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About 818 results

ALLMedicine™ Addison's Disease Center

Research & Reviews  262 results

Cognitive dysfunction in patients with primary adrenal insufficiency: A systematic review.
https://doi.org/10.1080/23279095.2022.2090256
Applied Neuropsychology. Adult; Ramos-Leví AM, Cañada E et. al.

Jun 30th, 2022 - Addison's disease (AD) entails a chronic insufficient production of gluco- and mineralocorticoids. Fatigue and decreased quality of life are frequently reported symptoms, but little is known about its effects on cognition. This study aims to explo...

The Staunton case revisited.
https://doi.org/10.1177/00258172221096635
The Medico-legal Journal; Nicholson DG

Jun 14th, 2022 - In 1877 Harriet Staunton died in Penge, Kent, and four members of her family were convicted of her murder by malicious starvation. The defence attempted to show that she had died from tuberculous meningitis, but reappraisal of the evidence leads t...

Multiple endocrine neoplasia type 2 and autoimmune polyendocrine syndromes (type 1 diab...
https://doi.org/10.1507/endocrj.EJ22-0084
Endocrine Journal; Park E, Kim MS et. al.

Jun 9th, 2022 - Multiple endocrine neoplasia type 2A (MEN2A) is caused by germline pathogenic variants in the RET proto-oncogene and is characterized by medullary thyroid cancer (MTC), pheochromocytoma, and hyperparathyroidism. Autoimmune polyendocrine syndromes ...

Adolescent onset of autoimmune polyglandular syndrome type 2.
https://doi.org/10.1136/bcr-2022-249839
BMJ Case Reports; Murphy SA, Mohd Din FH et. al.

May 24th, 2022 - An adolescent female was evaluated for fatigue, anorexia and unintentional weight loss of 7 kg. Initial investigations revealed subclinical autoimmune thyroid dysfunction, which progressed to overt hypothyroidism necessitating thyroxine replacemen...

P450 Side-Chain Cleavage Enzyme (P450-SCC) Is an Ovarian Autoantigen in a Mouse Model f...
https://doi.org/10.1007/s43032-022-00970-7 10.1289/ehp.929881 10.1128/JVI.00289-09 10.2174/1389200023337054 10.1021/acs.chemrestox.6b00226 10.1016/0960-0760(92)90307-5 10.1210/er.2003-0030 10.18388/abp.2002_3782 10.1007/s10815-019-01572-0 10.1172/JCI116843 10.1210/edrv.23.3.0466 10.1007/BF00195978 10.1111/j.1365-2249.1997.1137a.x 10.1055/s-0029-1212100 10.1056/NEJMcp0808697 10.1016/j.bpobgyn.2019.07.008 10.1093/humrep/17.8.2096 10.1038/nrendo.2013.212 10.1210/endo.140.8.6911 10.1007/s003350010053 10.1038/81547 10.1210/en.2011-0022 10.1093/humrep/17.4.903 10.1056/NEJMoa0706487 10.4049/jimmunol.166.7.4363 10.1038/ncomms9086 10.1136/jmedgenet-2018-105936 10.1111/cge.13744 10.1097/00007890-196301040-00011 10.1093/nar/gkx346 10.1186/1745-7580-2-2 10.1016/j.jim.2015.03.022 10.1111/j.1600-0897.1995.tb00929.x 10.1111/j.1600-0897.1995.tb00928.x 10.1097/00008571-199602000-00002 10.1172/JCI115573 10.1210/en.2003-1160 10.1084/jem.118.6.1089 10.1084/jem.161.1.72 10.1084/jem.156.6.1577 10.1084/jem.20041033 10.1371/journal.pone.0048963 10.1016/j.jep.2018.09.006 10.1095/biolreprod.106.052613 10.1016/j.fertnstert.2005.04.060 10.1177/1071557601008001S17
Reproductive Sciences (Thousand Oaks, Calif.); Tong ZB, Otsuka N et. al.

May 19th, 2022 - Steroid-producing cells contain key cytochrome P450 enzymes, such as side-chain cleavage (P450-SCC) and 17α-hydroxylase (17α-OH). They are required for steroid hormone synthesis and considered antigens associated with Addison's disease and autoimm...

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Guidelines  1 results

Consensus statement on the diagnosis, treatment and follow-up of patients with primary ...
https://doi.org/10.1111/joim.12162
Journal of Internal Medicine; Husebye ES, Allolio B et. al.

