About 693 results

ALLMedicine™ Yaws Center

Research & Reviews  116 results

LAMP4yaws: Treponema pallidum, Haemophilus ducreyi loop mediated isothermal amplificati...
BMJ Open; Handley BL, González-Beiras C et. al.

Mar 31st, 2022 - Yaws, caused by the bacterium Treponema pallidum subsp. pertenue, is a neglected tropical disease targeted for eradication by 2030. Improved diagnostics will be essential to meet this goal. Diagnosis of yaws has relied heavily on clinical and sero...

Yaws recurrence in children at continued risk of infection.
PLoS Neglected Tropical Diseases; Beiras CG, Marks M et. al.

Mar 22nd, 2022 - In yaws-endemic areas, children with Treponema pallidum subsp. pertenue infection may suffer recurrent episodes due to either reinfection or relapse. However, the possibility of infection with other cutaneous ulcer causative agents and difficultie...

Trial of Three Rounds of Mass Azithromycin Administration for Yaws Eradication.
The New England Journal of Medicine; John LN, Beiras CG et. al.

Jan 6th, 2022 - Treponema pallidum subspecies pertenue causes yaws. Strategies to better control, eliminate, and eradicate yaws are needed. In an open-label, cluster-randomized, community-based trial conducted in a yaws-endemic area of Papua New Guinea, we random...


Oct 25th, 2021 - Background Yaws is the most prevalent infectious, nonvenereal treponemal disease and is caused by Treponema pallidumpertenue. Yaws, endemic syphilis (bejel), and pinta collectively constitute the endemic treponematoses. Yaws is transmitted by dire...

Treponematosis (Endemic Syphilis, Yaws, and Pinta)

Oct 19th, 2021 - Background Treponematosis, also known as treponemiasis, traditionally refers to the group of nonvenereal diseases (including endemic syphilis [nonvenereal syphilis]) caused by Treponema species that are morphologically and serologically identical ...

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Drugs  153 results see all →

Clinicaltrials.gov  2 results

Safety of Co-administration of IDA and Azithromycin for NTDs ( ComboNTDs )

Feb 28th, 2019 - Recent studies have shown that single-dose combination therapy with three antifilarial drugs (Ivermectin [IVE] + DEC + ALB) called IDA is superior to current regimens used in LF elimination and may help accelerate LF elimination. WHO guidelines ha...

Single-dose Azithromycin for the Treatment of Yaws

Apr 13th, 2012 - Regulatory status: Investigational - Randomized Clinical Trial. Registered product for antibacterial therapy BACKGROUND Penicillin remains the drug of choice for the treatment of endemic treponematoses including yaws. This type of treatment is eff...

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News  6 results

Three Rounds of Antibiotic Therapy Superior to Targeted Treatment for Reducing Yaws Cases

Jan 6th, 2022 - (Reuters Health) - As a strategy for halting the spread of yaws, mass administration of three rounds of azithromycin at six-month intervals was four times more effective than a single round followed by two rounds of targeted treatment, according t...

What Neglected Tropical Diseases Teach Us About Stigma
Aileen Y. Chang, MD, Maria T. Ochoa, MD

Oct 3rd, 2019 - Neglected tropical diseases (NTDs) are a group of 20 diseases that typically are chronic and cause long-term disability, which negatively impacts work productivity, child survival, and school performance and attendance with adverse effect on futur.

ID Break: Clean Hands, Fewer Abx; $11 Million HIV Cure?; MenB Vax for Kids

Feb 14th, 2018 - It's official: influenza-associated hospitalizations are significantly higher this flu season than when the CDC started its current tracking system in 2010. The portion of pneumonia and influenza-associated deaths has passed the 10% threshold. Che...

Single Dose of Azithromycin Effective for Latent Yaws

Nov 11th, 2017 - NEW YORK (Reuters Health) – A single dose of azithromycin, known to cure active yaws, also effectively treat latent yaws, researchers say. Dr. Oriol Mitja of the University of Barcelona, Spain, told Reuters Health, "Yaws is a neglected tropical sk...

Rapidly Enlarging Noduloulcerative Lesions
Liaqat Ali, MD, Thomas Helm, MD et. al.

Sep 22nd, 2014 - The Diagnosis: Lues Maligna Biopsy revealed dense nodular aggregates of lymphocytes, histiocytes, and abundant plasma cells in both the superficial and deep dermis (Figure 1). There were perivascular and periadnexal aggregates of lymphocytes, hist.

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