - Droxidopa is an oral treatment for the stepwise treatment of neurogenic orthostatic hypotension from autonomic dysfunction. It has been shown to be useful predominantly with neurogenic orthostatic hypotension secondary to Parkinson's disease, but only a few cases have documented its usefulness in patients with neurogenic orthostatic hypotension due to amyloidosis, which is often severe and refr...

Management of neurogenic orthostatic hypotension in the heart failure patient.
https://doi.org/10.1016/j.autneu.2020.102691
Autonomic Neuroscience : Basic & Clinical; Dixon DD, Muldowney JAS

Jun 19th, 2020 - Neurogenic orthostatic hypotension (nOH) is a common comorbidity in patients with neurodegenerative diseases. It is associated with an increased risk of falls, incident cardiovascular disease, and all-cause mortality. There are over 5 million individuals in the U.S. with heart failure (HF) with an associated 50% mortality rate at 5 years. The prevalence of nOH and HF increase with age and, as t...

Midodrine hydrochloride - midodrine hydrochloride tablet-Drug Ocean LLC
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=70f909b8-461c-4929-8a92-83c5bb5e6f6b

Jun 18th, 2020 - Midodrine hydrochloride tablets are indicated for the treatment of symptomatic orthostatic hypotension (OH). Because midodrine hydrochloride tablets can cause marked elevation of supine blood pressure (BP > 200 mmHg systolic), it should be used in patients whose lives are considerably impaired despite standard clinical care, including non-pharmacologic treatment (such as support stockings), flu...

Skin Biopsy May Help to Distinguish Multiple System Atrophy-Parkinsonism from Parkinson...
https://doi.org/10.1002/mds.28126
Movement Disorders : Official Journal of the Movement Disorder Society References; Donadio V, Incensi A et. al.

Jun 17th, 2020 - The differential diagnosis between multiple system atrophy parkinsonism type (MSA-P) and Parkinson's disease with orthostatic hypotension (PD+OH) is difficult because the 2 diseases have a similar clinical picture. The aim of this study is to distinguish MSA-P from PD+OH by immunostaining for abnormal phosphorylated α-synuclein at serine 129 (p-syn) in cutaneous nerves. We recruited 50 patients...

Midodrine hydrochloride - midodrine hydrochloride tablet-Cardinal Health
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5e2443c2-f714-4b1d-bf2d-22742f411961

Jun 15th, 2020 - Midodrine hydrochloride is indicated for the treatment of symptomatic orthostatic hypotension (OH). Because midodrine hydrochloride can cause marked elevation of supine blood pressure (BP>200 mmHg systolic), it should be used in patients whose lives are considerably impaired despite standard clinical care, including non-pharmacologic treatment (such as support stockings), fluid expansion, and l...

A Longitudinal Skin Biopsy Study of Phosphorylated Alpha-Synuclein in a Patient With Pa...
https://doi.org/10.1093/jnen/nlaa048
Journal of Neuropathology and Experimental Neurology; Infante R, Scaglione C et. al.

Jun 12th, 2020 - The aim of our study was to assess the distribution of phosphorylated α-synuclein (p-syn) deposits in a patient affected by early stage Parkinson disease and orthostatic hypotension through a longitudinal skin biopsy study. We found widespread p-syn spatial diffusion from deep autonomic dermis nerve bundles to autonomic terminals, suggesting a centrifugal spread of p-syn from ganglia to the inn...

The impact of supine hypertension on target organ damage and survival in patients with ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415666
Parkinsonism & Related Disorders; Palma JA, Redel-Traub G et. al.

Jun 9th, 2020 - In addition to neurogenic orthostatic hypotension (nOH), patients with synucleinopathies frequently have hypertension when supine. The long-term consequences of both abnormalities are difficult to disentangle. We aimed to determine if supine hypertension is associated with target organ damage and worse survival in patients with nOH. Patients with nOH due to multiple system atrophy (MSA), Parkin...

