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About 61,478 results

ALLMedicine™ Tuberculosis Center

Research & Reviews  22,602 results

Modeling and Predicting Pulmonary Tuberculosis Incidence and Its Association with Air P...
https://doi.org/10.3390/ijerph19095385
International Journal of Environmental Research and Publi... Chen YP, Liu LF et. al.

May 15th, 2022 - The autoregressive integrated moving average with exogenous regressors (ARIMAX) modeling studies of pulmonary tuberculosis (PTB) are still rare. This study aims to explore whether incorporating air pollution and meteorological factors can improve ...

Lagged Effects of Exposure to Air Pollutants on the Risk of Pulmonary Tuberculosis in a...
https://doi.org/10.3390/ijerph19095752
International Journal of Environmental Research and Publi... Feng Y, Wei J et. al.

May 15th, 2022 - Although significant correlations have been observed between air pollutants and the development of pulmonary tuberculosis (PTB) in many developed countries, data are scarce for developing and highly polluted regions. A combined Poisson generalized...

Substrate recognition and cryo-EM structure of the ribosome-bound TAC toxin of Mycobact...
https://doi.org/10.1038/s41467-022-30373-w 10.1038/nchembio.2044 10.1016/j.molcel.2018.01.003 10.1016/j.tim.2020.12.001 10.1126/sciadv.abb6651 10.1093/nar/gkaa855 10.1016/j.molcel.2020.11.034 10.1038/s41589-018-0216-z 10.1038/s41598-019-41548-9 10.1093/nar/gky560 10.1016/j.molcel.2019.06.015 10.1016/j.molcel.2020.05.028 10.1128/jb.178.7.2044-2050.1996 10.1126/science.1244705 10.1371/journal.ppat.1002954 10.1038/nmicrobiol.2016.251 10.1371/journal.pcbi.1006946 10.3390/toxins6031002 10.1371/journal.pgen.1000767 10.1128/mBio.00100-11 10.1126/sciadv.aba6944 10.1093/nar/gky924 10.1038/ncomms7059 10.1006/bbrc.1996.1229 10.1016/j.cell.2009.11.015 10.1073/pnas.1101189108 10.1007/s12192-012-0396-5 10.3389/fmicb.2014.00666 10.1073/pnas.1710456114 10.1038/ncomms13339 10.1016/j.jmb.2021.166815 10.1038/s41467-019-08747-4 10.1046/j.1365-2958.2002.02779.x 10.1128/JB.00454-10 10.3389/fmicb.2021.748890 10.1111/mmi.12358 10.1016/bs.mie.2018.08.011 10.1038/nmicrobiol.2016.8 10.1093/nar/gkaa617 10.1111/j.1365-2958.2011.07888.x 10.1111/febs.15514 10.1093/nar/gkx138 10.1093/nar/gkw598 10.1261/rna.056218.116 10.1093/nar/gkt742 10.1073/pnas.1512959112 10.1093/nar/gkz760 10.1111/jam.14414 10.1074/jbc.M109.008763 10.1111/j.1365-2958.2006.05385.x 10.1111/j.1365-2958.2008.06572.x 10.1074/jbc.M110.108969 10.1038/s41586-019-1249-5 10.1371/journal.pcbi.1007618 10.3109/10409238.2012.678284 10.1186/gb-2009-10-11-r134 10.1371/journal.pgen.1005641 10.1093/bioinformatics/btx583 10.1107/S0907444994003112 10.1107/S0021889807021206 10.1107/S0907444910007493 10.1107/S0907444911001314 10.1038/nmeth.4193 10.1016/j.jsb.2015.11.003 10.1038/nmeth.4169 10.1038/nmeth.2115 10.1007/978-1-0716-0966-8_7 10.1002/jcc.20084 10.1107/S2059798318006551 10.1038/nmeth.2727 10.1002/pro.3330
Nature Communications; Mansour M, Giudice E et. al.

May 14th, 2022 - Toxins of toxin-antitoxin systems use diverse mechanisms to control bacterial growth. Here, we focus on the deleterious toxin of the atypical tripartite toxin-antitoxin-chaperone (TAC) system of Mycobacterium tuberculosis, whose inhibition require...

Interventions to improve linkage along the HIV-tuberculosis care cascades in low- and m...
https://doi.org/10.1371/journal.pone.0267511
PloS One; Salomon A, Law S et. al.

May 14th, 2022 - In support of global targets to end HIV/AIDS and tuberculosis (TB) by 2030, we reviewed interventions aiming to improve TB case-detection and anti-TB treatment among people living with HIV (PLHIV) and HIV testing and antiretroviral treatment initi...

Mycobacterium tuberculosis antigen-specific T cell responses in smear- negative pulmona...
https://doi.org/10.1093/cei/uxac049
Clinical and Experimental Immunology; Esmael A, Abebe T et. al.

May 14th, 2022 - Despite recent improvements in microbial detection, smear negative TB remains a diagnostic challenge. In this study, we investigated the potential discriminatory role of polychromatic flow cytometry of M. tuberculosis antigen-specific T cells to d...

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Guidelines  28 results

WHO consolidated guidelines on tuberculosis Module 5: Management of tuberculosis in children and adolescents
https://www.who.int/publications/i/item/9789240046764
World Health Organization (WHO)

Mar 21st, 2022 - The Updated guidelines on Management of tuberculosis in children and adolescents include new recommendations that cover diagnostic approaches for TB, shorter treatment for children with non-severe drug-susceptible TB, a new option for the treatmen...

Interim Guidance: 4-Month Rifapentine-Moxifloxacin Regimen for the Treatment of Drug-Su...
https://doi.org/10.15585/mmwr.mm7108a1
MMWR. Morbidity and Mortality Weekly Report; Carr W, Kurbatova E et. al.

