ALLMedicine™ Addison's Disease Center

May 24th, 2022 - An adolescent female was evaluated for fatigue, anorexia and unintentional weight loss of 7 kg. Initial investigations revealed subclinical autoimmune thyroid dysfunction, which progressed to overt hypothyroidism necessitating thyroxine replacemen...

May 19th, 2022 - Steroid-producing cells contain key cytochrome P450 enzymes, such as side-chain cleavage (P450-SCC) and 17α-hydroxylase (17α-OH). They are required for steroid hormone synthesis and considered antigens associated with Addison's disease and autoimm...

Apr 19th, 2022 - An altered secretion of adrenocortical and adrenomedullary hormones plays a role in the clinical syndromes of primary aldosteronism (PA), Cushing's and pheochromocytoma. Moreover, an altered production of adrenocortical hormones and/or an abnormal...

Apr 19th, 2022 - Endolymphatic hydrops is acommon inner ear dysfunction. This term often used with meniere's disease and meniere's syndrome. However meniere's is idiopathic by definition where as it can occur secondary to various processes interfering with normal ...

Mar 16th, 2022 - Sub-optimal replacement of glucocorticoids (GC) in autoimmune Addison's disease (AAD) may affect cognitive functioning. The present study therefore sought to investigate cognitive performance and self-reported problems with executive functions in ...

Dec 18th, 2013 - Primary adrenal insufficiency (PAI), or Addison's disease, is a rare, potentially deadly, but treatable disease. Most cases of PAI are caused by autoimmune destruction of the adrenal cortex. Consequently, patients with PAI are at higher risk of de...

Apr 19th, 2022 - Endolymphatic hydrops is acommon inner ear dysfunction. This term often used with meniere's disease and meniere's syndrome. However meniere's is idiopathic by definition where as it can occur secondary to various processes interfering with normal ...

Aug 28th, 2019 - Vitiligo is a common acquired disorder of pigmentation affecting 0.5% to 1% of the world population. Sharply demarcated patches of depigmentation, which can affect all ethnicities, and can lead to cosmetic disfiguration and psychosocial distress, ...

Aug 22nd, 2017 - Type 1 diabetes is an organ-specific autoimmune disease characterized by the selective destruction of pancreatic β-cells. The histopathology of type 1 diabetes is defined by a decreased β-cell mass infiltration of mononuclear cells into the islets...

Dec 21st, 2016 - The conventional glucocorticoid replacement therapy in primary adrenal insufficiency (Addison's disease) and congenital adrenal hyperplasia renders the cortisol levels unphysiological, which may cause symptoms and long-term complications. This the...

Feb 6th, 2013 - Autoimmune Addison's disease (AAD) is a rare and debilitating disease in which an autoimmune attack progressively destroys the adrenal cortex. Untreated it is universally fatal and treated people are absolutely dependent upon steroid medications l...

Dec 20th, 2020 - Paul G. Walfish, CM, OOnt Treatment with programmed cell death 1 (PD-1) immunotherapy across various oncology clinical trials has been associated with the induction of painless thyroiditis, characterized by transient thyrotoxicosis and hypothyroi...

May 26th, 2020 - Hyperkalemia—serum potassium greater than approximately 5.0-5.5 mEq/L in adults—is associated with kidney disease, a diet high in potassium, and drugs that impair renal potassium excretion. It can also appear in infants or children with certain ge...

May 26th, 2020 - Hyperkalemia—serum potassium greater than approximately 5.0-5.5 mEq/L in adults—is associated with kidney disease, a diet high in potassium, and drugs that impair renal potassium excretion. It can also appear in infants or children with certain ge...

Nov 4th, 2019 - Notwithstanding the usual suspects that hinder electronic health record (EHR) implementation—initial costs, interoperability problems, training burdens, and altered physician-patient dynamics—there's also the risk of a pure system malfunction. In ...

Nov 4th, 2019 - Notwithstanding the usual suspects that hinder electronic health record (EHR) implementation—initial costs, interoperability problems, training burdens, and altered physician-patient dynamics—there's also the risk of a pure system malfunction. In ...