Gastrointestinal motility evaluation in children with orthostatic intolerance: Mayo Cli...
https://doi.org/10.1111/nmo.13863
Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society REFERENCES; Manini ML, Barazi A et. al.

May 31st, 2020 - Orthostatic intolerance (OI) and autonomic dysfunction (AD) are common in adolescents and young adults. Patients experience multisystem symptoms including gastrointestinal (GI), postural orthostatic tachycardia syndrome (POTS), orthostatic hypotension (OH), or only symptoms of OI (SOI) without significant findings on 70-degree head-up tilt testing (HUT). We hypothesize that patients with POTS, ...

Orthostatic hypotension: clinical review and case study.
https://doi.org/10.12968/bjon.2020.29.9.506
British Journal of Nursing (Mark Allen Publishing); Bailey R, Mortimore G

May 14th, 2020 - Transient loss of consciousness (TLOC) accounts for 3% of all attendance in emergency departments within the UK. More than 90% of TLOC presentations are due to epileptic seizures, psychogenic seizures or syncope. However, in England and Wales in 2002, it was estimated that 92 000 patients were incorrectly diagnosed with epilepsy, at an additional annual cost to the NHS of up to £189 million. Th...

Familial Renal Amyloidosis Clinical Presentation
https://emedicine.medscape.com/article/246221-clinical

May 13th, 2020 - History Patients with familial renal amyloidosis (FRA) typically present with proteinuria and/or hypertension followed by progressive renal failure. The latter may evolve extremely slowly, and patients with hereditary apolipoprotein AI and lysozyme amyloidosis may not develop end-stage renal failure for several decades. In contrast to AL amyloidosis, orthostatic hypotension is unusual, probably...

The association between fear of falling and orthostatic hypotension in older adults.
https://doi.org/10.1007/s40520-020-01584-2
Aging Clinical and Experimental Research; Arik F, Soysal P et. al.

May 10th, 2020 - The aim of this study was to determine the relationship between the fear of falling/the degree of fear of falling (FoF) and orthostatic hypotension (OH) in older adults. This cross-sectional study was conducted with 314 older outpatients. If the total score of the Falls Efficacy Scale-International scale was 16-19, 20-27 and ≥ 28, it was assumed that there was low FoF, moderate FoF and high FoF...

Treatment of Antipsychotic-Induced Akathisia: Role of Serotonin 5-HT2a Receptor Antagon...
https://doi.org/10.1007/s40265-020-01312-0
Drugs Poyurovsky M, Weizman A

May 7th, 2020 - Akathisia is one of the most prevalent and distressing adverse effects associated with antipsychotic drug treatment. Propranolol, a non-selective beta-adrenergic receptor antagonist, is currently considered a first-line treatment for antipsychotic-induced akathisia (AIA). Surprisingly, the evidence for its anti-akathisia effect is modest. Propranolol's side effects (e.g. orthostatic hypotension...

The triad of orthostatic hypotension, blood pressure variability, and arterial stiffnes...
https://doi.org/10.1097/HJH.0000000000002411
Journal of Hypertension; Ram CVS

May 5th, 2020 - The triad of orthostatic hypotension, blood pressure variability, and arterial stiffness: a new syndrome?|2020|Ram CVS,|

Orthostatic hypotension: a marker of blood pressure variability and arterial stiffness:...
https://doi.org/10.1097/HJH.0000000000002374
Journal of Hypertension; Cremer A, Boutouyrie P et. al.

May 5th, 2020 - Orthostatic hypotension, blood pressure (BP) variability, and arterial stiffness are three markers of cardiovascular risk beyond the average BP. However, the relationships between these three parameters are not well known. To examine the relationships between orthostatic hypotension, BP variability, and arterial stiffness. In the Three-City study, a sample of 1151 elderly participants (mean age...