Feb 25th, 2022 - On May 5, 2021, CDC's Tuberculosis Trials Consortium and the National Institutes of Health (NIH)-sponsored AIDS Clinical Trials Group (ACTG) published results from a randomized controlled trial indicating that a 4-month regimen containing rifapent...

Cancer immunotherapy in special challenging populations: recommendations of the Advisor...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009216
Journal for Immunotherapy of Cancer; Gonzalez-Cao M, Puertolas T et. al.

Mar 31st, 2021 - Cancer immunotherapy based on the use of antibodies targeting the so-called checkpoint inhibitors, such as programmed cell death-1 receptor, its ligand, or CTLA-4, has shown durable clinical benefit and survival improvement in melanoma and other t...

Multisystem inflammatory syndrome in an adult with SARS-CoV-2 infection.
https://doi.org/10.1016/j.arbres.2020.03.021
European Heart Journal. Cardiovascular Imaging; Chowdhary A, Joy E et. al.

Sep 6th, 2020 - New evidence and knowledge about the clinical management of drug-resistant tuberculosis (TB) in the last 3 years, makes it necessary to update the recent guideline published by SEPAR in 2017, mainly in relation to new diagnostic methods, drug clas...

2019 update of the European AIDS Clinical Society Guidelines for treatment of people li...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754379
HIV Medicine; Ryom L, Cotter A et. al.

Sep 5th, 2020 - The European AIDS Clinical Society (EACS) Guidelines cover key aspects of HIV management with major updates every two years. The 2019 Guidelines were extended with a new section focusing on drug-drug interactions and other prescribing issues in pe...

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Drugs  382 results see all →

Clinicaltrials.gov  428 results

Using Biomarkers to Predict TB Treatment Duration
https://clinicaltrials.gov/ct2/show/NCT02821832

May 13th, 2022 - Shortening the duration of treatment for patients with drug sensitive tuberculosis from 6 to 4 months has been attempted many times in clinical trials but thus far all have failed. These failures reveal our incomplete understanding of factors driv...

Trial of Vitamin D Supplementation in Cape Town Primary Schoolchildren
https://clinicaltrials.gov/ct2/show/NCT02880982

May 13th, 2022 - The investigators will conduct a n=5,400 Phase 3, double-blind, individually randomised placebo-controlled clinical trial of 5 years' duration in primary schools in City of Cape Town Metropolitan Municipality, Western Cape Province, Republic of So...

The Influence of Malnutrition, Diabetes Mellitus, and Helminth Infections on Biosignatures in Latent Tuberculosis in a South Indian Population
https://clinicaltrials.gov/ct2/show/NCT04526613

May 13th, 2022 - Approximately 2 billion people worldwide are infected with Mycobacterium tuberculosis (TB), with 90% of individuals having latent infection (LTBI). The control of TB requires clearly delineated helper T cell (Th) 1 responses and, to a lesser exten...

NexGen EBA Radiologic and Immunologic Biomarkers of Sterilizing Drug Activity in Tuberculosis
https://clinicaltrials.gov/ct2/show/NCT02371681

May 13th, 2022 - Early bactericidal activity (EBA), which measures decline in serial sputum colony forming unit (CFU) counts over the first 2-14 days of treatment, has been used extensively as a means of initially evaluating the potency of individual or combinatio...

Characterization of Tissue-Specific Immune Responses to Bronchoscopic Instillation of Mycobacterial Antigens Into the Human Lung
https://clinicaltrials.gov/ct2/show/NCT05027958

May 13th, 2022 - We propose a pilot study in which we employ directed bronchoscopic instillation of Mycobacterium tuberculosis (Mtb)-derived Purified Protein Derivative (PPD) to evaluate local airway immune response in adults with or without latent tuberculosis in...

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News  1,127 results

New HIV Care Guidelines From the European AIDS Clinical Society
https://www.medscape.com/viewarticle/973524

May 5th, 2022 - Version 11.0 of the 2021 revised European AIDS Clinical Society (EACS) Guidelines updates all aspects of HIV care and adds recommendations on COVID-19 and antiretroviral treatment (ART) in children and adolescents, the guidelines authors report in...

Worst TB Outbreak in 20 Years Reported in Washington State
https://www.medscape.com/viewarticle/973417

May 4th, 2022 - Tuberculosis cases are increasing in Washington, which has put public health officials on "heightened alert," according to a recent announcement from the Washington State Department of Health. Widespread disruptions in health care and missed tuber...

Nail in the Coffin for Injectable Therapy in Drug-Resistant TB?
https://www.medpagetoday.com/infectiousdisease/tuberculosis/98532

May 3rd, 2022 - Oral treatment containing bedaquiline was associated with better outcomes for patients with drug-resistant tuberculosis (TB) compared with an injectable treatment regimen, a retrospective cohort study showed. In adjusted analyses, the rate of trea...

Tuberculosis Clinical Practice Guidelines (WHO, 2022)
https://www.medscape.com/viewarticle/972831

Apr 29th, 2022 - 2022 clinical practice guidelines for the management of tuberculosis (TB) in children and adolescents were published online on March 21 by the World Health Organization (WHO) as part of the WHO Consolidated Guidelines on Tuberculosis. New recommen...

RA: Real-world study highlights need for increased awareness of NTM in TNFi‐treated patients
https://www.mdedge.com/rheumatology/article/254099/rheumatoid-arthritis/ra-real-world-study-highlights-need-increased

Apr 26th, 2022 - Key clinical point: Patients with seropositive rheumatoid arthritis (RA) treated with tumor necrosis factor inhibitors (TNFi) were at higher risk of developing nontuberculous mycobacterium (NTM) infection in mycobacterium tuberculosis (MTB) endemi.

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Patient Education  24 results see all →