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About 723 results

ALLMedicine™ Addison's Disease Center

Research & Reviews  239 results

Adolescent onset of autoimmune polyglandular syndrome type 2.
https://doi.org/10.1136/bcr-2022-249839
BMJ Case Reports; Murphy SA, Mohd Din FH et. al.

May 24th, 2022 - An adolescent female was evaluated for fatigue, anorexia and unintentional weight loss of 7 kg. Initial investigations revealed subclinical autoimmune thyroid dysfunction, which progressed to overt hypothyroidism necessitating thyroxine replacemen...

P450 Side-Chain Cleavage Enzyme (P450-SCC) Is an Ovarian Autoantigen in a Mouse Model f...
https://doi.org/10.1007/s43032-022-00970-7 10.1289/ehp.929881 10.1128/JVI.00289-09 10.2174/1389200023337054 10.1021/acs.chemrestox.6b00226 10.1016/0960-0760(92)90307-5 10.1210/er.2003-0030 10.18388/abp.2002_3782 10.1007/s10815-019-01572-0 10.1172/JCI116843 10.1210/edrv.23.3.0466 10.1007/BF00195978 10.1111/j.1365-2249.1997.1137a.x 10.1055/s-0029-1212100 10.1056/NEJMcp0808697 10.1016/j.bpobgyn.2019.07.008 10.1093/humrep/17.8.2096 10.1038/nrendo.2013.212 10.1210/endo.140.8.6911 10.1007/s003350010053 10.1038/81547 10.1210/en.2011-0022 10.1093/humrep/17.4.903 10.1056/NEJMoa0706487 10.4049/jimmunol.166.7.4363 10.1038/ncomms9086 10.1136/jmedgenet-2018-105936 10.1111/cge.13744 10.1097/00007890-196301040-00011 10.1093/nar/gkx346 10.1186/1745-7580-2-2 10.1016/j.jim.2015.03.022 10.1111/j.1600-0897.1995.tb00929.x 10.1111/j.1600-0897.1995.tb00928.x 10.1097/00008571-199602000-00002 10.1172/JCI115573 10.1210/en.2003-1160 10.1084/jem.118.6.1089 10.1084/jem.161.1.72 10.1084/jem.156.6.1577 10.1084/jem.20041033 10.1371/journal.pone.0048963 10.1016/j.jep.2018.09.006 10.1095/biolreprod.106.052613 10.1016/j.fertnstert.2005.04.060 10.1177/1071557601008001S17
Reproductive Sciences (Thousand Oaks, Calif.); Tong ZB, Otsuka N et. al.

May 19th, 2022 - Steroid-producing cells contain key cytochrome P450 enzymes, such as side-chain cleavage (P450-SCC) and 17α-hydroxylase (17α-OH). They are required for steroid hormone synthesis and considered antigens associated with Addison's disease and autoimm...

Neuropeptide G Protein-Coupled Receptor Regulation of Adrenal Function: Bench to Bedsid...
https://doi.org/10.1210/endrev/bnac011
Endocrine Reviews; Lenzini L, Caroccia B et. al.

Apr 19th, 2022 - An altered secretion of adrenocortical and adrenomedullary hormones plays a role in the clinical syndromes of primary aldosteronism (PA), Cushing's and pheochromocytoma. Moreover, an altered production of adrenocortical hormones and/or an abnormal...

Early Detection of Endolymphatic Hydrops in Hypothyroid Patients
https://clinicaltrials.gov/ct2/show/NCT05334771

Apr 19th, 2022 - Endolymphatic hydrops is acommon inner ear dysfunction. This term often used with meniere's disease and meniere's syndrome. However meniere's is idiopathic by definition where as it can occur secondary to various processes interfering with normal ...

Young adult Swedish patients with autoimmune Addison's disease report difficulties with...
https://doi.org/10.1016/j.psyneuen.2022.105714
Psychoneuroendocrinology Van't Westeinde A, Ström S et. al.

Mar 16th, 2022 - Sub-optimal replacement of glucocorticoids (GC) in autoimmune Addison's disease (AAD) may affect cognitive functioning. The present study therefore sought to investigate cognitive performance and self-reported problems with executive functions in ...

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Guidelines  1 results

Consensus statement on the diagnosis, treatment and follow-up of patients with primary ...
https://doi.org/10.1111/joim.12162
Journal of Internal Medicine; Husebye ES, Allolio B et. al.