Management of hypertension in the very old: aggressive reduction of blood pressure is h...
https://doi.org/10.1038/s41371-020-0346-0
Journal of Human Hypertension; Ruilope LM, Ruiz-Hurtado G

May 5th, 2020 - Arterial hypertension is particularly prevalent in the elderly and treatment is required according to the literature. Treatment in subjects between 65 and 80 years of age resembles by characteristics and results that obtained in younger population. The treatment of arterial hypertension in the very elderly differs in a relevant percentage of them. It is quite similar in those with a good physic...

Sustained Effect of Droxidopa in Symptomatic Neurogenic Orthostatic Hypotension
https://clinicaltrials.gov/ct2/show/NCT02586623

May 4th, 2020 - This is a multi-site, placebo-controlled, double-blind, randomized withdrawal, time to intervention study with a duration of up to 36 weeks, consisting of 5 periods: Screening Period: up to 4 weeks duration; Open-Label Titration Period (Titration Period): up to 4 weeks duration; Open-Label Treatment Period (Open-Label Period): 12 weeks duration; Double-Blind Treatment Period (Double-Blind Perio...

Management of low blood pressure in ambulatory heart failure with reduced ejection frac...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540603
European Journal of Heart Failure References; Cautela J, Tartiere JM et. al.

Apr 30th, 2020 - Low blood pressure is common in patients with heart failure and reduced ejection fraction (HFrEF). While spontaneous hypotension predicts risk in HFrEF, there is only limited evidence regarding the relationship between hypotension observed during heart failure (HF) drug titration and outcome. Nevertheless, hypotension (especially orthostatic hypotension) is an important factor limiting the titr...

Northera - droxidopa capsule-Lundbeck Pharmaceuticals LLC
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2179f02c-48d7-48eb-8007-5ae43d8d16bc

Apr 15th, 2020 - NORTHERA is indicated for the treatment of orthostatic dizziness, lightheadedness, or the “feeling that you are about to black out” in adult patients with symptomatic neurogenic orthostatic hypotension (nOH) caused by primary autonomic failure (Parkinson's disease [PD], multiple system atrophy, and pure autonomic failure), dopamine beta-hydroxylase deficiency, and non-diabetic autonomic neuropa...

Midodrine hydrochloride - midodrine hydrochloride tablet-Cardinal Health
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=66bccee4-b466-4fe9-89d6-8c9eaaa92413

Apr 13th, 2020 - Midodrine hydrochloride tablets are indicated for the treatment of symptomatic orthostatic hypotension (OH). Because midodrine hydrochloride tablets can cause marked elevation of supine blood pressure (BP > 200 mmHg systolic), it should be used in patients whose lives are considerably impaired despite standard clinical care, including non-pharmacologic treatment (such as support stockings), flu...

Treatment of Supine Hypertension in Autonomic Failure (CPAP)
https://clinicaltrials.gov/ct2/show/NCT03312556

Apr 9th, 2020 - Supine hypertension is a common problem that affects at least 50% of patients with primary autonomic failure. Supine hypertension can be severe and complicates the treatment of orthostatic hypotension. Drugs used for the treatment of orthostatic hypotension (eg, fludrocortisone and pressor agents), worsen supine hypertension. High blood pressure may also cause target organ damage in this group ...

Local Heat Stress in Autonomic Failure Patients With Supine Hypertension
https://clinicaltrials.gov/ct2/show/NCT02417415

Apr 9th, 2020 - Primary autonomic failure is a neurodegenerative condition characterized by severe impairment of the autonomic nervous system. The clinical hallmark of autonomic failure is disabling orthostatic hypotension, but at least half of patients are also hypertensive while lying down. This supine hypertension can be severe and associated with end-organ damage and worsening of orthostatic hypotension du...

Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure
https://clinicaltrials.gov/ct2/show/NCT02429557

Apr 9th, 2020 - Patients with autonomic failure are characterized by disabling orthostatic hypotension (low blood pressure on standing) due to severe impairment of the autonomic nervous system. Compression garments such as waist-high stockings and abdominal binders have been shown to improve orthostatic hypotension in these patients. The purpose of this study is to determine the hemodynamic mechanisms by which...

