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About 345 results

ALLMedicine™ Evans Syndrome Center

Research & Reviews  130 results

Eltrombopag Combined With Low-dose Rituximab in the Treatment of Adult Immune Thrombocytopenia With Autoantibodies
https://clinicaltrials.gov/ct2/show/NCT04915482

May 11th, 2022 - This is a prospective, open-label, nonrandomized, multicenter clinical trial aiming at comparing the efficacy and safety of combined use of eltrombopag with low-dose rituximab vs. the best available therapy(BAT)in adult immune thrombocytopenia (...

Determinants of splenectomy long-term outcomes in pediatric autoimmune cytopenias.
https://doi.org/10.1182/blood.2022015508
Blood Pincez T, Aladjidi N et. al.

Apr 21st, 2022 - Splenectomy is effective in ~70-80% of pediatric chronic immune thrombocytopenia (cITP) and few data exist in autoimmune hemolytic anemia (AIHA) and Evans syndrome (ES). Because of the irreversibility of the procedure and the lack of predictor of ...

Complete recovery of deep venous thrombosis from Coombs (+) thrombotic thrombocytopenic...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935836
Journal of Cardiothoracic Surgery; Zhou M, Yin J

Mar 23rd, 2022 - Acute thrombotic thrombocytopenic purpura (TTP) is an aggressive thrombotic microangiopathy that if not treated, can have a 90% mortality rate. Timely, extensive plasma exchange (PEX) has been indicated to reduce the mortality rate to < 10%, but i...

Adult Evans' Syndrome.
https://doi.org/10.1016/j.hoc.2021.12.004
Hematology/oncology Clinics of North America; Michel M

Mar 15th, 2022 - Evans syndrome (ES) is a rare immune disorder defined as the simultaneous or sequential occurrence in a single patient of immune thrombocytopenia (ITP) and warm autoimmune hemolytic anemia (wAIHA) ± autoimmune neutropenia (AIN). ES represents appr...

Refractory immune thrombocytopenia successfully treated with bortezomib in a child with...
https://doi.org/10.1080/09537104.2021.2002835
Platelets Conti F, Gottardi F et. al.

Feb 9th, 2022 - Treatment of refractory autoimmune cytopenias (AICs) and Evans syndrome (ES) represent a great challenge in pediatric setting, where an underlying primary immunodeficiency is recurrent. Frequently, second or third line treatments are employed, wit...

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Clinicaltrials.gov  3 results

Eltrombopag Combined With Low-dose Rituximab in the Treatment of Adult Immune Thrombocytopenia With Autoantibodies
https://clinicaltrials.gov/ct2/show/NCT04915482

May 11th, 2022 - This is a prospective, open-label, nonrandomized, multicenter clinical trial aiming at comparing the efficacy and safety of combined use of eltrombopag with low-dose rituximab vs. the best available therapy(BAT)in adult immune thrombocytopenia (...

Autoimmune Cytopenia: Genetics and Pathophysiological Mechanism in Pediatric Evans Syndrome
https://clinicaltrials.gov/ct2/show/NCT03912129

Apr 11th, 2019 - Pediatric Evans syndrome (pES) is a rare and severe disease combining immunologic thrombocytopenic purpura (ITP) and autoimmune hemolytic anemia (AIHA). French patients from the 30 hematologic pediatric centers are from 2004 included in a prospect...

Tacrolimus Treatment for Refractory PRCA
https://clinicaltrials.gov/ct2/show/NCT03540472

May 30th, 2018 - Pure red cell aplasia (PRCA) is a rare normocytic normochromic anemia with reticulocytopenia, characterized by a reduction of erythroid precursors from the bone marrow, could be divided into congenital and acquired PRCA according to pathogenesis. ...

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News  5 results

BTK Inhibitor Shows Potential in Immune Thrombocytopenia
https://www.medpagetoday.com/hematologyoncology/hematology/98188

Apr 13th, 2022 - An investigational oral Bruton's tyrosine kinase (BTK) inhibitor was tolerable and yielded rapid and durable responses in pretreated patients with immune thrombocytopenia (ITP), according to results of an open-label phase I/II trial. In the 60-pat...

Expert Outlines Clinical Implications of Precision Medicine in GI Cancers
https://www.onclive.com/view/expert-outlines-clinical-implications-of-precision-medicine-in-gi-cancers

Dec 4th, 2020 - Shirley Michelle Shiller, DO Regarding precision medicine in gastrointestinal (GI) cancers, pathologists are working to determine which patient populations should undergo which molecular tests. Colorectal Cancer In a presentation during the 201...

Tylosis in a Patient With Howel-Evans Syndrome: Management With Acitretin
https://www.mdedge.com/dermatology/article/231119/mixed-topics/tylosis-patient-howel-evans-syndrome-management-acitretin
Sabra M. Abner, MD, Audra Isaac, MD et. al.

Nov 4th, 2020 - To the Editor: Tylosis with esophageal cancer was first described by Howel-Evans et al1 in 1958 in a family from Liverpool, England. The disease is inherited in an autosomal-dominant fashion with a mutation in the tylosis with esophageal cancer ge.

ASH: Genes affecting risk, severity of chronic ITP are identified
https://www.mdedge.com/pediatrics/article/104929/bleeding-disorders/ash-genes-affecting-risk-severity-chronic-itp-are
Mary Jo Dales

Dec 6th, 2015 - ORLANDO – Children with chronic immune thrombocytopenia (ITP) have an increased frequency of damaging variants in genes associated with cellular immunity, notably IFNA17 and IFNLR1, based on the results of whole genome sequencing. The links to IFN.

Immunosuppressant can treat autoimmune cytopenias
https://www.mdedge.com/hematology-oncology/article/187516/anemia/immunosuppressant-can-treat-autoimmune-cytopenias
HT Staff

Oct 27th, 2015 - Red and white blood cells New research suggests the immunosuppressant sirolimus may be a promising treatment option for patients with refractory autoimmune cytopenias. The drug proved particularly effective in children with autoimmune lymphoprolif.

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