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About 194 results

ALLMedicine™ 5q- Syndrome Center

Research & Reviews  97 results

p53 activation during ribosome biogenesis regulates normal erythroid differentiation.
https://doi.org/10.1182/blood.2019003439
Blood Le Goff S, Boussaid I et. al.

Aug 20th, 2020 - The role of ribosome biogenesis in erythroid development is supported by the recognition of erythroid defects in ribosomopathies in both Diamond-Blackfan anemia and 5q- syndrome. Whether ribosome biogenesis exerts a regulatory function on normal e...

Integrated analyses of translatome and proteome identify the rules of translation selec...
https://doi.org/10.3324/haematol.2019.239970
Haematologica Boussaid I, Le Goff S et. al.

Apr 24th, 2020 - In ribosomopathies, the Diamond-Blackfan anemia (DBA) or 5q- syndrome, ribosomal protein (RP) genes are affected by mutation or deletion, resulting in bone marrow erythroid hypoplasia. Unbalanced production of ribosomal subunits leading to a limit...

Loss of rps9 in Zebrafish Leads to p53-Dependent Anemia.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893189
G3 (Bethesda, Md.); Chen C, Huang H et. al.

Oct 17th, 2019 - Ribosome is a vital molecular machine for protein translation in the cell. Defects in several ribosomal proteins including RPS19, RPL11 and RPS14 have been observed in two types of anemia: Diamond Blackfan Anemia and 5q- syndrome. In zebrafish, de...

Rps14, Csnk1a1 and miRNA145/miRNA146a deficiency cooperate in the clinical phenotype an...
https://doi.org/10.1038/s41375-018-0350-3
Leukemia Ribezzo F, Snoeren IAM et. al.

Jan 17th, 2019 - RPS14, CSNK1A1, and miR-145 are universally co-deleted in the 5q- syndrome, but mouse models of each gene deficiency recapitulate only a subset of the composite clinical features. We analyzed the combinatorial effect of haploinsufficiency for Rps1...

Hematopoietic cell transplant for acute myeloid leukemia and myelodysplastic syndrome: ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113615
Blood Advances; Eapen M, Brazauskas R et. al.

Aug 23rd, 2018 - In this study, we sought to identify specific individual high-intensity or reduced-intensity conditioning regimens with the best relapse-free survival (RFS) rather than the global high- vs reduced-intensity regimen comparison. Patients (median age...

see more →

Clinicaltrials.gov  97 results

p53 activation during ribosome biogenesis regulates normal erythroid differentiation.
https://doi.org/10.1182/blood.2019003439
Blood Le Goff S, Boussaid I et. al.

Aug 20th, 2020 - The role of ribosome biogenesis in erythroid development is supported by the recognition of erythroid defects in ribosomopathies in both Diamond-Blackfan anemia and 5q- syndrome. Whether ribosome biogenesis exerts a regulatory function on normal e...

Integrated analyses of translatome and proteome identify the rules of translation selec...
https://doi.org/10.3324/haematol.2019.239970
Haematologica Boussaid I, Le Goff S et. al.

Apr 24th, 2020 - In ribosomopathies, the Diamond-Blackfan anemia (DBA) or 5q- syndrome, ribosomal protein (RP) genes are affected by mutation or deletion, resulting in bone marrow erythroid hypoplasia. Unbalanced production of ribosomal subunits leading to a limit...

Loss of rps9 in Zebrafish Leads to p53-Dependent Anemia.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893189
G3 (Bethesda, Md.); Chen C, Huang H et. al.

Oct 17th, 2019 - Ribosome is a vital molecular machine for protein translation in the cell. Defects in several ribosomal proteins including RPS19, RPL11 and RPS14 have been observed in two types of anemia: Diamond Blackfan Anemia and 5q- syndrome. In zebrafish, de...

Rps14, Csnk1a1 and miRNA145/miRNA146a deficiency cooperate in the clinical phenotype an...
https://doi.org/10.1038/s41375-018-0350-3
Leukemia Ribezzo F, Snoeren IAM et. al.

Jan 17th, 2019 - RPS14, CSNK1A1, and miR-145 are universally co-deleted in the 5q- syndrome, but mouse models of each gene deficiency recapitulate only a subset of the composite clinical features. We analyzed the combinatorial effect of haploinsufficiency for Rps1...

Hematopoietic cell transplant for acute myeloid leukemia and myelodysplastic syndrome: ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113615
Blood Advances; Eapen M, Brazauskas R et. al.

Aug 23rd, 2018 - In this study, we sought to identify specific individual high-intensity or reduced-intensity conditioning regimens with the best relapse-free survival (RFS) rather than the global high- vs reduced-intensity regimen comparison. Patients (median age...

see more →