Impact of depressive symptoms on self-perceived severity of autonomic dysfunction in mu...
https://doi.org/10.1007/s10286-020-00681-6
Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society; Martinez J, Palma JA et. al.

Apr 4th, 2020 - To assess the relationship between depressive symptoms and self-perceived severity of autonomic dysfunction in patients with multiple system atrophy (MSA). Cross-sectional evaluation of patients with MSA who underwent autonomic testing, Unified MSA Rating Scale (UMSARS)-1 and -2, rating of the presence and severity of depressive symptoms (Zung scale), quality of life (SF-36), body vigilance, an...

Association of orthostatic blood pressure with the symptoms of orthostatic hypotension ...
https://doi.org/10.1016/j.jocn.2020.03.040
Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia; Ueda M, Nakamura T et. al.

Apr 2nd, 2020 - The degree and frequency of orthostatic hypotension (OH) are high in patients with multiple system atrophy (MSA); however, the association of orthostatic blood pressure (BP) with the symptoms of OH and cognitive impairment in these patients remains unclear. The aim of this study was to clarify whether absolute BP and/or changes in BP during standing are related to OH symptoms and cognitive impa...

Symptom Recognition Is Impaired in Patients With Orthostatic Hypotension.
https://doi.org/10.1161/HYPERTENSIONAHA.119.13619
Hypertension (Dallas, Tex. : 1979); Freeman R, Illigens BMW et. al.

Mar 31st, 2020 - Failure to recognize symptoms of orthostatic hypotension (OH) may result in falls, syncope, and injuries. The relationship between orthostatic changes in blood pressure and symptom occurrence and severity is not known. The goal of the present study was to define the relationship between the occurrence and severity of the symptoms of orthostatic hypotension (OH) and (1) the upright systolic bloo...

Blood Pressure Drop Rate After Standing Up Is Associated With Frailty and Number of Fal...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428630
Journal of the American Heart Association; Mol A, Slangen LRN et. al.

Mar 31st, 2020 - Background The relationship between orthostatic hypotension and clinical outcome in older adults is poorly understood. Blood pressure drop rate (ie, speed of blood pressure drop) may particularly reflect the imposed challenge to the baroreflex and the associated clinical outcome (ie, frailty and number of falls). This study aimed to compare orthostatic blood pressure drop rate and drop magnitud...

Alterations of Attention in POTS Depending on Body Position and Hydration
https://clinicaltrials.gov/ct2/show/NCT03253120

Mar 24th, 2020 - Background Postural Tachycardia Syndrome (POTS) is a form of autonomic dysregulation, typically accompanied by symptoms of orthostatic intolerance (OI). OI is defined by the inability to tolerate the upright position and is improved by lying down. POTS is considered a syndrome that may include a number of several disorders. Symptoms should be persistent for at least 6 months to reach a diagnosi...

Cardiovascular Safety Considerations in the Treatment of Neurogenic Orthostatic Hypoten...
https://doi.org/10.1016/j.amjcard.2020.01.037
The American Journal of Cardiology; Olshansky B, Muldowney J

Mar 24th, 2020 - Neurogenic orthostatic hypotension (nOH), a drop in blood pressure upon standing resulting from autonomic malfunction, may cause debilitating symptoms that can affect independence in daily activities and quality-of-life. nOH may also be associated with cardiovascular comorbidities (e.g., supine hypertension, heart failure, diabetes, and arrhythmias), making treatment decisions complicated and r...

Home-measured orthostatic hypotension associated with cerebral small vessel disease in ...
https://doi.org/10.1038/s41440-020-0429-x
Hypertension Research : Official Journal of the Japanese Society of Hypertension; Cui Y, Zhang H et. al.