Dec 18th, 2013 - Primary adrenal insufficiency (PAI), or Addison's disease, is a rare, potentially deadly, but treatable disease. Most cases of PAI are caused by autoimmune destruction of the adrenal cortex. Consequently, patients with PAI are at higher risk of de...

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Drugs  14 results see all →

Clinicaltrials.gov  5 results

Early Detection of Endolymphatic Hydrops in Hypothyroid Patients
https://clinicaltrials.gov/ct2/show/NCT05334771

Apr 19th, 2022 - Endolymphatic hydrops is acommon inner ear dysfunction. This term often used with meniere's disease and meniere's syndrome. However meniere's is idiopathic by definition where as it can occur secondary to various processes interfering with normal ...

Combined Therapy With Narrow-Band Ultraviolet B Phototherapy and Apremilast for the Treatment of Vitiligo
https://clinicaltrials.gov/ct2/show/NCT03123016

Aug 28th, 2019 - Vitiligo is a common acquired disorder of pigmentation affecting 0.5% to 1% of the world population. Sharply demarcated patches of depigmentation, which can affect all ethnicities, and can lead to cosmetic disfiguration and psychosocial distress, ...

Hypothyroidism in Patients With Type 1 Diabetes
https://clinicaltrials.gov/ct2/show/NCT03257566

Aug 22nd, 2017 - Type 1 diabetes is an organ-specific autoimmune disease characterized by the selective destruction of pancreatic β-cells. The histopathology of type 1 diabetes is defined by a decreased β-cell mass infiltration of mononuclear cells into the islets...

Ultradian Subcutaneous Hydrocortisone Infusion in Addison Disease and Congenital Adrenal Hyperplasia
https://clinicaltrials.gov/ct2/show/NCT02096510

Dec 21st, 2016 - The conventional glucocorticoid replacement therapy in primary adrenal insufficiency (Addison's disease) and congenital adrenal hyperplasia renders the cortisol levels unphysiological, which may cause symptoms and long-term complications. This the...

Revival of Stem Cells in Addison's Study
https://clinicaltrials.gov/ct2/show/NCT01371526

Feb 6th, 2013 - Autoimmune Addison's disease (AAD) is a rare and debilitating disease in which an autoimmune attack progressively destroys the adrenal cortex. Untreated it is universally fatal and treated people are absolutely dependent upon steroid medications l...

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News  26 results

PD-1 Immunotherapies Induce Painless Thyroiditis in Patients With Metastatic Malignancies
https://www.onclive.com/view/pd-1-immunotherapies-induce-painless-thyroiditis-in-patients-with-metastatic-malignancies

Dec 20th, 2020 - Paul G. Walfish, CM, OOnt Treatment with programmed cell death 1 (PD-1) immunotherapy across various oncology clinical trials has been associated with the induction of painless thyroiditis, characterized by transient thyrotoxicosis and hypothyroi...

Fast Five Quiz: Can You Identify and Treat Hyperkalemia?
https://reference.medscape.com/viewarticle/849260_1

May 26th, 2020 - Hyperkalemia—serum potassium greater than approximately 5.0-5.5 mEq/L in adults—is associated with kidney disease, a diet high in potassium, and drugs that impair renal potassium excretion. It can also appear in infants or children with certain ge...

Fast Five Quiz: Can You Identify and Treat Hyperkalemia?
https://reference.medscape.com/viewarticle/849260

May 26th, 2020 - Hyperkalemia—serum potassium greater than approximately 5.0-5.5 mEq/L in adults—is associated with kidney disease, a diet high in potassium, and drugs that impair renal potassium excretion. It can also appear in infants or children with certain ge...

Malpractice Case: You're Liable, Even if Your EHR Malfunctions
https://www.staging.medscape.com/viewarticle/919804

Nov 4th, 2019 - Notwithstanding the usual suspects that hinder electronic health record (EHR) implementation—initial costs, interoperability problems, training burdens, and altered physician-patient dynamics—there's also the risk of a pure system malfunction. In ...

Malpractice Case: You're Liable, Even if Your EHR Malfunctions
https://www.medscape.com/viewarticle/919804

Nov 4th, 2019 - Notwithstanding the usual suspects that hinder electronic health record (EHR) implementation—initial costs, interoperability problems, training burdens, and altered physician-patient dynamics—there's also the risk of a pure system malfunction. In ...

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Patient Education  4 results see all →