About 340 results

ALLMedicine™ Autoimmune Lymphoproliferative Syndrome Center

Research & Reviews  131 results

The Contribution of Rare Copy Number Variants in FAS Towards Pathogenesis of Autoimmune...
Blood Advances; Jevtich KC, Price S et. al.

Apr 28th, 2022 - Autoimmune lymphoproliferative syndrome (ALPS) is characterized by chronic nonmalignant lymphadenopathy, splenomegaly, cytopenias, and other autoimmune manifestations. ALPS is caused by lymphocyte accumulation due to defects in FAS-mediated apopto...

A unique phenotype of longitudinal extensive transverse myelitis in autoimmune lymphopr...
Journal of Neuroimmunology; Dekeyser C, Naesens L et. al.

Apr 23rd, 2022 - A 49-year-old patient with a history of lymphoproliferation and autoimmune cytopenias presented with unexplained longitudinal extensive transverse myelitis. Flow cytometry on peripheral blood showed an elevated level of double negative T lymphocyt...

Inborn errors of immunity and immunodeficiencies: Antibody-mediated pathology and autoi...
European Journal of Immunology; Minguet S, Nyström A et. al.

Apr 21st, 2022 - B-cell tolerance to self-antigen is an active process that requires the temporal and spatial integration of signals of defined intensity. In common variable immune deficiency disorders, CTLA-4 deficiency, autoimmune lymphoproliferative syndrome, o...

ALPS, FAS, and beyond: from inborn errors of immunity to acquired immunodeficiencies.
Annals of Hematology; Consonni F, Gambineri E et. al.

Jan 22nd, 2022 - Autoimmune lymphoproliferative syndrome (ALPS) is a primary immune regulatory disorder characterized by benign or malignant lymphoproliferation and autoimmunity. Classically, ALPS is due to mutations in FAS and other related genes; however, recent...

see more →

Guidelines  1 results

Revised diagnostic criteria and classification for the autoimmune lymphoproliferative s...
Blood Oliveira JB, Bleesing JJ et. al.

Jun 12th, 2010 - Lymphadenopathy in children for which no infectious or malignant cause can be ascertained constitutes a challenging diagnostic dilemma. Autoimmune lymphoproliferative syndrome (ALPS) is a human genetic disorder of lymphocyte apoptosis resulting in...

see more →

Clinicaltrials.gov  3 results

Expression of CD19 Complex in Lymphoproliferative Disorders

Feb 4th, 2021 - Lymphoproliferative disorders (LPD)comprise a heterogeneous group of diseases characterized by uncontrolled production of lymphocytes that cause monoclonal lymphocytosis, lymphadenopathy and bone marrow infiltration.They Typically occur in people ...

Sirolimus for Autoimmune Disease of Blood Cells

Nov 19th, 2019 - Patients with autoimmune destruction of hematopoietic cells frequently have severe and debilitating disease requiring aggressive and frequent medical management. These patients are often treated with non-specific immunosuppressive medications with...

Tacrolimus Treatment for Refractory PRCA

May 30th, 2018 - Pure red cell aplasia (PRCA) is a rare normocytic normochromic anemia with reticulocytopenia, characterized by a reduction of erythroid precursors from the bone marrow, could be divided into congenital and acquired PRCA according to pathogenesis. ...

see more →

News  1 results

Immunosuppressant can treat autoimmune cytopenias
HT Staff

Oct 27th, 2015 - Red and white blood cells New research suggests the immunosuppressant sirolimus may be a promising treatment option for patients with refractory autoimmune cytopenias. The drug proved particularly effective in children with autoimmune lymphoprolif.

see more →