Mar 23rd, 2020 - This study aimed to investigate the relationship between cerebral small vessel disease (CSVD) and orthostatic hypotension (OH) using self-measured blood pressure at home in community-dwelling older subjects. Between May 2016 and October 2018, 663 community-dwelling adults aged ≥60 years were enrolled in Shandong, China. CSVD, including white matter hyperintensities (WMHs), lacunes, enlarged Vir...

Real-world droxidopa or midodrine treatment persistence in patients with neurogenic ort...
https://doi.org/10.1016/j.autneu.2020.102659
Autonomic Neuroscience : Basic & Clinical; Kymes SM, Sullivan C et. al.

Mar 22nd, 2020 - Neurogenic orthostatic hypotension (nOH) is a subtype of orthostatic hypotension (OH) observed in the presence of neuropathy and is associated with increased risk of falling, impaired function, and poor quality of life. Droxidopa and midodrine are approved in the United States to treat symptomatic nOH and OH in adults, respectively. In this study, we compared the treatment persistence of droxid...

What Is the Relationship Between Orthostatic Blood Pressure and Spatiotemporal Gait in ...
https://doi.org/10.1111/jgs.16379
Journal of the American Geriatrics Society References; Briggs R, Donoghue OA et. al.

Mar 13th, 2020 - Little work to date has examined the relationship between gait performance and blood pressure (BP) recovery after standing in later life. The aim of this study is to clarify the association of orthostatic BP with spatiotemporal gait parameters in a large cohort of older people. Cross-sectional study using multilevel linear regression to ascertain the difference in orthostatic BP patterns across...

Overcoming the Achilles' heel of orthostatic hypotension during interactive standing li...
https://doi.org/10.1111/jocd.13336
Journal of Cosmetic Dermatology REFERENCES; Chong K, Sun CK et. al.

Mar 11th, 2020 - Orthostatic hypotension (OH) is a major obstacle to standing liposculpture. To investigate the feasibility of a novel "interactive standing liposculpture" procedure under local anesthesia to avoid possible general anesthesia-related complications and overcome standing-associated OH. A total of 68 subjects undergoing IsLipo were divided into three groups: Individuals with normal body weight (18 ...

Canadian Cardiovascular Society Position Statement on Postural Orthostatic Tachycardia ...
https://doi.org/10.1016/j.cjca.2019.12.024
The Canadian Journal of Cardiology; Raj SR, Guzman JC et. al.

Mar 8th, 2020 - The current definition of postural orthostatic tachycardia syndrome (POTS) dates back to a small case series of patients with a subacute illness who presented with excessive orthostatic tachycardia and orthostatic intolerance, in the absence of another recognized disease. Conventional POTS criteria require an excessive orthostatic tachycardia in the absence of substantial orthostatic hypotensio...

Delayed versus classic orthostatic hypotension: clinical and prognostic implications.
https://doi.org/10.1080/08037051.2020.1733389
Blood Pressure; Tzur I, Barchel D et. al.

Mar 3rd, 2020 - Purpose: Orthostatic hypotension (OH) is a common disorder, especially among hospitalised patients. Classic OH is defined as occurring 3 or less minutes of orthostatic stress, and delayed OH as occurring after 3 min of stress. We aimed to compare clinical characteristics and prognosis between inpatients with classic vs. delayed OH.Methods: We performed a retrospective analysis of data from 358 ...

Prevention of postprandial hypotension-related syncope by caffeine in a patient with lo...
https://doi.org/10.1507/endocrj.EJ19-0370
Endocrine Journal; Furukawa K, Suzuki T et. al.

Feb 27th, 2020 - A 74-year-old man who had type 2 diabetes mellitus of a duration of 20 years was admitted for syncope after eating a high carbohydrate meal. Although he had had episodes of pallor or syncope after carbohydrate-rich meals, such as with large amounts of white rice, several times within a year and he had been taken to hospitals emergently, the etiology of these episodes had remained unclear despit...