Dec 18th, 2013 - Primary adrenal insufficiency (PAI), or Addison's disease, is a rare, potentially deadly, but treatable disease. Most cases of PAI are caused by autoimmune destruction of the adrenal cortex. Consequently, patients with PAI are at higher risk of de...

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Drugs  14 results see all →

Clinicaltrials.gov  20 results

Early Detection of Endolymphatic Hydrops in Hypothyroid Patients
https://clinicaltrials.gov/ct2/show/NCT05334771

Apr 19th, 2022 - Endolymphatic hydrops is acommon inner ear dysfunction. This term often used with meniere's disease and meniere's syndrome. However meniere's is idiopathic by definition where as it can occur secondary to various processes interfering with normal ...

SUSY Study (SUture StudY) Comparing Scarring With Polypropylene vs Polyglactin 910 Sutures
https://clinicaltrials.gov/ct2/show/NCT04724512

Nov 30th, 2021 - Purpose and design This study will be the first of its kind to address the difference in inflammatory reaction between these two sutures in entropion repair surgery. Both sutures are widely used in the NHS in eyelid surgery already. The study desi...

Screening and Stimulation Testing for Residual Secretion of Adrenal Steroid Hormones in Autoimmune Addison's Disease
https://clinicaltrials.gov/ct2/show/NCT03793114

Jul 9th, 2021 - Autoimmune destruction of the adrenal cortex is the main cause of primary adrenal insufficiency (Addison's disease, AD). Autoimmune AD (AAD) becomes clinically manifest when 90 % of cortex of adrenal gland is destroyed. Current dogma says that adr...

Biomarker(s) for Glucocorticoids
https://clinicaltrials.gov/ct2/show/NCT02152553

Apr 12th, 2021 - The investigators have shown that patients with adrenal insufficiency (Addison's disease), a rare disorder, have doubled the expected mortality rate in Sweden despite Standard of Care glucocorticoid (GC) replacement. One % of the Swedish populatio...

Once-daily Oral Modified Release Hydrocortisone in Patients With Adrenal Insufficiency
https://clinicaltrials.gov/ct2/show/NCT00915343

Nov 24th, 2020 - Adrenal insufficiency is a disease with more than 80% 1-year mortality before the availability of synthetic glucocorticoids. Current replacement therapy has improved this dramatically, but recent data suggest that outcome is still compromised. Pat...

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News  26 results

PD-1 Immunotherapies Induce Painless Thyroiditis in Patients With Metastatic Malignancies
https://www.onclive.com/view/pd-1-immunotherapies-induce-painless-thyroiditis-in-patients-with-metastatic-malignancies

Dec 20th, 2020 - Paul G. Walfish, CM, OOnt Treatment with programmed cell death 1 (PD-1) immunotherapy across various oncology clinical trials has been associated with the induction of painless thyroiditis, characterized by transient thyrotoxicosis and hypothyroi...

Fast Five Quiz: Can You Identify and Treat Hyperkalemia?
https://reference.medscape.com/viewarticle/849260_1

May 26th, 2020 - Hyperkalemia—serum potassium greater than approximately 5.0-5.5 mEq/L in adults—is associated with kidney disease, a diet high in potassium, and drugs that impair renal potassium excretion. It can also appear in infants or children with certain ge...

Fast Five Quiz: Can You Identify and Treat Hyperkalemia?
https://reference.medscape.com/viewarticle/849260

May 26th, 2020 - Hyperkalemia—serum potassium greater than approximately 5.0-5.5 mEq/L in adults—is associated with kidney disease, a diet high in potassium, and drugs that impair renal potassium excretion. It can also appear in infants or children with certain ge...

Malpractice Case: You're Liable, Even if Your EHR Malfunctions
https://www.staging.medscape.com/viewarticle/919804

Nov 4th, 2019 - Notwithstanding the usual suspects that hinder electronic health record (EHR) implementation—initial costs, interoperability problems, training burdens, and altered physician-patient dynamics—there's also the risk of a pure system malfunction. In ...

Malpractice Case: You're Liable, Even if Your EHR Malfunctions
https://www.medscape.com/viewarticle/919804

Nov 4th, 2019 - Notwithstanding the usual suspects that hinder electronic health record (EHR) implementation—initial costs, interoperability problems, training burdens, and altered physician-patient dynamics—there's also the risk of a pure system malfunction. In ...

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Patient Education  4 results see all →