ALLMedicine™ Autoimmune Lymphoproliferative Syndrome Center
Research & Reviews 131 results
Blood Advances; Jevtich KC, Price S et. al.
Apr 28th, 2022 - Autoimmune lymphoproliferative syndrome (ALPS) is characterized by chronic nonmalignant lymphadenopathy, splenomegaly, cytopenias, and other autoimmune manifestations. ALPS is caused by lymphocyte accumulation due to defects in FAS-mediated apopto...
Journal of Neuroimmunology; Dekeyser C, Naesens L et. al.
Apr 23rd, 2022 - A 49-year-old patient with a history of lymphoproliferation and autoimmune cytopenias presented with unexplained longitudinal extensive transverse myelitis. Flow cytometry on peripheral blood showed an elevated level of double negative T lymphocyt...
European Journal of Immunology; Minguet S, Nyström A et. al.
Apr 21st, 2022 - B-cell tolerance to self-antigen is an active process that requires the temporal and spatial integration of signals of defined intensity. In common variable immune deficiency disorders, CTLA-4 deficiency, autoimmune lymphoproliferative syndrome, o...
https://doi.org/10.1007/s10067-021-06044-4 10.1007/s10875-020-00758-x 10.1007/s10875-007-9103-1 10.1182/blood-2011-09-377945 10.1182/blood-2007-11-124545 10.1007/s10875-007-9075-1 10.1016/j.humimm.2010.10.014 10.1016/0049-0172(93)80073-o 10.1542/peds.111.5.e622 10.1097/00008480-199810060-00011 10.1002/art.27425 10.1007/s00296-017-3726-1 10.1016/j.jbspin.2013.09.003 10.3899/jrheum.080691 10.1002/art.22641 10.1191/0961203305lu2182xx 10.1002/1529-0131(199901)42:1<46::AID-ANR6>3.0.CO;2-2 10.3899/jrheum.111106 10.1002/art.11073 10.1136/ard.2008.093161 10.1016/s1568-9972(03)00006-5
Clinical Rheumatology; Padem N, Wright H et. al.
Feb 1st, 2022 - There is a gap in clinical knowledge regarding associations between specific inborn errors of immunity (IEIs) and rheumatologic diseases. This study reports the frequency of rheumatologic conditions in a large cohort of patients with IEI using the...
Annals of Hematology; Consonni F, Gambineri E et. al.
Jan 22nd, 2022 - Autoimmune lymphoproliferative syndrome (ALPS) is a primary immune regulatory disorder characterized by benign or malignant lymphoproliferation and autoimmunity. Classically, ALPS is due to mutations in FAS and other related genes; however, recent...
Guidelines 1 results
Blood Oliveira JB, Bleesing JJ et. al.
Jun 12th, 2010 - Lymphadenopathy in children for which no infectious or malignant cause can be ascertained constitutes a challenging diagnostic dilemma. Autoimmune lymphoproliferative syndrome (ALPS) is a human genetic disorder of lymphocyte apoptosis resulting in...
Clinicaltrials.gov 3 results
Feb 4th, 2021 - Lymphoproliferative disorders (LPD)comprise a heterogeneous group of diseases characterized by uncontrolled production of lymphocytes that cause monoclonal lymphocytosis, lymphadenopathy and bone marrow infiltration.They Typically occur in people ...
Nov 19th, 2019 - Patients with autoimmune destruction of hematopoietic cells frequently have severe and debilitating disease requiring aggressive and frequent medical management. These patients are often treated with non-specific immunosuppressive medications with...
May 30th, 2018 - Pure red cell aplasia (PRCA) is a rare normocytic normochromic anemia with reticulocytopenia, characterized by a reduction of erythroid precursors from the bone marrow, could be divided into congenital and acquired PRCA according to pathogenesis. ...
News 1 results
Oct 27th, 2015 - Red and white blood cells New research suggests the immunosuppressant sirolimus may be a promising treatment option for patients with refractory autoimmune cytopenias. The drug proved particularly effective in children with autoimmune lymphoprolif.